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公开(公告)号：US4613576A
公开(公告)日：1986-09-23
申请号：US473830
申请日：1983-03-09
申请人： Richard J. Cote , Donna M. Morrissey , Alan N. Houghton , Edward J. Beattie, Jr. , Herbert F. Oettgen , Lloyd J. Old
发明人： Richard J. Cote , Donna M. Morrissey , Alan N. Houghton , Edward J. Beattie, Jr. , Herbert F. Oettgen , Lloyd J. Old
IPC分类号： G01N33/574 , A61K39/395 , C07K14/00 , C07K14/705 , C07K16/00 , C07K16/30 , C12N5/10 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/531 , C12N15/00 , C12N5/00 , C12P21/00 , G01N33/53
CPC分类号： C07K16/3023 , C07K16/3015 , C07K16/3038 , C07K16/3061
摘要： Hybridomas which produce human monoclonal antibodies are disclosed. The hybridomas are formed by fusing lymphocytes from individuals with various cancers to an immortal cell line, such as a myeloma, from, e.g., a human cell line, or a mouse cell line.
摘要翻译： 公开了产生人单克隆抗体的杂交瘤。 杂交瘤通过将来自具有各种癌症的个体的淋巴细胞与来自例如人细胞系或小鼠细胞系的永生细胞系如骨髓瘤融合而形成。
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公开(公告)号：US4727021A
公开(公告)日：1988-02-23
申请号：US616271
申请日：1984-06-01
IPC分类号： G01N33/574 , A61K39/395 , C07K14/005 , C07K14/195 , C07K16/00 , C07K16/18 , C07K16/30 , C12N5/10 , C12N15/02 , C12P21/08 , C12R1/19 , G01N33/577 , A61K39/00 , C12N5/00 , G01N33/53
CPC分类号： C07K16/18 , C07K16/30 , Y10S435/948 , Y10S530/861 , Y10S530/865
摘要： Human monoclonal antibodies (HmAbs) capable of reacting with cytokeratin are disclosed. It has been found that HmAbs De8, M54, M307, Hull, C29, Hu22 and Pa24 may be used to detect these cytoskeletal proteins in various cells. By means of these HmAbs the embryological origin of cells may be determined. This information may be used to determine the possible tissue source of metastasized tumors and greatly affects the management of these cancers.
摘要翻译： 公开了能够与细胞角蛋白反应的人单克隆抗体（HmAbs）。 已经发现HmAbs De8，M54，M307，Hull，C29，Hu22和Pa24可用于检测各种细胞中的这些细胞骨架蛋白。 通过这些HmAb可以确定细胞的胚胎起源。 该信息可用于确定转移肿瘤的可能组织来源，并且极大地影响这些癌症的治疗。
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3.发明授权Human monoclonal antibodies from lymphocytes of patients with malignant melanoma 失效来自恶性黑色素瘤患者淋巴细胞的人单克隆抗体
公开(公告)号：US4693966A
公开(公告)日：1987-09-15
申请号：US474618
申请日：1983-03-11
IPC分类号： G01N33/574 , A61K38/00 , C07K14/00 , C07K14/705 , C07K16/00 , C07K16/30 , C07K19/00 , C12N5/10 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/577 , C07K15/04 , C12N5/00
CPC分类号： C07K16/3053 , C07K16/30 , A61K38/00 , Y10S435/96 , Y10S436/813 , Y10S530/865
摘要： Human monoclonal antibodies which specifically bind to antigens found on cell surfaces of renal, lung, and breast cancer cells, intracellular cytoskeletal antigens, nuclear antigens, and cytoplasmic reticular antigens are disclosed. The antibodies are the product of hybridoma cell lines, where the immortal cell line may be, e.g., a human cell line, or a murine cell line.
