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1.发明授权Methods and devices for crosslinking of corneal collagen and for treatment of disorders of the eye 有权用于交联角膜胶原和用于治疗眼睛疾病的方法和装置公开(公告)号：US09445870B2
公开(公告)日：2016-09-20
申请号：US13576589
申请日：2011-02-01
申请人： Roy S. Chuck , Barbara Ann Soltz , Robert Soltz
发明人： Roy S. Chuck , Barbara Ann Soltz , Robert Soltz
CPC分类号： A61B18/20 , A61F9/0079 , A61F2009/00872 , A61N5/062
摘要： Methods and devices for delivering therapeutic or diagnostic energy (e.g., light, ultrasound, ionizing radiation (e.g., x-ray), vibration, heat energy, etc.) into the eye. An energy emitting device is positioned on the eye and used to deliver energy into the eye. The device may be constructed to allow the subject's eyelids to open and close while the device is positioned on the eye. The device is useable for various energy based or energy-mediated therapies, including crosslinking of corneal collagen, light therapy, photodynamic therapy, photo-activation of drugs, etc.
摘要翻译： 用于将治疗或诊断能量（例如，光，超声，电离辐射（例如，x射线），振动，热能等）递送到眼睛中的方法和装置。 能量发射装置位于眼睛上，用于将能量输送到眼睛中。 该装置可被构造成允许被检者的眼皮在设备定位在眼睛上时打开和关闭。 该装置可用于各种基于能量或能量介导的疗法，包括角膜胶原交联，光疗法，光动力疗法，药物光激活等。
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2.发明申请Methods and Systems For Identifying and Isolating Stem Cells and For Observing Mitochondrial Structure and Distribution in Living Cells 失效用于鉴定和分离干细胞和观察线粒体结构和活细胞分布的方法和系统公开(公告)号：US20080193929A1
公开(公告)日：2008-08-14
申请号：US11667280
申请日：2005-11-08
申请人： Roy S. Chuck
发明人： Roy S. Chuck
CPC分类号： G01N33/5002
摘要： Methods and systems for a) identifying and isolating stem cells, b) assessing mitochondrial distribution and structure in living cells and c) performing fluorescence microscopy on living cells while the cells remain within a condition-controlled cell culture chamber.
摘要翻译： a）识别和分离干细胞的方法和系统，b）评估活细胞中的线粒体分布和结构; c）在细胞保留在病态细胞培养室内时，对活细胞进行荧光显微镜检查。
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公开(公告)号：US06679898B1
公开(公告)日：2004-01-20
申请号：US09965124
申请日：2001-09-27
申请人： Roy S. Chuck
发明人： Roy S. Chuck
IPC分类号： A61F900
CPC分类号： A61F9/0133
摘要： A system, apparatus and method for harvesting from the eye of a mammilian (e.g., cadaveric) donor a disc-shaped graft or lenticle consisting of corneal tissue and a quantity of scleral or pericorneal tissue wherein limbal stem cells are located. This graft or lenticle is then transplanted onto the eye of a human or veterinary patient to treat a disorder caused by the absence or deficiency of limbal stem cells in the patient's eye. The system of the present invention comprises a) an eye-contacting ring and cutter guide apparatus and b) a cutter apparatus. The eye-contacting ring and cutter guide apparatus is initially placed in contact with the donor eye such that a portion of the cornea and adjacent scleral or pericorneal tissue containing limbal stem cells protrudes upwardly through the center of the ring. The cutter is then engaged with guide member(s) formed on the ring and the cutter is advanced, severing the protruding cornea and stem-cell-containing pericorneal tissue. In this manner the desired lenticle is obtained for subsequent transplantation.
