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1.发明申请Piperidinyl-Indole Derivatives Complement Factor B Inhibitors and Uses Thereof 有权哌啶基 - 吲哚衍生物补体因子B抑制剂及其用途公开(公告)号：US20160152605A1
公开(公告)日：2016-06-02
申请号：US14904694
申请日：2014-07-14
申请人： Christopher ADAMS , Michael Paul CAPPARELLI , Takeru EHARA , Rajeshri Ganesh KARKI , Nello MAINOLFI , Chun ZHANG
发明人： Christopher Michael Adams , Michael Paul Capparelli , Takeru Ehara , Rajeshri Ganesh Karki , Nello Mainolfi , Chun Zhang
IPC分类号： C07D413/06 , A61K31/454 , C07D403/06 , A61K31/438 , C07D401/14 , A61K31/4439 , A61K31/5377 , A61K31/55 , C07D401/06 , A61K31/404
CPC分类号： C07D413/06 , A61K31/404 , A61K31/438 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K31/55 , C07D401/06 , C07D401/14 , C07D403/06 , C07D413/14 , C07D417/14
摘要： The present invention provides a compound of formula I: (I) a method for manufacturing the compounds of the invention, and its therapeutic uses as inhibitors of the complement alternative pathway, in particular of Factor B. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译： 本发明提供式I化合物：（I）制备本发明化合物的方法及其作为补体替代途径抑制剂，特别是因子B的治疗用途。本发明进一步提供了药理学上的组合 活性剂和药物组合物。
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公开(公告)号：US09475806B2
公开(公告)日：2016-10-25
申请号：US14774430
申请日：2014-03-13
申请人： Christopher Michael Adams , Charles Babu , Michael Paul Capparelli , Jian Ding , Takeru Ehara , Keith Jendza , Nan Ji , Rajeshri Ganesh Karki , Toshio Kawanami , Liang Xue , Nello Mainolfi , James J. Powers , Michael H. Serrano-Wu , Chun Zhang
发明人： Christopher Michael Adams , Charles Babu , Michael Paul Capparelli , Jian Ding , Takeru Ehara , Keith Jendza , Nan Ji , Rajeshri Ganesh Karki , Toshio Kawanami , Liang Xue , Nello Mainolfi , James J. Powers , Michael H. Serrano-Wu , Chun Zhang
IPC分类号： C07D401/14 , A61K31/4353 , A61K31/437 , C07D471/04
CPC分类号： C07D471/04
摘要： The present invention provides a compound of formula (I): wherein X is N or CH, Y is NH, O or S, methods for manufacturing these compounds, and their uses as Factor B inhibitors for the treatment of conditions and diseases associated with complement alternative pathway activation such as age-related macular degeneration, diabetic retinopathy and related ophthalmic diseases. The present invention further provides pharmaceutical compositions and combinations of pharmacologically active agents.
