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    Sensor head for use with implantable devices
    4.
    发明授权
    Sensor head for use with implantable devices 有权

    公开(公告)号：US08509871B2

    公开(公告)日：2013-08-13

    申请号：US12260017

    申请日：2008-10-28

    申请人： Rathbun K. Rhodes ,  Mark A. Tapsak ,  James H. Brauker ,  Mark C. Shults

    发明人： Rathbun K. Rhodes ,  Mark A. Tapsak ,  James H. Brauker ,  Mark C. Shults

    IPC分类号： A61B5/05

    CPC分类号： G01N27/3272 ,  A61B5/14532 ,  A61B5/14865 ,  C12Q1/002 ,  C12Q1/006 ,  G01N33/48707 ,  G01N33/48785

    摘要： The present invention provides a sensor head for use in an implantable device that measures the concentration of an analyte in a biological fluid which includes: a non-conductive body; a working electrode, a reference electrode and a counter electrode, wherein the electrodes pass through the non-conductive body forming an electrochemically reactive surface at one location on the body and forming an electronic connection at another location on the body, further wherein the electrochemically reactive surface of the counter electrode is greater than the surface area of the working electrode; and a multi-region membrane affixed to the nonconductive body and covering the working electrode, reference electrode and counter electrode. In addition, the present invention provides an implantable device including at least one of the sensor heads of the invention and methods of monitoring glucose levels in a host utilizing the implantable device of the invention.

    SENSOR HEAD FOR USE WITH IMPLANTABLE DEVICES
    5.
    发明申请
    SENSOR HEAD FOR USE WITH IMPLANTABLE DEVICES 有权
    传感器头用于可移植设备

    公开(公告)号：US20090045055A1

    公开(公告)日：2009-02-19

    申请号：US12260017

    申请日：2008-10-28

    申请人： Rathbun K. Rhodes ,  Mark C. Shults ,  Mark A. Tapsak ,  James H. Brauker

    发明人： Rathbun K. Rhodes ,  Mark C. Shults ,  Mark A. Tapsak ,  James H. Brauker

    IPC分类号： G01N27/26

    CPC分类号： G01N27/3272 ,  A61B5/14532 ,  A61B5/14865 ,  C12Q1/002 ,  C12Q1/006 ,  G01N33/48707 ,  G01N33/48785

    摘要： The present invention provides a sensor head for use in an implantable device that measures the concentration of an analyte in a biological fluid which includes: a non-conductive body; a working electrode, a reference electrode and a counter electrode, wherein the electrodes pass through the non-conductive body forming an electrochemically reactive surface at one location on the body and forming an electronic connection at another location on the body, further wherein the electrochemically reactive surface of the counter electrode is greater than the surface area of the working electrode; and a multi-region membrane affixed to the nonconductive body and covering the working electrode, reference electrode and counter electrode. In addition, the present invention provides an implantable device including at least one of the sensor heads of the invention and methods of monitoring glucose levels in a host utilizing the implantable device of the invention.

    摘要翻译： 本发明提供了一种用于可植入装置的传感器头，其用于测量生物流体中分析物的浓度，其包括：非导电体; 工作电极，参考电极和对电极，其中电极穿过非导电体，其在身体的一个位置处形成电化学反应性表面，并在身体的另一位置形成电子连接，其中电化学反应性 对电极的表面大于工作电极的表面积; 以及附着在非导体上并覆盖工作电极，参比电极和对电极的多区域膜。 此外，本发明提供一种可植入装置，其包括本发明的至少一个传感器头和利用本发明的可植入装置监测主机中的葡萄糖水平的方法。

    Sensor head for use with implantable devices
    9.
    发明授权
    Sensor head for use with implantable devices 有权
    用于植入式设备的传感器头

    公开(公告)号：US07471972B2

    公开(公告)日：2008-12-30

    申请号：US11021162

    申请日：2004-12-22

    申请人： Rathbun Rhodes ,  Mark A. Tapsak ,  James H. Brauker ,  Mark C. Shults

    发明人： Rathbun Rhodes ,  Mark A. Tapsak ,  James H. Brauker ,  Mark C. Shults

    IPC分类号： A61B5/05

    CPC分类号： G01N27/3272 ,  A61B5/14532 ,  A61B5/14865 ,  C12Q1/002 ,  C12Q1/006 ,  G01N33/48707 ,  G01N33/48785

    摘要： The present invention provides a sensor head for use in an implantable device that measures the concentration of an analyte in a biological fluid which includes: a non-conductive body; a working electrode, a reference electrode and a counter electrode, wherein the electrodes pass through the non-conductive body forming an electrochemically reactive surface at one location on the body and forming an electronic connection at another location on the body, further wherein the electrochemically reactive surface of the counter electrode is greater than the surface area of the working electrode; and a multi-region membrane affixed to the nonconductive body and covering the working electrode, reference electrode and counter electrode. In addition, the present invention provides an implantable device including at least one of the sensor heads of the invention and methods of monitoring glucose levels in a host utilizing the implantable device of the invention.

    摘要翻译： 本发明提供了一种用于可植入装置的传感器头，其用于测量生物流体中分析物的浓度，其包括：非导电体; 工作电极，参考电极和对电极，其中电极穿过非导电体，其在身体的一个位置处形成电化学反应性表面，并在身体的另一位置形成电子连接，其中电化学反应性 对电极的表面大于工作电极的表面积; 以及附着在非导体上并覆盖工作电极，参比电极和对电极的多区域膜。 此外，本发明提供一种可植入装置，其包括本发明的至少一个传感器头和利用本发明的可植入装置监测主机中的葡萄糖水平的方法。

    Porous membranes for use with implantable devices
    10.
    发明授权
    Porous membranes for use with implantable devices 有权
    多孔膜用于可植入装置

    公开(公告)号：US08118877B2

    公开(公告)日：2012-02-21

    申请号：US11654135

    申请日：2007-01-17

    申请人： James H. Brauker ,  Mark A. Tapsak ,  Mark C. Shults

    发明人： James H. Brauker ,  Mark A. Tapsak ,  Mark C. Shults

    IPC分类号： A61F2/02

    CPC分类号： A61L31/146 ,  A61L31/10 ,  A61L31/14

    摘要： A membrane for implantation in soft tissue comprising a first domain that supports tissue ingrowth, disrupts contractile forces typically found in a foreign body response, encourages vascularity, and interferes with barrier cell layer formation, and a second domain that is resistant to cellular attachment, is impermeable to cells and cell processes, and allows the passage of analytes. The membrane allows for long-term analyte transport in vivo and is suitable for use as a biointerface for implantable analyte sensors, cell transplantation devices, drug delivery devices, and/or electrical signal delivering or measuring devices. The membrane architecture, including cavity size, depth, and interconnectivity, provide long-term robust functionality of the membrane in vivo.

    摘要翻译： 用于植入软组织中的膜包括支撑组织向内生长的第一结构域，破坏通常在异物反应中发现的收缩力，促进血管分布，并妨碍阻隔细胞层的形成，以及抵抗细胞附着的第二结构域是 对细胞和细胞过程不可渗透，并允许分析物通过。 该膜允许体内长期的分析物输送，并且适用于可植入分析物传感器，细胞移植装置，药物递送装置和/或电信号传递或测量装置的生物界面。 膜结构，包括腔体尺寸，深度和互连性，在体内提供膜的长期稳定的功能。