公开(公告)号：US20070068810A1

公开(公告)日：2007-03-29

申请号：US11545182

申请日：2006-10-10

申请人： Ross Tsukashima ,  Jeffery Schipper ,  Leo Roucher ,  Erich Wolf ,  Charles Bankert

发明人： Ross Tsukashima ,  Jeffery Schipper ,  Leo Roucher ,  Erich Wolf ,  Charles Bankert

IPC分类号： G01N27/26

CPC分类号： A61B5/083 ,  A61B5/08 ,  A61B5/082 ,  A61B5/14539 ,  A61B5/682 ,  G01N33/497

摘要： Disclosed is a system and method for monitoring the breath chemistry of a patient's breath using a specially designed self-condensing sensor module mounted in a mask, nasal cannula, headband with boom apparatus, or similar device for directing the patients' breath towards the self-condensing sensor. Monitoring of a patient's breath pH provided by the miniaturized self-condensing pH sensor provides for real-time monitoring of patient airway pH values. The specially designed self-condensing sensor module incorporates a data transfer means, e.g. direct wiring or by providing a transmitter with an antenna for wireless transferring of the pH data to a processing receiver. The self-condensing pH sensor comprises a multi-tubular design with the outer tubular member housing a silver chloride reference element, an ion conducting path, and an antimony sensor plug isolated in an inner tubular member that is co-linearly or coaxially configured with the outer tubular member. A transmitter with an antenna transfers the observed pH data by employing one of many wireless methods, such as radio-frequency (RF) energy. Alternately, the transfer of observed pH data is accomplished by direct wire methods. The pH data is transferred or updated at specific intervals, which can be varied according to the patient's needs, to the processing receiver that is engaged to the treatment apparatus. In the therapeutic configuration, the processing receiver computes and diagnoses the breath chemistry data and determines at what frequency the treatment apparatus should be activated.

摘要翻译： 公开了一种用于使用安装在面罩，鼻插管，带有吊杆装置的头带的专门设计的自冷凝传感器模块或类似装置来监测患者呼吸的呼吸化学的系统和方法， 冷凝传感器 监测由小型化自冷凝pH传感器提供的患者呼吸pH提供对患者气道pH值的实时监测。 专门设计的自会聚传感器模块包含数据传输装置，例如 直接布线或通过向发射机提供用于将pH数据无线传输到处理接收器的天线。 自冷凝pH传感器包括多管状设计，其中外部管状构件容纳氯化银参考元件，离子传导路径和隔离在内部管状构件中的锑传感器插塞，其与线性或同轴配置为 外管状构件。 具有天线的发射机通过采用诸如射频（RF）能量的许多无线方法之一来传送观察到的pH数据。 或者，观察到的pH数据的转移通过直接线法实现。 将pH数据以特定间隔传送或更新，其可以根据患者的需要而变化到接合到治疗设备的处理接收器。 在治疗配置中，处理接收器计算和诊断呼吸化学数据，并确定治疗装置应以什么频率被激活。

公开(公告)号：US20060270936A1

公开(公告)日：2006-11-30

申请号：US11137459

申请日：2005-05-25

申请人： Ross Tsukashima ,  Erich Wolf ,  Jeffery Schipper ,  Charles Bankert ,  Leo Roucher ,  Thomas Wallner

发明人： Ross Tsukashima ,  Erich Wolf ,  Jeffery Schipper ,  Charles Bankert ,  Leo Roucher ,  Thomas Wallner

IPC分类号： A61B5/02

CPC分类号： A61B5/14542 ,  A61B5/145 ,  A61B5/14539 ,  A61B5/1473 ,  A61B5/1495 ,  A61B2560/0276 ,  A61B2562/02

摘要： The present invention pertains to an apparatus for evaluating the signal strength from the pH sensor to determine whether the sensor is hydrated sufficiently to accurately measure pH. This is accomplished by utilizing circuitry that periodically sends a low voltage signal to a suitable pH sensor and then receiving the resulting waveforms which are analyzed by a processing receiver. The electrical connection between a suitable pH sensor and hydration monitoring circuitry is generally hard wired. In one embodiment, a processing receiver is coupled with the hydration monitoring circuitry as a single apparatus. In a second embodiment, the processing receiver can be independent and located remote from the hydration monitoring circuitry. In this embodiment, the hydration monitoring circuitry and the processing receiver are electrically connected using either hard wired techniques or wireless technology. In addition, the processing receiver can include data recording capability.

