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公开(公告)号:US20070044163A1
公开(公告)日:2007-02-22
申请号:US10558800
申请日:2004-06-21
申请人: Richard Fagan , Yolande Chvatchko , Alex Gutteridge , Christine Power , Ursula Boschert , Christopher Phelps
发明人: Richard Fagan , Yolande Chvatchko , Alex Gutteridge , Christine Power , Ursula Boschert , Christopher Phelps
CPC分类号: G01N33/6866 , A61K38/00 , G01N33/74 , Y02A50/412
摘要: This invention relates to a novel protein, termed INSP101, herein identified as a novel splice variant of human pituitary growth hormone and to the use of this protein and nucleic acid sequence from the encoding genes in the diagnosis, prevention, and treatment of disease.
摘要翻译: 本发明涉及一种称为INSP101的新型蛋白质,在本文中被鉴定为人垂体生长激素的新型剪接变体,以及来自编码基因的该蛋白质和核酸序列在疾病的诊断,预防和治疗中的用途。
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公开(公告)号:US20060252117A1
公开(公告)日:2006-11-09
申请号:US10539847
申请日:2003-12-23
申请人: Richard Fagan , Christopher Phelps , Christine Power , Richard Mitter , Ursula Boschert , Yolande Chvatchko
发明人: Richard Fagan , Christopher Phelps , Christine Power , Richard Mitter , Ursula Boschert , Yolande Chvatchko
CPC分类号: C12N9/6489 , C12N15/52
摘要: This invention relates to proteins termed INSPOO5a and INSPOO5b, herein identified as secreted proteins, in particular members of the metalloprotease family and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention, and treatment of disease.
摘要翻译: 本发明涉及称为INSPOO5a和INSPOO5b的蛋白质,这里鉴定为分泌蛋白质,特别是金属蛋白酶家族的成员,以及来自编码基因的这些蛋白质和核酸序列在诊断,预防和治疗疾病中的用途。
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公开(公告)号:US20050042731A1
公开(公告)日:2005-02-24
申请号:US10873332
申请日:2004-06-21
IPC分类号: A01K67/027 , A61K31/7088 , A61K35/12 , A61K35/76 , A61K38/00 , A61K39/00 , A61K45/00 , A61K48/00 , A61P1/00 , A61P1/04 , A61P1/16 , A61P1/18 , A61P3/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P7/00 , A61P7/02 , A61P7/06 , A61P9/00 , A61P9/04 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/00 , A61P15/08 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/00 , A61P19/02 , A61P19/06 , A61P19/08 , A61P19/10 , A61P21/00 , A61P21/04 , A61P25/00 , A61P25/28 , A61P27/02 , A61P27/16 , A61P29/00 , A61P31/00 , A61P31/04 , A61P31/12 , A61P31/18 , A61P31/22 , A61P33/06 , A61P35/00 , A61P35/02 , A61P37/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P39/00 , A61P39/02 , A61P43/00 , C07H21/04 , C07K14/52 , C07K14/57 , C07K14/575 , C07K14/705 , C07K16/18 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/00 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566
CPC分类号: C07K14/52 , A01K2217/075 , A61K38/00 , A61K39/00 , C07K14/5759 , Y02A50/412
摘要: This invention relates to novel proteins (INSP032, INSP033, INSP034, INSP036, INSP038), herein identified as members of the four helical bundle cytokine family and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.
摘要翻译: 本发明涉及本文鉴定为四螺旋束细胞因子家族的成员的新型蛋白质(INSP032,INSP033,INSP034,INSP036,INSP038)以及来自编码基因的这些蛋白质和核酸序列在诊断,预防和 治疗疾病。
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公开(公告)号:US20050112618A1
公开(公告)日:2005-05-26
申请号:US10872859
申请日:2004-06-21
CPC分类号: C07K14/5759 , A01K2217/075 , A61K38/00 , A61K39/00 , C07K14/52 , Y02A50/412
摘要: This invention relates to novel protein INSP037, herein identified as a member of the four helical bundle cytokine family and to the use of this protein and the nucleic acid sequence from the encoding gene in the diagnosis, prevention and treatment of disease.
摘要翻译: 本发明涉及本文鉴定为四螺旋束细胞因子家族的成员的新型蛋白质INSP037以及该蛋白质的用途和来自编码基因的核酸序列在疾病的诊断,预防和治疗中的用途。
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公开(公告)号:US20050106679A1
公开(公告)日:2005-05-19
申请号:US10872598
申请日:2004-06-21
IPC分类号: A01K67/027 , A61K31/7088 , A61K35/12 , A61K35/76 , A61K38/00 , A61K39/00 , A61K45/00 , A61K48/00 , A61P1/00 , A61P1/04 , A61P1/16 , A61P1/18 , A61P3/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P7/00 , A61P7/02 , A61P7/06 , A61P9/00 , A61P9/04 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/00 , A61P15/08 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/00 , A61P19/02 , A61P19/06 , A61P19/08 , A61P19/10 , A61P21/00 , A61P21/04 , A61P25/00 , A61P25/28 , A61P27/02 , A61P27/16 , A61P29/00 , A61P31/00 , A61P31/04 , A61P31/12 , A61P31/18 , A61P31/22 , A61P33/06 , A61P35/00 , A61P35/02 , A61P37/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P39/00 , A61P39/02 , A61P43/00 , C07H21/04 , C07K14/52 , C07K14/57 , C07K14/575 , C07K14/705 , C07K16/18 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/00 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566
CPC分类号: C07K14/52 , A01K2217/075 , A61K38/00 , A61K39/00 , C07K14/5759 , Y02A50/412
摘要: This invention relates to novel protein INSP035, herein identified as a member of the four helical bundle cytokine family and to the use of this protein and the nucleic acid sequence from the encoding gene in the diagnosis, prevention and treatment of disease.
