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    Pro-Neurogenic Compounds
    6.
    发明申请
    Pro-Neurogenic Compounds 有权
    前神经源性化合物

    公开(公告)号：US20140057900A1

    公开(公告)日：2014-02-27

    申请号：US13974642

    申请日：2013-08-23

    申请人： Board of Regents of The University of Texas System

    发明人： Steven L. McKnight ,  Andrew A. Pieper ,  Joseph M. Ready ,  Enrique Fernandez

    IPC分类号： C07D471/04 ,  C07D403/06 ,  C07D209/90 ,  C07D405/06 ,  C07D223/24 ,  C07D487/04

    CPC分类号： C07D471/04 ,  A61K31/403 ,  A61K31/519 ,  A61K31/55 ,  C07D209/90 ,  C07D223/24 ,  C07D403/06 ,  C07D405/06 ,  C07D487/04

    摘要： Compounds and methods for stimulating neurogenesis (e.g., post-natal neurogenesis, including post-natal hippocampal and hypothalamic neurogenesis) and/or protecting neuronal cell from cell death are disclosed herein. In vivo activity tests suggest that these compounds may have therapeutic benefits in neuropsychiatric and/or neurodegenerative diseases such as schizophrenia, major depression, bipolar disorder, normal aging, epilepsy, traumatic brain injury, post-traumatic stress disorder, Parkinson's disease, Alzheimer's disease, Down syndrome, spinocerebellar ataxia, amyotrophic lateral sclerosis, Huntington's disease, stroke, radiation therapy, chronic stress, abuse of a neuro-active drug, retinal degeneration, spinal cord injury, peripheral nerve injury, physiological weight loss associated with various conditions, as well as cognitive decline associated with normal aging, chemotherapy, and the like.

    摘要翻译： 本文公开了用于刺激神经发生（例如，产后神经发生，包括产后海马和下丘脑神经发生）和/或保护神经细胞免于细胞死亡的化合物和方法。 体内活性测试表明，这些化合物可能在神经精神和/或神经变性疾病如精神分裂症，主要抑郁症，双相性精神障碍，正常衰老，癫痫，创伤性脑损伤，创伤后应激障碍，帕金森病，阿尔茨海默病， 唐氏综合征，脊髓小脑性共济失调，肌萎缩性侧索硬化，亨廷顿病，中风，放射治疗，慢性应激，神经活性药物滥用，视网膜变性，脊髓损伤，周围神经损伤，与各种病症相关的生理体重减轻 作为与正常老化，化学疗法等相关的认知衰退。