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公开(公告)号：US20060069305A1
公开(公告)日：2006-03-30
申请号：US10955905
申请日：2004-09-30
CPC分类号： A61B1/00055 , A61B1/00062 , A61B1/00103 , A61B2090/0814 , A61B2560/0276
摘要： In one aspect, the present invention is a medical device that reduces the likelihood of an operator improperly reusing it. The medical device includes (a) a device body; (b) a substrate comprising a contrast material that covers at least a portion of the device body; and (c) an outer layer comprising a hydrophilic material that covers at least a portion of the substrate. The outer layer comprising hydrophilic material is capable of absorbing water-soluble contaminants during clinical use that, once absorbed, are visible against the background of the substrate comprising the contrast material. In another aspect, the device includes (a) a device body and (b) an outer layer comprising a usage indicator reagent. In another aspect, the invention provides methods of preventing re-use of a single use medical device.
摘要翻译： 一方面，本发明是减少操作者不当地重用它的可能性的医疗装置。 医疗装置包括（a）装置主体; （b）包括覆盖所述装置主体的至少一部分的对比材料的基板; 和（c）包含覆盖基材的至少一部分的亲水材料的外层。 包含亲水材料的外层能够在临床使用期间吸收水溶性污染物，其一旦被吸收就可以抵抗包含造影剂材料的底物的背景而可见。 在另一方面，该装置包括（a）装置主体和（b）包含使用指示剂试剂的外层。 在另一方面，本发明提供了防止单次使用的医疗装置的再次使用的方法。
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2.发明申请公开(公告)号：US20050255046A1
公开(公告)日：2005-11-17
申请号：US11151044
申请日：2005-06-13
申请人： Sheng-Ping Zhong , Ronald Sahatjian
发明人： Sheng-Ping Zhong , Ronald Sahatjian
摘要： The present invention relates to an elongated medical device for intralumenal manipulation during a process of magnetic resonance imaging. The device includes an elongated body. An extrusion material is integrated with the elongated body and includes a hydrophilic polymer that incorporates a substance having a plurality of paramagnetic ions. The extrusion material is configured to enhance magnetic resonance visibility during said process of magnetic resonance imaging.
摘要翻译： 本发明涉及一种用于在磁共振成像过程中进行腔内操作的细长医疗装置。 该装置包括细长体。 挤出材料与细长体结合在一起并且包括含有具有多个顺磁离子的物质的亲水聚合物。 挤出材料构造成在磁共振成像的所述过程期间增强磁共振可见度。
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3.发明申请Implantable or insertable medical devices visible under magnetic resonance imaging 有权可植入或可插入的医疗器械在磁共振成像下可见公开(公告)号：US20070167735A1
公开(公告)日：2007-07-19
申请号：US11637263
申请日：2006-12-12
申请人： Sheng-Ping Zhong , Ronald Sahatjian , Enxin Ma
发明人： Sheng-Ping Zhong , Ronald Sahatjian , Enxin Ma
IPC分类号： A61B5/05
CPC分类号： G01R33/286 , A61L29/145 , A61L29/18 , A61L31/145 , A61L31/18 , A61M25/0045 , A61M25/0108
摘要： Disclosed is an implantable or insertable medical device comprising (a) a substrate and (b) a hydrogel polymer coating at a least a portion of the surface of the substrate, wherein the hydrogel polymer is adapted to render the medical device visible under magnetic resonance imaging (MRI) upon insertion or implantation of the medical device into a patient. Also disclosed is the use of such a hydrogel coated implantable or insertable medical device in a medical procedure, wherein during or after insertion or implantation of the medical device in a patient, the position of the medical device is viewed under MRI. The use of a hydrogel polymer for coating a medical device wherein the hydrogel polymer is adapted to render a medical device coated with the hydrogel polymer visible under MRI and a hydrogel polymer adapted to render a medical device coated therewith visible under MRI are also disclosed.
