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    Three knuckle hinge with bushing inserts in center knuckle and method of making same
    1.
    发明授权
    Three knuckle hinge with bushing inserts in center knuckle and method of making same 失效
    三角铰链，带有中心指节的衬套插入件及其制造方法

    公开(公告)号：US4573239A

    公开(公告)日：1986-03-04

    申请号：US642033

    申请日：1984-08-17

    申请人： Richard L. Valenti ,  Daniel J. McCormick

    发明人： Richard L. Valenti ,  Daniel J. McCormick

    IPC分类号： E05D5/10 ,  E05D5/12 ,  E05D11/00

    CPC分类号： E05D5/127 ,  E05D5/10 ,  E05D9/00 ,  E05D2003/027 ,  E05D2005/102 ,  E05D5/12 ,  E05Y2600/508 ,  Y10S16/27 ,  Y10S16/42 ,  Y10T16/537 ,  Y10T16/553 ,  Y10T16/557 ,  Y10T29/24

    摘要： A hinge has a pair of leaves, one of which has a spaced pair of knuckles and the other has a central knuckle disposed therebetween. Disposed in the single knuckle are a pair of tubular bushing inserts received in opposite ends of its passage and having radial flanges disposed between the adjacent knuckles. The two knuckle hinge leaf is engaged with a pair of hinge pin elements extending inwardly from the opposite end of the leaf so as to prevent relative rotation therebetween, while the hinge pin elements extend into and are freely rotatable in the inserts. In the method of assembly, the bearing inserts are placed in the single knuckle leaf, and the two knuckle leaf is then aligned therewith and the hinge pin elements are inserted and engaged with the two knuckle leaf to prevent relative rotation therebetween.

    摘要翻译： 铰链具有一对叶片，其中一个叶片具有间隔开的一对转向节，而另一个具有设置在它们之间的中心转向节。 在单关节中设置的是一对管状套管插入件，其接纳在其通道的相对端部并且具有设置在相邻转向节之间的径向凸缘。 两个转向铰链叶片与从叶片的相对端向内延伸的一对铰链销元件接合，以防止它们之间的相对旋转，同时铰链销元件延伸到插入件中并且可自由旋转。 在组装方法中，将轴承插入件放置在单关节叶中，然后将两个转向节叶片对齐，并且铰链销元件被插入并与两个转向节接合，以防止它们之间的相对旋转。

    Neo-tryptophan
    8.
    发明授权
    Neo-tryptophan 有权
    新色氨酸

    公开(公告)号：US06765099B2

    公开(公告)日：2004-07-20

    申请号：US10265099

    申请日：2002-10-04

    申请人： Elliott Richelson ,  Bernadette Marie Cusack ,  Yuan-Ping Pang ,  Daniel J. McCormick ,  Abdul Fauq

    发明人： Elliott Richelson ,  Bernadette Marie Cusack ,  Yuan-Ping Pang ,  Daniel J. McCormick ,  Abdul Fauq

    IPC分类号： C07D20914

    CPC分类号： C07K7/083 ,  A61K38/00 ,  C07D209/08 ,  C07K7/14 ,  C07K7/18 ,  C07K14/70 ,  C07K14/702

    摘要： The invention provides a novel amino acid, neo-tryptophan, as well as polypeptides containing this novel amino acid such as neurotensin analogs. In addition, the invention provides neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and polypeptides containing such derivatives. The invention also provides methods for making neo-tryptophan, neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and compositions containing these compounds. Further, the invention provides methods for inducing a neurotensin response in a mammal as well as methods for treating a mammal having a serotonin recognition molecule.

    摘要翻译： 本发明提供了新的氨基酸，新色氨酸，以及含有这种新型氨基酸的多肽，如神经降压素类似物。 此外，本发明提供新色氨酸衍生物，5-羟色胺样新色氨酸衍生物和含有这些衍生物的多肽。 本发明还提供了制备新色氨酸，新色氨酸衍生物，血清素样新色氨酸衍生物和含有这些化合物的组合物的方法。 此外，本发明提供了在哺乳动物中诱导神经降压素反应的方法以及用于治疗具有5-羟色胺识别分子的哺乳动物的方法。