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公开(公告)号：US12046333B2
公开(公告)日：2024-07-23
申请号：US17986726
申请日：2022-11-14
发明人： Bo Ye , Changsong Hu , Huan Qi , Wenbo Zheng
CPC分类号： G16B45/00 , G01N1/14 , G01N1/31 , G01N15/1459 , G01N33/5094 , G01N2001/1418 , G01N2015/016 , G01N2015/018 , G01N2015/1486
摘要： A blood cell analysis method and a blood cell analyzer are provided. In the method and analyzer, characteristic information of white blood cell fragments is obtained based on side scattered light information and fluorescence information, characteristic information of platelets is obtained based on forward scattered light information and fluorescence information and then a count value for the platelets is acquired based on the characteristic information of the platelets and the characteristic information of the white blood cell fragments. The present invention can avoid the influence of the white blood cell fragments on the platelet counting, thereby ensuring the accuracy of the platelet counting without increasing costs.
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公开(公告)号：US11709123B2
公开(公告)日：2023-07-25
申请号：US17353406
申请日：2021-06-21
发明人： Guanzhen Wang , Bo Ye , Huan Qi
CPC分类号： G01N15/14 , G01N21/64 , G01N2015/0069 , G01N2015/0073 , G01N2015/1481
摘要： A method for analyzing nucleated red blood cells in a blood sample includes obtaining fluorescence signals and scattered light signals of cells in a blood sample; classifying and counting ghost particles, white blood cells, and nucleated red blood cells in the blood sample according to the fluorescence signals and the scattered light signals; obtaining a characteristic value of a characteristic particle population related to the nucleated red blood cells; and ascertaining a final nucleated red blood cell detection result according to the classifying and counting result of the nucleated red blood cells and the characteristic value of the characteristic particle group.
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公开(公告)号：US11105742B2
公开(公告)日：2021-08-31
申请号：US15638902
申请日：2017-06-30
发明人： Bo Ye , Huan Qi , Cheng Qian
摘要： Disclosed are nucleated red blood cell warning devices and methods, and flow cytometers using the same. The devices, methods and flow cytometers can warn whether nucleated red blood cells exist in a blood sample. The warning device may obtain forward-scattered light information, side-scattered light information and fluorescence information when cells in the blood sample pass through a detection region of the flow cytometer. The warning device may generate a side-scattered light-fluorescence dot plot, so as to classify leucocytes into four groups, and may generate a forward-scattered light-fluorescence dot plot, where the forward-scattered light-fluorescence dot plot can include a leucocyte group region. The warning device may obtain a predetermined feature region located at the left side of the leucocyte group region, perform statistics on the amount of characterization cells in the predetermined feature region, and provide a warning when the number of the characterization cells exceeds a threshold value.
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公开(公告)号：US11781983B2
公开(公告)日：2023-10-10
申请号：US17078705
申请日：2020-10-23
发明人： Huan Qi , Wenbo Zheng , Bo Ye , Zhaoyang Li , Yi Ye
IPC分类号： G01N33/80 , G01N15/14 , G01N15/00 , G01N21/64 , G01N15/06 , G01N21/47 , G01N27/02 , G01N33/487 , G08B21/18
CPC分类号： G01N21/6428 , G01N15/06 , G01N15/1429 , G01N15/1436 , G01N21/47 , G01N27/02 , G01N33/48707 , G01N33/80 , G08B21/185 , G01N15/1404 , G01N2015/008 , G01N2015/0069 , G01N2015/0084 , G01N2015/0693 , G01N2015/1402 , G01N2021/6439
摘要： A method, system and storage medium for providing an alarm for indicating that an abnormality is present in a sample analyzer are provided. The method includes: mixing a first aliquot of a blood sample with a diluent agent to prepare a first test sample; mixing a second aliquot of the blood sample with a lytic reagent to prepare a second test sample; detecting electrical impedance signals of the first test sample; detecting at least two types of optical signals of the second test sample; acquiring first platelet detection data based on the electrical impedance signals; acquiring second platelet detection data based on the at least two types of optical signals; acquiring an evaluation result based on a difference between the first platelet detection data and the second platelet detection data; determining whether the evaluation result meets a preset condition to provide an alarm.
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公开(公告)号：US10983042B2
公开(公告)日：2021-04-20
申请号：US16801544
申请日：2020-02-26
发明人： Bo Ye , Guanzhen Wang , Jiantao Di , Ying Zhang , Huan Qi
摘要： A cell analyzer and a sorting method for the cell analyzer are disclosed. Multiple optical signals generated by each of particles irradiated with light in a blood sample in a detection region are collected. The particles includes a first category of particles and a second category of particles. For each of the particles, Intensities of a first group of optical signals, which includes at least two optical signals selected from the multiple optical signals, and a pulse width of a second group of optical signals, which includes at least one optical signal selected from the multiple optical signals are acquired. For each of the particles, one or more reinforcement signals related to the particle are calculated based on an intensity of a first optical signal selected from the first group of optical signals and a pulse width of a second optical signal selected from the second group of optical signals, where the first optical signal is as same as or different from the second optical signal. The first category of particles and the second category of particles are distinguished from each other based at least partially on the one or more reinforcement signals related to each of the particles.