摘要翻译： 公开了特异性结合肾，肺和乳腺癌细胞的细胞表面上发现的抗原的人单克隆抗体，细胞内细胞骨架抗原，核抗原和细胞质网状抗原。 抗体是杂交瘤细胞系的产物，其中永生细胞系可以是例如人细胞系或鼠细胞系。
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公开(公告)号：US4695538A
公开(公告)日：1987-09-22
申请号：US616397
申请日：1984-06-01
申请人： Richard J. Cote , Timothy M. Thomson , Alan N. Houghton , Herbert F. Oettgen , Lloyd J. Old , Carlos C. Cardo
发明人： Richard J. Cote , Timothy M. Thomson , Alan N. Houghton , Herbert F. Oettgen , Lloyd J. Old , Carlos C. Cardo
IPC分类号： G01N33/574 , A61K39/395 , C07K14/005 , C07K14/195 , C07K16/00 , C07K16/30 , C07K19/00 , C12N5/10 , C12N15/02 , C12P21/08 , C12R1/19 , G01N33/567 , G01N33/577 , G01N33/53
CPC分类号： G01N33/567 , C07K16/30 , Y10S435/96 , Y10S436/813 , Y10S436/828
摘要： Human monoclonal antibodies (HmAbs) capable of reacting with cell surface antigens and intracellular components are disclosed. It has been found that HmAbs Ev248, Ch-5, Ch-13, Te-39, Hu44, Ge-1, Gr-431, Gr169 and Sp909 may be used to detect these antigens in various cells. By means of these HmAbs malignant cells may be determined. This information may be used to screen metastasized tumors and primary tumors for tissue source and greatly affects the management of these cancers.
摘要翻译： 公开了能够与细胞表面抗原和胞内成分反应的人单克隆抗体（HmAb）。 已经发现HmAbs Ev248，Ch-5，Ch-13，Te-39，Hu44，Ge-1，Gr-431，Gr169和Sp909可用于检测各种细胞中的这些抗原。 通过这些HmAb可以确定恶性细胞。 该信息可用于筛选转移肿瘤和原发性肿瘤用于组织来源，并且极大地影响这些癌症的治疗。
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公开(公告)号：US4562160A
公开(公告)日：1985-12-31
申请号：US482153
申请日：1983-04-01
申请人： Francisco X. Real , M. Jules Mattes , Alan N. Houghton , Philip O. Livingston , Kenneth O. Lloyd , Herbert F. Oettgen , Lloyd J. Old
发明人： Francisco X. Real , M. Jules Mattes , Alan N. Houghton , Philip O. Livingston , Kenneth O. Lloyd , Herbert F. Oettgen , Lloyd J. Old
IPC分类号： C07K16/30 , A61K39/395 , A61K39/44 , A61K43/00
CPC分类号： C07K16/3053 , Y10S435/948 , Y10S435/961 , Y10S436/804 , Y10S436/813 , Y10S436/815 , Y10S436/823 , Y10S530/806 , Y10S530/807 , Y10S530/828
摘要： The present invention concerns novel immunoprecipitating autologous antibodies which recognize the Class 1 gp90 antigen on melanoma cells. These antibodies, optionally tagged with a chromophoric or radioactive label and immobilized on an inert support, may be used to recognize and isolate the gp90 antigen from melanoma cell extracts. Monoclonal antibodies to melanoma may be screened with the gp90 antigen for those which recognize epitopes other than the FD antigenic system.The cell line containing the gp90 antigen which has been cultured in vitro is a source of gp90 antigen for generation of monoclonal antibodies which will be useful in analyzing the gp90 antigen for those epitopes which may be of diagnostic value in immunoassay of melanoma.