摘要翻译: 本发明涉及新型蛋白质INSP035,本文中鉴定为四螺旋束细胞因子家族的成员,以及该蛋白质的使用和编码基因的核酸序列在疾病的诊断,预防和治疗中的用途。
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公开(公告)号:US20060234218A1
公开(公告)日:2006-10-19
申请号:US10475517
申请日:2002-04-26
申请人: Richard Fagan , Christopher Phelps , Tom Philips , Valerie Pierron , Kathryn Allen , Alex Gutteridge
发明人: Richard Fagan , Christopher Phelps , Tom Philips , Valerie Pierron , Kathryn Allen , Alex Gutteridge
CPC分类号: C12N9/0071 , A61K38/00
摘要: This invention relates to proteins, termed BAA92678.1 and BAA31683.1, herein identified as P450 enzymes and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.
摘要翻译: 本发明涉及称为BAA92678.1和BAA31683.1,本文中鉴定为P450酶的蛋白质,以及来自编码基因的这些蛋白质和核酸序列在诊断,预防和治疗疾病中的用途。
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公开(公告)号:US20070141569A1
公开(公告)日:2007-06-21
申请号:US10539962
申请日:2003-12-19
IPC分类号: C12Q1/68 , A61K38/18 , C07K14/475 , C07H21/04 , C12P21/06
CPC分类号: C07K14/61
摘要: This invention relates to a protein, termed INSP105, herein identified as a splice variant of human placental growth hormone and to the use of this protein and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.
摘要翻译: 本发明涉及一种称为INSP105的蛋白质,在本文中被鉴定为人胎盘生长激素的剪接变体,以及来自编码基因的该蛋白质和核酸序列在诊断,预防和治疗疾病中的用途。
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公开(公告)号:US20070021588A1
公开(公告)日:2007-01-25
申请号:US10531751
申请日:2003-10-16
CPC分类号: C07K14/8107
摘要: This invention relates to two proteins, termed INSP087, herein identified as members of the alpha macroglobulin family, in particular as alpha-2-macroglobulin-like proteinase inhibitors, and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention, and treatment of disease.
摘要翻译: 本发明涉及称为INSP087的两种蛋白质,在本文中被鉴定为α巨球蛋白家族的成员,特别是作为α-2-巨球蛋白样蛋白酶抑制剂,以及来自编码基因的这些蛋白质和核酸序列的使用 诊断,预防和治疗疾病。
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公开(公告)号:US20060121475A1
公开(公告)日:2006-06-08
申请号:US10526722
申请日:2003-09-05
CPC分类号: C12N9/1205 , A01K2217/05 , A01K2217/075
摘要: The present invention relates to novel proteins, termed INSP081, INSP082, and INSP091, herein identified as members of the Germinal Center Kinase (GCK) subfamily of the STE20 family of protein kinases, preferably as NCK-interacting kinases (NIKs) and more preferably as NIK-like embryo specific kinases (NESKs), and to the use of these and nucleic acid sequences from the encoding genes in the diagnosis, prevention, and treatment of disease.
摘要翻译: 本发明涉及称为INSP081,INSP082和INSP091的新蛋白质,其在本文中被鉴定为STE20家族蛋白激酶的生发中心激酶(GCK)亚家族的成员,优选作为NCK相互作用的激酶(NIK),更优选为 NIK样胚胎特异性激酶(NESKs),以及来自编码基因的这些和核酸序列在疾病的诊断,预防和治疗中的应用。
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公开(公告)号:US20050186663A1
公开(公告)日:2005-08-25
申请号:US10872898
申请日:2004-06-21
申请人: Mark Davies , Christopher Phelps , Richard Fagan , Christine Power , Melanie Yorke , Mark Ibberson
发明人: Mark Davies , Christopher Phelps , Richard Fagan , Christine Power , Melanie Yorke , Mark Ibberson
IPC分类号: A01K67/027 , A61K38/00 , A61K39/00 , A61P3/00 , A61P9/00 , A61P25/00 , A61P29/00 , A61P31/04 , A61P35/00 , A61P37/06 , C07H21/04 , C07K14/475 , C07K14/52 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/19 , C12P21/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53
摘要: This invention relates to a novel protein (INSP002), herein identified as a secreted protein that is a member of the Dan family of the cystine-knot fold cytokine superfamily and to the use of this protein and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.
摘要翻译: 本发明涉及一种新型蛋白质(INSP002),其被鉴定为分泌型蛋白质,其是胱氨酸 - 结折叠细胞因子超家族的丹氏家族的成员,并且使用该蛋白质和来自编码基因的核酸序列 诊断,预防和治疗疾病。
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