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公开(公告)号：US20080207590A1
公开(公告)日：2008-08-28
申请号：US11925151
申请日：2007-10-26
申请人： Robert Deziel , Silvana Leit , Patrick Beaulieu , Yves Andre Chantigny , John Mancuso , Pierre Tessier , Gideon Shapiro , Richard Chesworth , David Smil
发明人： Robert Deziel , Silvana Leit , Patrick Beaulieu , Yves Andre Chantigny , John Mancuso , Pierre Tessier , Gideon Shapiro , Richard Chesworth , David Smil
IPC分类号： A61K31/553 , C07D267/10 , C07D239/28 , A61K31/5513 , A61P43/00 , A61K31/506 , C07D243/14
CPC分类号： C07D498/04 , C07C259/06 , C07C259/10 , C07D209/02 , C07D209/08 , C07D209/52 , C07D209/94 , C07D221/12 , C07D223/16 , C07D223/20 , C07D223/22 , C07D223/24 , C07D223/26 , C07D223/28 , C07D225/08 , C07D239/28 , C07D239/34 , C07D239/42 , C07D243/24 , C07D243/38 , C07D265/38 , C07D267/14 , C07D267/18 , C07D267/20 , C07D279/22 , C07D279/26 , C07D281/16 , C07D285/36 , C07D291/08 , C07D295/155 , C07D313/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/06 , C07D413/12 , C07D471/04 , C07D471/08 , C07D471/14 , C07D487/04 , C07D487/08 , C07D487/14 , C07D491/08 , C07D495/04 , C07D513/04 , C07H13/10
摘要： This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula (I) wherein Q, J, L and Z are as defined in the specification.
摘要翻译： 本发明涉及抑制组蛋白脱乙酰酶的化合物。 更具体地说，本发明提供式（I）化合物，其中Q，J，L和Z如说明书中所定义。
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![Dibenzo[B,F][1,4]Oxazepin-11-yl-N-Hydroxybenzamides as HDAC Inhibitors](/abs-image/US/2014/01/09/US20140011988A1/abs.jpg.150x150.jpg)
2.发明申请Dibenzo[B,F][1,4]Oxazepin-11-yl-N-Hydroxybenzamides as HDAC Inhibitors 有权二苯并[B，F] [1,4]氧氮杂-11-基-N-羟基苯甲酰胺作为HDAC抑制剂公开(公告)号：US20140011988A1
公开(公告)日：2014-01-09
申请号：US13767478
申请日：2013-02-14
申请人： Robert Deziel , Silvana Leit , Patrick Beaulieu , Yves Andre Chantigny , John Mancuso , Pierre Tessier , Gideon Shapiro , Richard Chesworth , David Smil
发明人： Robert Deziel , Silvana Leit , Patrick Beaulieu , Yves Andre Chantigny , John Mancuso , Pierre Tessier , Gideon Shapiro , Richard Chesworth , David Smil
IPC分类号： C07H13/10 , C07D243/38 , C07D498/04 , C07D487/08 , C07D295/155 , C07D487/14 , C07D413/12 , C07D487/04 , C07D267/20 , C07D281/16
CPC分类号： C07D498/04 , C07C259/06 , C07C259/10 , C07D209/02 , C07D209/08 , C07D209/52 , C07D209/94 , C07D221/12 , C07D223/16 , C07D223/20 , C07D223/22 , C07D223/24 , C07D223/26 , C07D223/28 , C07D225/08 , C07D239/28 , C07D239/34 , C07D239/42 , C07D243/24 , C07D243/38 , C07D265/38 , C07D267/14 , C07D267/18 , C07D267/20 , C07D279/22 , C07D279/26 , C07D281/16 , C07D285/36 , C07D291/08 , C07D295/155 , C07D313/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/06 , C07D413/12 , C07D471/04 , C07D471/08 , C07D471/14 , C07D487/04 , C07D487/08 , C07D487/14 , C07D491/08 , C07D495/04 , C07D513/04 , C07H13/10
摘要： This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula (I) wherein Q, J, L and Z are as defined in the specification.
