-
公开(公告)号：US20090124722A1
公开(公告)日：2009-05-14
申请号：US11938488
申请日：2007-11-12
IPC分类号： C08F120/56
CPC分类号： A61L27/16 , A61L27/52 , C08F8/00 , C08J3/075 , C08J2329/04 , Y10S524/916 , C08L29/04 , C08F16/06
摘要： The present invention provides a hydrogel composition comprising a mixture of a hydrophilic polymer and a polymer chain modifying agent, wherein the polymer chain modifying agent is selected from the group consisting of an aromatic tetracarboxylic dianhydride, a titanate, and a polyetherimide. The present invention also provides a method for producing a phase separated, branched, copolymer hydrogel comprising a mixture of a hydrophilic polymer and a polymer chain modifying agent. The present invention also provides an implantable medical device comprising a phase separated, branched, copolymer hydrogel wherein the phase separated, branched, copolymer hydrogel is formed of a hydrophilic polymer and a polymer chain modifying agent.
摘要翻译： 本发明提供包含亲水性聚合物和聚合物链改性剂的混合物的水凝胶组合物，其中所述聚合物链改性剂选自芳族四羧酸二酐，钛酸酯和聚醚酰亚胺。 本发明还提供一种制备包含亲水性聚合物和聚合物链改性剂的混合物的相分离的支链共聚物水凝胶的方法。 本发明还提供了一种可植入医疗装置，其包括相分离的支链共聚物水凝胶，其中相分离的支化共聚物水凝胶由亲水性聚合物和聚合物链改性剂形成。
-
公开(公告)号：US07919542B2
公开(公告)日：2011-04-05
申请号：US11938488
申请日：2007-11-12
CPC分类号： A61L27/16 , A61L27/52 , C08F8/00 , C08J3/075 , C08J2329/04 , Y10S524/916 , C08L29/04 , C08F16/06
摘要： The present invention provides a hydrogel composition comprising a mixture of a hydrophilic polymer and a polymer chain modifying agent, wherein the polymer chain modifying agent is selected from the group consisting of an aromatic tetracarboxylic dianhydride, a titanate, and a polyetherimide. The present invention also provides a method for producing a phase separated, branched, copolymer hydrogel comprising a mixture of a hydrophilic polymer and a polymer chain modifying agent. The present invention also provides an implantable medical device comprising a phase separated, branched, copolymer hydrogel wherein the phase separated, branched, copolymer hydrogel is formed of a hydrophilic polymer and a polymer chain modifying agent.
摘要翻译： 本发明提供包含亲水性聚合物和聚合物链改性剂的混合物的水凝胶组合物，其中所述聚合物链改性剂选自芳族四羧酸二酐，钛酸酯和聚醚酰亚胺。 本发明还提供一种制备包含亲水性聚合物和聚合物链改性剂的混合物的相分离的支链共聚物水凝胶的方法。 本发明还提供了一种可植入医疗装置，其包括相分离的支链共聚物水凝胶，其中相分离的支化共聚物水凝胶由亲水性聚合物和聚合物链改性剂形成。
-
公开(公告)号：US07766965B2
公开(公告)日：2010-08-03
申请号：US11428120
申请日：2006-06-30
IPC分类号： A61F2/44
CPC分类号： C08G18/4854 , A61B1/00165 , A61B17/00234 , A61B17/16 , A61B17/17 , A61B17/7097 , A61B2017/00535 , A61F2/07 , A61F2/28 , A61F2/30756 , A61F2/30767 , A61F2/3099 , A61F2/32 , A61F2/38 , A61F2/4081 , A61F2/4202 , A61F2/441 , A61F2/442 , A61F2/4601 , A61F2/4611 , A61F2/82 , A61F2/945 , A61F2002/30016 , A61F2002/30024 , A61F2002/3008 , A61F2002/30235 , A61F2002/30563 , A61F2002/30578 , A61F2002/30583 , A61F2002/30601 , A61F2002/30841 , A61F2002/30929 , A61F2002/30957 , A61F2002/4233 , A61F2002/444 , A61F2002/4627 , A61F2002/4635 , A61F2210/0085 , A61F2230/0069 , A61F2250/0019 , A61F2250/0021 , A61F2250/0098 , A61L27/18 , A61L29/041 , A61L29/06 , A61L2430/38 , B01F2215/0039 , C08G18/10 , C08G18/69 , Y10S606/907 , Y10S606/91 , C08L83/04 , C08L75/04 , C08L23/00 , C08L67/02 , C08G18/3206
摘要： A method of treating a diseased or damaged intervertebral disc having a nucleus pulposus and an annulus. The method includes the steps of accessing and preparing the intervertebral disc for receipt of the biomaterial by removing at least a portion of the nucleus pulposus to create a nuclear cavity. A quantity of the curable biomaterial is delivered under pressure to the nuclear cavity. The delivered biomaterial is at least partially cured in such a manner to retain it in the nuclear cavity. The at least partially cured biomaterial is contoured to achieve a desired conformation approximating that of the nuclear cavity.