摘要翻译： 本发明涉及一种用于评估来自pH传感器的信号强度以确定传感器是否足够水合以准确测量pH的装置。 这是通过利用周期性地向合适的pH传感器发送低电压信号然后接收由处理接收器分析的结果波形的电路来实现的。 合适的pH传感器和水合监测电路之间的电气连接通常是硬连线的。 在一个实施例中，处理接收器作为单一设备与水合监控电路耦合。 在第二实施例中，处理接收器可以是独立的并且位于远离水合监测电路的位置。 在该实施例中，水合监测电路和处理接收器使用硬接线技术或无线技术进行电连接。 此外，处理接收器可以包括数据记录能力。

公开(公告)号：US20060270940A1

公开(公告)日：2006-11-30

申请号：US11137600

申请日：2005-05-25

申请人： Ross Tsukashima ,  Erich Wolf ,  Jeffery Schipper ,  Charles Bankert ,  Leo Roucher ,  Thomas Wallner

发明人： Ross Tsukashima ,  Erich Wolf ,  Jeffery Schipper ,  Charles Bankert ,  Leo Roucher ,  Thomas Wallner

IPC分类号： A61B5/08

CPC分类号： A61B5/083 ,  A61B5/14539

摘要： The present invention is a system for monitoring a patient's breath chemistry comprising a plurality of components, including a self-condensing pH sensor distally mounted on a catheter, a transmitter with hydration sensing circuitry for the pH sensor, and processing receiver/data recorder. A specially designed self-condensing pH sensor is located on the distal end of a tubular catheter which is designed to be inserted into the patient's airway. Monitoring of a patient's breath pH is accomplished by using the miniaturized self-condensing pH sensor, providing for real-time monitoring of patient airway pH values. The self-condensing pH sensor comprises a multi-tubular design with the catheter tubular member housing a silver chloride reference element, an ion conducting path, and an antimony sensor element isolated within an inner tubular member that is co-linearly or coaxially configured with the outer catheter tubular member. A separation means may be employed in close proximity to the pH sensor to keep the pH sensor from direct mucosal contact along the wall of the patient's airway which could possibly affect the sensor's ability to accurately measure breath pH. Centimeter markings imprinted on the catheter body and an optional light source located near the distal tip of the catheter is used to aid in proper positioning. A transmitter with an antenna is engaged to the proximal end of the catheter and transfers the observed pH data by employing one of many wireless methods, such as radio-frequency (RF) energy. Alternately, the transfer of observed pH data is accomplished by direct wire methods. A processing receiver/data recorder receives the data and provides a means for storing and retrieving the data for study by a physician. The transmitter also includes a means to evaluate the signal strength of the sensor, which comprises of periodically sending a low voltage signal to the pH sensor and reviewing the resulting wave forms. The signal strength system can detect if the pH sensor is non-hydrated, partially hydrated, or fully hydrated. The pH data is transferred or updated at specific intervals, which can be varied according to the patient's needs, to the processing receiver/data recorder that can include an alarming means for predetermined pH values.