摘要翻译： 本发明涉及抑制组蛋白脱乙酰酶的化合物。 更具体地说，本发明提供式（I）化合物，其中Q，J，L和Z如说明书中所定义。
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公开(公告)号：US20110196147A1
公开(公告)日：2011-08-11
申请号：US13079458
申请日：2011-04-04
申请人： Robert Déziel , Silvana Leit , Patrick Beaulieu , Yves Andre Chantigny , John Mancuso , Pierre Tessier , Gideon Shapiro , Richard Chesworth , David Smil
发明人： Robert Déziel , Silvana Leit , Patrick Beaulieu , Yves Andre Chantigny , John Mancuso , Pierre Tessier , Gideon Shapiro , Richard Chesworth , David Smil
IPC分类号： C07D267/16 , C07D223/24 , C07C233/01 , C07D243/24 , C07D471/04 , C07D239/42 , C07D291/08 , C07D403/14 , C07D279/22 , C07D265/38
CPC分类号： C07D498/04 , C07C259/06 , C07C259/10 , C07D209/02 , C07D209/08 , C07D209/52 , C07D209/94 , C07D221/12 , C07D223/16 , C07D223/20 , C07D223/22 , C07D223/24 , C07D223/26 , C07D223/28 , C07D225/08 , C07D239/28 , C07D239/34 , C07D239/42 , C07D243/24 , C07D243/38 , C07D265/38 , C07D267/14 , C07D267/18 , C07D267/20 , C07D279/22 , C07D279/26 , C07D281/16 , C07D285/36 , C07D291/08 , C07D295/155 , C07D313/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/06 , C07D413/12 , C07D471/04 , C07D471/08 , C07D471/14 , C07D487/04 , C07D487/08 , C07D487/14 , C07D491/08 , C07D495/04 , C07D513/04 , C07H13/10
摘要： This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula (I) wherein Q, J, L and Z are as defined in the specification.
摘要翻译： 本发明涉及抑制组蛋白脱乙酰酶的化合物。 更具体地说，本发明提供式（I）化合物，其中Q，J，L和Z如说明书中所定义。
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![Dibenzo[b,f][1,4]oxazepin-11-yl-N-hydroxybenzamides as HDAC inhibitors](/abs-image/US/2013/03/19/US08399452B2/abs.jpg.150x150.jpg)
公开(公告)号：US08399452B2
公开(公告)日：2013-03-19
申请号：US11925151
申请日：2007-10-26
申请人： Robert Déziel , Silvana Leit , Patrick Beaulieu , Yves Andre Chantigny , John Mancuso , Pierre Tessier , Gideon Shapiro , Richard Chesworth , David Smil
发明人： Robert Déziel , Silvana Leit , Patrick Beaulieu , Yves Andre Chantigny , John Mancuso , Pierre Tessier , Gideon Shapiro , Richard Chesworth , David Smil
IPC分类号： A61K31/553 , A61K31/554 , C07D267/16
CPC分类号： C07D498/04 , C07C259/06 , C07C259/10 , C07D209/02 , C07D209/08 , C07D209/52 , C07D209/94 , C07D221/12 , C07D223/16 , C07D223/20 , C07D223/22 , C07D223/24 , C07D223/26 , C07D223/28 , C07D225/08 , C07D239/28 , C07D239/34 , C07D239/42 , C07D243/24 , C07D243/38 , C07D265/38 , C07D267/14 , C07D267/18 , C07D267/20 , C07D279/22 , C07D279/26 , C07D281/16 , C07D285/36 , C07D291/08 , C07D295/155 , C07D313/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/06 , C07D413/12 , C07D471/04 , C07D471/08 , C07D471/14 , C07D487/04 , C07D487/08 , C07D487/14 , C07D491/08 , C07D495/04 , C07D513/04 , C07H13/10
摘要： This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula (I) wherein Q, J, L and Z are as defined in the specification.