摘要翻译： 一种治疗患有或受损的具有髓核和环的椎间盘的方法。 该方法包括以下步骤：通过去除髓核的至少一部分以产生核腔来获取和准备用于接收生物材料的椎间盘。 一定量的可固化生物材料在压力下输送到核腔。 递送的生物材料至少部分地固化以将其保持在核腔中。 所述至少部分固化的生物材料的轮廓是实现与核腔近似的所需构型。
-
公开(公告)号：US07713301B2
公开(公告)日：2010-05-11
申请号：US11277887
申请日：2006-03-29
IPC分类号： A61F2/44
CPC分类号： C08G18/4854 , A61B1/00165 , A61B17/00234 , A61B17/16 , A61B17/17 , A61B17/7097 , A61B2017/00535 , A61F2/07 , A61F2/28 , A61F2/30756 , A61F2/30767 , A61F2/3099 , A61F2/32 , A61F2/38 , A61F2/4081 , A61F2/4202 , A61F2/441 , A61F2/442 , A61F2/4601 , A61F2/4611 , A61F2/82 , A61F2/945 , A61F2002/30016 , A61F2002/30024 , A61F2002/3008 , A61F2002/30235 , A61F2002/30563 , A61F2002/30578 , A61F2002/30583 , A61F2002/30601 , A61F2002/30841 , A61F2002/30929 , A61F2002/30957 , A61F2002/4233 , A61F2002/444 , A61F2002/4627 , A61F2002/4635 , A61F2210/0085 , A61F2230/0069 , A61F2250/0019 , A61F2250/0021 , A61F2250/0098 , A61L27/18 , A61L29/041 , A61L29/06 , A61L2430/38 , B01F2215/0039 , C08G18/10 , C08G18/69 , Y10S606/907 , Y10S606/91 , C08L83/04 , C08L75/04 , C08L23/00 , C08L67/02 , C08G18/3206
摘要： A system for repairing an intervertebral disc by delivering and curing a biomaterial in situ within the disc. The system includes both a device, having an insertable balloon and related lumen, controls and adapters, as well as an in situ curable biomaterial (and related biomaterial delivery means). The system can allow the doctor to determine a suitable endpoint for biomaterial delivery, by controlling distraction and/or biomaterial delivery pressure, and in turn, to deliver a desired quantity of biomaterial to the balloon in order to achieve improved polymer cure and implant characteristics. Also provided is a related method for repairing an intervertebral disc by using such a system to deliver and cure the biomaterial in situ. The system can be used to implant a prosthetic total disc, or a prosthetic disc nucleus in a manner that leaves the surrounding disc tissue substantially intact.