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4.发明授权Design and synthesis of bispecific reagents: use of double stranded DNAs as chemically and spatially defined cross-linkers 失效双特异性试剂的设计和合成：使用双链DNA作为化学和空间定义的交联剂
公开(公告)号：US5849878A
公开(公告)日：1998-12-15
申请号：US481065
申请日：1995-06-07
申请人： Charles R. Cantor , Roy S. Chuck , Doris B. Tse
发明人： Charles R. Cantor , Roy S. Chuck , Doris B. Tse
CPC分类号： C07K16/2812 , C07K16/2809 , C07K16/468
摘要： The invention relates to bis-protein-DNA conjugates. A protein having a specific ligand binding activity is covalently linked to each end of a derivatized DNA molecule. These bis-protein-DNA conjugates can be used for immunoassays, PCR assays and measuring distances between proteins at up to 3.4 A resolution. The invention also relates to methods of synthesizing these bis-protein-DNA conjugates. Synthesis of the conjugates entails derivatizing the 5' or 3' end of a DNA oligonucleotide and covalently linking that DNA to a protein. The DNA can be conjugated to the proteins, including antibodies or Fab' fragments, using disulfide bond linkage.
摘要翻译： 本发明涉及双蛋白-DNA缀合物。 具有特异性配体结合活性的蛋白质与衍生的DNA分子的每个末端共价连接。 这些双蛋白-DNA缀合物可用于免疫测定，PCR测定和测量蛋白质之间的距离，高达3.4A分辨率。 本发明还涉及合成这些双蛋白-DNA缀合物的方法。 共轭物的合成需要衍生DNA寡核苷酸的5'或3'末端并共价连接该DNA与蛋白质。 使用二硫键可将DNA与蛋白质缀合，包括抗体或Fab'片段。
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5.发明授权Implantable devices and methods for measuring intraocular, subconjunctival or subdermal pressure and/or analyte concentration 有权用于测量眼内，结膜下或皮下压力和/或分析物浓度的可植入装置和方法公开(公告)号：US09474487B2
公开(公告)日：2016-10-25
申请号：US13185277
申请日：2011-07-18
申请人： Roy S. Chuck , George Baerveldt , Jim-Son Chou
发明人： Roy S. Chuck , George Baerveldt , Jim-Son Chou
CPC分类号： A61B3/16 , A61B5/0084 , A61B5/686 , A61B5/6867 , A61F2/14 , A61F2/16 , A61F2002/1681
摘要： Methods, apparatus and systems for measuring pressure and/or for quantitative or qualitative measurement of analytes within the eye or elsewhere in the body. Optical pressure sensors and/or optical analyte sensors are implanted in the body and light is cast from an extracorporeal light source, though the cornea, conjunctiva or dermis, and onto a reflective element located within each pressure sensor or analyte sensor. The position or configuration of each sensor's reflective element varies with pressure or analyte concentration. Thus, the reflectance spectra of light reflected by the sensors' reflective elements will vary with changes in pressure or changes in analyte concentration. A spectrometer or other suitable instrument is used to process and analyze the reflectance spectra of the reflected light, thereby obtaining an indication of pressure or analyte concentration adjacent to the sensor(s). The wavelength of the interrogating beam of light may vary to control out potential interference or inaccuracies in the system.