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公开(公告)号：US08217064B2
公开(公告)日：2012-07-10
申请号：US12341201
申请日：2008-12-22
申请人： Gideon Shapiro , Richard Chesworth
发明人： Gideon Shapiro , Richard Chesworth
IPC分类号： A61K31/4245 , A61K31/433 , A61K31/192 , C07D498/00 , C07C59/48
CPC分类号： C07C51/09 , C07C51/42 , C07C59/72 , C07C67/343 , C07C67/48 , C07C69/734 , C07C69/757 , C07C205/37 , C07C205/55 , C07C205/56 , C07C229/42 , C07C255/57 , C07C323/18 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D271/12 , C07D277/64 , C07D285/14 , C07D309/08
摘要： Tetrasubstituted benzenes that act as modulators of gamma secretase and their use in the treatment of one or more symptoms of treating neurodegenerative disorders, e.g., Alzheimer's disease, are described.
摘要翻译： 描述了作为γ分泌酶的调节剂的四氮取代的苯及其在治疗治疗神经变性疾病例如阿尔茨海默病的一种或多种症状中的用途。
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公开(公告)号：US20110183976A1
公开(公告)日：2011-07-28
申请号：US13001359
申请日：2009-06-25
申请人： Amy Ripka , Gideon Shapiro , Richard Chesworth
发明人： Amy Ripka , Gideon Shapiro , Richard Chesworth
IPC分类号： A61K31/5377 , C07D401/12 , C07D413/14 , C07D401/14 , C07D405/14 , C07D405/12 , C07D471/04 , A61K31/4709 , A61K31/498 , A61K31/4375 , A61K31/517 , A61K31/501 , A61K31/53 , A61P25/00 , A61P3/04 , A61P15/00 , A61P25/34 , A61P25/18 , A61P25/14
CPC分类号： A61K31/53 , A61K31/4375 , A61K31/4439 , A61K31/4709 , A61K31/498 , A61K31/501 , A61K31/506 , A61K31/517 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： 5- and 6-membered heterocyclic compounds which are inhibitors of phosphodiesterase 10 are described as are processes, pharmaceutical compositions, pharmaceutical preparations and pharmaceutical use of the compounds in the treatment of mammals, including human(s) for central nervous system (CNS) disorders and other disorders which may affect CNS function. Also described is the treatment of neurological, neurodegenerative and psychiatric disorders including but not limited to those comprising cognitive deficits or schizophrenic symptoms.
摘要翻译： 作为磷酸二酯酶10的抑制剂的5-和6-元杂环化合物被描述为方法，药物组合物，药物制剂和化合物在治疗哺乳动物（包括中枢神经系统（CNS）病症的人）中的药物用途 和其他可能影响CNS功能的疾病。 还描述了治疗神经系统，神经变性和精神病学障碍，包括但不限于包括认知缺陷或精神分裂症状的那些。
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7.发明申请Method of treating neurological disorders using clotrimazole and derivatives thereof 审中-公开使用克霉唑及其衍生物治疗神经障碍的方法公开(公告)号：US20070037800A1
公开(公告)日：2007-02-15
申请号：US11473479
申请日：2006-06-23
IPC分类号： A61K31/5375 , A61K31/4196 , A61K31/4192 , A61K31/415 , A61K31/41
CPC分类号： A61K31/415 , A61K31/41 , A61K31/4192 , A61K31/4196 , A61K31/5375
摘要： Methods and pharmaceutical compositions are disclosed for treating neurological disorders, such as Huntington's disease or Alzheimer's disease. The methods involve the administration of a triarylmethane compound, such as clotrimazole, or a salt thereof.