摘要翻译： 一种通过在盘内原位递送和固化生物材料来修复椎间盘的系统。 该系统包括具有可插入球囊和相关内腔的装置，对照和适配器，以及原位可固化生物材料（和相关的生物材料递送装置）。 该系统可以允许医生通过控制牵引和/或生物材料输送压力来确定用于生物材料递送的合适的终点，并且反过来，将气体中所需量的生物材料输送到气囊中，以实现改进的聚合物固化和植入特征。 还提供了一种通过使用这种系统来原位递送和固化生物材料来修复椎间盘的相关方法。 该系统可以用于以使得周围的盘组织基本上完整的方式植入假体总盘或假体椎间盘细胞核。
-
公开(公告)号：US07645301B2
公开(公告)日：2010-01-12
申请号：US11332622
申请日：2006-01-13
申请人： Robert Garryl Hudgins , Bruce Robie
发明人： Robert Garryl Hudgins , Bruce Robie
IPC分类号： A61F2/44
CPC分类号： A61F2/441 , A61F2/30965 , A61F2002/2817 , A61F2002/30011 , A61F2002/30136 , A61F2002/30144 , A61F2002/302 , A61F2002/30291 , A61F2002/30311 , A61F2002/30441 , A61F2002/30578 , A61F2002/30579 , A61F2002/30841 , A61F2002/30892 , A61F2002/4435 , A61F2002/444 , A61F2220/0041 , A61F2230/0004 , A61F2230/0017 , A61F2230/0065 , A61F2230/0091 , A61F2250/0023 , A61F2310/00017 , A61F2310/00023 , A61F2310/00796 , A61F2310/00976
摘要： The present disclosure concerns implants to at least partially replace the nucleus of a spinal disc. In one embodiment, a prosthetic implant is provided which includes a bag structure having a fixation component or member, the bag operable to contain at least one internal implant within the bag. In other embodiments, a bag structure is provided with a flange adaptable to anchor the structure to a vertebral body and a sinusoidal-shaped structure made of a flexible material is provided with various unique configurations. In one embodiment, for delivery, a bag structure with a flange may be attached to a vertebral body. In another embodiment, a sinusoidal-shaped implant structure is alternately woven from one end to the other with a second sinusoidal-shaped structure.
摘要翻译： 本公开涉及至少部分地替代脊椎盘的核的植入物。 在一个实施例中，提供了一种假体植入物，其包括具有固定部件或构件的袋结构，所述袋可操作以在袋内容纳至少一个内部植入物。 在其他实施例中，袋结构设置有适于将结构锚定到椎体的凸缘，并且由柔性材料制成的正弦形结构具有各种独特的构造。 在一个实施例中，为了输送，具有凸缘的袋结构可以附接到椎体。 在另一个实施例中，正弦形植入物结构从一端交替地以第二正弦形结构编织。
-
公开(公告)号：US07618457B2
公开(公告)日：2009-11-17
申请号：US11201837
申请日：2005-08-10
IPC分类号： A61F2/44
CPC分类号： A61F2/441 , A61F2002/30004 , A61F2002/30136 , A61F2002/30588 , A61F2002/444 , A61F2002/4495 , A61F2230/0004 , A61F2250/0014 , A61F2310/00017 , A61F2310/00023 , A61F2310/0097 , A61F2310/00976
摘要： The present disclosure concerns implants to at least partially replace the nucleus of a spinal disc. In one embodiment, a prosthetic structure is provided which includes a bag operable to contain at least one internal implant within the bag. In another embodiment, a sinusoidal-shaped structure made of a flexible material is provided with various unique configurations to act as the internal implant and once released from a stretched or compressed configuration resumes nearly its original shape. In one embodiment, for delivery, a sinusoidal-shaped structure may be in a reduced amplitude state. In another embodiment, a sinusoidal-shaped structure is alternately woven from one end to the other with a second sinusoidal-shaped structure.
