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    Transport System for Nanoparticles and Method for the Operation Thereof
    3.
    发明申请
    Transport System for Nanoparticles and Method for the Operation Thereof 失效
    纳米粒子运输系统及其运行方法

    公开(公告)号：US20080023087A1

    公开(公告)日：2008-01-31

    申请号：US11628498

    申请日：2005-06-08

    申请人： Jens Jensen ,  Ursus Kruger ,  Volkmar Luthen ,  Heike Schiewe

    发明人： Jens Jensen ,  Ursus Kruger ,  Volkmar Luthen ,  Heike Schiewe

    IPC分类号： F15B21/06

    CPC分类号： C23C14/246 ,  Y10T137/0391 ,  Y10T137/2082 ,  Y10T137/2191

    摘要： A transport system for dry nanoparticles (18b). According to the invention, the nanoparticles (18b) are magnetized or electrically charged for transportation, a magnetic or electrical field is produced by a field generator (20a, 20) in the transport channel, and the nanoparticles (18b) migrate through the transport channel (12). The nanoparticles can be discharged through a discharge opening (13) which enables dosing to take place. In order to agglomerate the nanoparticles (18b) or to prevent attachment onto the inner wall (26), a coating (27) of the wall can be offset in oscillations by piezo electric actuators (28), the oscillations being transferred to the nanoparticles (18b). The dry nanoparticles can be handled in an advantageous manner due to the transport system, such that the dry nanoparticles need not be treated as a suspension.

    摘要翻译： 干燥纳米颗粒的输送系统（18b）。 根据本发明，纳米颗粒（18b）被磁化或带电用于运输，磁场或电场由输送通道中的场发生器（20a，20）产生，并且纳米颗粒（18b）迁移通过 运输通道（12）。 纳米颗粒可以通过排出口（13）排出，这使得能够进行计量。 为了使纳米颗粒（18b）附聚或防止附着到内壁（26）上，壁的涂层（27）可以通过压电致动器（28）的摆动来偏移，振荡被转移到纳米颗粒 （18b）。 由于运输系统，干燥的纳米颗粒可以以有利的方式处理，使得干燥的纳米颗粒不需要被视为悬浮液。

    Method, system and software arrangement, for measuring magnetic field correlation
    5.
    发明申请
    Method, system and software arrangement, for measuring magnetic field correlation 有权
    方法，系统和软件安排，用于测量磁场相关性

    公开(公告)号：US20060160242A1

    公开(公告)日：2006-07-20

    申请号：US10564697

    申请日：2004-07-08

    申请人： Jens Jensen ,  Joseph Helpern ,  Glyn Johnson ,  Ramesh Chandra

    发明人： Jens Jensen ,  Joseph Helpern ,  Glyn Johnson ,  Ramesh Chandra

    IPC分类号： G01N24/00

    CPC分类号： G01R33/50 ,  G01R33/56341 ,  G01R33/56536 ,  Y10T436/24

    摘要： Methods, systems, software arrangements and storage medium for measuring the magnetic field correlation function (“MFC”), and more particularly, to methods for measuring the magnetic field correlation function utilizing asymmetric spin echoes. Asymmetric Dual Spin Echo Sequences (“ADSE”) and Echo Planar Imaging Asymmetric Dual Spin Echo Sequences (“EPI-ADSE”) may be employed to apply multiple echoes to a sample and acquire data from which the MFC may be determined.

    摘要翻译： 用于测量磁场相关函数（“MFC”）的方法，系统，软件布置和存储介质，更具体地说，涉及利用非对称自旋回波测量磁场相关函数的方法。 可以采用非对称双自旋回波序列（“ADSE”）和回波平面成像不对称双自旋回波序列（“EPI-ADSE”）将多个回波应用于样本，并获取可以确定MFC的数据。

    Open unipolar magnetic structure
    6.
    发明授权
    Open unipolar magnetic structure 失效
    开放单极磁结构

