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公开(公告)号：US4963483A
公开(公告)日：1990-10-16
申请号：US107812
申请日：1987-10-13
IPC分类号： C07K14/195 , A61K38/00 , A61K39/29 , C07K14/005 , C07K14/02 , C07K14/10 , C07K14/18 , C07K14/705 , C12N1/16 , C12N15/09 , C12N15/51 , C12N15/81 , C12P21/00 , C12R1/865 , G01N33/576
CPC分类号： C07K14/005 , C12N15/81 , G01N33/5764 , A61K38/00 , C12N2730/10122
摘要： The hepatitis B virus preS2 antigen gene linked in one contiguous reading frame to the hepatitis B virus surface antigen gene has been expressed in Saccharomyces cerevisiae utilizing an optimized plasmid construction. The expressed protein aggregates into a particulate form which displays the major antigenic sites encoded by both domains, thereby highlighting the utility of yeast as a host for the high level expression of the preS2 as well as the S domain. This protein is useful in in vitro diagnostic systems and as a vaccine for the treatment and prevention of hepatitis B virus-induced diseases and/or infections.
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公开(公告)号：US4816564A
公开(公告)日：1989-03-28
申请号：US824405
申请日：1986-01-31
IPC分类号： C12N15/09 , A61K39/29 , C07K1/22 , C07K14/00 , C07K14/02 , C07K14/10 , C07K14/18 , C12N1/16 , C12N1/19 , C12N15/00 , C12N15/81 , C12P21/00 , C12P21/02 , C12R1/645 , C12R1/85 , C07K7/10 , C07K13/00
CPC分类号： C07K14/005 , C12N15/81 , C12N2730/10122 , Y10S930/223
摘要： The entire hepatitis B Virus pre-S antigen gene linked in one contiguous reading frame to the hepatitis B virus surface antigen gene has been expressed in Saccharomyces cerevisiae. The expressed protein aggregates into a particulate form which displays the major antigenic sites encoded by both domains, thereby highlighting the utility of yeast as a host for the expression of pre-S domains. This protein is useful in in vitro diagnostic systems and as a vaccine for the treatment and prevention of hepatitis B virus-induced diseases and/or infections.
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3.发明授权Hepatitis B virus surface proteins with reduced host carbohydrate content 失效乙型肝炎病毒表面蛋白质具有降低的宿主碳水化合物含量
公开(公告)号：US5614384A
公开(公告)日：1997-03-25
申请号：US368287
申请日：1995-01-04
申请人： Peter J. Kniskern , Arpi Hagopian
发明人： Peter J. Kniskern , Arpi Hagopian
IPC分类号： A61K39/29 , A61P31/12 , C07K1/22 , C07K14/00 , C07K14/02 , C07K14/10 , C07K14/18 , C12N1/19 , C12N15/09 , C12N15/36 , C12P21/02 , C12R1/865 , G01N33/53 , G01N33/576
CPC分类号： C07K14/005 , C12N2730/10122
摘要： In order to produce hepatitis B virus (HBV) surface proteins in the form of particles with substantially reduced entrapped carbohydrate content, DNA encoding the HBV surface proteins was expressed in a recombinant yeast host which is deficient in its ability to glycosylate proteins. These HBV surface proteins display the antigenie sites genetically encoded by the S domain of the HBV virion envelope open reading frame and contains substantially reduced levels of entrapped carbohydrate when compared with HBsAg particles produced in "wild-type" yeast cells. These particles are useful as a vaccine for both the active and passive treatment or prevention of disease and/or infection caused by HBV or other agents serologically related to HBV.
