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    OPEN-JUNCTION IONIC TRANSISTOR
    2.
    发明申请
    OPEN-JUNCTION IONIC TRANSISTOR 审中-公开

    公开(公告)号：US20200378918A1

    公开(公告)日：2020-12-03

    申请号：US16887895

    申请日：2020-05-29

    申请人： Seoul National University R&DB Foundation

    发明人： Jeong-Yun SUN ,  Young-Chang Joo ,  Taek Dong Chung ,  Hae-Ryung LEE ,  Seung-Min LIM ,  Seok Hee HAN ,  Hyunjae YOO

    IPC分类号： G01N27/414

    摘要： Disclosed is an open-junction ionic transistor which includes: a substrate; a p type gel which is formed as a polyelectrolyte gel on the substrate; an n type gel which is formed as the polyelectrolyte gel on the substrate and having one side contacting one side of the p type gel; a first reservoir contacting the other side of the p type gel; a second reservoir contacting the other side of the n type gel; and an encapsulation layer covering the p type gel, the n type gel, the first reservoir, and the second reservoir, in which on the encapsulation layer, an injection unit for injecting an ion input is formed at a location corresponding to an interface contacting the p type gel and the n type gel and when reverse bias voltage is applied between the p type gel and the n type gel, the ion input injected through the injection unit is amplified and ionic current peak is generated.

    Open-junction ionic transistor
    4.
    发明授权
    Open-junction ionic transistor 有权

    公开(公告)号：US11474069B2

    公开(公告)日：2022-10-18

    申请号：US16887895

    申请日：2020-05-29

    申请人： Seoul National University R&DB Foundation

    发明人： Jeong-Yun Sun ,  Young-Chang Joo ,  Taek Dong Chung ,  Hae-Ryung Lee ,  Seung-Min Lim ,  Seok Hee Han ,  Hyunjae Yoo

    IPC分类号： G01N27/414

    摘要： Disclosed is an open-junction ionic transistor which includes: a substrate; a p type gel which is formed as a polyelectrolyte gel on the substrate; an n type gel which is formed as the polyelectrolyte gel on the substrate and having one side contacting one side of the p type gel; a first reservoir contacting the other side of the p type gel; a second reservoir contacting the other side of the n type gel; and an encapsulation layer covering the p type gel, the n type gel, the first reservoir, and the second reservoir, in which on the encapsulation layer, an injection unit for injecting an ion input is formed at a location corresponding to an interface contacting the p type gel and the n type gel and when reverse bias voltage is applied between the p type gel and the n type gel, the ion input injected through the injection unit is amplified and ionic current peak is generated.

    Virus-microbead complex and use thereof
    5.
    发明授权
    Virus-microbead complex and use thereof 有权

    公开(公告)号：US10107805B2

    公开(公告)日：2018-10-23

    申请号：US14758126

    申请日：2013-09-02

    申请人： SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION

    发明人： Taek Dong Chung ,  Inseong Hwang ,  Chang Su Jeon

    IPC分类号： G01N33/543 ,  G01N33/554 ,  G01N33/553

    摘要： The present invention relates to a virus-microbead complex including a microbead and a virus layer, in which linear viruses are bound individually to the surface of the microbead, and an immunoassay kit including the same.The virus-microbead complex of the present invention is characterized in that the linear viruses are bound to the surface of the microbead so that the orientations of the linear viruses are regulated using the interaction of streptavidin-biotin introduced thereon, thereby providing a significantly increased volume to surface area ratio, increasing the number of antibodies or ligands capable of binding thereto, and as a result, mediating the binding of antibodies or ligands to a unit bead with high density, which eventually leads to an increased sensitivity in immunoassays, and an application into a suspension array. Additionally, it was confirmed that cardiac troponin I (cTnI) in serum can be detected up to 20 pg/mL by introducing a self-assembled monolayer (SAM) containing PEG to remove a non-specific adsorption.

    Artificial synapse inducer and method of making the same
    6.
    发明授权
    Artificial synapse inducer and method of making the same 有权

    公开(公告)号：US10689426B2

    公开(公告)日：2020-06-23

    申请号：US16155209

    申请日：2018-10-09

    申请人： SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION

    发明人： Taek Dong Chung ,  In Seong Hwang ,  Eun Joong Kim ,  Chang Su Jeon

    IPC分类号： C07K14/475 ,  C07K14/705 ,  C07K14/435 ,  C12N5/0793

    摘要： Disclosed is a polypeptide containing an extracellular domain of a synaptogenic protein, and a method for manufacturing a nerve cell, a complex containing a biotin tagged at the C-terminus of the polypeptide, an artificial synapse inducer for coupling the composite to a streptavidin (SAV)-coated substrate and a nerve cell. The complex tagged with a biotin at the C-terminus of the polypeptide containing the extracellular domain of the synaptogenic protein, such as neuroligin-1, can display activity by being attached to the SAV-coated substrate to adjust the orientation thereof without help of a supported lipid bilayer. The complex containing an additional RFP between the extracellular domain and the biotin of the synaptogenic protein not only facilitates easier mass-production, quantification, and tracking, but also displays activity of a normal synaptogenic protein, thereby inducing excitatory or inhibitory synaptic differentiation by being fixed to the substrate and added to the nerve cell culture.