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    Drug delivery system making use of a hydrogel polymer coating
    1.
    发明授权
    Drug delivery system making use of a hydrogel polymer coating 失效
    使用水凝胶聚合物涂层的药物递送系统

    公开(公告)号：US5304121A

    公开(公告)日：1994-04-19

    申请号：US795976

    申请日：1991-11-22

    申请人： Ronald Sahatjian

    发明人： Ronald Sahatjian

    IPC分类号： A61M25/00 ,  A61F2/00 ,  A61F2/90 ,  A61K9/00 ,  A61K38/49 ,  A61K48/00 ,  A61L29/08 ,  A61L29/14 ,  A61L29/16 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61M16/04 ,  A61M29/02 ,  A61M31/00

    CPC分类号： A61K9/0024 ,  A61F2/90 ,  A61K38/49 ,  A61K48/00 ,  A61L29/085 ,  A61L29/145 ,  A61L29/16 ,  A61L31/10 ,  A61L31/145 ,  A61L31/16 ,  A61M16/0481 ,  A61M25/104 ,  A61F2230/0013 ,  A61F2250/0067 ,  A61L2300/416 ,  A61L2300/42 ,  A61M2025/0057 ,  A61M2025/09183 ,  A61M2025/105 ,  A61M2025/1086 ,  A61M2205/0266

    摘要： The invention features a catheter and methods for delivering drug to tissue at a desired location of the wall of a body lumen. The catheter is constructed for insertion in a body lumen and has a catheter shaft and an expandable portion mounted on the catheter shaft. The expandable portion is expandable to a controlled pressure to fill the cross-section of the body lumen and press against the wall of the body lumen. In one embodiment, at least a portion of the exterior surface of the expandable portion is defined by a coating of a tenaciously adhered swellable hydrogel polymer. Incorporated in the hydrogel polymer is an aqueous solution of a preselected drug to be delivered to the tissue or plaque. The hydrogel polymer and drug are selected to allow rapid release of a desired dosage of the drug from the hydrogel polymer coating during compression of the hydrogel polymer coating against the wall of the lumen when the expandable portion is expanded. In other embodiments the polymer is released from the expandable portion in response to pressure, to coat the wall of the body lumen.

    摘要翻译： 本发明的特征在于导管和用于将药物递送到体腔壁的所需位置处的组织的方法。 导管被构造成用于插入体腔，并且具有导管轴和安装在导管轴上的可扩张部分。 可膨胀部分可膨胀至受控的压力以填充体腔的横截面并压靠身体腔的壁。 在一个实施例中，可膨胀部分的外表面的至少一部分由强力粘附的可溶胀水凝胶聚合物的涂层限定。 掺入水凝胶聚合物中的是待递送至组织或斑块的预选药物的水溶液。 选择水凝胶聚合物和药物，以便当可膨胀部分膨胀时，水凝胶聚合物涂层在水凝胶聚合物涂层压靠内腔壁时，从水凝胶聚合物涂层快速释放所需剂量的药物。 在其它实施方案中，聚合物响应于压力从可膨胀部分释放，以涂覆体腔的壁。

    High elongation linear elastic guidewire
    2.
    发明授权
    High elongation linear elastic guidewire 失效
    高伸长线性弹性导丝

    公开(公告)号：US5238004A

    公开(公告)日：1993-08-24

    申请号：US954469

    申请日：1992-09-30

    申请人： Ronald Sahatjian ,  Fernando Alvarez de Toledo

    发明人： Ronald Sahatjian ,  Fernando Alvarez de Toledo

    IPC分类号： A61M25/00

    CPC分类号： A61M25/09 ,  A61M25/0015 ,  A61F2002/9665 ,  A61M2025/09175 ,  A61M25/0009

    摘要： A guidewire and a method for its manufacture, wherein at least the distal portion of the guidewire comprises an element made of a precursor of a superelastic alloy such as a Ni--Ti linear elastic alloy. The element exhibits a stress strain curve with a linear stress-strain relationship and a yield point. At room temperature to body temperature the precursor is in the martensitic phase. The distal portion of the guidewire is deformable beyond the yield point by the physician in the field to a desired set shape and exhibits resistance to kinking during insertion into the body as a result of its elasticity.

