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公开(公告)号:US20110196147A1
公开(公告)日:2011-08-11
申请号:US13079458
申请日:2011-04-04
申请人: Robert Déziel , Silvana Leit , Patrick Beaulieu , Yves Andre Chantigny , John Mancuso , Pierre Tessier , Gideon Shapiro , Richard Chesworth , David Smil
发明人: Robert Déziel , Silvana Leit , Patrick Beaulieu , Yves Andre Chantigny , John Mancuso , Pierre Tessier , Gideon Shapiro , Richard Chesworth , David Smil
IPC分类号: C07D267/16 , C07D223/24 , C07C233/01 , C07D243/24 , C07D471/04 , C07D239/42 , C07D291/08 , C07D403/14 , C07D279/22 , C07D265/38
CPC分类号: C07D498/04 , C07C259/06 , C07C259/10 , C07D209/02 , C07D209/08 , C07D209/52 , C07D209/94 , C07D221/12 , C07D223/16 , C07D223/20 , C07D223/22 , C07D223/24 , C07D223/26 , C07D223/28 , C07D225/08 , C07D239/28 , C07D239/34 , C07D239/42 , C07D243/24 , C07D243/38 , C07D265/38 , C07D267/14 , C07D267/18 , C07D267/20 , C07D279/22 , C07D279/26 , C07D281/16 , C07D285/36 , C07D291/08 , C07D295/155 , C07D313/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/06 , C07D413/12 , C07D471/04 , C07D471/08 , C07D471/14 , C07D487/04 , C07D487/08 , C07D487/14 , C07D491/08 , C07D495/04 , C07D513/04 , C07H13/10
摘要: This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula (I) wherein Q, J, L and Z are as defined in the specification.
摘要翻译: 本发明涉及抑制组蛋白脱乙酰酶的化合物。 更具体地说,本发明提供式(I)化合物,其中Q,J,L和Z如说明书中所定义。
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公开(公告)号:US08399452B2
公开(公告)日:2013-03-19
申请号:US11925151
申请日:2007-10-26
申请人: Robert Déziel , Silvana Leit , Patrick Beaulieu , Yves Andre Chantigny , John Mancuso , Pierre Tessier , Gideon Shapiro , Richard Chesworth , David Smil
发明人: Robert Déziel , Silvana Leit , Patrick Beaulieu , Yves Andre Chantigny , John Mancuso , Pierre Tessier , Gideon Shapiro , Richard Chesworth , David Smil
IPC分类号: A61K31/553 , A61K31/554 , C07D267/16
CPC分类号: C07D498/04 , C07C259/06 , C07C259/10 , C07D209/02 , C07D209/08 , C07D209/52 , C07D209/94 , C07D221/12 , C07D223/16 , C07D223/20 , C07D223/22 , C07D223/24 , C07D223/26 , C07D223/28 , C07D225/08 , C07D239/28 , C07D239/34 , C07D239/42 , C07D243/24 , C07D243/38 , C07D265/38 , C07D267/14 , C07D267/18 , C07D267/20 , C07D279/22 , C07D279/26 , C07D281/16 , C07D285/36 , C07D291/08 , C07D295/155 , C07D313/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/06 , C07D413/12 , C07D471/04 , C07D471/08 , C07D471/14 , C07D487/04 , C07D487/08 , C07D487/14 , C07D491/08 , C07D495/04 , C07D513/04 , C07H13/10
摘要: This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula (I) wherein Q, J, L and Z are as defined in the specification.
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公开(公告)号:US20080207590A1
公开(公告)日:2008-08-28
申请号:US11925151
申请日:2007-10-26
申请人: Robert Deziel , Silvana Leit , Patrick Beaulieu , Yves Andre Chantigny , John Mancuso , Pierre Tessier , Gideon Shapiro , Richard Chesworth , David Smil
发明人: Robert Deziel , Silvana Leit , Patrick Beaulieu , Yves Andre Chantigny , John Mancuso , Pierre Tessier , Gideon Shapiro , Richard Chesworth , David Smil
IPC分类号: A61K31/553 , C07D267/10 , C07D239/28 , A61K31/5513 , A61P43/00 , A61K31/506 , C07D243/14
CPC分类号: C07D498/04 , C07C259/06 , C07C259/10 , C07D209/02 , C07D209/08 , C07D209/52 , C07D209/94 , C07D221/12 , C07D223/16 , C07D223/20 , C07D223/22 , C07D223/24 , C07D223/26 , C07D223/28 , C07D225/08 , C07D239/28 , C07D239/34 , C07D239/42 , C07D243/24 , C07D243/38 , C07D265/38 , C07D267/14 , C07D267/18 , C07D267/20 , C07D279/22 , C07D279/26 , C07D281/16 , C07D285/36 , C07D291/08 , C07D295/155 , C07D313/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/06 , C07D413/12 , C07D471/04 , C07D471/08 , C07D471/14 , C07D487/04 , C07D487/08 , C07D487/14 , C07D491/08 , C07D495/04 , C07D513/04 , C07H13/10
摘要: This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula (I) wherein Q, J, L and Z are as defined in the specification.
