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公开(公告)号：US20070044163A1
公开(公告)日：2007-02-22
申请号：US10558800
申请日：2004-06-21
申请人： Richard Fagan , Yolande Chvatchko , Alex Gutteridge , Christine Power , Ursula Boschert , Christopher Phelps
发明人： Richard Fagan , Yolande Chvatchko , Alex Gutteridge , Christine Power , Ursula Boschert , Christopher Phelps
CPC分类号： G01N33/6866 , A61K38/00 , G01N33/74 , Y02A50/412
摘要： This invention relates to a novel protein, termed INSP101, herein identified as a novel splice variant of human pituitary growth hormone and to the use of this protein and nucleic acid sequence from the encoding genes in the diagnosis, prevention, and treatment of disease.
摘要翻译： 本发明涉及一种称为INSP101的新型蛋白质，在本文中被鉴定为人垂体生长激素的新型剪接变体，以及来自编码基因的该蛋白质和核酸序列在疾病的诊断，预防和治疗中的用途。
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公开(公告)号：US20060252117A1
公开(公告)日：2006-11-09
申请号：US10539847
申请日：2003-12-23
申请人： Richard Fagan , Christopher Phelps , Christine Power , Richard Mitter , Ursula Boschert , Yolande Chvatchko
发明人： Richard Fagan , Christopher Phelps , Christine Power , Richard Mitter , Ursula Boschert , Yolande Chvatchko
CPC分类号： C12N9/6489 , C12N15/52
摘要： This invention relates to proteins termed INSPOO5a and INSPOO5b, herein identified as secreted proteins, in particular members of the metalloprotease family and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention, and treatment of disease.
摘要翻译： 本发明涉及称为INSPOO5a和INSPOO5b的蛋白质，这里鉴定为分泌蛋白质，特别是金属蛋白酶家族的成员，以及来自编码基因的这些蛋白质和核酸序列在诊断，预防和治疗疾病中的用途。
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公开(公告)号：US20050112618A1
公开(公告)日：2005-05-26
申请号：US10872859
申请日：2004-06-21
CPC分类号： C07K14/5759 , A01K2217/075 , A61K38/00 , A61K39/00 , C07K14/52 , Y02A50/412
摘要： This invention relates to novel protein INSP037, herein identified as a member of the four helical bundle cytokine family and to the use of this protein and the nucleic acid sequence from the encoding gene in the diagnosis, prevention and treatment of disease.
摘要翻译： 本发明涉及本文鉴定为四螺旋束细胞因子家族的成员的新型蛋白质INSP037以及该蛋白质的用途和来自编码基因的核酸序列在疾病的诊断，预防和治疗中的用途。
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公开(公告)号：US20050106679A1
公开(公告)日：2005-05-19
申请号：US10872598
申请日：2004-06-21
IPC分类号： A01K67/027 , A61K31/7088 , A61K35/12 , A61K35/76 , A61K38/00 , A61K39/00 , A61K45/00 , A61K48/00 , A61P1/00 , A61P1/04 , A61P1/16 , A61P1/18 , A61P3/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P7/00 , A61P7/02 , A61P7/06 , A61P9/00 , A61P9/04 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/00 , A61P15/08 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/00 , A61P19/02 , A61P19/06 , A61P19/08 , A61P19/10 , A61P21/00 , A61P21/04 , A61P25/00 , A61P25/28 , A61P27/02 , A61P27/16 , A61P29/00 , A61P31/00 , A61P31/04 , A61P31/12 , A61P31/18 , A61P31/22 , A61P33/06 , A61P35/00 , A61P35/02 , A61P37/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P39/00 , A61P39/02 , A61P43/00 , C07H21/04 , C07K14/52 , C07K14/57 , C07K14/575 , C07K14/705 , C07K16/18 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/00 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566
CPC分类号： C07K14/52 , A01K2217/075 , A61K38/00 , A61K39/00 , C07K14/5759 , Y02A50/412
摘要： This invention relates to novel protein INSP035, herein identified as a member of the four helical bundle cytokine family and to the use of this protein and the nucleic acid sequence from the encoding gene in the diagnosis, prevention and treatment of disease.
摘要翻译： 本发明涉及新型蛋白质INSP035，本文中鉴定为四螺旋束细胞因子家族的成员，以及该蛋白质的使用和编码基因的核酸序列在疾病的诊断，预防和治疗中的用途。
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公开(公告)号：US07622555B2
公开(公告)日：2009-11-24
申请号：US10706691
申请日：2003-11-12
申请人： Andrew Robert Davids , Richard Joseph Fagan , Christopher Benjamin Phelps , Christine Power , Yolande Chvatchko , Ursula Boschert
发明人： Andrew Robert Davids , Richard Joseph Fagan , Christopher Benjamin Phelps , Christine Power , Yolande Chvatchko , Ursula Boschert
CPC分类号： C07K14/70503
摘要： This invention relates to a novel protein (INSP052), herein identified as an immunoglobulin domain-containing cell surface recognition molecule and to the use of this proteins and nucleic acid sequences from the encoding gene in the diagnosis, prevention and treatment of disease. The invention also relates to the identification of the extracellular domain of INSP052.
摘要翻译： 本发明涉及本文鉴定为含有免疫球蛋白结构域的细胞表面识别分子的新型蛋白质（INSP052），以及来自编码基因的该蛋白质和核酸序列在诊断，预防和治疗疾病中的用途。 本发明还涉及INSP052细胞外结构域的鉴定。
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公开(公告)号：US07557079B2
公开(公告)日：2009-07-07
申请号：US10539847
申请日：2003-12-23
申请人： Richard Joseph Fagan , Christopher Benjamin Phelps , Christine Power , Richard James Mitter , Ursula Boschert , Yolande Chvatchko
发明人： Richard Joseph Fagan , Christopher Benjamin Phelps , Christine Power , Richard James Mitter , Ursula Boschert , Yolande Chvatchko
CPC分类号： C12N9/6489 , C12N15/52
摘要： This invention relates to proteins termed INSP005a and INSP005b, herein identified as secreted proteins, in particular members of the metalloprotease family and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention, and treatment of disease.
