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    Magnetic Gradient Targeting And Sequestering Of Therapeutic Formulations And Therapeutic Systems Thereof
    1.
    发明申请
    Magnetic Gradient Targeting And Sequestering Of Therapeutic Formulations And Therapeutic Systems Thereof 审中-公开
    治疗配方及其治疗系统的磁性梯度靶向和螯合

    公开(公告)号：US20090216320A1

    公开(公告)日：2009-08-27

    申请号：US12297971

    申请日：2007-04-20

    申请人： Robert J. Levy ,  Ivan Alferlev ,  Michael Chorny ,  Ilia Fishbein ,  Gennady Friedman ,  Boris Polyak ,  Darryl Williams

    发明人： Robert J. Levy ,  Ivan Alferlev ,  Michael Chorny ,  Ilia Fishbein ,  Gennady Friedman ,  Boris Polyak ,  Darryl Williams

    IPC分类号： A61M37/00 ,  A61N2/00 ,  A61F2/82

    CPC分类号： A61K9/0009 ,  A61B2017/00876 ,  A61B2017/00893 ,  A61K9/0019 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/624 ,  A61L2400/12 ,  A61N2/002 ,  A61N2/06

    摘要： A therapeutic system and a method that uses stents, and/or other implantable devices (104) for local delivery of a therapeutic agent is disclosed. A therapeutic formulation (102) may include particles of a biocompatible magnetic or magnetizable material that carry the therapeutic agent, or magnetically responsive cells. The therapeutic formulation (102) is intravenously administered to a mammalian subject. A portion of the formulation (102) is delivered to the proximity of a device (104) implanted in the vascular system of the subject by externally generating a magnetic field gradient (106) on the implantable device (104). The portion of the therapeutic formulation (102) not delivered to the proximity of the implantable device (104) is removed from the vascular system. The method allows for the repeated administration of the same or different therapeutic agent, and further, has the option of locally injecting, or alternatively, peripherally administering, the therapeutic agent.

    摘要翻译： 公开了一种治疗系统和使用支架的方法，和/或用于局部递送治疗剂的其它可植入装置（104）。 治疗剂（102）可以包括携带治疗剂或磁反应性细胞的生物相容性磁性或可磁化材料的颗粒。 将治疗制剂（102）静脉内施用于哺乳动物受试者。 制剂（102）的一部分通过在可植入装置（104）上外部产生磁场梯度（106）而输送到植入受试者的血管系统中的装置（104）附近。 从血管系统中去除未被输送到可植入装置（104）附近的部分治疗剂（102）。 该方法允许相同或不同的治疗剂的重复给药，此外，还可以选择局部注射或替代地外周施用治疗剂。

    Methods and devices for the treatment and prevention of malignancy in enteric diseases using non-thermal plasma
    7.
    发明授权
    Methods and devices for the treatment and prevention of malignancy in enteric diseases using non-thermal plasma 有权
    使用非热等离子体治疗和预防肠道疾病恶性肿瘤的方法和装置

    公开(公告)号：US08992518B2

    公开(公告)日：2015-03-31

    申请号：US13256313

    申请日：2010-03-16

    申请人： Gregory Fridman ,  Danil V. Dobrynin ,  Alexander Fridman ,  Gennady Friedman ,  Kalyan Chakravarthy ,  Sreekant Murthy

    发明人： Gregory Fridman ,  Danil V. Dobrynin ,  Alexander Fridman ,  Gennady Friedman ,  Kalyan Chakravarthy ,  Sreekant Murthy

