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公开(公告)号：US20150366791A1
公开(公告)日：2015-12-24
申请号：US14751527
申请日：2015-06-26
Applicant: Solazyme, Inc.
Inventor： Jeff Avila , Geoffrey Brooks , Anthony G. Day , Aravind Somanchi
CPC classification number: A61K8/0241 , A61K8/73 , A61K8/9706 , A61Q19/08 , C08B37/0003 , C12P19/04 , C12R1/89
Abstract: Provided herein are microalgal skin care compositions and methods of improving the health and appearance of skin. Also provided are methods of using polysaccharides for applications such as topical personal care products, cosmetics, and wrinkle reduction compositions. The invention also provides novel decolorized microalgal compositions useful for improving the health and appearance of skin. The invention also includes insoluble polysaccharide particles for application to human skin.
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公开(公告)号：US20130296591A1
公开(公告)日：2013-11-07
申请号：US13889221
申请日：2013-05-07
Applicant: Solazyme, Inc.
Inventor： Anthony G. Day , Geoffrey Brooks , Scott Franklin
IPC: C11B3/02
CPC classification number: C11B3/02 , A23D7/00 , A23D9/00 , C11D9/26 , C12P7/6418 , C12P7/6463 , C12P7/649 , Y02E50/13
Abstract: Chemically modified lipids and methods for their preparation are provided.
Abstract translation: 提供化学修饰的脂质及其制备方法。
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3.发明授权Methods of treating impaired glucose metabolism via administration of algal biomass 有权通过施用藻类生物量来治疗糖代谢紊乱的方法公开(公告)号：US09345730B2
公开(公告)日：2016-05-24
申请号：US14266715
申请日：2014-04-30
Applicant: Solazyme, Inc. , University of Manitoba
Inventor： David Brinkmann , Anthony G. Day , Peter J. H. Jones , Scott Harding
CPC classification number: A61K36/02 , A23L33/105 , A23V2002/00 , A61K31/202 , A61K36/05
Abstract: The invention is directed to methods of using Chlorella protothecoides microalgal biomass in the treatment of individuals having impaired glucose metabolism. In some cases, the patient has impaired fasting glucose, impaired glucose tolerance, or diabetes. In some methods, algal biomass is used to reduce blood glucose and/or body fat in a subject, or to increase the relative abundance of beneficial gut microflora in a subject. In preferred embodiments, the biomass is derived from Chlorella protothecoides cultures grown heterotrophically in which the algal cells comprise at least 15% algal oil by dry weight.
Abstract translation: 本发明涉及使用原小球藻微藻生物质处理葡萄糖代谢受损个体的方法。 在某些情况下，患者空腹血糖受损，糖耐量异常或糖尿病。 在一些方法中，藻类生物质用于降低受试者的血糖和/或体脂肪，或增加受试者中有益的肠道微生物群落的相对丰度。 在优选的实施方案中，生物质衍生自异养生长的球藻藻细胞培养物，其中藻类细胞含有至少15％的干重的藻油。
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公开(公告)号：US20160010025A1
公开(公告)日：2016-01-14
申请号：US14801172
申请日：2015-07-16
Applicant: Solazyme, Inc.
Inventor： Harrison F. Dillon , Dan Elefant , Anthony G. Day , Scott Franklin , Jon Wittenberg
CPC classification number: C11B1/10 , C10L1/026 , C11B1/106 , C11C3/003 , C11C3/04 , C12P7/6463 , C12P7/649 , Y02E50/13 , Y02T50/678
Abstract: The invention generally relates to the production of hydrocarbon compositions, such as a lipid, in microorganisms. In particular, the invention provides methods for extracting, recovering, isolating and obtaining a lipid from a microorganism and compositions comprising the lipid. The invention also discloses methods for producing hydrocarbon compositions for use as biodiesel, renewable diesel, jet fuel, and other materials.
Abstract translation: 本发明一般涉及微生物中烃类组合物如脂质的生产。 特别地，本发明提供从微生物中提取，回收，分离和获得脂质以及包含脂质的组合物的方法。 本发明还公开了用于生产用作生物柴油，可再生柴油，喷气燃料和其它材料的烃组合物的方法。
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公开(公告)号：US20140093945A1
公开(公告)日：2014-04-03
申请号：US14055763
申请日：2013-10-16
Applicant: Solazyme, Inc.
Inventor： Harrison F. Dillon , Dan Elefant , Anthony G. Day , Scott Franklin , Jon Wittenberg
IPC: C11B1/10
CPC classification number: C11B1/10 , C10L1/026 , C11B1/106 , C11C3/003 , C11C3/04 , C12P7/6463 , C12P7/649 , Y02E50/13 , Y02T50/678
Abstract: The invention generally relates to the production of hydrocarbon compositions, such as a lipid, in microorganisms. In particular, the invention provides methods for extracting, recovering, isolating and obtaining a lipid from a microorganism and compositions comprising the lipid. The invention also discloses methods for producing hydrocarbon compositions for use as biodiesel, renewable diesel, jet fuel, and other materials.