摘要翻译: 本发明涉及抑制组蛋白脱乙酰酶的化合物。 更具体地说,本发明提供式(I)化合物,其中Q,J,L和Z如说明书中所定义。
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4.Dibenzo[B,F][1,4]Oxazepin-11-yl-N-Hydroxybenzamides as HDAC Inhibitors 有权
标题翻译: 二苯并[B,F] [1,4]氧氮杂-11-基-N-羟基苯甲酰胺作为HDAC抑制剂公开(公告)号:US20140011988A1
公开(公告)日:2014-01-09
申请号:US13767478
申请日:2013-02-14
申请人: Robert Deziel , Silvana Leit , Patrick Beaulieu , Yves Andre Chantigny , John Mancuso , Pierre Tessier , Gideon Shapiro , Richard Chesworth , David Smil
发明人: Robert Deziel , Silvana Leit , Patrick Beaulieu , Yves Andre Chantigny , John Mancuso , Pierre Tessier , Gideon Shapiro , Richard Chesworth , David Smil
IPC分类号: C07H13/10 , C07D243/38 , C07D498/04 , C07D487/08 , C07D295/155 , C07D487/14 , C07D413/12 , C07D487/04 , C07D267/20 , C07D281/16
CPC分类号: C07D498/04 , C07C259/06 , C07C259/10 , C07D209/02 , C07D209/08 , C07D209/52 , C07D209/94 , C07D221/12 , C07D223/16 , C07D223/20 , C07D223/22 , C07D223/24 , C07D223/26 , C07D223/28 , C07D225/08 , C07D239/28 , C07D239/34 , C07D239/42 , C07D243/24 , C07D243/38 , C07D265/38 , C07D267/14 , C07D267/18 , C07D267/20 , C07D279/22 , C07D279/26 , C07D281/16 , C07D285/36 , C07D291/08 , C07D295/155 , C07D313/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D413/06 , C07D413/12 , C07D471/04 , C07D471/08 , C07D471/14 , C07D487/04 , C07D487/08 , C07D487/14 , C07D491/08 , C07D495/04 , C07D513/04 , C07H13/10
摘要: This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula (I) wherein Q, J, L and Z are as defined in the specification.
摘要翻译: 本发明涉及抑制组蛋白脱乙酰酶的化合物。 更具体地说,本发明提供式(I)化合物,其中Q,J,L和Z如说明书中所定义。
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公开(公告)号:US09096565B2
公开(公告)日:2015-08-04
申请号:US12100200
申请日:2008-04-09
申请人: Pierre Tessier , Silvana Leit , David Smil , Robert Deziel , Alain Ajamian , Yves Andre Chantigny , Celia Dominguez
发明人: Pierre Tessier , Silvana Leit , David Smil , Robert Deziel , Alain Ajamian , Yves Andre Chantigny , Celia Dominguez
IPC分类号: C07D295/088 , A61K31/5375 , C07D307/79 , C07C259/06 , C07C275/42 , C07C311/08 , C07C311/21 , C07C323/52 , C07D205/04 , C07D207/263 , C07D207/337 , C07D209/08 , C07D209/44 , C07D211/34 , C07D211/46 , C07D211/52 , C07D211/64 , C07D211/76 , C07D213/56 , C07D213/64 , C07D213/70 , C07D213/74 , C07D215/26 , C07D219/04 , C07D231/14 , C07D233/84 , C07D235/16 , C07D235/28 , C07D239/26 , C07D239/34 , C07D239/38 , C07D239/42 , C07D249/06 , C07D267/20 , C07D277/36 , C07D277/74 , C07D285/12 , C07D295/155 , C07D295/192 , C07D295/205 , C07D295/26 , C07D311/84 , C07D317/50 , C07D333/24 , C07D401/04 , C07D401/06 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/06 , C07D471/04 , C07D491/08 , C07D491/10 , C07D513/04