    摘要翻译： 导丝及其制造方法，其中至少导丝的远端部分包括由诸如Ni-Ti线弹性合金的超弹性合金的前体制成的元件。 该元素呈现出具有线性应力 - 应变关系和屈服点的应力应变曲线。 在室温至体温下，前体处于马氏体相。 导丝的远端部分可以由外科医生在现场的屈服点之外变形到期望的固定形状，并且由于其弹性而在插入身体期间表现出抗扭结作用。

    Device for heating tissue in a patient's body
    3.
    发明授权
    Device for heating tissue in a patient's body 失效
    用于加热患者身体中的组织的装置

    公开(公告)号：US5191883A

    公开(公告)日：1993-03-09

    申请号：US527047

    申请日：1990-05-22

    申请人： Charles D. Lennox ,  Richard A. Noddin ,  Ronald Sahatjian

    发明人： Charles D. Lennox ,  Richard A. Noddin ,  Ronald Sahatjian

    IPC分类号： A61B17/00 ,  A61B17/22 ,  A61B18/04 ,  A61B18/08

    CPC分类号： A61B18/08 ,  A61B18/082 ,  A61B17/22 ,  A61B2017/00084 ,  A61B2017/00088 ,  A61B2017/00132 ,  A61B2017/00274 ,  A61B2017/22062 ,  A61B2018/0022 ,  A61B2018/00547 ,  A61B2018/00559 ,  A61B2018/00577 ,  A61B2018/00791 ,  A61B2018/044

    摘要： Device and method for heating tissue, the device having a catheter shaft for insertion into a patient's body, a chamber formed by a collapsible balloon mounted on the catheter shaft and filled with an electrically conductive fluid, two or more electrical contacts enclosed within the chamber, a power supply for applying an electrical potential to the contacts, and a two or more conductors for connecting each of the contacts to the power supply. The fluid is heated on the basis of I.sup.2 R losses by a radio frequency electric current flowing between the electrodes, and the fluid in turn heats the surrounding tissue by heat transfer through the wall of the chamber. According to the method, the apparatus is inserted into the patient's body, the chamber is filled with an electrically conductive fluid, and an electrical potential is applied to the contacts. The apparatus functions as a temperature source. A thermister sensor in the balloon or in contact with tissue responds to the heating effect to control the application of the current. Advantageously, by periodic sensing of temperature, and application of controlled rf power, a preset constant temperature is maintained at the selected sensing point, either at the internal body site or the liquid within the balloon. In this way carefully controlled therapy can be conducted at constant temperature.

    摘要翻译： 用于加热组织的装置和方法，所述装置具有用于插入患者体内的导管轴，由可安装在导管轴上并填充有导电流体的可折叠气囊形成的腔室，封闭在腔室内的两个或更多个电触点， 用于向触点施加电势的电源，以及用于将每个触点连接到电源的两个或更多个导体。 基于I2R损耗，通过在电极之间流动的射频电流来加热流体，并且流体又通过腔室壁的热传递来加热周围组织。 根据该方法，将该装置插入到患者体内，对该腔室填充有导电性流体，并向触点施加电位。 该装置用作温度源。 气囊中的热敏传感器或与组织接触的热敏电阻传感器响应加热效应以控制电流的施加。 有利地，通过周期性地检测温度和施加受控射频功率，在所选择的感测点处，在内部身体部位或球囊内的液体中保持预设的恒定温度。 以这种方式，可以在恒温下进行精心控制的治疗。

    Methods and devices having electrically actuatable surfaces
    7.
    发明申请
    Methods and devices having electrically actuatable surfaces 审中-公开
    具有电致动表面的方法和装置

    公开(公告)号：US20070225800A1

    公开(公告)日：2007-09-27

    申请号：US11388301

    申请日：2006-03-24

    申请人： Ronald Sahatjian ,  Timothy O'Shea

    发明人： Ronald Sahatjian ,  Timothy O'Shea

    IPC分类号： A61F2/06

    CPC分类号： A61F2/91 ,  A61F2210/0076 ,  A61F2250/0035 ,  A61F2250/0043 ,  A61F2250/0056 ,  A61F2250/0067 ,  A61L29/14 ,  A61L31/14

    摘要： The present invention generally relates to the field of insertable or implantable medical devices, such as balloon catheters, stents and other similar diagnostic or therapeutic devices which may be provided within the body for treatment and/or diagnosis of diseases and conditions. In particular, the present invention relates to devices whose surfaces are electrically actuatable between a hydrophobic state and a less hydrophobic state or a hydrophilic state. Such devices include drug-eluting devices such as balloon catheters and stents which release therapeutic agents upon the application of an electric field. Such devices further include devices such as balloon catheters and stents whose lubricity may be modulated in situ by the application of an electric field.