摘要翻译： 公开了用于治疗诸如亨廷顿病或阿尔茨海默氏病之类的神经障碍的方法和药物组合物。 所述方法包括施用三芳基甲烷化合物，例如克霉唑或其盐。
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![Crystalline Form of (R)-7-Chloro-N-(Quinuclidin-3-yl)benzo[B]thiophene-2-Carboxamide Hydrochloride Monohydrate](/abs-image/US/2013/07/18/US20130183380A1/abs.jpg.150x150.jpg)
8.发明申请Crystalline Form of (R)-7-Chloro-N-(Quinuclidin-3-yl)benzo[B]thiophene-2-Carboxamide Hydrochloride Monohydrate 有权（R）-7-氯-N-（奎宁环-3-基）苯并[b]噻吩-2-甲酰胺盐酸盐一水合物的结晶形式公开(公告)号：US20130183380A1
公开(公告)日：2013-07-18
申请号：US13698759
申请日：2011-05-17
申请人： Patricia Oliver-Shaffer , Gideon Shapiro , Richard Chesworth , Muneki Kishida , Takayuki Ishige
发明人： Patricia Oliver-Shaffer , Gideon Shapiro , Richard Chesworth , Muneki Kishida , Takayuki Ishige
IPC分类号： C07D453/02
CPC分类号： C07D453/02 , A61K9/4833 , A61K31/439 , C07B2200/13 , C30B29/54
摘要： Crystalline Forms I and II of (R)-7-chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride monohydrate and compositions, methods of manufacture and therapeutic uses thereof are described.
摘要翻译： （R）-7-氯-N-（奎宁环-3-基）苯并[b]噻吩-2-甲酰胺盐酸盐一水合物的结晶形式I和II及其制备方法及其治疗用途。
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公开(公告)号：US08343973B2
公开(公告)日：2013-01-01
申请号：US12642026
申请日：2009-12-18
申请人： Amy Ripka , Gideon Shapiro , Richard Chesworth
发明人： Amy Ripka , Gideon Shapiro , Richard Chesworth
IPC分类号： C07D487/04 , A61K31/5025 , A61P25/28
CPC分类号： C07D487/04 , C07D405/04 , C07D471/04
摘要： Phenoxymethyl compounds that inhibit at least one phosphodiesterase 10 are described as are pharmaceutical compositions containing such compounds an methods for treating various CNS disorders by administering such compounds to a patient in need thereof.
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公开(公告)号：US08071595B2
公开(公告)日：2011-12-06
申请号：US12490808
申请日：2009-06-24
申请人： Amy Ripka , Gideon Shapiro , Richard Chesworth
发明人： Amy Ripka , Gideon Shapiro , Richard Chesworth
IPC分类号： A61K31/53 , A61K31/498 , A61K31/501 , A61K31/506 , A61K31/517 , A61K31/4375 , A61K31/4709 , A61K31/4439 , C07D405/14 , C07D403/14 , C07D471/04 , C07D417/14 , C07D413/14
CPC分类号： A61K31/53 , A61K31/4375 , A61K31/4439 , A61K31/4709 , A61K31/498 , A61K31/501 , A61K31/506 , A61K31/517 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： 1,2-disubstituted heterocyclic compounds which are inhibitors of phosphodiesterase 10 are described. Also described are processes, pharmaceutical compositions, pharmaceutical preparations and pharmaceutical use of the compounds in the treatment of mammals, including human(s) for central nervous system (CNS) disorders and other disorders which may affect CNS function. Among the disorders which may be treated are neurological, neurodegenerative and psychiatric disorders including, but not limited to, those associated with cognitive deficits or schizophrenic symptoms.
摘要翻译： 描述了作为磷酸二酯酶10抑制剂的1,2-二取代杂环化合物。 还描述了化合物在治疗哺乳动物（包括中枢神经系统（CNS）病症的人）和可能影响CNS功能的其它疾病中的方法，药物组合物，药物制剂和药物用途。 可以治疗的疾病包括神经学，神经变性和精神病学障碍，包括但不限于与认知缺陷或精神分裂症状相关的疾病。
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