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    Analog filtering with symmetrical timing using a single comparator
    1.
    发明授权
    Analog filtering with symmetrical timing using a single comparator 有权
    使用单个比较器进行对称定时的模拟滤波

    公开(公告)号：US06407626B1

    公开(公告)日：2002-06-18

    申请号：US09715759

    申请日：2000-11-17

    申请人： John H. Carpenter, Jr. ,  Joseph A. Devore ,  Tohru Tanaka ,  Ross E. Teggatz

    发明人： John H. Carpenter, Jr. ,  Joseph A. Devore ,  Tohru Tanaka ,  Ross E. Teggatz

    IPC分类号： H03K500

    CPC分类号： H03K5/1252 ,  H03K5/082

    摘要： Provided is a symmetrical filter that uses a single comparator. In addition to a voltage divider, a current regulator, and a comparator, the filter of the invention provides control logic that turns on or off a pull up switch and/or pull down switch in order to fully charge or fully discharge a capacitor. Accordingly, in one aspect, the invention is a control logic for a symmetrical filter. Furthermore, timing logic is provided to provide for a more rigorous symmetrical filter performance.

    摘要翻译： 提供了使用单个比较器的对称滤波器。 除了分压器，电流调节器和比较器之外，本发明的滤波器还提供控制逻辑，其接通或断开上拉开关和/或下拉开关以便完全充电或完全放电电容器。 因此，一方面，本发明是用于对称滤波器的控制逻辑。 此外，提供定时逻辑以提供更严格的对称滤波器性能。

    Cancer heat therapy-enhancing agent
    4.
    发明授权
    Cancer heat therapy-enhancing agent 有权
    癌症热疗增强剂

    公开(公告)号：US09012502B2

    公开(公告)日：2015-04-21

    申请号：US13820303

    申请日：2011-09-12

    申请人： Taku Chibazakura ,  Tohru Tanaka ,  Kiwamu Takahashi ,  Motowo Nakajima ,  Fuminori Abe

    发明人： Taku Chibazakura ,  Tohru Tanaka ,  Kiwamu Takahashi ,  Motowo Nakajima ,  Fuminori Abe

    IPC分类号： A61K31/221 ,  C07C229/22 ,  A61K31/197

    CPC分类号： C07C229/22 ,  A61K31/197

    摘要： Provided is an enhancer for cancer thermotherapy not combined with photodynamic therapy. Cancer treatment not combined with photodynamic therapy is made available by using, as an enhancer for cancer thermotherapy, 5-aminolevulinic acids represented by formula (1): R2R1NCH2COCH2CH2COR3  (1) [wherein R1 and R2 each independently represent a hydrogen atom, an alkyl group, an acyl group, an alkoxycarbonyl group, an aryl group, or an aralkyl group; and R3 represents a hydroxy group, an alkoxy group, an acyloxy group, an alkoxycarbonyloxy group, an aryloxy group, an aralkyloxy group, or an amino group] or a salt thereof.

    摘要翻译： 提供了不与光动力疗法结合的癌症热疗的增强剂。 通过使用作为癌症热疗的增强剂，可以通过使用由式（1）表示的5-氨基乙酰丙酸获得癌症治疗：R2R1NCH2COCH2CH2COR3（1）[其中R1和R2各自独立地表示氢原子，烷基 ，酰基，烷氧基羰基，芳基或芳烷基; R3表示羟基，烷氧基，酰氧基，烷氧基羰基氧基，芳氧基，芳烷氧基或氨基）或其盐。

    PHOTODYNAMIC THERAPY USING PHOTOSENSITIZING AGENT OR 5-AMINOLEVULINIC ACID
    6.
    发明申请
    PHOTODYNAMIC THERAPY USING PHOTOSENSITIZING AGENT OR 5-AMINOLEVULINIC ACID 有权
    光敏性治疗使用光敏剂或5-氨基酸