摘要翻译： 用于测量眼睛或身体其他部位的分析物的压力和/或定量或定性测量的方法，装置和系统。 将光学压力传感器和/或光学分析物传感器植入体内，并从体外光源（通过角膜，结膜或真皮）和位于每个压力传感器或分析物传感器内的反射元件上投射光。 每个传感器的反射元件的位置或配置随压力或分析物浓度而变化。 因此，由传感器的反射元件反射的光的反射光谱随着压力的变化或分析物浓度的变化而变化。 使用光谱仪或其他合适的仪器来处理和分析反射光的反射光谱，从而获得邻近传感器的压力或分析物浓度的指示。 询问光束的波长可能会变化，以控制系统中的潜在干扰或不准确。
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6.发明申请Implantable Devices and Methods for Measuring Intraocular, Subconjunctival or Subdermal Pressure and/or Analyte Concentration 有权用于测量眼内，结膜下或皮下压力和/或分析物浓度的植入式装置和方法公开(公告)号：US20120041552A1
公开(公告)日：2012-02-16
申请号：US13185277
申请日：2011-07-18
申请人： Roy S. Chuck , George Baerveldt , Jim-Son Chou
发明人： Roy S. Chuck , George Baerveldt , Jim-Son Chou
CPC分类号： A61B3/16 , A61B5/0084 , A61B5/686 , A61B5/6867 , A61F2/14 , A61F2/16 , A61F2002/1681
摘要： Methods, apparatus and systems for measuring pressure and/or for quantitative or qualitative measurement of analytes within the eye or elsewhere in the body. Optical pressure sensors and/or optical analyte sensors are implanted in the body and light is cast from an extracorporeal light source, though the cornea, conjunctiva or dermis, and onto a reflective element located within each pressure sensor or analyte sensor. The position or configuration of each sensor's reflective element varies with pressure or analyte concentration. Thus, the reflectance spectra of light reflected by the sensors' reflective elements will vary with changes in pressure or changes in analyte concentration. A spectrometer or other suitable instrument is used to process and analyze the reflectance spectra of the reflected light, thereby obtaining an indication of pressure or analyte concentration adjacent to the sensor(s). The wavelength of the interrogating beam of light may vary to control out potential interference or inaccuracies in the system.
摘要翻译： 用于测量眼睛或身体其他部位的分析物的压力和/或定量或定性测量的方法，装置和系统。 将光学压力传感器和/或光学分析物传感器植入体内，并从体外光源（通过角膜，结膜或真皮）以及位于每个压力传感器或分析物传感器内的反射元件上投射光。 每个传感器的反射元件的位置或配置随压力或分析物浓度而变化。 因此，由传感器的反射元件反射的光的反射光谱随着压力的变化或分析物浓度的变化而变化。 使用光谱仪或其他合适的仪器来处理和分析反射光的反射光谱，从而获得邻近传感器的压力或分析物浓度的指示。 询问光束的波长可能会变化，以控制系统中的潜在干扰或不准确。
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7.发明授权公开(公告)号：US07336989B2
公开(公告)日：2008-02-26
申请号：US10407848
申请日：2003-04-03
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A61B5/0071 , A61B5/0075 , A61B5/411 , A61B5/441 , A61B5/7267 , G01J3/4406 , G01N21/64 , G01N21/6402 , G01N21/6408 , G01N21/645 , G01N21/718 , G01N2021/1782 , G01N2021/6417 , G01N2201/06113 , G01N2201/0633 , G01N2201/0697 , G01N2201/1296
摘要： Methods and systems for determination of one or more substances within a material are described. A flow of fluorescence-exciting/ablative energy (e.g., laser pulse(s), preferably in the ultraviolet region (e.g. 193-nm)), is directed onto the material to ablate a thin layer of the material using photochemical decomposition. Simultaneously, the laser energy induces fluorescence of the substance(s) within the ablated layer of the material. The fluorescence emitted by the substance(s) is then received by a device, which measures the spectrum of the received fluorescence. The fluorescence spectra are then transmitted to a spectral processing device adapted to determine, on the basis of the fluorescence spectra, whether the substance(s) of interest is/are present in the material and/or the concentration at which the substance(s) of interest is/are present in the material. This process may be repeated for each layer of the material to determine the concentration gradient of the substance(s) of interest in the material.