摘要翻译： 公开了一种可植入或可插入的医疗装置，其包括（a）基底和（b）在所述基底表面的至少一部分表面上的水凝胶聚合物涂层，其中所述水凝胶聚合物适于使所述医疗装置在磁共振成像 （MRI）在将医疗装置插入或植入患者体内时。 还公开了在医疗过程中使用这种水凝胶涂覆的可植入或可插入的医疗装置，其中在将医疗装置插入或植入患者体内或之后，在MRI下观察医疗装置的位置。 还公开了使用水凝胶聚合物涂覆医疗装置，其中水凝胶聚合物适于使涂覆有水凝胶聚合物的医疗装置在MRI下可见，并且还公开了适于使其涂覆的医疗装置在MRI下可见的水凝胶聚合物。
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公开(公告)号：US20050075625A1
公开(公告)日：2005-04-07
申请号：US10891286
申请日：2004-07-14
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/1214 , A61B90/39 , A61B2017/00292 , A61B2017/00867 , A61B2017/1205 , A61B2090/3925 , A61B2090/3954 , A61M25/0041 , A61M25/0043 , A61M25/0074 , A61M25/0158
摘要： A medical device, such as, for example, a catheter, includes a tubular member having a first portion having a shape memory polymer.
摘要翻译： 医疗装置，例如导管，包括具有第一部分的管状部件，该第一部分具有形状记忆聚合物。
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公开(公告)号：US08435285B2
公开(公告)日：2013-05-07
申请号：US10962567
申请日：2004-10-13
IPC分类号： A61F2/82
CPC分类号： A61F2/82 , A61F2/07 , A61F2/86 , A61F2/90 , A61F2002/075 , A61F2210/0076 , A61F2220/0008 , A61F2220/0041 , A61F2220/005 , A61F2220/0066 , A61F2220/0075 , A61F2250/0067 , A61L31/129 , A61L31/146 , B05D1/002
摘要： An endoprosthesis comprising a stent, a cover fully covering the stent wherein the cover has variable porosity in the radial direction; and an adhesion layer connecting the stent to the cover. Another aspect of the invention is a method of implanting an endoprosthesis which includes a stent, providing a cover with variable porosity in the radial direction, connecting the stent to the cover with an adhesion layer to form a covered stent, and implanting the covered stent within a body lumen of a patient.
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公开(公告)号：US07792568B2
公开(公告)日：2010-09-07
申请号：US10390202
申请日：2003-03-17
IPC分类号： A61B5/05
CPC分类号： G01R33/286 , A61B90/39 , A61B2090/3933 , A61B2090/3954 , A61M25/00 , A61M25/0009 , A61M25/0127 , A61M2025/1079
摘要： A medical device includes a body, a member in the body, and a contrast agent in the member. The device can be visible by magnetic resonance imaging.
摘要翻译： 医疗装置包括主体，身体中的构件和构件中的造影剂。 该装置可以通过磁共振成像可见。
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公开(公告)号：US20070020307A1
公开(公告)日：2007-01-25
申请号：US11184196
申请日：2005-07-19
申请人： Sheng-Ping Zhong , Enxin Ma , Eun-Hyun Jang
发明人： Sheng-Ping Zhong , Enxin Ma , Eun-Hyun Jang
摘要： The present invention relates generally to radiation-resistant medical devices which contain polymer regions for release of therapeutic agents. The present invention also relates to radiation-resistant copolymer materials for use in connection with insertable or implantable medical devices. The radiation-sterilized medical device comprises (a) a release region and (b) at least one therapeutic agent and the release region comprises a phenoxy resin block.