摘要翻译： 本发明涉及识别黑素瘤细胞上的1类gp90抗原的新型免疫沉淀自体抗体。 可以使用任选地标记有发色或放射性标记并固定在惰性载体上的这些抗体来识别和分离来自黑素瘤细胞提取物的gp90抗原。 可以用gp90抗原筛选黑素瘤单克隆抗体，以识别除FD抗原系统以外的表位。 含有体外培养的gp90抗原的细胞系是用于产生单克隆抗体的gp90抗原的来源，其可用于分析可能在黑素瘤免疫测定中具有诊断价值的那些表位的gp90抗原。
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6.发明授权
公开(公告)号：US5160723A
公开(公告)日：1992-11-03
申请号：US671132
申请日：1991-03-18
申请人： Sydney Welt , Chaitanya R. Divgi , Samual Yeh , Lloyd J. Old , Herbert F. Oettgen , Francisco X. Real , Junichi Sakamoto
发明人： Sydney Welt , Chaitanya R. Divgi , Samual Yeh , Lloyd J. Old , Herbert F. Oettgen , Francisco X. Real , Junichi Sakamoto
CPC分类号： A61K51/1063 , C07K16/3046 , A61K2039/505 , A61K2121/00 , C07K2317/24 , C07K2317/55 , Y10S436/808 , Y10S436/813 , Y10S530/808 , Y10S530/809 , Y10S530/866
摘要： This invention provides a method of imaging a colorectal carcinoma lesion in a human patient which comprises administering to the patient a monoclonal antibody capable of binding to a cell surface antigen associated with the coloretal carcinoma lesion and which is labeled with an imaging agent under conditions so as to form a complex between the monoclonal antibody and the cell surface antigen, imaging any complex so formed, and thereby imaging the colorectal carcinoma lesion.This invention also provides a monoclonal antibody designated AS 33 (ATCC Accession No. HB 8779) and the hybridoma which produces it.
摘要翻译： 本发明提供了一种在人类患者中对结肠直肠癌病变进行成像的方法，其包括向患者施用能够结合与该结肠癌病变相关的细胞表面抗原的单克隆抗体，并在成像剂的条件下进行标记， 在单克隆抗体和细胞表面抗原之间形成复合物，对如此形成的任何复合物进行成像，从而对结肠直肠癌病变进行成像。 本发明还提供了称为AS33（ATCC登录号HB 8779）和产生它的杂交瘤的单克隆抗体。
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7.发明授权
公开(公告)号：US5643550A
公开(公告)日：1997-07-01
申请号：US312633
申请日：1994-09-27
申请人： Sydney Welt , Chaitanya R. Divgi , Samual Yeh , Lloyd J. Old , Herbert F. Oettgen , Francisco X. Real , Junichi Sakamoto
发明人： Sydney Welt , Chaitanya R. Divgi , Samual Yeh , Lloyd J. Old , Herbert F. Oettgen , Francisco X. Real , Junichi Sakamoto
CPC分类号： A61K51/1063 , C07K16/3046 , A61K2039/505 , A61K2121/00 , C07K2317/24 , C07K2317/55 , Y10S436/808 , Y10S436/813 , Y10S530/808 , Y10S530/809 , Y10S530/837
摘要： This invention provides a method of imaging a colorectal carcinoma lesion in a human patient which comprises administering to the patient a monoclonal antibody capable of binding to a cell surface antigen associated with the colorectal carcinoma lesion and which is labeled with an imaging agent under conditions so as to form a complex between the monoclonal antibody and the cell surface antigen, imaging any complex so formed, and thereby imaging the colorectal carcinoma lesion.This invention also provides a monoclonal antibody designated AS 33 (ATCC Accession No. HB 8779) and the hybridoma which produces it.
摘要翻译： 本发明提供了一种对人类患者的结肠直肠癌病变进行成像的方法，其包括向患者施用能够结合与结肠直肠癌病变相关的细胞表面抗原的单克隆抗体，并在成像剂的条件下进行标记， 在单克隆抗体和细胞表面抗原之间形成复合物，对如此形成的任何复合物进行成像，从而对结肠直肠癌病变进行成像。 本发明还提供了称为AS33（ATCC登录号HB 8779）和产生它的杂交瘤的单克隆抗体。
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公开(公告)号：US5006470A
公开(公告)日：1991-04-09
申请号：US39479
申请日：1987-04-16
申请人： Hiroshi Yamaguchi , Koichi Furukawa , Philip O. Livingston , Kenneth O. Lloyd , Herbert F. Oettgen , Lloyd J. Old , Sheila R. Fortunato
发明人： Hiroshi Yamaguchi , Koichi Furukawa , Philip O. Livingston , Kenneth O. Lloyd , Herbert F. Oettgen , Lloyd J. Old , Sheila R. Fortunato
CPC分类号： A61K47/48569 , A61K47/48623 , C07K16/30 , C07K16/3053 , A61K38/00 , Y10S424/808 , Y10S435/948 , Y10S530/865
摘要： This invention provides a monoclonal antibody, produced by the hybridoma cell line designated GXM1, which specifically binds to a human class 1tumor antigen. This invention also provides a human monoclonal antibody, produced by a hybridoma cell line designated HJM1, which specifically binds to each of the ganglioside antigens GD2, GD3, GM3 and GD1b. This invention further provides a human monoclonal antibody, produced by a hybridoma cell line designated FCM1, which specifically binds to the ganglioside antigens GM3 and GD1a. Finally, this invention provides a human monoclonal antibody, produced by a hybridoma cell line designated DSM1, which specifically binds to a human class 2 tumor protein antigen.