公开(公告)号：US20060266366A1

公开(公告)日：2006-11-30

申请号：US11137619

申请日：2005-05-25

申请人： Ross Tsukashima ,  Erich Wolf ,  Jeffery Schipper ,  Charles Bankert ,  Leo Roucher

发明人： Ross Tsukashima ,  Erich Wolf ,  Jeffery Schipper ,  Charles Bankert ,  Leo Roucher

IPC分类号： A62B9/06 ,  A61M16/00

CPC分类号： A61M16/0488 ,  A61B5/065 ,  A61B5/14539 ,  A61M16/0411

摘要： The present invention is a system comprising an illumination means and is mounted on a catheter wherein said illumination is generally located in the distal end of the catheter. Locating the illumination means near the distal end will simplify and facilitate precise placement of a measurement device in close proximity to the desired location. In one example, a catheter with a distally mounted pH sensor benefits from the use of an illumination means in the patient's airway such as in the oropharynx region. The illumination source of the present invention addresses catheter insertion and location using a continuous or flashing light emitting diode (LED) embedded in the distal end of the catheter to provide a visual sighting means for the physician. When the catheter, with the illumination means is inserted in the patient's airway, the illumination means functions to illuminate the distal end of the catheter and the anatomical features of the patient's airway for observation by the clinician, thereby facilitating proper placement of the measurement device.

摘要翻译： 本发明是一种包括照明装置并且安装在导管上的系统，其中所述照明通常位于导管的远端。 在远端附近定位照明装置将简化和便于将测量装置精确放置在紧邻所需位置的位置。 在一个示例中，具有远端安装的pH传感器的导管受益于在患者的气道（例如口咽部）中使用照明装置。 本发明的照明源解决导管插入和使用嵌入在导管的远端中的连续或闪光的发光二极管（LED）的位置，以提供医生的视觉瞄准装置。 当将具有照明装置的导管插入患者的气道中时，照明装置用于照亮导管的远端和患者气道的解剖特征以供临床医生观察，从而便于测量装置的正确放置。

公开(公告)号：US20070068811A1

公开(公告)日：2007-03-29

申请号：US11545281

申请日：2006-10-10

申请人： Ross Tsukashima ,  Jeffery Schipper ,  Leo Roucher ,  Erich Wolf

发明人： Ross Tsukashima ,  Jeffery Schipper ,  Leo Roucher ,  Erich Wolf

IPC分类号： G01N27/26

CPC分类号： A61B5/083 ,  A61B5/08 ,  A61B5/082 ,  A61B5/14539 ,  A61B5/682 ,  G01N33/497

摘要： Disclosed is a system and method for monitoring, diagnosing, and treating certain respiratory conditions, such as asthma. The system includes a mask apparatus fitted with a pH sensor and thermocouple, a continuous positive airway pressure (CPAP) device, a processing receiver, and a therapeutic nebulizer/atomizer/humidifier device. The mask apparatus, CPAP device and therapeutic nebulizer/atomizer/humidifier device are connected by a pneumatic means. The pH sensor and the thermocouple are in electrical communication with the processing receiver that controls, through an electronic means, the CPAP device and therapeutic nebulizer/atomizer/humidifier device. The electrical communications can be in the form of a plurality of wires or employ wireless means.

摘要翻译： 公开了一种用于监测，诊断和治疗某些呼吸道疾病如哮喘的系统和方法。 该系统包括配备有pH传感器和热电偶，连续正气道压力（CPAP）装置，处理接收器和治疗雾化器/雾化器/加湿器装置的掩模装置。 掩模装置，CPAP装置和治疗雾化器/雾化器/加湿装置通过气动装置连接。 pH传感器和热电偶与处理接收器电连接，处理接收器通过电子装置控制CPAP装置和治疗雾化器/雾化器/加湿器装置。 电通信可以是多条电线的形式或采用无线装置。

公开(公告)号：US08262878B2

公开(公告)日：2012-09-11

申请号：US11881021

申请日：2007-07-25

申请人： Erich H. Wolf ,  Charles Bankert ,  Ross Tsukashima ,  Elmer Custodio

发明人： Erich H. Wolf ,  Charles Bankert ,  Ross Tsukashima ,  Elmer Custodio

IPC分类号： G01N27/414

CPC分类号： G01N27/4035

摘要： The present invention pertains to a means of combining and configuring specific hydrophilic and dielectric materials in such a way as to allow an antimony/reference electrode pH sensor to be packaged and stored dry yet become fully hydrated to an activated state after exposure to aqueous liquids. The sensor is packaged and stored dry to maintain component stability and minimize component degradation. When the user removes the sensor from the package and the sensor tip is submerged in a hydration (ion conduction) media or solution, the hydrophilic coating along with the impregnated reference wick, absorb the fluid to create an electrolytic gel inside the reference wick, which activates the pH sensor.