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公开(公告)号：US09682968B2
公开(公告)日：2017-06-20
申请号：US14904694
申请日：2014-07-14
申请人： Christopher Michael Adams , Michael Paul Capparelli , Takeru Ehara , Rajeshri Ganesh Karki , Nello Mainolfi , Chun Zhang
发明人： Christopher Michael Adams , Michael Paul Capparelli , Takeru Ehara , Rajeshri Ganesh Karki , Nello Mainolfi , Chun Zhang
IPC分类号： C07D401/06 , A61K31/55 , C07D413/06 , C07D401/14 , C07D413/14 , C07D403/06 , C07D417/14 , A61K31/404 , A61K31/438 , A61K31/4439 , A61K31/454 , A61K31/5377
CPC分类号： C07D413/06 , A61K31/404 , A61K31/438 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K31/55 , C07D401/06 , C07D401/14 , C07D403/06 , C07D413/14 , C07D417/14
摘要： The present invention provides a compound of formula I: (I) a method for manufacturing the compounds of the invention, and its therapeutic uses as inhibitors of the complement alternative pathway, in particular of Factor B. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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公开(公告)号：US09056874B2
公开(公告)日：2015-06-16
申请号：US13826725
申请日：2013-03-14
申请人： Christopher Michael Adams , Charles Babu , Michael Paul Capparelli , Jian Ding , Takeru Ehara , Keith Jendza , Nan Ji , Rajeshri Ganesh Karki , Toshio Kawanami , Liang Xue , Nello Mainolfi , James J. Powers , Michael H. Serrano-Wu , Chun Zhang
发明人： Christopher Michael Adams , Charles Babu , Michael Paul Capparelli , Jian Ding , Takeru Ehara , Keith Jendza , Nan Ji , Rajeshri Ganesh Karki , Toshio Kawanami , Liang Xue , Nello Mainolfi , James J. Powers , Michael H. Serrano-Wu , Chun Zhang
IPC分类号： C07D403/06 , C07D403/04 , C07D403/08 , C07D403/14 , C07D401/14 , C07D413/14 , C07D487/04 , C07D491/048 , A61K31/4184 , C07D413/06 , A61K31/423 , A61K31/4439 , A61K45/06
CPC分类号： A61K31/4184 , A61K31/423 , A61K31/4245 , A61K31/4439 , A61K45/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/08 , C07D403/14 , C07D413/06 , C07D413/14 , C07D487/04 , C07D491/048
摘要： The present invention provides a compound of formula I: a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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公开(公告)号：US09676728B2
公开(公告)日：2017-06-13
申请号：US15032872
申请日：2014-10-29
申请人： Christopher Adams , Takeru Ehara , Keith Jendza , Nan Ji , Rajeshri Ganesh Karki , Toshio Kawanami , Nello Mainolfi , James Powers , Michael Serrano-Wu , Chun Zhang
发明人： Christopher Adams , Takeru Ehara , Keith Jendza , Nan Ji , Rajeshri Ganesh Karki , Toshio Kawanami , Nello Mainolfi , James Powers , Michael Serrano-Wu , Chun Zhang
IPC分类号： C07D235/10 , C07D235/12 , C07D235/14 , C07D235/16 , A61K31/4184 , A61K45/06
CPC分类号： C07D235/12 , A61K31/4184 , A61K45/06 , C07D235/14 , A61K2300/00
摘要： The present invention provides a compound of formula (I) a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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公开(公告)号：US08394858B2
公开(公告)日：2013-03-12
申请号：US12956146
申请日：2010-11-30
申请人： David Barnes , Gregory Raymond Bebernitz , Scott Louis Cohen , Robert Edson Damon , Robert Francis Day , Monish Jain , Rajeshri Ganesh Karki , Louise Clare Kirman , Tajesh Jayprakash Patel , Brian Kenneth Raymer , Herbert Franz Schuster , Wei Zhang
发明人： David Barnes , Gregory Raymond Bebernitz , Scott Louis Cohen , Robert Edson Damon , Robert Francis Day , Monish Jain , Rajeshri Ganesh Karki , Louise Clare Kirman , Tajesh Jayprakash Patel , Brian Kenneth Raymer , Herbert Franz Schuster , Wei Zhang