    公开(公告)号：US20140128799A1

    公开(公告)日：2014-05-08

    申请号：US14126929

    申请日：2012-06-20

    申请人： Tohru Tanaka ,  Katsushi Inoue ,  Takuya Ishii ,  Tokato Yoshida

    发明人： Tohru Tanaka ,  Katsushi Inoue ,  Takuya Ishii ,  Tokato Yoshida

    IPC分类号： A61N5/06 ,  A61K41/00

    CPC分类号： A61N5/062 ,  A61K31/197 ,  A61K41/0061 ,  A61K41/0071 ,  A61K49/0052

    摘要： It is to provide photodynamic therapy (PDT) and photodynamic diagnosis (PDD) which are suitable for the diagnosis and therapy of a part requiring a certain degree of deep penetration, such as subcutaneous cancer and lymph nodes surrounded by blood vessels and fat. This is solved by performing PDT and PDD targeting cancer by administering a composition comprising a photosensitizing agent such as a tetrapyrrole-based compound (photofrin, protoporphyrin IX, etc.) or ALAs such as 5-aminolevulinic acid (ALA), ALA methyl ester, ALA ethyl ester, ALA propyl ester, ALA butyl ester, ALA pentyl ester, or a hydrochloride, phosphate, or sulfate thereof followed by irradiation with excitation light at a wavelength of 480 to 580 nm.

    摘要翻译： 它是提供光动力疗法（PDT）和光动力学诊断（PDD），适用于诊断和治疗需要一定程度深度穿透的部位，如皮下癌和由血管和脂肪包围的淋巴结。 通过施用包含光敏剂如四吡咯基化合物（光调节素，原卟啉IX等）或ALA的组合物，例如5-氨基乙酰丙酸（ALA），ALA甲酯， ALA乙酯，ALA丙酯，ALA丁酯，ALA戊酯或其盐酸盐，磷酸盐或硫酸盐，然后用波长480〜580nm的激发光照射。

    Antimalarial Drug Comprising Alaremycin or Derivative Thereof as Active Ingredient
    7.
    发明申请
    Antimalarial Drug Comprising Alaremycin or Derivative Thereof as Active Ingredient 有权
    包括阿拉霉素或其衍生物的抗疟药物作为活性成分

    公开(公告)号：US20130217913A1

    公开(公告)日：2013-08-22

    申请号：US13883038

    申请日：2011-11-09

    申请人： Masaaki Wachi ,  Shigeharu Sato ,  Tohru Tanaka ,  Kiwamu Takahashi

    发明人： Masaaki Wachi ,  Shigeharu Sato ,  Tohru Tanaka ,  Kiwamu Takahashi

    IPC分类号： A61K31/197 ,  A61K31/16 ,  A61K31/221

    CPC分类号： A61K31/197 ,  A61K9/0019 ,  A61K9/107 ,  A61K9/2018 ,  A61K9/2027 ,  A61K31/16 ,  A61K31/221 ,  Y02A50/411

    摘要： Provided is a preventive and/or therapeutic agent for malaria, comprising, as an active ingredient, 5-acetamido-4-oxo-5-hexenoic acid (Alaremycin) or a derivative thereof. A preventive and/or therapeutic agent for malaria is used which comprises, as an active ingredient, Alaremycin or a derivative thereof represented by formula (I) (wherein R1 represents a hydroxy group, an amino group, or a substituted or unsubstituted straight chain or branched alkoxy group or alkylamino group having 1 to 8 carbons; R2 represents hydrogen, a substituted or unsubstituted straight chain or branched alkyl group having 1 to 8 carbons, or a substituted or unsubstituted aromatic group having 4 to 10 carbons; and R3 represents hydrogen or a methyl group).

    摘要翻译： 本发明提供疟疾的预防和/或治疗剂，其包含作为活性成分的5-乙酰氨基-4-氧代-5-己烯酸（阿拉霉霉素）或其衍生物。 使用疟疾的预防和/或治疗剂，其包含作为活性成分的由式（I）表示的阿拉霉素或其衍生物（其中R 1表示羟基，氨基或取代或未取代的直链或 支链烷氧基或碳原子数为1〜8的烷基氨基; R2表示氢，取代或未取代的碳原子数1〜8的直链或支链烷基或取代或未取代的碳原子数4〜10的芳基，R3表示氢或 甲基）。