摘要翻译： 本发明涉及一种组合和配置特定的亲水和介电材料的方法，其方法是允许锑/参比电极pH传感器在暴露于含水液体之后被干燥而被充分水合至活化状态。 传感器被包装并储存干燥，以保持部件的稳定性并最大程度降低部件的退化。 当使用者从传感器中取出传感器并将传感器尖端浸没在水合（离子传导）介质或溶液中时，亲水涂层与浸渍的参考油芯一起吸收流体，以在参考油芯内部产生电解凝胶， 激活pH传感器。

公开(公告)号：US20090026078A1

公开(公告)日：2009-01-29

申请号：US11881021

申请日：2007-07-25

申请人： Erich H. Wolf ,  Charles Bankert ,  Ross Tsukashima ,  Elmer Custodio

发明人： Erich H. Wolf ,  Charles Bankert ,  Ross Tsukashima ,  Elmer Custodio

IPC分类号： G01N27/406

CPC分类号： G01N27/4035

摘要： The present invention pertains to a means of combining and configuring specific hydrophilic and dielectric materials in such a way as to allow an antimony/reference electrode pH sensor to be packaged and stored dry yet become fully hydrated to an activated state after exposure to aqueous liquids. The sensor is packaged and stored dry to maintain component stability and minimize component degradation. When the user removes the sensor from the package and the sensor tip is submerged in a hydration (ion conduction) media or solution, the hydrophilic coating along with the impregnated reference wick, absorb the fluid to create an electrolytic gel inside the reference wick, which activates the pH sensor.

摘要翻译： 本发明涉及一种组合和配置特定的亲水和介电材料的方法，其方法是允许锑/参比电极pH传感器在暴露于含水液体之后被干燥而被充分水合至活化状态。 传感器被包装并储存干燥，以保持部件的稳定性并最大程度降低部件的退化。 当使用者从传感器中取出传感器并将传感器尖端浸没在水合（离子传导）介质或溶液中时，亲水涂层与浸渍的参考油芯一起吸收流体，以在参考油芯内部产生电解凝胶， 激活pH传感器。

公开(公告)号：US08518107B2

公开(公告)日：2013-08-27

申请号：US13198582

申请日：2011-08-04

申请人： Ross Tsukashima ,  Samuel M. Shaolian ,  Maurice Buchbinder ,  Brian C. Gray ,  Victor S. Packham ,  Hung H. Cao

发明人： Ross Tsukashima ,  Samuel M. Shaolian ,  Maurice Buchbinder ,  Brian C. Gray ,  Victor S. Packham ,  Hung H. Cao

IPC分类号： A61F2/24

CPC分类号： A61F2/2466 ,  A61F2/2442 ,  A61F2/2445 ,  A61F2/2448 ,  A61F2210/0014 ,  A61F2220/0016 ,  A61F2220/0033 ,  A61F2220/0075 ,  A61F2250/0004 ,  A61F2250/001 ,  A61F2250/0067 ,  A61F2250/0096

摘要： Apparatus, systems, and methods are provided for repairing heart valves through percutaneous transcatheter delivery and fixation of annuloplasty rings to heart valves. An annuloplasty ring includes an outer hollow member including a plurality of segments. Adjacent segments cooperate with one another to change the outer hollow member from an elongate insertion geometry to an annular operable geometry. The annuloplasty ring also includes an internal anchor member located at least partially within the outer hollow member. The internal anchor member includes a plurality of anchors configured to attach the annuloplasty ring to tissue of a heart valve annulus. The internal anchor member is configured to move the plurality of anchors with respect to a plurality of windows in the outer hollow member to selectively deploy the plurality of anchors through the respective windows.

