公开(公告)号：US06188474B1

公开(公告)日：2001-02-13

申请号：US09310552

申请日：1999-05-12

申请人： Richard A. Dussault ,  William R. Eppes ,  Ronald S. Scharlack

发明人： Richard A. Dussault ,  William R. Eppes ,  Ronald S. Scharlack

IPC分类号： G01N2103

CPC分类号： G01N21/0303 ,  G01N21/05 ,  G01N2021/0346

摘要： A sample cell for use in spectroscopy includes two cell portions that are mutually adjustable to enable a user to vary the cross sectional geometry of sample cell flow path thereof between at least two discrete configurations or positions. In a first position, the flow path may be provided with a relatively small cross-sectional area to provide a relatively small pathlength and generate high velocity fluid flow therethrough. The small pathlength enables use of relatively small sample volumes and facilitates optical measurement of samples, such as blood, which have relatively high optical density, absorbance or light scattering properties. In a second position, the flow path provides a larger cross-section adapted to permit larger agglomerations or clots to pass through the flow path to facilitate cleaning of the sample cell. The cell portions are maintained in slidable engagement with one another so that the adjustability of the flow path is accomplished by sliding movement of the cell portions relative to one another. In one embodiment, the cell portions are engaged along generally planar mating surfaces and the adjustability is accomplished by sliding the mating surfaces relative to one another. In another embodiment, the mating surfaces are superposed in spaced relation to one another, and the adjustability is accomplished by varying the distance therebetween.

摘要翻译： 用于光谱学的样品池包括相互可调节的两个单元部分，以使用户能够在至少两个离散构造或位置之间改变其样品池流动路径的横截面几何形状。 在第一位置，流动路径可以设置有相对小的横截面面积，以提供相对小的路径长度并且产生通过其中的高速流体流动。 小光程可以使用相对小的样品体积，并且便于对具有相对高的光密度，吸光度或光散射性质的样品（例如血液）进行光学测量。 在第二位置，流动路径提供更大的横截面，其适于允许更大的聚集或凝块通过流动路径以便于清洁样品池。 电池部分保持彼此滑动接合，使得流动路径的可调节性通过电池部分相对于彼此的滑动来实现。 在一个实施例中，细胞部分沿着大致平面的配合表面接合，并且可调节性通过相对于彼此滑动配合表面来实现。 在另一个实施例中，配合表面彼此间隔开地重叠，并且通过改变它们之间的距离来实现可调节性。

公开(公告)号：US5372782A

公开(公告)日：1994-12-13

申请号：US891553

申请日：1992-05-29

申请人： Peter N. Karkantis ,  Beat R. Degen ,  Richard A. Dussault ,  Richard L. Schulkind ,  Norman K. Parker

发明人： Peter N. Karkantis ,  Beat R. Degen ,  Richard A. Dussault ,  Richard L. Schulkind ,  Norman K. Parker

IPC分类号： G01N1/00 ,  G01N1/10 ,  G01N30/18 ,  G01N30/24 ,  G01N35/00 ,  G01N35/02 ,  G01N35/10 ,  G01N33/48

CPC分类号： G01N35/10 ,  G01N2030/185 ,  G01N2035/00237 ,  G01N2035/00277 ,  G01N30/24 ,  G01N35/1004 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/119163 ,  Y10T436/2575

摘要： A novel fluid sampling device has been developed. This device provides for sample entry to be handled automatically by the instrument, thus allowing the operator to be involved in other activities while the sampling process is underway. It also assures reproduceable sample size, automatically cleans the sampling device between samples, and reduces the risk of user injury. Furthermore, the sampling system allows for the use of any forseeable collection mechanism.

