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公开(公告)号：US07868144B2
公开(公告)日：2011-01-11
申请号：US10492230
申请日：2002-10-08
申请人： Sabine Diller , Renate Grassl , Stefan Miller , Ingrid Robl , Michael Schütz , Thomas Zander
发明人： Sabine Diller , Renate Grassl , Stefan Miller , Ingrid Robl , Michael Schütz , Thomas Zander
IPC分类号： A23J1/00 , G01N33/00 , G01N33/53 , G01N33/567
CPC分类号： C12N15/1013 , C12N1/02
摘要： The present invention relates to a method for unspecific enrichment of bacterial cells by means of cationic or anionic polymers and magnetic carriers.
摘要翻译： 本发明涉及通过阳离子或阴离子聚合物和磁性载体非特异性富集细菌细胞的方法。
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公开(公告)号：US20050019827A1
公开(公告)日：2005-01-27
申请号：US10492230
申请日：2002-10-08
申请人： Sabine Diller , Renate Grassl , Stefan Miller , Ingrid Robl , Michael Schultz , Thomas Zander
发明人： Sabine Diller , Renate Grassl , Stefan Miller , Ingrid Robl , Michael Schultz , Thomas Zander
CPC分类号： C12N15/1013 , C12N1/02
摘要： The present invention relates to a method for unspecific enrichment of bacterial cells by means of cationic or anionic polymers and magnetic carriers.
摘要翻译： 本发明涉及通过阳离子或阴离子聚合物和磁性载体非特异性富集细菌细胞的方法。
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公开(公告)号：US20100047895A1
公开(公告)日：2010-02-25
申请号：US12510553
申请日：2009-07-28
申请人： Michael Schütz , Renate Grassl , Roman Meyer , Sibylle Frick , Ingrid Robl , Thomas Zander , Stefan Miller
发明人： Michael Schütz , Renate Grassl , Roman Meyer , Sibylle Frick , Ingrid Robl , Thomas Zander , Stefan Miller
CPC分类号： C07K14/005 , C12N15/1013 , C12N2795/10222 , Y10S436/802 , Y10T436/10
摘要： The present invention relates to a method for the selective purification of bacterial cells and/or cell components, whereby the purification is performed by means of a solid support.
摘要翻译： 本发明涉及一种选择性纯化细菌细胞和/或细胞成分的方法，由此通过固体支持物进行纯化。
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公开(公告)号：US07579142B2
公开(公告)日：2009-08-25
申请号：US10482235
申请日：2002-06-24
申请人： Michael Schütz , Renate Grassl , Roman Meyer , Sibylle Frick , Ingrid Robl , Thomas Zander , Stefan Miller
发明人： Michael Schütz , Renate Grassl , Roman Meyer , Sibylle Frick , Ingrid Robl , Thomas Zander , Stefan Miller
IPC分类号： C12Q1/70 , C12Q1/00 , G01N33/53 , G01N33/554 , G01N33/563 , G01N33/543
CPC分类号： C07K14/005 , C12N15/1013 , C12N2795/10222 , Y10S436/802 , Y10T436/10
摘要： The present invention relates to a method for the selective purification of bacterial cells and/or cell components, whereby the purification is performed by means of a solid support.
摘要翻译： 本发明涉及一种选择性纯化细菌细胞和/或细胞成分的方法，由此通过固体支持物进行纯化。
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公开(公告)号：US08932580B2
公开(公告)日：2015-01-13
申请号：US12510553
申请日：2009-07-28
申请人： Michael Schutz , