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    Ceramide 3 derivatives based on monounsaturated fatty acids
    4.
    发明授权
    Ceramide 3 derivatives based on monounsaturated fatty acids 失效
    基于单不饱和脂肪酸的神经酰胺3衍生物

    公开(公告)号：US5693677A

    公开(公告)日：1997-12-02

    申请号：US647980

    申请日：1996-05-30

    申请人： Johannes Wilhelmus Jacobus Lambers ,  Jan Verweij

    发明人： Johannes Wilhelmus Jacobus Lambers ,  Jan Verweij

    IPC分类号： A61K47/06 ,  A61K8/00 ,  A61K8/30 ,  A61K8/42 ,  A61K8/68 ,  A61Q19/00 ,  C07C231/02 ,  C07C233/20 ,  A61K6/00

    CPC分类号： C07C233/20 ,  A61K8/68 ,  A61Q19/00 ,  A61K2800/75 ,  Y10S514/847

    摘要： The present invention discloses ceramide 3 derivatives based on monounsaturated fatty acids. A preferred compound is N-oleoylphytosphingosine (Ceramide IIIB). A method for preparing these compounds is also disclosed. The solubility of these compounds is higher than the solubility of the corresponding saturated ceramide 3 derivatives, whereas their stability is comparable to saturated ceramide 3 stabilities. In addition, a method is described for maintaining the water permeability characteristics of the skin by topical application of a formulation containing a monounsaturated ceramide 3 derivative.

    摘要翻译： PCT No.PCT / EP95 / 03908 Sec。 371日期：1996年5月30日 102（e）日期1996年5月30日PCT提交1995年10月2日PCT公布。 公开号WO96 / 10557 日期：1996年04月11日本发明公开了基于单不饱和脂肪酸的神经酰胺3衍生物。 优选的化合物是N-油酰基鞘氨醇（神经酰胺IIIB）。 还公开了制备这些化合物的方法。 这些化合物的溶解度高于相应的饱和神经酰胺3衍生物的溶解度，而它们的稳定性与饱和的神经酰胺3稳定性相当。 此外，描述了通过局部施用含有单不饱和神经酰胺3衍生物的制剂来维持皮肤的透水性的方法。

    Process for preparing cephalosporin derivatives
    5.
    发明授权
    Process for preparing cephalosporin derivatives 失效
    制备头孢菌素衍生物的方法

    公开(公告)号：US4046761A

    公开(公告)日：1977-09-06

    申请号：US664056

    申请日：1976-03-04

    申请人： Jan Verweij ,  Hong Sheng Tan

    发明人： Jan Verweij ,  Hong Sheng Tan

    IPC分类号： C07D207/46 ,  C07D209/48 ,  C07D501/10 ,  C07D501/02 ,  A61K31/545

    CPC分类号： C07D209/48 ,  C07D207/46

    摘要： Novel azetidine derivatives of the formula ##STR1## wherein R.sub.1 is an acylamido group, R.sub.2 is selected from the group consisting of ##STR2## wherein R.sub.4, R.sub.5 and R.sub.6 are individually selected from the group consisting of hydrogen, lower alkyl and lower alkenyl, n is 2 or 3 and -- in the case when formula IIB is a phenyl -- this group may carry 1 to 4 substituents selected from the group consisting of halogen, lower alkyl, lower alkenyl and phenyl, and R.sub.3 is lower alkyl optionally substituted with 1 or 2 phenyls which phenyl groups may be substituted with nitro and a process for their preparation and process for the preparation of cephalosporanic acid derivatives using the azetidines of formula I as intermediates.This is a division of Serial No. 547,948, filed Feb. 7, 1975 now Pat. No. 4,007,202.

