-
1.发明授权
公开(公告)号：US5639759A
公开(公告)日：1997-06-17
申请号：US411251
申请日：1995-03-27
申请人： Ronald Louis Magolda , William John Pitts , Irina Cipora Jacobson , Carl Henry Behrens , Michael James Orwat , Douglas Guy Batt
发明人： Ronald Louis Magolda , William John Pitts , Irina Cipora Jacobson , Carl Henry Behrens , Michael James Orwat , Douglas Guy Batt
IPC分类号： A61K31/47 , A61K31/473 , A61K31/4738 , A61P29/00 , A61P37/00 , A61P37/06 , C07D221/18 , C07D405/04 , C07D409/04 , C07D471/04 , C07D487/14 , C07D491/04 , C07D491/048 , C07D491/052 , C07D491/147 , C07D495/04 , C07D495/14 , A61K31/44 , C07D215/02
CPC分类号： C07D405/04 , C07D221/18 , C07D409/04 , C07D471/04 , C07D491/04 , C07D495/04 , C07D495/14
摘要： This invention relates to carbocyclic and heterocyclic fused-ring quinolinecarboxylic acid compounds, to pharmaceutical compositions comprising such compounds, and to methods of using such compounds for the treatment and/or prevention of organ transplantation rejection, graft versus host disease, autoimmune diseases, chronic inflammatory diseases, including but not limited to psoriasis and rheumatoid arthritis, and cancer in a mammal.
摘要翻译： 本发明涉及碳环和杂环稠环喹啉羧酸化合物，包含这些化合物的药物组合物，以及使用这些化合物治疗和/或预防器官移植排斥反应，移植物抗宿主病，自身免疫疾病，慢性炎症的方法 疾病，包括但不限于牛皮癣和类风湿性关节炎，以及哺乳动物的癌症。
-
2.发明授权
公开(公告)号：US5874441A
公开(公告)日：1999-02-23
申请号：US820222
申请日：1997-03-18
申请人： Ronald Louis Magolda , William John Pitts , Irina Cipora Jacobson , Carl Henry Behrens , Michael James Orwat , Douglas Guy Batt
发明人： Ronald Louis Magolda , William John Pitts , Irina Cipora Jacobson , Carl Henry Behrens , Michael James Orwat , Douglas Guy Batt
IPC分类号： A61K31/47 , A61K31/473 , A61K31/4738 , A61P29/00 , A61P37/00 , A61P37/06 , C07D221/18 , C07D405/04 , C07D409/04 , C07D471/04 , C07D487/14 , C07D491/04 , C07D491/048 , C07D491/052 , C07D491/147 , C07D495/04 , C07D495/14 , A01N43/42 , C07D471/00
CPC分类号： C07D405/04 , C07D221/18 , C07D409/04 , C07D471/04 , C07D491/04 , C07D495/04 , C07D495/14
摘要： This invention relates to carbocyclic and heterocyclic fused-ring quinolinecarboxylic acid compounds, to pharmaceutical compositions comprising such compounds, and to methods of using such compounds for the treatment and/or prevention of organ transplantation rejection, graft versus host disease, autoimmune diseases, chronic inflammatory diseases, including but not limited to psoriasis and rheumatoid arthritis, and cancer in a mammal.
摘要翻译： 本发明涉及碳环和杂环稠环喹啉羧酸化合物，包含这些化合物的药物组合物，以及使用这些化合物治疗和/或预防器官移植排斥反应，移植物抗宿主病，自身免疫疾病，慢性炎症的方法 疾病，包括但不限于牛皮癣和类风湿性关节炎，以及哺乳动物的癌症。
-
3.发明授权
公开(公告)号：US06110910A
公开(公告)日：2000-08-29
申请号：US195366
申请日：1998-11-18
申请人： Ronald Louis Magolda , William John Pitts , Irina Cipora Jacobson , Carl Henry Behrens , Michael James Orwat , Douglas Guy Batt
发明人： Ronald Louis Magolda , William John Pitts , Irina Cipora Jacobson , Carl Henry Behrens , Michael James Orwat , Douglas Guy Batt
IPC分类号： A61K31/47 , A61K31/473 , A61K31/4738 , A61P29/00 , A61P37/00 , A61P37/06 , C07D221/18 , C07D405/04 , C07D409/04 , C07D471/04 , C07D487/14 , C07D491/04 , C07D491/048 , C07D491/052 , C07D491/147 , C07D495/04 , C07D495/14 , A61K31/55 , C07D281/08 , C07D471/00
CPC分类号： C07D405/04 , C07D221/18 , C07D409/04 , C07D471/04 , C07D491/04 , C07D495/04 , C07D495/14
摘要： This invention relates to carbocyclic and heterocyclic fused-ring quinolinecarboxylic acid compounds, to pharmaceutical compositions comprising such compounds, and to methods of using such compounds for the treatment and/or prevention of organ transplantation rejection, graft versus host disease, autoimmune diseases, chronic inflammatory diseases, including but not limited to psoriasis and rheumatoid arthritis, and cancer in a mammal.