IPC分类号： A01N37/18 , A61K31/16 , C07C327/48
CPC分类号： C07D413/10 , C07B2200/05 , C07C311/20 , C07C311/29 , C07C311/37 , C07C311/46 , C07C311/47 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/44 , C07C2603/74 , C07D207/06 , C07D207/08 , C07D207/263 , C07D211/16 , C07D211/18 , C07D213/40 , C07D213/71 , C07D241/04 , C07D241/08 , C07D265/30 , C07D277/26 , C07D279/12 , C07D295/088 , C07D401/06
摘要： The present invention provides a compound of formula I; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译： 本发明提供式I化合物; 制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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公开(公告)号：US09789118B2
公开(公告)日：2017-10-17
申请号：US14188647
申请日：2014-02-24
申请人： David Weninger Barnes , Gregory Raymond Bebernitz , Kevin Clairmont , Scott Louis Cohen , Robert Edson Damon, II , Robert Francis Day , Stephanie Kay Dodd , Christoph Gaul , Hatice Belgin Gulgeze Efthymiou , Monish Jain , Rajeshri Ganesh Karki , Louise Clare Kirman , Kai Lin , Justin Yik Ching Mao , Tajesh Jayprakash Patel , Brian Kenneth Raymer , Su Liansheng
发明人： David Weninger Barnes , Gregory Raymond Bebernitz , Kevin Clairmont , Scott Louis Cohen , Robert Edson Damon, II , Robert Francis Day , Stephanie Kay Dodd , Christoph Gaul , Hatice Belgin Gulgeze Efthymiou , Monish Jain , Rajeshri Ganesh Karki , Louise Clare Kirman , Kai Lin , Justin Yik Ching Mao , Tajesh Jayprakash Patel , Brian Kenneth Raymer , Su Liansheng
IPC分类号： C07D215/36 , C07D235/18 , C07D263/57 , C07D401/04 , C07D401/12 , C07D403/04 , C07D405/04 , C07D413/12 , C07D471/04 , C07D513/04 , A61K31/542 , A61K31/4184 , A61K9/00 , A61K9/08 , A61K9/107 , C12N9/00 , A61K31/404 , A61K31/423 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D209/24 , C07D235/08 , C07D235/12 , C07D235/16 , C07D235/30 , C07D405/14
CPC分类号： A61K31/542 , A61K9/0014 , A61K9/0019 , A61K9/0095 , A61K9/08 , A61K9/1075 , A61K31/404 , A61K31/4184 , A61K31/423 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D209/24 , C07D215/36 , C07D235/08 , C07D235/12 , C07D235/16 , C07D235/18 , C07D235/30 , C07D263/57 , C07D401/04 , C07D401/12 , C07D403/04 , C07D405/04 , C07D405/14 , C07D413/12 , C07D471/04 , C07D513/04 , C12N9/93 , C12Y604/01002
摘要： The present invention provides compounds of formula (IV); or pharmaceutically acceptable salts thereof, wherein the variables are defined as herein. The present invention provides a method for manufacturing the compounds of formula (IV), their therapeutic uses, combinations with other of pharmacologically active agents, and a pharmaceutical compositions.
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8.发明授权Tetrahydropyrido-pyridine and tetrahydropyrido-pyrimidine compounds and use thereof as C5A receptor modulators 有权四氢吡啶并吡啶和四氢吡啶并嘧啶化合物及其作为C5A受体调节剂的用途公开(公告)号：US09505755B2
公开(公告)日：2016-11-29
申请号：US14455848
申请日：2014-08-08
申请人： Christopher Michael Adams , Veronique Darsigny , Alec Nathanson Flyer , Christine Fang Gelin , Timothy Brian Hurley , Nan Ji , Rajeshri Ganesh Karki , Toshio Kawanami , Erik Meredith , Chang Rao , Michael H. Serrano-Wu , Catherine Fooks Solovay
发明人： Christopher Michael Adams , Veronique Darsigny , Alec Nathanson Flyer , Christine Fang Gelin , Timothy Brian Hurley , Nan Ji , Rajeshri Ganesh Karki , Toshio Kawanami , Erik Meredith , Chang Rao , Michael H. Serrano-Wu , Catherine Fooks Solovay