摘要翻译： 已经开发了一种新颖的流体取样装置。 该设备提供样品输入，由仪器自动处理，从而允许操作人员在采样过程中参与其他活动。 它还保证可重复的样品量，自动清洗样品之间的取样装置，并降低用户受伤的风险。 此外，采样系统允许使用任何可预见的收集机制。

公开(公告)号：US5391499A

公开(公告)日：1995-02-21

申请号：US158107

申请日：1993-11-24

申请人： Peter N. Karkantis ,  Beat R. Degen ,  Richard A. Dussault ,  Richard L. Schulkind ,  Norman K. Parker

发明人： Peter N. Karkantis ,  Beat R. Degen ,  Richard A. Dussault ,  Richard L. Schulkind ,  Norman K. Parker

IPC分类号： G01N1/00 ,  G01N1/10 ,  G01N30/18 ,  G01N30/24 ,  G01N35/00 ,  G01N35/02 ,  G01N35/10 ,  G01N33/48

CPC分类号： G01N35/10 ,  G01N2030/185 ,  G01N2035/00237 ,  G01N2035/00277 ,  G01N30/24 ,  G01N35/1004 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/119163 ,  Y10T436/2575

摘要： A novel fluid sampling device has been developed. This device provides for sample entry to be handled automatically by the instrument, thus allowing the operator to be involved in other activities while the sampling process is underway. It also assures reproduceable sample size, automatically cleans the sampling device between samples, and reduces the risk of user injury. Furthermore, the sampling system allows for the use of any forseeable collection mechanism.

摘要翻译： 已经开发了一种新颖的流体取样装置。 该设备提供样品输入，由仪器自动处理，从而允许操作人员在采样过程中参与其他活动。 它还保证可重复的样品量，自动清洗样品之间的取样装置，并降低用户受伤的风险。 此外，采样系统允许使用任何可预见的收集机制。

公开(公告)号：US5261415A

公开(公告)日：1993-11-16

申请号：US729509

申请日：1991-07-12

申请人： Richard A. Dussault

发明人： Richard A. Dussault

IPC分类号： A61B5/083 ,  G01N21/35 ,  A61B5/08

CPC分类号： A61B5/0836 ,  G01N21/3504 ,  A61B5/7242

摘要： A capnography system has a 4.2 micron LED emitter of narrow-band radiation having a center wavelength very close to the 4.26 micron absorption band of CO.sub.2 breathing gas in a breathing tube. The radiation passes through windows in an insert in the breathing passage between the LED source and an infrared detector in an opposite side of the insert. A mirror is optionally placed in the opposite wall to reflect the radiation back to the detector which is then placed on the same side as the emitter. The LED emitter is pulsed at a low frequency repetition rate with a regulated voltage from a power supply. The detector output is applied to processing electronics which includes amplification and dual integrators that integrate the detector output on two signal paths, one the integration of each pulse and the other the integration of detector background with the two differences to provide self calibration against drift and noise. A heater heats the emitter, infrared detector, local electronics and the windows thereby stabilizing these temperature sensitive components to minimize the measured CO.sub.2 value error to a few mm of mercury and to prevent condensation on the insert particularly in the windows. A second emitter is optionally used as a reference and/or to detect additional gas concentrations.

摘要翻译： 二氧化碳监测系统具有4.2微米窄带辐射的LED发射器，其中心波长非常接近呼吸管中CO 2呼吸气体的4.26微米吸收带。 辐射穿过位于插入件相对侧的LED源和红外检测器之间的呼吸通道中的插入物中的窗口。 镜子可选地放置在相对的壁中以将辐射反射回检测器，然后将检测器放置在与发射器相同的一侧。 LED发射器以来自电源的稳压电压以低频重复率脉冲。 检测器输出应用于处理电子设备，包括放大和双积分器，将检测器输出集成在两个信号路径上，一个是每个脉冲的集成，另一个集成检测器背景与两个差异，以提供对漂移和噪声的自校准 。 加热器加热发射器，红外探测器，本地电子设备和窗户，从而稳定这些温度敏感组件，以将测得的二氧化碳值误差最小化为几毫米汞柱，并防止特别是在窗户中的插入物上的冷凝。 任选地使用第二发射体作为参考和/或检测另外的气体浓度。

公开(公告)号：US5421189A

公开(公告)日：1995-06-06

申请号：US184315

申请日：1994-01-21

申请人： Richard A. Dussault

发明人： Richard A. Dussault

IPC分类号： G01N27/26 ,  G01N27/28 ,  G01N33/00 ,  H01R13/648 ,  H01R13/66 ,  H01R13/703 ,  H01R29/00 ,  G01N27/00

CPC分类号： H01R29/00 ,  G01N33/007 ,  H01R13/7033 ,  H01R13/648 ,  H01R13/66

摘要： An electrochemical/gas analyzer providing a rugged contact system for removable sensors capable of withstanding inexpert sensor insertion or removal, providing protection for high impedance input electronics against electrostatic discharge (ESD) damage, and providing automatic connection to diagnostic circuitry upon sensor removal has been developed. The contact system includes a plurality of stamped contacts electrically connecting a diagnostic circuit, including a source of diagnostic signals and a ground path, to analyzer signal processing circuitry. Removal of a sensor from this system electrically connects the sensor signal processing electronics to the diagnostic circuit. Insertion of the sensor interrupts electrical connection between the diagnostic circuit and the stamped contact, which connects the sensor terminals to the signal processing circuitry.