摘要翻译： 本发明一般涉及含有用于释放治疗剂的聚合物区域的耐辐射医疗装置。 本发明还涉及用于与可插入或可植入的医疗装置相结合的耐辐射共聚物材料。 辐射消毒的医疗装置包括（a）释放区和（b）至少一种治疗剂，并且释放区包含苯氧树脂嵌段。
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8.发明授权
公开(公告)号：US5869127A
公开(公告)日：1999-02-09
申请号：US877825
申请日：1997-06-18
申请人： Sheng-Ping Zhong
发明人： Sheng-Ping Zhong
IPC分类号： A61M25/00 , A61L29/00 , A61L29/08 , A61L29/16 , A61L31/00 , A61L31/10 , A61L31/16 , C03C17/32 , C08J7/04 , C08L33/02 , C08L75/00 , C08L75/04 , C09D201/00 , B05D3/10 , A61L33/00 , B05D3/00
CPC分类号： A61L31/16 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/208 , A61L2300/21 , A61L2300/236 , A61L2300/25 , A61L2300/42 , A61L2300/608 , A61L2300/61 , Y10S623/92
摘要： Disclosed is a method of enhancing the biocompatibility of a substrate by providing the substrate with a continuous bio-active surface coating. This method includes applying to the substrate a first coating which includes an aqueous dispersion or emulsion of a polymer containing an organic acid functional group and an excess of a polyfunctional cross-linking agent which is reactive with the organic acid groups of the polymer. A continuous bio-active surface coating is then formed over the dried first coating by applying thereover a bio-active agent containing an organic acid functional group or metal salt thereof. The first and second coatings are then dried to covalently bond the organic acid functional groups of the bio-active agent to the polymer through the excess unreacted polyfunctional cross-linking agent.
摘要翻译： 公开了通过向基材提供连续的生物活性表面涂层来提高基底的生物相容性的方法。 该方法包括向基材施加第一涂层，该涂层包括含有有机酸官能团的聚合物的水性分散体或乳液，以及过量的与聚合物的有机酸基团反应的多官能交联剂。 然后通过在其上施加含有有机酸官能团或其金属盐的生物活性剂，在干燥的第一涂层上形成连续的生物活性表面涂层。 然后干燥第一和第二涂层，以通过过量的未反应的多官能交联剂将生物活性剂的有机酸官能团与聚合物共价键合。
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公开(公告)号：US08722074B2
公开(公告)日：2014-05-13
申请号：US11184196
申请日：2005-07-19
申请人： Sheng-Ping Zhong , Enxin Ma , Eun-Hyun Jang
发明人： Sheng-Ping Zhong , Enxin Ma , Eun-Hyun Jang
IPC分类号： A61F2/02
摘要： The present invention relates generally to radiation-resistant medical devices which contain polymer regions for release of therapeutic agents. The present invention also relates to radiation-resistant copolymer materials for use in connection with insertable or implantable medical devices. The radiation-sterilized medical device comprises (a) a release region and (b) at least one therapeutic agent and the release region comprises a phenoxy resin block.
摘要翻译： 本发明一般涉及含有用于释放治疗剂的聚合物区域的耐辐射医疗装置。 本发明还涉及用于与可插入或可植入的医疗装置相结合的耐辐射共聚物材料。 辐射消毒的医疗装置包括（a）释放区和（b）至少一种治疗剂，并且释放区包含苯氧树脂嵌段。
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10.发明授权公开(公告)号：US07483732B2
公开(公告)日：2009-01-27
申请号：US10826960
申请日：2004-04-15
CPC分类号： G01R33/285
摘要： Medical devices incorporate therein imaging materials having selected MRI detectable nuclei to provide useful magnetic resonance images of the medical devices and proximate body tissue. Also, a method generates MRI images of such a medical device, and involves performing first and second MRI processes on a body portion including at least a portion of the medical device to obtain, respectively, first and second image data. The first MRI process is adapted to detect MRI detectable nuclei present in the proximate body tissue, and the second MRI process is adapted to detect the selected MRI detectable nuclei contained in the device's imaging material. The selected MRI detectable nuclei incorporated in the imaging material is not the same nuclei that the first MRI process is adapted to detect. The second image data are combined with the first image data to produce image data for the medical device and the proximate body tissue.
摘要翻译： 医疗装置包括具有选定的MRI可检测核的成像材料，以提供医疗装置和邻近身体组织的有用的磁共振图像。 此外，一种方法产生这种医疗装置的MRI图像，并且涉及在包括医疗装置的至少一部分的主体部分上执行第一和第二MRI处理，以分别获得第一和第二图像数据。 第一MRI过程适于检测存在于邻近身体组织中的MRI可检测核，并且第二MRI过程适于检测包含在装置的成像材料中的所选择的MRI可检测核。 在成像材料中并入的所选择的MRI检测核并不是第一个MRI过程适用于检测的核。 第二图像数据与第一图像数据组合以产生用于医疗装置和邻近身体组织的图像数据。
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