摘要翻译： 为了产生具有显着降低的夹带碳水化合物含量的颗粒形式的乙型肝炎病毒（HBV）表面蛋白质，编码HBV表面蛋白的DNA在重组酵母宿主中表达，其缺乏糖基化蛋白质的能力。 这些HBV表面蛋白质显示由HBV病毒粒子包膜开放阅读框架的S结构域遗传编码的抗原位点，与“野生型”酵母细胞中产生的HBsAg颗粒相比，含有显着降低的包埋碳水化合物水平。 这些颗粒可用作活性和被动治疗或预防HBV或与HBV血清学相关的其他试剂引起的疾病和/或感染的疫苗。
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公开(公告)号：US4407949A
公开(公告)日：1983-10-04
申请号：US271335
申请日：1981-06-08
IPC分类号： A61K39/102 , C12P21/00 , C12P19/04 , C12R1/21
CPC分类号： C12P21/005 , A61K39/102 , Y10S424/831 , Y10S435/851
摘要： A high molecular weight capsular polysaccharide from H. influenza type b is an effective immunogenic agent against infection caused by the H. influenza type b bacterium.
摘要翻译： 来自b型流感嗜血杆菌的高分子量荚膜多糖是针对由流感B型细菌引起的感染的有效的免疫原性试剂。
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公开(公告)号：US5130248A
公开(公告)日：1992-07-14
申请号：US409190
申请日：1989-09-19
申请人： Peter J. Kniskern , Arpi Hagopian , Pamela Burke
发明人： Peter J. Kniskern , Arpi Hagopian , Pamela Burke
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C07K2319/735 , C12N2730/10122 , C12N2740/16222
摘要： The present invention relates to recombinant fusion polypeptides of HIV envelope and HBsAg, suitable as vaccines against AIDS and/or ARC and hepatitis, as well as immunogens for inducing antibodies for passive protection or treatment of AIDS and/or ARC.
摘要翻译： 本发明涉及HIV包膜和HBsAg的重组融合多肽，其适合作为针对AIDS和/或ARC和肝炎的疫苗，以及用于诱导用于被动保护或治疗AIDS和/或ARC的抗体的免疫原。
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公开(公告)号：US4307080A
公开(公告)日：1981-12-22
申请号：US189416
申请日：1980-09-22
IPC分类号： A61K39/102 , A61K39/00
CPC分类号： A61K39/102
摘要： A high molecular weight capsular polysaccharide from H. influenza type b is an effective immunogenic agent against infection caused by the H. influenza type b bacterium.
摘要翻译： 来自b型流感嗜血杆菌的高分子量荚膜多糖是针对由流感B型细菌引起的感染的有效的免疫原性试剂。
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公开(公告)号：US4264764A
公开(公告)日：1981-04-28
申请号：US78430
申请日：1979-09-24
IPC分类号： A61K39/102 , C07G3/00
CPC分类号： A61K39/102 , Y10S424/831 , Y10S514/898
摘要： A high molecular weight capsular polysaccharide from H. influenza type b is an effective immunogenic agent against infection caused by the H. influenza type b bacterium.
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8.发明授权
公开(公告)号：US4250265A
公开(公告)日：1981-02-10
申请号：US84973
申请日：1979-10-15
CPC分类号： A61K39/099 , A61K2039/552 , Y10S424/825
摘要： A sub-cellular antigenic fraction of Bordetella bronchiseptica protects against the incidence and severity of swine atropic rhinitis.
摘要翻译： 支气管炎博德特氏菌的亚细胞抗原级分可以防止猪嗜性性鼻炎的发生率和严重程度。
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公开(公告)号：US5847112A
公开(公告)日：1998-12-08
申请号：US970460
申请日：1997-11-14
申请人： Peter J. Kniskern , William J. Miller , Arpi Hagopian , Charlotte C. Ip , John P. Hennessey, Jr. , Dennis J. Kubek , Pamela D. Burke
发明人： Peter J. Kniskern , William J. Miller , Arpi Hagopian , Charlotte C. Ip , John P. Hennessey, Jr. , Dennis J. Kubek , Pamela D. Burke
IPC分类号： A61K39/00 , A61K39/09 , A61P31/04 , C07H1/08 , C08B37/00 , C12N1/20 , C12P19/00 , C12P19/04 , C12R1/46
CPC分类号： A61K39/092 , C12P19/04
摘要： Type-specific capsular polysaccharide preparations from Streptococcus pneumoniae, having on average less than about 1000 oligosaccharide repeat units per molecule, polydispersities between 1.0 and 1.4, intrinsic viscosities between 0.6 and 3.0 dL/g, and less than 3% contamination of type-specific polysaccharide by group-specific C-polysaccharide, are produced by a novel process. The novel type specific polysaccharide products are useful in the preparation of vaccines, especially covalent conjugates comprising the novel polysaccharide linked to a T-cell stimulatory carrier protein. Vaccines comprising the novel polysaccharides are useful in the prevention of infection and of diseases associated with infection by Streptococcus pneumoniae.