    摘要翻译： 新颖的式Ⅰa的氮杂环丁烷衍生物，其中R1是酰氨基，R2选自由下列组成的组：其中R 4，R 5和R 6分别选自氢，低级 烷基和低级烯基，n为2或3， - 在式IIB为苯基的情况下，该基团可以携带1至4个选自卤素，低级烷基，低级烯基和苯基的取代基，且R3较低 任选被1或2个苯基取代的烷基，该苯基可以被硝基取代，其制备方法和使用式I的氮杂环丁烷作为中间体制备头孢烷酸衍生物的方法。

    Adjusting device
    6.
    发明授权
    Adjusting device 失效
    调整装置

    公开(公告)号：US08276526B2

    公开(公告)日：2012-10-02

    申请号：US12937452

    申请日：2009-04-09

    申请人： Jan Verweij

    发明人： Jan Verweij

    IPC分类号： A47B9/00

    CPC分类号： A47B9/20 ,  A47B9/04

    摘要： An adjusting device having an inner tubular body, an outer tubular body configured to slide concentrically over the inner tubular body such that the inner tubular body and the outer tubular body can slide telescopically from a retracted position to an extended position. An actuator is configured to move the inner tubular body and the outer tubular body along the longitudinal axis in relation to one another and a supporting tube is provided and configured to slide concentrically on the inside of the outer tubular body.

    摘要翻译： 一种调节装置，其具有内部管状体，外部管状体构造成同心地在内部管状体上滑动，使得内部管状体和外部管状体可以从缩回位置伸缩地滑动到延伸位置。 致动器构造成使内管状体和外管体相对于彼此的纵向轴线移动，并且提供支撑管并构造成同心地在外管体的内侧滑动。

    Preparation of 7-substituted amino-desacetoxycephalosporanic acid compounds
    8.
    发明授权
    Preparation of 7-substituted amino-desacetoxycephalosporanic acid compounds 失效
    7-取代氨基 - 脱乙酰氧基头孢烷酸化合物的制备

    公开(公告)号：US4035352A

    公开(公告)日：1977-07-12

    申请号：US575024

    申请日：1975-05-06

    申请人： Jan Verweij ,  Hong Sheng Tan ,  Hermanus Jacobus Kooreman

    发明人： Jan Verweij ,  Hong Sheng Tan ,  Hermanus Jacobus Kooreman

    IPC分类号： C07D499/00 ,  C07D501/10 ,  C07D499/32

    CPC分类号： C07D501/10 ,  C07D499/00

    摘要： Novel 6-substituted amino-penicillanic acid anhydrides useful in the process for the preparation of 7-substituted amino-desacetoxycephalosporanic derivatives comprising converting a 6-substituted amino-penicillanic acid sulfoxide into an anhydride of a 6-substituted amino-penicillanic acid sulfoxide, heating the said acid anhydride intermediate at a temperature up to at most 160.degree. C in a dry inert organic solvent with an anhydrous acid which is capable of causing ring expansion of the penam ring to a .DELTA..sup.3 -cephem ring, in the presence of a silicon-containing compound capable of (a) removing water formed during the ring enlargement of the penam structure fast enough to prevent water hydrolysis of the acid anhydride moiety present and (b) forming neutral or basic products on hydrolysis, the aforesaid acid being strong enough not to be, or not to a substantial extent to be, silylated under the reaction conditions employed, and hydrolyzing the resulting compound in situ to form the .DELTA..sup.3 -7-substituted amino-desacetoxycephalosporanic acid as such or as a salt, such as alkali metal, alkaline earth metal or amine salt.

    摘要翻译： 用于制备7-取代氨基 - 脱乙酰氧基头孢烷衍生物的方法中的6-取代氨基 - 青霉烷酸酐包括将6-取代氨基 - 青霉烷酸亚砜转化成6-取代氨基 - 青霉烷酸亚砜的酸酐，加热 所述酸酐中间体在干燥的惰性有机溶剂中在至多160℃的温度下与无水酸反应，所述无水酸在硅的存在下能够引起环吡嗪环向DELTA 3-头孢烯环的扩展 能够（a）在Penam结构的环扩大期间形成的水快速去除以防止存在的酸酐部分的水解，和（b）在水解时形成中性或碱性产物，上述酸不足够 在所使用的反应条件下是或不在很大程度上甲硅烷基化，并原位水解所得化合物以形成DEL TA 3-7取代的氨基 - 脱乙酰氧基头孢烷酸，或作为盐，如碱金属，碱土金属或胺盐。