    公开(公告)号：US06265959B1

    公开(公告)日：2001-07-24

    申请号：US09069389

    申请日：1998-04-29

    申请人： Manlio G. Abele ,  Jens Jensen ,  Henry Rusinek

    发明人： Manlio G. Abele ,  Jens Jensen ,  Henry Rusinek

    IPC分类号： H01F500

    CPC分类号： H01F7/0278 ,  G01R33/3806 ,  G01R33/383

    摘要： A magnetic structure generating a uniform magnetic field within a region of interest using permanently magnetized prism-shaped blocks of magnetic material positioned around a cavity and which constitute the predominant generator of the uniform magnetic field in the desired region of interest. The magnetic structure has a plane surface comprising a high permeability ferromagnetic member interfacing with a first side of the cavity and forming a single pole piece of the magnetic structure. The magnetic structure produces within the cavity adjacent the single pole piece the uniform magnetic field and collects the magnetic flux flowing through the single pole piece and through the cavity, with the region of interest being located adjacent the single pole piece. A second side of the cavity generally opposite to the first side is open to a surrounding medium and forms an interface with the surrounding medium but not with a magnetic member. The magnetic structure is designed assuming a hypothetical high permeability membrane parallel to the single pole piece and located where the open second side of the cavity will be made, the high permeability membrane forming an equipotential surface at the interface with the surrounding medium. This minimizes the fringe field generated in the surrounding medium when the second side of the cavity is opened.

    摘要翻译： 一种磁性结构，其在感兴趣的区域内使用位于空腔周围的永久磁化的棱柱形磁性材料块产生均匀磁场，并且构成所需感兴趣区域中均匀磁场的主要发生器。 磁性结构具有包括与空腔的第一侧接合的高磁导率铁磁构件的平面，并形成磁结构的单极片。 磁性结构在与单极片相邻的腔内产生均匀的磁场，并收集流过单极片并通过腔的磁通量，感兴趣区域位于单极片附近。 大致与第一侧相对的空腔的第二侧对周围的介质是开放的，并与周围的介质形成界面而不与磁性构件形成界面。 磁性结构被设计为假设与单极片平行的假想高渗透膜，并且位于将形成空腔的开口第二侧的位置，高渗透膜在与周围介质的界面处形成等电位面。 当空腔的第二侧被打开时，这最小化周围介质中产生的边缘场。

    Generation of highly uniform magnetic fields with magnetized wedges
    7.
    发明授权
    Generation of highly uniform magnetic fields with magnetized wedges 失效
    用磁化楔形成高度均匀的磁场

    公开(公告)号：US06225887B1

    公开(公告)日：2001-05-01

    申请号：US08885095

    申请日：1997-06-30

    申请人： Jens Jensen ,  Manlio G. Abele ,  Henry Rusinek

    发明人： Jens Jensen ,  Manlio G. Abele ,  Henry Rusinek

    IPC分类号： H01F702

    CPC分类号： G01R33/3808 ,  G01R33/383 ,  H01F7/0278

    摘要： A magnetic structure generating a substantially uniform magnetic field within a region of interest using permanently magnetized wedge-shaped blocks of magnetic material. In a preferred embodiment, the permanently magnetized wedge-shaped blocks are provided in pairs positioned on opposite sides of the x z plane of an arbitrary x,y,z coordinate system, and each of the blocks are magnetized in certain directions. The uniform field is created in the vicinity of the z axis. In another embodiment, the parts of the structure below the x-axis are replaced by a high-permeability, soft magnetic plate to form a so-called mirror system. In still another embodiment, permanently magnetized blocks positioned outside of the wedge-shaped blocks are employed as the main compensation means for field distortions arising from the practical need to truncate the wedge-shaped blocks to a practical size. An important application for the magnetic structure of the invention is MRI, as it can be configured as an open structure accessible to medical intervention during the MRI.

    摘要翻译： 一种使用永久磁化的楔形磁性材料块在感兴趣区域内产生基本上均匀的磁场的磁性结构。 在优选实施例中，永久磁化的楔形块成对地设置成位于任意x，y，z坐标系的x z平面的相对侧上，并且每个块在某些方向被磁化。 在z轴附近产生均匀场。 在另一个实施例中，x轴下方的结构部分由高磁导率软磁性板替代，形成所谓的反射镜系统。 在另一个实施例中，位于楔形块之外的永久磁化块被用作由实际需要将楔形块截截到实际尺寸而产生的场失真的主要补偿装置。 本发明的磁性结构的重要应用是MRI，因为其可以被配置为在MRI期间医学干预可接近的开放结构。

    Strapped open magnetic structure
    8.
    发明授权
    Strapped open magnetic structure 失效
    带状开放磁结构