摘要翻译： 一种电化学/气体分析仪，为可移动传感器提供坚固的接触系统，能够承受最差的传感器插入或移除，为防止静电放电（ESD）损坏的高阻抗输入电路提供保护，并且开发了传感器去除后自动连接诊断电路 。 接触系统包括多个冲压接点，将包括诊断信号源和接地路径的诊断电路电连接到分析器信号处理电路。 从该系统中去除传感器将传感器信号处理电子器件电连接到诊断电路。 传感器的插入会中断诊断电路和冲压触点之间的电气连接，将触点连接到信号处理电路。

公开(公告)号：US4414197A

公开(公告)日：1983-11-08

申请号：US360119

申请日：1982-03-19

申请人： Richard A. Dussault

发明人： Richard A. Dussault

IPC分类号： G01N1/28 ,  G02B21/34

CPC分类号： G01N1/28 ,  G02B21/34 ,  Y10T436/25375

摘要： Methods and apparatus wherein a very small number of sorted cells are attached to specified locations on a microscope slide circumscribed by well areas of a retainer slip. The cells are deposited in the wells and during centrifugation of the slide-retainer sandwich, are contacted with and attached to the serum albumin present in the well and coated on the slide. Removal of excess fluids, optional clamping means and the retainer slip followed by air drying provides for permanent attachment of rare, sorted cells in a localized, known area for subsequent staining, examination and analysis.

摘要翻译： 方法和装置，其中非常少数量的分选细胞附着在由保持器滑移的井区限定的显微镜载玻片上的指定位置。 将细胞沉积在孔中，并且在滑动保持器夹心物的离心过程中，与存在于孔中的血清白蛋白接触并连接到载玻片上。 去除多余的液体，可选择的夹紧装置和保持器滑动随后进行空气干燥，可将罕见的分类细胞永久性附着在局部的已知区域中，用于随后的染色，检查和分析。

公开(公告)号：US4317520A

公开(公告)日：1982-03-02

申请号：US68112

申请日：1979-08-20

申请人： Igino Lombardo ,  Richard A. Dussault

发明人： Igino Lombardo ,  Richard A. Dussault

IPC分类号： G01N15/14 ,  B07C5/342

CPC分类号： G01N15/1404 ,  G01N2015/1406 ,  G01N2015/149 ,  Y10S209/906

摘要： A novel method and system are disclosed for detecting the breakpoint of a perturbed flow stream. The scattering and extinction of light caused by a perturbed stream at a preselected flow stream sensing point therealong is measured to produce a real time waveform proportional thereto. The real time waveform is differentiated to produce a differentiated waveform, which is then selectively monitored to distinguish a waveform exhibiting substantially three (positive and negative) peaks per cycle, whereby such detection indicates that at least a portion of the breakpoint region of said flow stream corresponds with said flow stream sensing point. In order to align the stream sensing point with respect to a preselected point within the breakpoint region of the flow stream, the breakpoint region of the stream is caused to move with respect to the stream sensing point until the breakpoint pulse width of one of the peaks corresponds with a preselected pulse width reference.

摘要翻译： 公开了一种用于检测扰动流动流的断点的新颖方法和系统。 被测量在预选流动流感测点处的扰动流引起的光的散射和消光以产生与其成比例的实时波形。 差分实时波形以产生微分波形，然后选择性地监测该波形，以便区分每个周期基本上呈现三个（正和负）峰值的波形，由此这种检测指示所述流动流的断点区域的至少一部分 对应于所述流动流感测点。 为了使流感测点相对于流动流的断点区域内的预选点对准，使流的断点区域相对于流感测点移动，直到其中一个峰值的断点脉冲宽度 对应于预选的脉冲宽度参考。