    摘要翻译： 本发明总体上涉及可插入或可植入的医疗装置领域，例如球囊导管，支架和可在身体内提供用于治疗和/或诊断疾病和病症的其它类似的诊断或治疗装置。 特别地，本发明涉及其表面在疏水状态和较少疏水状态或亲水状态之间可电致动的装置。 这样的装置包括药物洗脱装置，例如球囊导管和在施加电场时释放治疗剂的支架。 这样的装置还包括诸如球囊导管和支架的装置，其可以通过施加电场来原位调节其润滑性。

    Implantable or insertable medical devices visible under magnetic resonance imaging
    8.
    发明申请
    Implantable or insertable medical devices visible under magnetic resonance imaging 有权
    可植入或可插入的医疗器械在磁共振成像下可见

    公开(公告)号：US20070167735A1

    公开(公告)日：2007-07-19

    申请号：US11637263

    申请日：2006-12-12

    申请人： Sheng-Ping Zhong ,  Ronald Sahatjian ,  Enxin Ma

    发明人： Sheng-Ping Zhong ,  Ronald Sahatjian ,  Enxin Ma

    IPC分类号： A61B5/05

    CPC分类号： G01R33/286 ,  A61L29/145 ,  A61L29/18 ,  A61L31/145 ,  A61L31/18 ,  A61M25/0045 ,  A61M25/0108

    摘要： Disclosed is an implantable or insertable medical device comprising (a) a substrate and (b) a hydrogel polymer coating at a least a portion of the surface of the substrate, wherein the hydrogel polymer is adapted to render the medical device visible under magnetic resonance imaging (MRI) upon insertion or implantation of the medical device into a patient. Also disclosed is the use of such a hydrogel coated implantable or insertable medical device in a medical procedure, wherein during or after insertion or implantation of the medical device in a patient, the position of the medical device is viewed under MRI. The use of a hydrogel polymer for coating a medical device wherein the hydrogel polymer is adapted to render a medical device coated with the hydrogel polymer visible under MRI and a hydrogel polymer adapted to render a medical device coated therewith visible under MRI are also disclosed.

    摘要翻译： 公开了一种可植入或可插入的医疗装置，其包括（a）基底和（b）在所述基底表面的至少一部分表面上的水凝胶聚合物涂层，其中所述水凝胶聚合物适于使所述医疗装置在磁共振成像 （MRI）在将医疗装置插入或植入患者体内时。 还公开了在医疗过程中使用这种水凝胶涂覆的可植入或可插入的医疗装置，其中在将医疗装置插入或植入患者体内或之后，在MRI下观察医疗装置的位置。 还公开了使用水凝胶聚合物涂覆医疗装置，其中水凝胶聚合物适于使涂覆有水凝胶聚合物的医疗装置在MRI下可见，并且还公开了适于使其涂覆的医疗装置在MRI下可见的水凝胶聚合物。

    Device with enhanced indication of use and prevention of re-use
    9.
    发明申请
    Device with enhanced indication of use and prevention of re-use 审中-公开
    具有增强的使用指示和防止再次使用的装置

    公开(公告)号：US20060069305A1

    公开(公告)日：2006-03-30

    申请号：US10955905

    申请日：2004-09-30

    申请人： Lucien Couvillon ,  Sheng-Ping Zhong ,  Michael Banik ,  Ronald Sahatjian

    发明人： Lucien Couvillon ,  Sheng-Ping Zhong ,  Michael Banik ,  Ronald Sahatjian

    IPC分类号： A61B1/00 ,  A61B17/00

    CPC分类号： A61B1/00055 ,  A61B1/00062 ,  A61B1/00103 ,  A61B2090/0814 ,  A61B2560/0276

    摘要： In one aspect, the present invention is a medical device that reduces the likelihood of an operator improperly reusing it. The medical device includes (a) a device body; (b) a substrate comprising a contrast material that covers at least a portion of the device body; and (c) an outer layer comprising a hydrophilic material that covers at least a portion of the substrate. The outer layer comprising hydrophilic material is capable of absorbing water-soluble contaminants during clinical use that, once absorbed, are visible against the background of the substrate comprising the contrast material. In another aspect, the device includes (a) a device body and (b) an outer layer comprising a usage indicator reagent. In another aspect, the invention provides methods of preventing re-use of a single use medical device.

    摘要翻译： 一方面，本发明是减少操作者不当地重用它的可能性的医疗装置。 医疗装置包括（a）装置主体; （b）包括覆盖所述装置主体的至少一部分的对比材料的基板; 和（c）包含覆盖基材的至少一部分的亲水材料的外层。 包含亲水材料的外层能够在临床使用期间吸收水溶性污染物，其一旦被吸收就可以抵抗包含造影剂材料的底物的背景而可见。 在另一方面，该装置包括（a）装置主体和（b）包含使用指示剂试剂的外层。 在另一方面，本发明提供了防止单次使用的医疗装置的再次使用的方法。