Abstract translation: 本发明一般涉及微生物中烃类组合物如脂质的生产。 特别地，本发明提供从微生物中提取，回收，分离和获得脂质以及包含脂质的组合物的方法。 本发明还公开了用于生产用作生物柴油，可再生柴油，喷气燃料和其它材料的烃组合物的方法。
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Patent Agency Ranking
公开(公告)号：US20130330790A1
公开(公告)日：2013-12-12
申请号：US13849330
申请日：2013-03-22
Applicant: SOLAZYME, INC.
Inventor： Donald E. Trimbur , Chung-Soon Im , Harrison F. Dillon , Anthony G. Day , Scott Franklin , Anna Coragliotti
CPC classification number: C10L1/026 , C07H21/04 , C10L1/06 , C10L2200/0484 , C10L2270/026 , C10L2270/04 , C11C3/00 , C12N1/12 , C12N1/32 , C12N9/0006 , C12N9/0008 , C12N9/1205 , C12N9/14 , C12N9/16 , C12N9/20 , C12N9/2408 , C12N9/2431 , C12N9/88 , C12N15/79 , C12P5/02 , C12P7/6409 , C12P7/6436 , C12P7/6445 , C12P7/6463 , C12P7/649 , C12P21/06 , C12Y302/01026 , Y02E50/10 , Y02E50/13 , Y02E50/343 , Y02P20/52 , Y02T50/678
Abstract: The invention provides methods of cultivating oil-bearing microbes using xylose alone or in combination with other depolymerized cellulosic material. Also provided are microorganisms comprising an exogenous gene encoding a polysaccharide degrading enzyme, such as a cellulase, a hemicellulase, a pectinase, or a driselase. Some methods of microbial fermentation are provided that comprise the use of xylose and depolymerized cellulosic materials for the production of oil-bearing microorgansims.
Abstract translation: 本发明提供了使用单独的木糖或与其它解聚的纤维素材料组合培养含油微生物的方法。 还提供了包含编码多糖降解酶的外源基因如纤维素酶，半纤维素酶，果胶酶或者碎裂酶的微生物。 提供了微生物发酵的一些方法，其包括使用木糖和解聚的纤维素材料来生产含油微生物。
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公开(公告)号：US09434909B2
公开(公告)日：2016-09-06
申请号：US14184288
申请日：2014-02-19
Applicant: Solazyme, Inc.
Inventor： Donald E. Trimbur , Chung-Soon Im , Harrison F. Dillon , Anthony G. Day , Scott Franklin , Anna Coragliotti
IPC: A61K48/00 , C07H21/04 , C12N1/12 , C12N9/14 , C12P7/20 , C11C3/00 , C10L1/02 , C12N1/32 , C12N9/04 , C12N9/02 , C12N9/12 , C12N9/16 , C12N9/20 , C12N9/26 , C12N9/88 , C12P5/02 , C10L1/06 , C12P7/64
CPC classification number: C10L1/026 , C07H21/04 , C10L1/06 , C10L2200/0484 , C10L2270/026 , C10L2270/04 , C11C3/00 , C12N1/12 , C12N1/32 , C12N9/0006 , C12N9/0008 , C12N9/1205 , C12N9/14 , C12N9/16 , C12N9/20 , C12N9/2408 , C12N9/2431 , C12N9/88 , C12N15/79 , C12P5/02 , C12P7/6409 , C12P7/6436 , C12P7/6445 , C12P7/6463 , C12P7/649 , C12P21/06 , C12Y302/01026 , Y02E50/10 , Y02E50/13 , Y02E50/343 , Y02P20/52 , Y02T50/678
Abstract: The invention provides methods of manufacturing alkanes from triglyceride oils produced through fermentation of oil-bearing microbes. The processes provided herein can utilize a variety of carbohydrate feedstocks including cane bagasse, sugar beet pulp, corn stover, glycerol, corn starch, sorghum, molasses, waste glycerol, and other renewable materials. These processes further comprise hydrotreating, hydrocracking, isomerization, distillation, and other petrochemical processes for use with oil-bearing microbes and products derived therefrom to manufacture fuels. Particular embodiments include the manufacture of ASTM D975 and ASTM D1655 compliant fuels. Genetically engineered microbes provided herein can be used in the manufacture of renewable diesel and renewable jet fuel.