    公开(公告)号：US5798680A

    公开(公告)日：1998-08-25

    申请号：US613756

    申请日：1996-02-26

    申请人： Manlio G. Abele ,  Henry Rusinek ,  Jens Jensen

    发明人： Manlio G. Abele ,  Henry Rusinek ,  Jens Jensen

    IPC分类号： A61B5/055 ,  G01R33/38 ,  G01R33/383 ,  H01F7/02

    CPC分类号： H01F7/0278 ,  G01R33/3806 ,  G01R33/383

    摘要： Strapped open magnetic structure, particularly useful in nuclear magnetic resonance imaging applications, which provides a substantially uniform magnetic field within a region of interest while allowing access by a surgeon to a patient via an opening at the top of the magnetic structure. The magnetic structure comprises nested inner and outer magnetic structures separated by ferromagnetic material or pole pieces and surrounded by a ferromagnetic yoke. The structure contains one or more thin layers or straps of high magnetic permeability material aligned substantially along equipotential surface(s) of an associated closed magnetic structure of ideal properties. Structures and techniques are also provided for replacing thick, heavy blocks of ferromagnetic material with thin straps and for extending the magnetostatic potential of a component in a magnetic structure by connecting a thin strap thereto and embedding the strap in the magnetic structure along an equipotential surface of the magnetic field generated by the magnetic structure.

    摘要翻译： 带状的开放式磁结构，特别适用于核磁共振成像应用，其在感兴趣区域内提供基本均匀的磁场，同时允许外科医生通过磁性结构顶部的开口进入患者。 磁性结构包括由铁磁材料或极片分离并被铁磁轭环绕的嵌套的内部和外部磁性结构。 该结构包含一个或多个基本上沿着理想特性的关联闭合磁性结构的等电位表面排列的薄磁层或高磁导率材料带。 还提供了结构和技术，用于用薄带替代厚厚的强磁性材料块，并且通过将薄带连接到其上并通过将薄带连接到磁性结构中并将带嵌入磁性结构中，从而将组件的静磁电位延伸到磁性结构中 由磁性结构产生的磁场。

    System, Method and Computer Accessible Medium for Providing Real-Time Diffusional Kurtosis Imaging and for Facilitating Estimation of Tensors and Tensor- Derived Measures in Diffusional Kurtosis Imaging
    10.
    发明申请
    System, Method and Computer Accessible Medium for Providing Real-Time Diffusional Kurtosis Imaging and for Facilitating Estimation of Tensors and Tensor- Derived Measures in Diffusional Kurtosis Imaging 有权
    系统，方法和计算机可访问介质，用于提供实时扩散性血液饱和成像和促进传感器估计和弥漫性高血压成像中的传感器测量

    公开(公告)号：US20120002851A1

    公开(公告)日：2012-01-05

    申请号：US13022488

    申请日：2011-02-07

    申请人： Jens Jensen ,  Joseph Helpern ,  Ali Tabesh ,  Els Fieremans

    发明人： Jens Jensen ,  Joseph Helpern ,  Ali Tabesh ,  Els Fieremans

    IPC分类号： G06K9/00

    CPC分类号： G01R33/56341

    摘要： Exemplary method, system, and computer-accessible medium can be provided for determining a measure of diffusional kurtosis by receiving data relating to at least one diffusion weighted image, and determining a measure of a diffusional kurtosis as a function of the received data using a closed form solution procedure. In accordance with certain exemplary embodiments of the present disclosure, provided herein are computer-accessible medium, systems and methods for, e.g., imaging in an MRI system, and, more particularly for facilitating estimation of tensors and tensor-derived measures in diffusional kurtosis imaging (DKI). For example, DKI can facilitate a characterization of non-Gaussian diffusion of water molecules in biological tissues. The diffusion and kurtosis tensors parameterizing the DKI model can typically be estimated via unconstrained least squares (LS) methods. In the presence of noise, motion, and imaging artifacts, these methods can be prone to producing physically and/or biologically implausible tensor estimates. The exemplary embodiments of the present disclosure can address at least this deficiency by formulating an exemplary estimation problem, e.g., as linearly constrained linear LS, where the constraints can ensure acceptable tensor estimates.

    摘要翻译： 可以提供示例性方法，系统和计算机可访问介质，用于通过接收与至少一个扩散加权图像相关的数据来确定扩散峰度的度量，并且使用闭合的方法确定作为接收数据的函数的扩散峰度的度量 形式解决程序。 根据本公开的某些示例性实施例，本文提供了用于例如在MRI系统中成像的计算机可访问介质，系统和方法，并且更具体地，用于促进扩散峭度成像中的张量和张量导出测量的估计 （DKI）。 例如，DKI可以促进水分子在生物组织中的非高斯扩散的表征。 参数化DKI模型的扩散和峰度张量通常可以通过非约束最小二乘法（LS）方法估计。 在存在噪声，运动和成像伪像的情况下，这些方法可能容易产生物理和/或生物学不可信的张量估计。 本公开的示例性实施例可以通过制定示例性估计问题（例如线性约束线性LS）来解决至少该缺陷，其中约束可以确保可接受的张量估计。