摘要翻译： 本公开涉及至少部分地替代脊椎盘的核的植入物。 在一个实施例中，提供了一种假体结构，其包括可操作以在袋内容纳至少一个内部植入物的袋。 在另一个实施例中，由柔性材料制成的正弦形结构被提供有各种独特的构造以用作内部植入物，并且一旦从拉伸或压缩构型释放，恢复到几乎其原始形状。 在一个实施例中，为了传送，正弦形结构可以处于减小的幅度状态。 在另一个实施例中，正弦形结构从一端交替地以第二正弦形结构编织。
-
公开(公告)号：US08017139B2
公开(公告)日：2011-09-13
申请号：US11358383
申请日：2006-02-21
IPC分类号： A61F13/00
CPC分类号： C08L29/04 , A61K31/728 , A61K35/545 , A61K38/18 , C08J3/005 , C08J3/075 , C08J3/097 , C08J3/11 , C08J2325/08 , C08J2329/04 , C08J2367/02 , C08K5/0016 , C08L23/26 , C08L25/08 , C08L67/02 , C08L101/14 , C08L2666/04 , C08L2666/02 , C08L2666/14
摘要： The present invention provides blend water-swellable materials and hydrogels suitable for use in biomedical or other applications. The blend water swellable materials and hydrogels have at least one hydrophilic polymer and at least one other polymer or oligomer having both hydrophobic and hydrophilic recurring units where the blend phase separates and is opaque and immiscible in the presence of water. Methods of making these blend water-swellable materials and hydrogels are also described.
摘要翻译： 本发明提供了适用于生物医学或其他应用的共混水溶胀性材料和水凝胶。 共混水可溶胀材料和水凝胶具有至少一种亲水聚合物和至少一种具有疏水和亲水性重复单元的其它聚合物或低聚物，其中共混物相分离并且在水存在下是不透明的和不混溶的。 还描述了制备这些共混水溶胀性材料和水凝胶的方法。
-
公开(公告)号：US08007535B2
公开(公告)日：2011-08-30
申请号：US11421571
申请日：2006-06-01
申请人： Robert Garryl Hudgins , Melanie Chapman , Guido Casutt , Rosemary Thompson , Thomas O. Viker , Hugh D. Hestad
发明人： Robert Garryl Hudgins , Melanie Chapman , Guido Casutt , Rosemary Thompson , Thomas O. Viker , Hugh D. Hestad
IPC分类号： A61F2/44
CPC分类号： A61F2/441 , A61F2/4455 , A61F2/4601 , A61F2/4611 , A61F2002/30067 , A61F2002/302 , A61F2002/30448 , A61F2002/30461 , A61F2002/30583 , A61F2002/4627 , A61F2210/0085 , A61F2220/005 , A61F2220/0075 , A61F2230/0065 , A61F2310/00353
摘要： The present invention provides an injectable annular ring useful in treating a deteriorating spinal disc. When used, the annular ring may be collapsed or folded in order for it to be placed through a small opening in a prepared intervertebral space within the annulus using minimally invasive techniques. Deployment or unfolding the ring in the intervertebral space provides an interior cavity bordered by the ring that is in direct contact with the vertebral endplates. When an internal volume of the ring is inject or filled with a load-bearing, hardenable material, the filled ring maintains the intervertebral spacing and prevents the ring from being expelled from the interior cavity through the small annular opening.