IPC分类号： C07D471/04 , C07D491/107 , C07D491/044 , C07D471/10 , C07D471/08
CPC分类号： C07D471/04 , C07D471/08 , C07D471/10 , C07D491/044 , C07D491/107
摘要： The present invention provides a compound of formula I: a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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公开(公告)号：US08394853B2
公开(公告)日：2013-03-12
申请号：US12788766
申请日：2010-05-27
申请人： Gary Mark Coppola , Yuki Iwaki , Rajeshri Ganesh Karki , Toshio Kawanami , Gary Michael Ksander , Muneto Mogi , Robert Sun
发明人： Gary Mark Coppola , Yuki Iwaki , Rajeshri Ganesh Karki , Toshio Kawanami , Gary Michael Ksander , Muneto Mogi , Robert Sun
IPC分类号： A61K31/235 , C07C229/34
CPC分类号： C07D317/34 , A61K31/197 , A61K31/216 , A61K31/325 , A61K31/351 , A61K31/357 , A61K31/41 , A61K31/421 , A61K31/44 , A61K31/505 , A61K31/5375 , A61K45/00 , A61K45/06 , C07B2200/05 , C07C233/47 , C07C233/49 , C07C233/51 , C07C233/56 , C07C233/63 , C07C235/12 , C07C235/78 , C07C237/16 , C07C237/22 , C07C255/60 , C07C271/22 , C07C275/24 , C07C311/08 , C07C311/51 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D213/82 , C07D239/28 , C07D239/34 , C07D239/36 , C07D257/04 , C07D261/18 , C07D263/32 , C07D265/30 , C07D271/06 , C07D295/15 , C07D309/32
摘要： The present invention provides a compound of formula I′; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, B1, X and n are defined herein. The invention also relates a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译： 本发明提供式I'化合物; 或其药学上可接受的盐，其中R 1，R 2，R 3，R 5，B 1，X和n如本文所定义。 本发明还涉及制备本发明化合物及其治疗用途的方法。 本发明还提供药理活性剂和药物组合物的组合。
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公开(公告)号：US09006249B2
公开(公告)日：2015-04-14
申请号：US13490562
申请日：2012-06-07
申请人： Gary Mark Coppola , Yuki Iwaki , Rajeshri Ganesh Karki , Toshio Kawanami , Gary Michael Ksander , Muneto Mogi , Robert Sun
发明人： Gary Mark Coppola , Yuki Iwaki , Rajeshri Ganesh Karki , Toshio Kawanami , Gary Michael Ksander , Muneto Mogi , Robert Sun
IPC分类号： A61K31/505 , A61K31/44 , A61K31/415 , A61K31/40 , A61K31/38 , A61K31/34 , A61K31/335 , A61K31/195 , C07D239/24 , C07D211/00 , C07D213/81 , C07D233/54 , C07D231/10 , C07D207/30 , C07D333/38 , C07D229/02 , C07C233/87 , C07C233/47 , C07C233/63 , C07C235/52 , C07C251/12 , C07C257/06 , C07C271/12 , C07C275/16 , C07C311/19 , C07C317/44 , C07D207/34 , C07D209/18 , C07D213/56 , C07D213/82 , C07D231/14 , C07D239/28 , C07D271/10 , C07D277/64 , C07D285/12 , C07D303/48 , C07D307/68 , C07D309/40 , C07D333/24 , C07D333/40 , C07D261/18
CPC分类号： A61K31/194 , A61K45/06 , C07C233/47 , C07C233/63 , C07C233/87 , C07C235/52 , C07C235/74 , C07C235/82 , C07C251/12 , C07C257/06 , C07C271/12 , C07C275/16 , C07C311/19 , C07C317/44 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07D207/34 , C07D209/18 , C07D213/56 , C07D213/81 , C07D213/82 , C07D231/14 , C07D239/28 , C07D261/18 , C07D271/10 , C07D277/64 , C07D285/12 , C07D303/48 , C07D307/68 , C07D309/40 , C07D333/24 , C07D333/40
摘要： The present invention provides a compound of formula I′; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, X and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译： 本发明提供式I'化合物; 或其药学上可接受的盐，其中R1，R2，R3，X和n如本文所定义。 本发明还涉及制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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