    IPC分类号： A61B18/18 ,  A61N1/40 ,  H05H1/24

    CPC分类号： A61N1/40 ,  H05H1/24 ,  H05H1/2406 ,  H05H2001/2412 ,  H05H2001/245 ,  H05H2240/20 ,  H05H2245/122

    摘要： Non-thermal plasma is a partly ionized gas, which can be generated by a high-voltage electric field at a low pressure. Disclosed herein are apparatuses and methods for treating an enteric disease in vivo using non-thermal plasma. The disclosed apparatuses have a first conduit comprising a lumen and a tip; a first electrode disposed within the lumen of the first conduit; a second electrode comprised of a metal conduit disposed within the first conduit; an insulator disposed within the lumen of the first conduit, the insulator configured to electrically insulate the first electrode from the second electrode; and a gas channel disposed between the outer surface of the metal conduit and the inner surface of the first conduit, the gas channel being capable of feeding a gas from a gas source to the tip, wherein when the potential is applied, the gas is ionized to produce the non-thermal plasma.

    摘要翻译： 非热等离子体是部分电离的气体，其可以通过低压下的高压电场产生。 本文公开了使用非热等离子体在体内治疗肠道疾病的装置和方法。 所公开的装置具有包括内腔和尖端的第一导管; 设置在所述第一导管的内腔内的第一电极; 第二电极，包括设置在第一导管内的金属导管; 设置在所述第一导管的内腔内的绝缘体，所述绝缘体被配置为使所述第一电极与所述第二电极电绝缘; 以及设置在金属导管的外表面和第一导管的内表面之间的气体通道，气体通道能够将气体从气体源供给到尖端，其中当施加电位时，气体被电离 以产生非热等离子体。

    METHODS AND DEVICES FOR THE TREATMENT AND PREVENTION OF MALIGNANCY IN ENTERIC DISEASES USING NON-THERMAL PLASMA
    9.
    发明申请
    METHODS AND DEVICES FOR THE TREATMENT AND PREVENTION OF MALIGNANCY IN ENTERIC DISEASES USING NON-THERMAL PLASMA 有权
    使用非热等离子体治疗和预防肠疾病恶性肿瘤的方法和装置

    公开(公告)号：US20120253265A1

    公开(公告)日：2012-10-04

    申请号：US13256313

    申请日：2010-03-16

    申请人： Gregory Fridman ,  Danil V. Dobrynin ,  Alexander Fridman ,  Gennady Friedman ,  Kaylan Chakravarthy ,  Sreekant Murthy

    发明人： Gregory Fridman ,  Danil V. Dobrynin ,  Alexander Fridman ,  Gennady Friedman ,  Kaylan Chakravarthy ,  Sreekant Murthy

    IPC分类号： A61M37/00

    CPC分类号： A61N1/40 ,  H05H1/24 ,  H05H1/2406 ,  H05H2001/2412 ,  H05H2001/245 ,  H05H2240/20 ,  H05H2245/122

    摘要： Non-thermal plasma is a partly ionized gas, which can be generated by a high-voltage electric field at a low pressure. Disclosed herein are apparatuses and methods for treating an enteric disease in vivo using non-thermal plasma. The disclosed apparatuses have a first conduit comprising a lumen and a tip; a first electrode disposed within the lumen of the first conduit; a second electrode comprised of a metal conduit disposed within the first conduit; an insulator disposed within the lumen of the first conduit, the insulator configured to electrically insulate the first electrode from the second electrode; and a gas channel disposed between the outer surface of the metal conduit and the inner surface of the first conduit, the gas channel being capable of feeding a gas from a gas source to the tip, wherein when the potential is applied, the gas is ionized to produce the non-thermal plasma.

    摘要翻译： 非热等离子体是部分电离的气体，其可以通过低压下的高压电场产生。 本文公开了使用非热等离子体在体内治疗肠道疾病的装置和方法。 所公开的装置具有包括内腔和尖端的第一导管; 设置在所述第一导管的内腔内的第一电极; 第二电极，包括设置在第一导管内的金属导管; 设置在所述第一导管的内腔内的绝缘体，所述绝缘体被配置为使所述第一电极与所述第二电极电绝缘; 以及设置在金属导管的外表面和第一导管的内表面之间的气体通道，气体通道能够将气体从气体源供给到尖端，其中当施加电位时，气体被电离 以产生非热等离子体。