CPC分类号: C07D307/79 , C07C259/06 , C07C275/42 , C07C311/08 , C07C311/21 , C07C323/52 , C07D205/04 , C07D207/263 , C07D207/337 , C07D209/08 , C07D209/44 , C07D211/34 , C07D211/46 , C07D211/52 , C07D211/64 , C07D211/76 , C07D213/56 , C07D213/64 , C07D213/70 , C07D213/74 , C07D215/26 , C07D219/04 , C07D231/14 , C07D233/84 , C07D235/16 , C07D235/28 , C07D239/26 , C07D239/34 , C07D239/38 , C07D239/42 , C07D249/06 , C07D267/20 , C07D277/36 , C07D277/74 , C07D285/12 , C07D295/088 , C07D295/155 , C07D295/192 , C07D295/205 , C07D295/26 , C07D311/84 , C07D317/50 , C07D333/24 , C07D401/04 , C07D401/06 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/06 , C07D471/04 , C07D491/08 , C07D491/10 , C07D513/04
摘要: This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of the Formula (I) and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, and racemic and scalemic mixtures, diastereomers and enantiomers thereof, wherein groups L, M, X and Y are as defined herein.
摘要翻译: 本发明涉及抑制组蛋白脱乙酰酶的化合物。 更具体地说,本发明提供式(I)的化合物及其N-氧化物,水合物,溶剂化物,其药学上可接受的盐,前体药物和复合物,以及其外消旋和可比混合物,非对映异构体和对映异构体,其中基团L,M,X 和Y如本文所定义。
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公开(公告)号:US20090181943A1
公开(公告)日:2009-07-16
申请号:US12100200
申请日:2008-04-09
申请人: Pierre Tessier , Silvana Leit , David Smil , Robert Deziel , Alain Ajamian , Yves Andre Chantigny , Celia Dominguez
发明人: Pierre Tessier , Silvana Leit , David Smil , Robert Deziel , Alain Ajamian , Yves Andre Chantigny , Celia Dominguez
IPC分类号: A61K31/553 , C07D307/78 , A61K31/343 , C07C233/01 , A61K31/164 , C07D211/32 , A61K31/445 , C07D249/04 , A61K31/4192 , C07C311/15 , A61K31/18 , C07D235/04 , A61K31/4184 , C07D285/12 , A61K31/433 , C07D241/04 , A61K31/495 , C07D403/02 , A61P37/00 , A61P9/00 , A61P29/00 , A61P3/10 , A61P35/00 , C12N9/99 , A61K31/496 , C07D279/12 , A61K31/54 , C07D295/00 , A61K31/5375 , C07D213/56 , A61K31/44 , C07D219/02 , A61K31/435 , C07D267/16
CPC分类号: C07D307/79 , C07C259/06 , C07C275/42 , C07C311/08 , C07C311/21 , C07C323/52 , C07D205/04 , C07D207/263 , C07D207/337 , C07D209/08 , C07D209/44 , C07D211/34 , C07D211/46 , C07D211/52 , C07D211/64 , C07D211/76 , C07D213/56 , C07D213/64 , C07D213/70 , C07D213/74 , C07D215/26 , C07D219/04 , C07D231/14 , C07D233/84 , C07D235/16 , C07D235/28 , C07D239/26 , C07D239/34 , C07D239/38 , C07D239/42 , C07D249/06 , C07D267/20 , C07D277/36 , C07D277/74 , C07D285/12 , C07D295/088 , C07D295/155 , C07D295/192 , C07D295/205 , C07D295/26 , C07D311/84 , C07D317/50 , C07D333/24 , C07D401/04 , C07D401/06 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/06 , C07D471/04 , C07D491/08 , C07D491/10 , C07D513/04
摘要: This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula compounds of the Formula (I) and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, and racemic and scalemic mixtures, diastereomers and enantiomers thereof, wherein groups L, M, X and Y are as defined herein.
摘要翻译: 本发明涉及抑制组蛋白脱乙酰酶的化合物。 更具体地,本发明提供式(I)的式化合物及其N-氧化物,水合物,溶剂合物,药学上可接受的盐,前体药物和复合物的化合物及其外消旋和可饱和的混合物,非对映异构体和对映异构体,其中基团L, M,X和Y如本文所定义。
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