摘要翻译： 本发明提供了由称为GXM1的杂交瘤细胞系产生的单克隆抗体，其特异性结合人类1型肿瘤抗原。 本发明还提供了通过与每种神经节苷脂抗原GD2，GD3，GM3和GD1b特异性结合的称为HJM1的杂交瘤细胞系产生的人单克隆抗体。 本发明还提供了通过特异性结合神经节苷脂抗原GM3和GD1a的称为FCM1的杂交瘤细胞系产生的人单克隆抗体。 最后，本发明提供了通过特异性结合人2型肿瘤蛋白抗原的称为DSM1的杂交瘤细胞系产生的人单克隆抗体。
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公开(公告)号：US4851332A
公开(公告)日：1989-07-25
申请号：US718162
申请日：1985-04-01
申请人： Wolfgang J. Rettig , Carlos Cordon-Cardo , John P. Koulos , John L. Lewis, Jr. , Herbert F. Oettgen , Lloyd J. Old
发明人： Wolfgang J. Rettig , Carlos Cordon-Cardo , John P. Koulos , John L. Lewis, Jr. , Herbert F. Oettgen , Lloyd J. Old
IPC分类号： G01N33/574 , A61K39/395 , A61K45/00 , C07K14/005 , C07K14/195 , C07K16/00 , C07K16/30 , C12N5/10 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/577
CPC分类号： C07K16/30
摘要： Monoclonal antibodies to specific cell surface antigens of human choriocarcinoma, teratocarcinoma, and normal trophoblasts are disclosed. Additionally, panels of monoclonal antibodies which may be used in phenotyping cell and tissue samples are disclosed as well.
摘要翻译： 公开了针对人绒毛膜癌，畸胎癌和正常滋养细胞的特异性细胞表面抗原的单克隆抗体。 此外，还公开了可用于表型细胞和组织样品中的单克隆抗体片段。
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10.发明授权
公开(公告)号：US4762800A
公开(公告)日：1988-08-09
申请号：US604080
申请日：1984-04-26
申请人： Wolfgang Rettig , Carolos Cordon-Cardo , Herbert F. Oettgen , Lloyd J. Old , Kenneth O. Lloyd , Jennifer Ng
发明人： Wolfgang Rettig , Carolos Cordon-Cardo , Herbert F. Oettgen , Lloyd J. Old , Kenneth O. Lloyd , Jennifer Ng
IPC分类号： C07K16/30 , C12N5/00 , A61K39/395 , G01N33/533 , G01N33/534
CPC分类号： C07K16/30 , Y10S530/864
摘要： Antibody-producing hybridoma cell lines made by fusion of NS/1 cells with spleen cells of mice after immunization with human teratocarcinoma cells are presented. Monoclonal antibodies from these cell lines recognize the K4, K2 and P12 antigenic systems and are thus useful in detecting and differentiating between normal and cancerous cells. These monoclonal antibodies are especially useful in pathologic analysis of human tumors, especially teratocarcinomas.
摘要翻译： 提出了通过用人类畸胎癌细胞免疫后将NS / 1细胞与小鼠的脾细胞融合而制备的产生抗体的杂交瘤细胞系。 来自这些细胞系的单克隆抗体识别K4，K2和P12抗原系统，因此可用于检测和鉴别正常细胞与癌细胞。 这些单克隆抗体特别适用于人类肿瘤，特别是畸胎癌的病理分析。
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