摘要翻译： 本发明提供了一种可用于治疗恶化的脊椎盘的可注射环形环。 当使用时，环形圈可以折叠或折叠，以便通过使用微创技术在环形空间内的准备好的椎间空间中的小开口放置环形环。 在椎间空间中展开或展开环提供了与椎骨端板直接接触的环邻接的内部空腔。 当环的内部体积被注入或填充有承载的可硬化材料时，填充的环保持椎间间隔，并且防止环通过小的环形开口从内部空腔排出。
-
公开(公告)号：US07077865B2
公开(公告)日：2006-07-18
申请号：US10365842
申请日：2003-02-13
IPC分类号： A61F2/44
CPC分类号： C08G18/4854 , A61B1/00165 , A61B17/00234 , A61B17/16 , A61B17/17 , A61B17/7097 , A61B2017/00535 , A61F2/07 , A61F2/28 , A61F2/30756 , A61F2/30767 , A61F2/3099 , A61F2/32 , A61F2/38 , A61F2/4081 , A61F2/4202 , A61F2/441 , A61F2/442 , A61F2/4601 , A61F2/4611 , A61F2/82 , A61F2/945 , A61F2002/30016 , A61F2002/30024 , A61F2002/3008 , A61F2002/30235 , A61F2002/30563 , A61F2002/30578 , A61F2002/30583 , A61F2002/30601 , A61F2002/30841 , A61F2002/30929 , A61F2002/30957 , A61F2002/4233 , A61F2002/444 , A61F2002/4627 , A61F2002/4635 , A61F2210/0085 , A61F2230/0069 , A61F2250/0019 , A61F2250/0021 , A61F2250/0098 , A61L27/18 , A61L29/041 , A61L29/06 , A61L2430/38 , B01F2215/0039 , C08G18/10 , C08G18/69 , Y10S606/907 , Y10S606/91 , C08L83/04 , C08L75/04 , C08L23/00 , C08L67/02 , C08G18/3206
摘要： A system for repairing an intervertebral disc by delivering and curing a biomaterial in situ within the disc. The system includes both a device, having an insertable balloon and related lumen, controls and adapters, as well as an in situ curable biomaterial (and related biomaterial delivery means). The system can allow the doctor to determine a suitable endpoint for biomaterial delivery, by controlling distraction and/or biomaterial delivery pressure, and in turn, to deliver a desired quantity of biomaterial to the balloon in order to achieve improved polymer cure and implant characteristics. Also provided is a related method for repairing an intervertebral disc by using such a system to deliver and cure the biomaterial in situ. The system can be used to implant a prosthetic total disc, or a prosthetic disc nucleus in a manner that leaves the surrounding disc tissue substantially intact.
-
公开(公告)号：US07001431B2
公开(公告)日：2006-02-21
申请号：US10365868
申请日：2003-02-13
IPC分类号： A61F2/44
CPC分类号： C08G18/4854 , A61B1/00165 , A61B17/00234 , A61B17/16 , A61B17/17 , A61B17/7097 , A61B2017/00535 , A61F2/07 , A61F2/28 , A61F2/30756 , A61F2/30767 , A61F2/3099 , A61F2/32 , A61F2/38 , A61F2/4081 , A61F2/4202 , A61F2/441 , A61F2/442 , A61F2/4601 , A61F2/4611 , A61F2/82 , A61F2/945 , A61F2002/30016 , A61F2002/30024 , A61F2002/3008 , A61F2002/30235 , A61F2002/30563 , A61F2002/30578 , A61F2002/30583 , A61F2002/30601 , A61F2002/30841 , A61F2002/30929 , A61F2002/30957 , A61F2002/4233 , A61F2002/444 , A61F2002/4627 , A61F2002/4635 , A61F2210/0085 , A61F2230/0069 , A61F2250/0019 , A61F2250/0021 , A61F2250/0098 , A61L27/18 , A61L29/041 , A61L29/06 , A61L2430/38 , B01F2215/0039 , C08G18/10 , C08G18/69 , Y10S606/907 , Y10S606/91 , C08L83/04 , C08L75/04 , C08L23/00 , C08L67/02 , C08G18/3206
摘要： A system for repairing an intervertebral disc by delivering and curing a biomaterial in situ within the disc. The system includes both a device, having an insertable balloon and related lumen, controls and adapters, as well as an in situ curable biomaterial (and related biomaterial delivery means). The system can allow the doctor to determine a suitable endpoint for biomaterial delivery, by controlling distraction and/or biomaterial delivery pressure, and in turn, to deliver a desired quantity of biomaterial to the balloon in order to achieve improved polymer cure and implant characteristics. Also provided is a related method for repairing an intervertebral disc by using such a system to deliver and cure the biomaterial in situ. The system can be used to implant a prosthetic total disc, or a prosthetic disc nucleus in a manner that leaves the surrounding disc tissue substantially intact.
-
-
-
-
-
-
-
-
-
搜索结果
23 条记录 (耗时 0.034 秒)