摘要翻译： 描述了用于确定材料内的一种或多种物质的方法和系统。 荧光激发/消融能量（例如，激光脉冲，优选在紫外区域（例如193nm））的流动被引导到材料上以使用光化学分解来消融材料的薄层。 同时，激光能量在材料的烧蚀层中引起物质的荧光。 物质发射的荧光然后被测量所接收荧光光谱的装置接收。 然后将荧光光谱传输到光谱处理装置，其适于基于荧光光谱确定目的物质是否存在于材料中和/或物质的浓度， 感兴趣的是/存在于材料中。 可以针对材料的每层重复该过程以确定材料中感兴趣的物质的浓度梯度。
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8.发明申请公开(公告)号：US20170215727A1
公开(公告)日：2017-08-03
申请号：US15259852
申请日：2016-09-08
申请人： Roy S. Chuck , George Baerveldt , Jim-Son Chou
发明人： Roy S. Chuck , George Baerveldt , Jim-Son Chou
CPC分类号： A61B3/16 , A61B5/0084 , A61B5/686 , A61B5/6867 , A61F2/14 , A61F2/16 , A61F2002/1681
摘要： Methods, apparatus and systems for measuring pressure and/or for quantitative or qualitative measurement of analytes within the eye or elsewhere in the body. Optical pressure sensors and/or optical analyte sensors are implanted in the body and light is cast from an extracorporeal light source, though the cornea, conjunctiva or dermis, and onto a reflective element located within each pressure sensor or analyte sensor. The position or configuration of each sensor's reflective element varies with pressure or analyte concentration. Thus, the reflectance spectra of light reflected by the sensors' reflective elements will vary with changes in pressure or changes in analyte concentration. A spectrometer or other suitable instrument is used to process and analyze the reflectance spectra of the reflected light, thereby obtaining an indication of pressure or analyte concentration adjacent to the sensor(s). The wavelength of the interrogating beam of light may vary to control out potential interference or inaccuracies in the system.
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9.发明申请Methods and Devices for Crosslinking of Corneal Collagen and For Treatment of Disorders of the Eye 有权用于角膜胶原交联和眼部疾病治疗的方法和装置公开(公告)号：US20130211389A1
公开(公告)日：2013-08-15
申请号：US13576589
申请日：2011-02-01
申请人： Roy S. Chuck , Barbara Ann Soltz , Robert Soltz
发明人： Roy S. Chuck , Barbara Ann Soltz , Robert Soltz
IPC分类号： A61B18/20
CPC分类号： A61B18/20 , A61F9/0079 , A61F2009/00872 , A61N5/062
摘要： Methods and devices for delivering therapeutic or diagnostic energy (e.g., light, ultrasound, ionizing radiation (e.g., x-ray), vibration, heat energy, etc.) into the eye. An energy emitting device is positioned on the eye and used to deliver energy into the eye. The device may be constructed to allow the subject's eyelids to open and close while the device is positioned on the eye. The device is useable for various energy based or energy-mediated therapies, including crosslinking of corneal collagen, light therapy, photodynamic therapy, photo-activation of drugs, etc.
摘要翻译： 用于将治疗或诊断能量（例如，光，超声，电离辐射（例如，x射线），振动，热能等）递送到眼睛中的方法和装置。 能量发射装置位于眼睛上，用于将能量输送到眼睛中。 该装置可被构造成允许被检者的眼皮在设备定位在眼睛上时打开和关闭。 该装置可用于各种基于能量或能量介导的疗法，包括角膜胶原交联，光疗法，光动力疗法，药物光激活等。
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10.发明申请METHODS AND SYSTEMS FOR IDENTIFYING AND ISOLATING STEM CELLS AND FOR OBSERVING MITOCHONDRIAL STRUCTURE AND DISTRIBUTION IN LIVING CELLS 审中-公开用于鉴定和分离干细胞的方法和系统以及用于观察生物细胞中的细胞结构和分布公开(公告)号：US20110027787A1
公开(公告)日：2011-02-03
申请号：US12831108
申请日：2010-07-06
申请人： Roy S. Chuck
发明人： Roy S. Chuck
CPC分类号： G01N33/5002
摘要： Methods and systems for a) identifying and isolating stem cells, b) assessing mitochondrial distribution and structure in living cells and c) performing fluorescence microscopy on living cells while the cells remain within a condition-controlled cell culture chamber.
摘要翻译： a）识别和分离干细胞的方法和系统，b）评估活细胞中的线粒体分布和结构; c）在细胞保留在病态细胞培养室内时，对活细胞进行荧光显微镜检查。
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