摘要翻译： 本发明涉及称为INSP005a和INSP005b的蛋白质，在本文中鉴定为分泌蛋白质，特别是金属蛋白酶家族的成员，以及来自编码基因的这些蛋白质和核酸序列在诊断，预防和治疗疾病中的用途。
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公开(公告)号：US20050042731A1
公开(公告)日：2005-02-24
申请号：US10873332
申请日：2004-06-21
IPC分类号： A01K67/027 , A61K31/7088 , A61K35/12 , A61K35/76 , A61K38/00 , A61K39/00 , A61K45/00 , A61K48/00 , A61P1/00 , A61P1/04 , A61P1/16 , A61P1/18 , A61P3/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P7/00 , A61P7/02 , A61P7/06 , A61P9/00 , A61P9/04 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/00 , A61P15/08 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/00 , A61P19/02 , A61P19/06 , A61P19/08 , A61P19/10 , A61P21/00 , A61P21/04 , A61P25/00 , A61P25/28 , A61P27/02 , A61P27/16 , A61P29/00 , A61P31/00 , A61P31/04 , A61P31/12 , A61P31/18 , A61P31/22 , A61P33/06 , A61P35/00 , A61P35/02 , A61P37/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P39/00 , A61P39/02 , A61P43/00 , C07H21/04 , C07K14/52 , C07K14/57 , C07K14/575 , C07K14/705 , C07K16/18 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/00 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566
CPC分类号： C07K14/52 , A01K2217/075 , A61K38/00 , A61K39/00 , C07K14/5759 , Y02A50/412
摘要： This invention relates to novel proteins (INSP032, INSP033, INSP034, INSP036, INSP038), herein identified as members of the four helical bundle cytokine family and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.
摘要翻译： 本发明涉及本文鉴定为四螺旋束细胞因子家族的成员的新型蛋白质（INSP032，INSP033，INSP034，INSP036，INSP038）以及来自编码基因的这些蛋白质和核酸序列在诊断，预防和 治疗疾病。
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8.发明授权Method of treatment comprising administration of a cytokine antagonist molecule 失效包括给予细胞因子拮抗剂分子的治疗方法公开(公告)号：US07803383B2
公开(公告)日：2010-09-28
申请号：US10579113
申请日：2004-11-12
申请人： Richard Joseph Fagan , Andrew Robert Davids , Christopher Benjamin Phelps , Christine Power , Ursula Boschert , Yolande Chvatchko
发明人： Richard Joseph Fagan , Andrew Robert Davids , Christopher Benjamin Phelps , Christine Power , Ursula Boschert , Yolande Chvatchko
IPC分类号： A61K39/00 , A61K39/395 , C07K14/00
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/10 , C07K2319/30 , Y02A50/401
摘要： This invention relates to novel uses of a protein sequence (INSP052EC), herein identified as an immunoglobulin domain-containing cell surface recognition, in the diagnosis, prevention and treatment of diseases, in particular those related to the excessive expression and/or secretion of cytokines.
摘要翻译： 本发明涉及本文鉴定为含有免疫球蛋白结构域的细胞表面识别的蛋白质序列（INSP052EC）在疾病的诊断，预防和治疗中的新用途，特别是与细胞因子的过度表达和/或分泌相关的那些 。
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公开(公告)号：US20080025951A1
公开(公告)日：2008-01-31
申请号：US10579113
申请日：2004-11-12
申请人： Richard Joseph Fagan , Andrew Robert Davids , Christopher Benjamin Phelps , Christine Power , Ursula Boschert , Yolande Chvatchko
发明人： Richard Joseph Fagan , Andrew Robert Davids , Christopher Benjamin Phelps , Christine Power , Ursula Boschert , Yolande Chvatchko
IPC分类号： A61K38/16 , A01K67/00 , A61K48/00 , A61P31/12 , C07H21/00 , C12N1/00 , C12N15/63 , C07K14/00 , A61P37/00 , A61P17/00 , A61K31/7088
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/10 , C07K2319/30 , Y02A50/401
摘要： This invention relates to novel uses of a protein sequence (INSP052EC), herein identified as an immunoglobulin domain-containing cell surface recognition, in the diagnosis, prevention and treatment of diseases, in particular those related to the excessive expression and/or secretion of cytokines.
摘要翻译： 本发明涉及本文鉴定为含有免疫球蛋白结构域的细胞表面识别的蛋白质序列（INSP052EC）在疾病的诊断，预防和治疗中的新用途，特别是与细胞因子的过度表达和/或分泌相关的那些 。
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公开(公告)号：US20070128600A1
公开(公告)日：2007-06-07
申请号：US10534242
申请日：2003-11-07
CPC分类号： C07K14/8107
摘要： This invention relates to a protein, termed INSP097, herein identified as a member of the alpha macroglobulin family, in particular as an alpha-2-macroglobulin-like proteinase inhibitor, and to the use of this protein and nucleic acid sequences from the encoding gene in the diagnosis, prevention and treatment of disease.
摘要翻译： 本发明涉及一种称为INSP097的蛋白质，其在本文中被鉴定为α巨球蛋白家族的成员，特别是作为α-2-巨球蛋白样蛋白酶抑制剂，以及该编码基因使用该蛋白质和核酸序列 在诊断，预防和治疗疾病。
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