    HOP ALPHA ACID OR HOP OIL CONTENT ENHANCER
    9.
    发明申请
    HOP ALPHA ACID OR HOP OIL CONTENT ENHANCER 审中-公开
    HOP ALPHA酸或HOP油含量增强剂

    公开(公告)号：US20100105948A1

    公开(公告)日：2010-04-29

    申请号：US12525167

    申请日：2008-01-30

    申请人： Tohru Tanaka ,  Satofumi Kawata

    发明人： Tohru Tanaka ,  Satofumi Kawata

    IPC分类号： C07C229/22

    CPC分类号： A01N37/44

    摘要： To provide a hop alpha acid or hop oil content enhancer, which increases the content of a hop alpha acid or a hop oil.A hop alpha acid or hop oil content enhancer, which comprises 5-aminolevulinic acid, or a derivative thereof represented by the following formula (1), or a salt thereof as an active ingredient: R2R1NCH2COCH2CH2COR3  (1) wherein R1 and R2 each independently represents a hydrogen atom, an alkyl group, an acyl group, an alkoxycarbonyl group, an aryl group, or an aralkyl group; R3 represents a hydroxyl group, an alkoxy group, an acyloxy group, an alkoxycarbonyloxy group, an aryloxy group, an aralkyloxy group, or an amino group.

    摘要翻译： 提供一种啤酒花α酸或啤酒花油含量增强剂，其增加了啤酒花酸或啤酒花油的含量。 包含由下式（1）表示的5-氨基乙酰丙酸或其衍生物或其盐作为活性成分的啤酒花α酸或啤酒花油含量增强剂：R2R1NCH2COCH2CH2COR3（1）其中R1和R2各自独立地表示 氢原子，烷基，酰基，烷氧基羰基，芳基或芳烷基; R3表示羟基，烷氧基，酰氧基，烷氧基羰基氧基，芳氧基，芳烷氧基或氨基。

    Diagnostic Agent for Tumor
    10.
    发明申请
    Diagnostic Agent for Tumor 有权
    肿瘤诊断剂

    公开(公告)号：US20080108701A1

    公开(公告)日：2008-05-08

    申请号：US11664065

    申请日：2005-09-22

    申请人： Ichiro Okura ,  Toshiaki Kamachi ,  Shunichiro Ogura ,  Masahiro Ishizuka ,  Tohru Tanaka

    发明人： Ichiro Okura ,  Toshiaki Kamachi ,  Shunichiro Ogura ,  Masahiro Ishizuka ,  Tohru Tanaka

    IPC分类号： A61K31/197 ,  A61P43/00 ,  C07C229/22

    CPC分类号： C07C229/22 ,  A61K49/0021 ,  G01N33/574

    摘要： According to the present invention, a tumor diagnostic agent which carries out early stage detection, monitoring of therapeutic effect and prognostic diagnosis of all tumors The tumor diagnostic agent of the present invention is a tumor diagnostic agent comprising δ-aminolevulinic acid represented by formula (I), a derivative thereof and a salt thereof: R2R1NCH2COCH2CH2COR3   (I) wherein R1 and R2 each independently represents hydrogen, alkyl, acyl, alkoxycarbonyl, aryl or aralkyl; and R3 represents hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, aryloxy, aralkyloxy or amino, which is used for diagnoses by measuring porphyrins in a sample collected from the inside or outside of the body after its administration.

    摘要翻译： 根据本发明，进行早期检测，所有肿瘤的治疗效果和预后诊断的肿瘤诊断剂本发明的肿瘤诊断剂是包含由式（I）表示的δ-氨基乙酰丙酸的肿瘤诊断剂 ），其衍生物及其盐：<？in-line-formula description =“In-line formula”end =“lead”？> R＆lt; 2＆lt; 1＆gt; NCH 2 COCH 2 CH 2 2（3）（I）<？in-line-formula description =“In 其中R 1和R 2各自独立地表示氢，烷基，酰基，烷氧基羰基，芳基或芳烷基; R 3表示羟基，烷氧基，酰氧基，烷氧基羰基氧基，芳氧基，芳烷氧基或氨基，其用于通过测量在其施用后从身体内部或外部收集的样品中的卟啉进行诊断。