摘要翻译： 本发明涉及碳环和杂环稠环喹啉羧酸化合物，包含这些化合物的药物组合物，以及使用这些化合物治疗和/或预防器官移植排斥反应，移植物抗宿主病，自身免疫疾病，慢性炎症的方法 疾病，包括但不限于牛皮癣和类风湿性关节炎，以及哺乳动物的癌症。
-
公开(公告)号：US5691381A
公开(公告)日：1997-11-25
申请号：US632973
申请日：1996-04-16
IPC分类号： C07D233/56 , A61K31/165 , A61K31/17 , A61K31/195 , A61K31/198 , A61K31/215 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/4015 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/445 , A61K31/4458 , A61P1/02 , A61P9/00 , A61P27/02 , A61P29/00 , A61P35/00 , A61P37/00 , A61P43/00 , C07C237/22 , C07C259/06 , C07C259/08 , C07D207/16 , C07D207/40 , C07D211/60 , C07D213/40 , C07D233/64 , C07D263/48 , C07D277/20 , C07D277/30 , C07D277/40 , C07D307/24 , C07D333/38 , A61K31/19 , C07D211/72
CPC分类号： C07D333/38 , C07C237/22 , C07C259/06 , C07C259/08 , C07D207/16 , C07D307/24 , C07C2101/08 , C07C2101/14
摘要： The present invention provides novel hydroxamic acids and carbocyclic acids and derivatives thereof and to pharmaceutical compositions and methods of use of these novel compounds for the inhibition of matrix metalloproteinases, such as stromelysin, and inhibit the production of tumor necrosis factor alpha, and for the treatment of arthritis and other related inflammatory diseases. These novel compounds are represented by Formula I below: ##STR1##
摘要翻译： 本发明提供新的异羟肟酸和碳环酸及其衍生物，以及这些新化合物用于抑制基质金属蛋白酶如基质溶素的药物组合物和方法，并抑制肿瘤坏死因子α的产生和治疗 的关节炎和其他相关的炎性疾病。 这些新化合物由下式I表示：式I
-
公开(公告)号：US06281352B1
公开(公告)日：2001-08-28
申请号：US08856223
申请日：1997-05-14
申请人： Chu-Bio Xue , Carl P. Decicco , Robert J. Cherney , Elizabeth Arner , William F. DeGrado , Jingwu Duan , Xiaohua He , Irina Cipora Jacobson , Ronald L. Magolda , David Nelson
发明人： Chu-Bio Xue , Carl P. Decicco , Robert J. Cherney , Elizabeth Arner , William F. DeGrado , Jingwu Duan , Xiaohua He , Irina Cipora Jacobson , Ronald L. Magolda , David Nelson
IPC分类号： A61K3133
CPC分类号： C07D231/12 , A61K38/00 , C07D233/56 , C07D245/02 , C07D249/08 , C07D255/02 , C07D267/00 , C07D273/02 , C07D291/02 , C07D401/12 , C07D403/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D419/12 , C07K5/0606 , C07K5/06078 , C07K5/06139 , C07K5/06191 , C12Q1/37
摘要： This invention relates to macrocyclic molecules which inhibit metalloproteinases, including aggrecanase, and the production of tumor necrosis factor (TNF). In particular, the compounds are inhibitors of metalloproteinases involved in tissue degradation and inhibitors of the release of tumor necrosis factor. The present invention also relates to pharmaceutical compositions comprising such compounds and to methods of using these compounds for the treatment of inflammatory diseases.
摘要翻译： 本发明涉及抑制金属蛋白酶（包括聚蛋白聚糖蛋白酶）和肿瘤坏死因子（TNF）的产生的大环分子。 特别地，化合物是参与组织降解的金属蛋白酶抑制剂和肿瘤坏死因子释放抑制剂。 本发明还涉及包含这些化合物的药物组合物和使用这些化合物治疗炎性疾病的方法。
-
公开(公告)号：US5703092A
公开(公告)日：1997-12-30
申请号：US632863
申请日：1996-04-16
IPC分类号： C07D233/64 , A61K31/415 , A61K31/4184 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/426 , A61P29/00 , A61P35/00 , C07C233/05 , C07C233/11 , C07C259/06 , C07D233/54 , C07D233/68 , C07D235/14 , C07D235/16 , C07D261/08 , C07D263/32 , C07D277/28 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , C07D471/04 , A61K31/435
CPC分类号： C07D233/64 , C07C233/05 , C07C233/11 , C07C259/06 , C07D235/14 , C07D471/04
摘要： The present invention provides novel hydroxamic acids and carbocyclic acids and derivatives thereof and to pharmaceutical compositions and methods of use of these novel compounds for the inhibition of matrixmetalloproteinases, such as stromelysin and other matrix metalloproteinases, and also inhibit the production of tumor necrosis factor (TNF), and are therefore useful for the treatment of arthritis and other related inflammatory diseases. These novel compounds are represented by Formula I below: ##STR1##
摘要翻译： 本发明提供了新的异羟肟酸和碳环酸及其衍生物，以及这些新化合物用于抑制基质金属蛋白酶如基质溶血素和其他基质金属蛋白酶的药物组合物和方法，并且还抑制肿瘤坏死因子（TNF ），因此可用于治疗关节炎和其它相关的炎性疾病。 这些新化合物由下式I表示：式I
-
-
-
-
-
搜索结果
6 条记录 (耗时 0.033 秒)