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公开(公告)号：US20200209224A1
公开(公告)日：2020-07-02
申请号：US16814846
申请日：2020-03-10
发明人： Bo Ye , Cheng Qian , Huan Qi
摘要： The present disclosure relates to the field of medical technology, which provides methods and apparatuses for identifying red blood cells infected by plasmodium. The methods may include: obtaining a forward-scattered light signal, a side-scattered light signal and an optional fluorescence signal from cells in a blood sample; obtaining a first two-dimensional scattergram according to the forward-scattered light signal and the side-scattered light signal, or obtaining a three-dimensional scattergram according to the forward-scattered light signal, the side-scattered light signal and the fluorescence signal; and identifying cells located in a predetermined area of the first two-dimensional scattergram or the three-dimensional scattergram as the red blood cells infected by plasmodium. The apparatuses perform the methods. The methods and apparatuses can have better identification accuracy.
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公开(公告)号：US10656143B2
公开(公告)日：2020-05-19
申请号：US14355544
申请日：2012-10-31
发明人： Bo Ye , Cheng Qian , Huan Qi
摘要： The present disclosure relates to the field of medical technology, which provides methods and apparatuses for identifying red blood cells infected by plasmodium. The methods may include: obtaining a forward-scattered light signal, a side-scattered light signal and an optional fluorescence signal from cells in a blood sample; obtaining a first two-dimensional scattergram according to the forward-scattered light signal and the side-scattered light signal, or obtaining a three-dimensional scattergram according to the forward-scattered light signal, the side-scattered light signal and the fluorescence signal; and identifying cells located in a predetermined area of the first two-dimensional scattergram or the three-dimensional scattergram as the red blood cells infected by plasmodium. The apparatuses perform the methods. The methods and apparatuses can have better identification accuracy.
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公开(公告)号：US12085513B2
公开(公告)日：2024-09-10
申请号：US18115627
申请日：2023-02-28
CPC分类号： G01N21/8901 , G01N33/49 , G01N35/00029 , G01N2021/1765 , G01N2035/00039
摘要： Embodiments of the present invention relate to a sample image photographing method and a corresponding sample image photographing apparatus. The method comprises: transporting a sample carrier to be tested to an imaging device; determining a focusing surface representation function of said current sample carrier according to a feature of a sample on said current sample carrier, the focusing surface representation function representing a relationship between horizontal position coordinates and a focusing parameter of each point to be photographed in a sample area of said current sample carrier: controlling a horizontal drive component of a driving device such that said current sample carrier moves continuously horizontally relative to the imaging device; and causing said current sample carrier to always satisfy the focusing surface representation function during the continuous horizontal motion, so that the imaging device continuously photographs an area of interest of said current sample carrier during the continuous horizontal motion.
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公开(公告)号：US11874212B2
公开(公告)日：2024-01-16
申请号：US17078740
申请日：2020-10-23
发明人： Bo Ye , Wenbo Zheng , Huan Qi , Zhaoyang Li
CPC分类号： G01N15/1429 , G01N15/1031 , G01N33/49
摘要： A blood analysis method, a blood analysis system, and a storage medium are provided. The blood analysis method includes: providing a blood sample; mixing a first aliquot of the blood sample with a diluent to prepare a first test sample; mixing a second aliquot of the blood sample with a lytic reagent to prepare a second test sample; detecting electrical impedance signals of the first test sample to obtain first volume distribution data; detecting at least two types of optical signals of the second test sample to obtain second volume distribution data; acquiring red blood cell test data of the blood sample; determining, based on the first volume distribution data, the second volume distribution data, and the red blood cell test data, whether the blood sample contains schistocytes; and if the determination result is yes, providing a warning that the blood sample may contain schistocytes.
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公开(公告)号：US11841358B2
公开(公告)日：2023-12-12
申请号：US17075603
申请日：2020-10-20
发明人： Huan Qi , Bo Ye , Wenbo Zheng , Changsong Hu , Qi Yu
IPC分类号： C12Q1/00 , G01N33/49 , G16H40/67 , G16H10/40 , G16H15/00 , G01N15/06 , G01N33/487 , G01N15/00
CPC分类号： G01N33/49 , G01N15/0656 , G01N33/48707 , G16H10/40 , G16H15/00 , G16H40/67 , G01N2015/0084 , G01N2015/0693
摘要： Disclosed are a method for determining a platelet concentration of a blood sample, a hematology system (100) and a storage medium. The method for determining a platelet concentration in a blood sample includes: forming a first suspension by mixing a first aliquot of the blood sample with a diluent; forming a second suspension by mixing a second aliquot of the blood sample with a lytic agent and a fluorescent dye to lyse red blood cells and stain white blood cells; measuring DC impedance signals of the first suspension passing through an aperture; measuring light scatter signals and fluorescent signals of the second suspension passing through an optical flow cell (20); analyzing DC impedance signals of the first suspension to obtain a first platelet distribution; analyzing light scatter signals and fluorescent signals of the second suspension to differentiate platelets from white blood cells and to obtain a second platelet distribution; and determining platelet data, such as the platelet concentration of the blood sample using the first and second platelet distributions.
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