摘要翻译： 提供装置，系统和方法用于通过经皮经导管递送和瓣膜成形术环固定到心脏瓣膜来修复心脏瓣膜。 瓣膜成形术环包括包括多个段的外部中空构件。 相邻的部分彼此协作以将外部空心构件从细长插入几何形状改变为环形可操作的几何形状。 瓣膜成形术环还包括至少部分地位于外部中空构件内部的内部锚定构件。 内部锚固构件包括构造成将瓣环成形术环附接到心脏瓣膜环的组织的多个锚固件。 内部锚固构件被构造成相对于外部中空构件中的多个窗口移动多个锚固件，以选择性地将多个锚定件展开通过相应的窗口。

公开(公告)号：US20120197392A1

公开(公告)日：2012-08-02

申请号：US13386331

申请日：2010-07-20

申请人： Jeffrey P. DuMontelle ,  Maurice Buchbinder ,  Samuel M. Shaolian ,  Ninh H. Dang ,  Paul A. Molloy ,  Ross Tsukashima ,  Brian C. Gray ,  Daniel C. Anderson

发明人： Jeffrey P. DuMontelle ,  Maurice Buchbinder ,  Samuel M. Shaolian ,  Ninh H. Dang ,  Paul A. Molloy ,  Ross Tsukashima ,  Brian C. Gray ,  Daniel C. Anderson

IPC分类号： A61F2/24

CPC分类号： A61L27/50 ,  A61F2/2445 ,  A61F2210/0023 ,  A61F2210/0033 ,  A61F2250/001 ,  A61L27/507

摘要： Annuloplasty rings are employed to treat heart valve defects, such as regurgitation. Synching the heart tissue to the ring restores the valve opening to its approximate original size and operating efficiency. Adjustable annuloplasty rings allow for a proper degree of synching both during open heart surgery and over the patient's lifetime. A subcutaneous port may be coupled to an adjustable annuloplasty ring such that an external activation energy generator can be used to heat the adjustable annuloplasty ring and thereby adjust the size of the annuloplasty ring.

摘要翻译： 使用瓣环成形术来治疗心脏瓣膜缺损，例如反流。 将心脏组织同步到环将瓣膜开口恢复到其近似的原始尺寸和操作效率。 可调环形成形术环允许在心脏开放心脏手术期间和患者生命周期内均匀适应程度的同步。 皮下端口可以联接到可调节瓣环成形术环，使得外部激活能量发生器可以用于加热可调节瓣环成形术环，从而调节瓣环成形术环的尺寸。

公开(公告)号：US06689056B1

公开(公告)日：2004-02-10

申请号：US09544373

申请日：2000-04-06

申请人： John T. Kilcoyne ,  Ross Tsukashima ,  George M. Johnson ,  Christopher Klecher

发明人： John T. Kilcoyne ,  Ross Tsukashima ,  George M. Johnson ,  Christopher Klecher

IPC分类号： A61B500

CPC分类号： A61B5/6882 ,  A61B1/00147 ,  A61B1/041 ,  A61B5/0008 ,  A61B5/0031 ,  A61B5/037 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/4211 ,  A61B5/4233 ,  Y10S128/903

摘要： Disclosed is an ambulatory system for monitoring one or more physiological parameters in a body lumen, such as the esophagus. The system includes an implantable probe having a sensor for the physiological parameter and a transmitter for transmitting data to an external receiver. The probe may be used for monitoring any of various physiological parameters, including pH, temperature, and pressure, within the esophagus or other body lumens. Methods and deployment catheters are also disclosed.

摘要翻译： 公开了一种用于监测体腔（例如食道）中的一个或多个生理参数的移动系统。 该系统包括具有用于生理参数的传感器的可植入探针和用于将数据发送到外部接收器的发射器。 探针可用于监测食道或其他体腔内的各种生理参数，包括pH，温度和压力。 还公开了方法和部署导管。