摘要翻译： 来自肺炎链球菌的特异性荚膜多糖制剂，其平均每分子平均小于约1000个寡糖重复单位，多分散性在1.0至1.4之间，特性粘度在0.6至3.0dL / g之间，小于3％的特异性多糖污染 通过组特异性C-多糖通过新方法产生。 新型特异性多糖产物可用于制备疫苗，特别是包含与T细胞刺激性载体蛋白连接的新型多糖的共价缀合物。 包含新型多糖的疫苗可用于预防感染和与肺炎链球菌感染相关的疾病。
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公开(公告)号：US5623057A
公开(公告)日：1997-04-22
申请号：US246394
申请日：1994-05-20
申请人： Stephen Marburg , Richard L. Tolman , Peter J. Kniskern , William J. Miller , Arpi Hagopian , Charlotte C. Ip , John P. Hennessey, Jr. , Dennis J. Kubek , Pamela D. Burke
发明人： Stephen Marburg , Richard L. Tolman , Peter J. Kniskern , William J. Miller , Arpi Hagopian , Charlotte C. Ip , John P. Hennessey, Jr. , Dennis J. Kubek , Pamela D. Burke
IPC分类号： A61K39/00 , A61K38/16 , A61K39/02 , A61K39/09 , A61K39/095 , A61K39/295 , A61K39/395 , A61K47/36 , A61P29/00 , C07K20060101 , C07K1/113 , C07K1/14 , C07K14/00 , C07K14/195 , C07K14/22 , C07K14/315 , C07K14/41 , C07K17/02 , C07K17/10 , C08B37/00 , C12P19/04 , C12P21/00 , C12R1/36 , C12R1/46 , A61K39/385
CPC分类号： A61K39/095 , A61K39/092 , A61K2039/6068 , A61K2039/627
摘要： A novel conjugate vaccine comprising partially hydrolyzed, highly purified, capsular polysaccharide (Ps) from Streptococcus pneumoniae bacteria (pneumococci, Pn) linked to an immunogenic carrier protein, is produced by a new process. The conjugate is useful in the prevention of pneumococcal infections. Vaccines comprising a mixture of from one to ten different pneumococcal polysaccharide-immunogenic protein (Pn-Ps-PRO) conjugates induce broadly protective recipient immune responses against the cognate pathogens from which the polysaccharide components are derived. Young children and infants younger than 2 years old, normally unable to mount a protective immune response to the Pn-Ps alone, exhibit protective immune responses upon vaccination with these Pn-Ps-PRO conjugates.
摘要翻译： 通过新方法生产包含与免疫原性载体蛋白连接的来自肺炎链球菌（Streptococcus pneumoniae）（肺炎球菌，Pn））的部分水解，高度纯化的荚膜多糖（Ps）的新型缀合疫苗。 该缀合物可用于预防肺炎球菌感染。 包含1至10种不同的肺炎球菌多糖 - 免疫原性蛋白（Pn-Ps-PRO）缀合物的混合物的疫苗诱导针对多糖成分衍生的同源病原体的广泛保护性受体免疫应答。 年龄小于2岁的幼儿和婴儿通常无法对Pn-Ps单独施加保护性免疫应答，在用这些Pn-Ps-PRO缀合物接种疫苗后，会显示出保护性的免疫应答。
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