Abstract translation: 本发明提供了通过含油微生物发酵产生的甘油三酯油制备烷烃的方法。 本文提供的方法可以利用多种碳水化合物原料，包括甘蔗渣，甜菜浆，玉米秸秆，甘油，玉米淀粉，高粱，糖蜜，废甘油和其他可再生材料。 这些方法还包括与含油微生物一起使用的加氢处理，加氢裂化，异构化，蒸馏和其它石油化学方法以及由其衍生的产物来制造燃料。 具体实施方案包括制造ASTM D975和符合ASTM D1655的燃料。 本文提供的基因工程微生物可用于制造可再生柴油和可再生喷气燃料。
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8.发明申请Microalgae-Derived Compositions for Improving the Health and Appearance of Skin 有权微藻衍生的组合物，用于改善皮肤的健康和外观公开(公告)号：US20150140051A1
公开(公告)日：2015-05-21
申请号：US14563486
申请日：2014-12-08
Applicant: Solazyme, Inc.
Inventor： Harrison F. Dillon , Anwar Zaman , Anthony G. Day , Anna Coragliotti
CPC classification number: A61K8/042 , A23K10/30 , A23L7/115 , A23L33/105 , A23L33/11 , A23L33/135 , A23L33/15 , A61K8/678 , A61K8/73 , A61K8/735 , A61K8/9706 , A61K31/715 , A61K36/04 , A61K2800/412 , A61Q19/00 , A61Q19/08 , Y10T428/2982
Abstract: Provided herein are microalgal skin care compositions and methods of improving the health and appearance of skin. Also provided are methods of using polysaccharides for applications such as topical personal care products, cosmetics, and wrinkle reduction compositions. The invention also provides novel decolorized microalgal compositions useful for improving the health and appearance of skin. The invention also includes insoluble polysaccharide particles for application to human skin.
Abstract translation: 本文提供的是微藻皮肤护理组合物和改善皮肤健康和外观的方法。 还提供了使用多糖用于例如局部个人护理产品，化妆品和皱纹减少组合物的方法。 本发明还提供了用于改善皮肤健康和外观的新型脱色微藻组合物。 本发明还包括用于人皮肤的不溶性多糖颗粒。
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9.发明申请Methods of Treating Impaired Glucose Metabolism via Administration of Algal Biomass 有权通过施用藻类生物量治疗葡萄糖代谢障碍的方法公开(公告)号：US20140328906A1
公开(公告)日：2014-11-06
申请号：US14266715
申请日：2014-04-30
Applicant: Solazyme, Inc. , University of Manitoba
Inventor： David Brinkmann , Anthony G. Day , Peter J.H. Jones , Scott Harding
IPC: A61K36/02 , A23L1/30 , A61K31/202
CPC classification number: A61K36/02 , A23L33/105 , A23V2002/00 , A61K31/202 , A61K36/05
Abstract: The invention is directed to methods of using Chlorella protothecoides microalgal biomass in the treatment of individuals having impaired glucose metabolism. In some cases, the patient has impaired fasting glucose, impaired glucose tolerance, or diabetes. In some methods, algal biomass is used to reduce blood glucose and/or body fat in a subject, or to increase the relative abundance of beneficial gut microflora in a subject. In preferred embodiments, the biomass is derived from Chlorella protothecoides cultures grown heterotrophically in which the algal cells comprise at least 15% algal oil by dry weight.
Abstract translation: 本发明涉及使用小球藻原生藻微生物量处理葡萄糖代谢受损个体的方法。 在某些情况下，患者空腹血糖受损，糖耐量异常或糖尿病。 在一些方法中，藻类生物质用于降低受试者的血糖和/或体脂肪，或增加受试者中有益的肠道微生物群落的相对丰度。 在优选的实施方案中，生物质衍生自异养生长的小球藻原生培养物，其中藻类细胞含有至少15％的干重的藻类油。
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公开(公告)号：US08822176B2
公开(公告)日：2014-09-02
申请号：US13889214
申请日：2013-05-07
Applicant: Solazyme, Inc.
Inventor： Anthony G. Day , Geoffrey Brooks , Scott Franklin
IPC: C12P1/00
CPC classification number: C11B3/02 , A23D7/00 , A23D9/00 , C11D9/26 , C12P7/6418 , C12P7/6463 , C12P7/649 , Y02E50/13
Abstract: Provided are methods for preparing chemically modified lipids. The lipids are obtained from heterotrophically cultured microalgae and are subjected to a transesterification or interesterification reaction. The microalgae include those from the genus Parachlorella, Prototheca, Chlorella, or strains having at least 85% nucleotide sequence identity in 23S rRNA sequences to a Parachlorella, Prototheca, or Chlorella strain that are cultured in a bioreactor substantially in the absence of light.
Abstract translation: 提供制备化学修饰的脂质的方法。 脂质从异养培养的微藻获得并进行酯交换或酯交换反应。 微藻包括来自Parachlorella属，Prototheca属，小球藻属或在23S rRNA序列中与在不存在光的生物反应器中培养的Parachlorella，Prototheca或Chlorella菌株具有至少85％核苷酸序列同一性的微藻。
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