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    CONTROL OF PATHOGENS AND PARASITES
    1.
    发明申请
    CONTROL OF PATHOGENS AND PARASITES 审中-公开
    病原体和寄生虫的控制

    公开(公告)号：US20130315883A1

    公开(公告)日：2013-11-28

    申请号：US13880931

    申请日：2011-10-24

    申请人： Richard Sayre ,  Anil Kumar

    发明人： Richard Sayre ,  Anil Kumar

    IPC分类号： A61K31/713 ,  A23K1/16

    CPC分类号： A61K31/713 ,  A23K20/153 ,  C12N15/113 ,  C12N15/79 ,  C12N15/8214 ,  C12N15/8218 ,  C12N15/8286 ,  C12N2310/14 ,  Y02A40/162

    摘要： The present invention relates to the genetic control of parasites and pathogens via the expression of silencing RNA in transgenic plants, including microalgae. In one aspect, the invention exploits the ability of plants to express the silencing RNA in a form within chloroplasts that is efficiently taken up, after ingestion where it can act to suppress the expression of target genes within the pathogen or parasite.

    摘要翻译： 本发明涉及通过转基因植物（包括微藻）中沉默RNA表达对寄生虫和病原体的遗传控制。 一方面，本发明利用了植物以叶绿体中形式表达沉默RNA的能力，其在摄取后被有效地吸收，其中它可以起抑制病原体或寄生虫中靶基因的表达的作用。

    Method of making microalgal-based animal foodstuff supplements, microalgal-supplemented animal foodstuffs and method of animal nutrition
    5.
    发明申请
    Method of making microalgal-based animal foodstuff supplements, microalgal-supplemented animal foodstuffs and method of animal nutrition 审中-公开
    制造微藻类动物食品添加剂，微藻补充动物食品和动物营养方法的方法

    公开(公告)号：US20120183572A9

    公开(公告)日：2012-07-19

    申请号：US10914391

    申请日：2004-08-09

    申请人： Richard Sayre ,  Richard Wagner

    发明人： Richard Sayre ,  Richard Wagner

    IPC分类号： C12P21/06 ,  A23K1/165 ,  A61K35/80

    CPC分类号： A23K20/30 ,  A23K10/16 ,  A23K10/30 ,  A23K20/147 ,  A23K50/10 ,  A61K9/5068 ,  A61K39/05 ,  A61K39/12 ,  A61K2039/517 ,  A61K2039/523 ,  A61K2039/542 ,  A61K2039/552 ,  C07K14/195 ,  C12N1/12 ,  C12N7/00 ,  C12N15/8214 ,  C12N15/8257 ,  C12N2710/18022 ,  C12N2710/18034

    摘要： The present invention is to a safe, biodegradable trace metal binding system that effectively delivers chromium, cobalt, copper, iron, manganese, molybdenum, selenium and zinc to animals. The method of preparing an animal foodstuff composition involves the steps of: providing transgenic algal cells comprising a nucleotide sequence, the nucleotide sequence being capable of expressing a non-native metal-binding protein in the transgenic algal cells; binding the metal-binding protein with at least one metal so as to produce a metal-bound adduct of the metal-binding protein; and admixing the metal-bound adduct with animal foodstuff. The invention is also to a animal foodstuff composition comprising animal foodstuff and transgenic algal cells expressing a non-native metal-binding protein in the transgenic algal cells, such that the transgenic algal cells contain the metal-binding protein and the metal-binding protein being bound to a metal.

    摘要翻译： 本发明涉及一种安全，可生物降解的痕量金属结合体系，其能够将铬，钴，铜，铁，锰，钼，硒和锌有效地传递给动物。 制备动物食品组合物的方法包括以下步骤：提供包含核苷酸序列的转基因藻细胞，所述核苷酸序列能够在转基因藻细胞中表达非天然金属结合蛋白; 将金属结合蛋白与至少一种金属结合以产生金属结合蛋白的金属结合加合物; 并将金属结合的加合物与动物食品混合。 本发明还涉及包含在转基因藻类细胞中表达非天然金属结合蛋白的动物食品和转基因藻类细胞的动物食品组合物，使得转基因藻细胞含有金属结合蛋白，金属结合蛋白是 绑在金属上。

    MODIFICATION OF MICROALGAE FOR MAGNETIC PROPERTIES
    6.
    发明申请
    MODIFICATION OF MICROALGAE FOR MAGNETIC PROPERTIES 审中-公开
    用于磁性的微晶的修饰

    公开(公告)号：US20130224822A1

    公开(公告)日：2013-08-29

    申请号：US13808746

    申请日：2011-07-07

    申请人： Richard Sayre ,  Brad Postier

    发明人： Richard Sayre ,  Brad Postier

    IPC分类号： C12N13/00

    CPC分类号： C12N13/00 ,  C07K14/47 ,  C12N1/02 ,  C12N1/12

    摘要： Genetically engineered algae strains for biofuels and bioproduct production have improved iron utilization including iron uptake and storage, and exhibit improved growth characteristics, magnetic separation, and magnetic hysteresis induced cell lysis. Pond production algal strain embodiments with high iron scavenging capabilities limit iron availability to contaminating microorganisms and invading species. Accumulation of high iron and other paramagnetic elements content in the form of ferritin enhances the cells magnetic susceptibility improving efficiency of magnetic separation and magnetic hysteresis induced cell lysis. Several genes of the embodiments are capable of improving iron acquisition including the ferritin gene fer1, iron transport gene fea1, and iron reductase gene fre1. Other genes which improve growth in the high iron conditions permitting higher accumulation of iron include radical scavenging enzymes such as superoxide dismutase, peroxidase, catalase, glutathione peroxidase and the Ferritin like DPR/DPS genes which also bind iron and protect DNA from reactive oxygen species.

    摘要翻译： 用于生物燃料和生物产品生产的基因工程藻类菌株具有改善的铁利用率，包括铁摄取和储存，并且表现出改善的生长特性，磁分离和磁滞诱导的细胞裂解。 具有高铁清除能力的池塘生产藻类菌株实施方案限制了铁可用性以污染微生物和入侵物种。 高铁和其他顺磁元素以铁蛋白形式的含量的积累增强了细胞磁化率提高磁分离和磁滞诱导细胞裂解的效率。 实施方案的几个基因能够改善铁的获取，包括铁蛋白基因fer1，铁转运基因fea1和铁还原酶基因fre1。 改善高铁条件下生长的其他基因允许更高的铁含量包括自由基清除酶，如超氧化物歧化酶，过氧化物酶，过氧化氢酶，谷胱甘肽过氧化物酶和铁蛋白如DPR / DPS基因，其也结合铁并保护DNA免受活性氧。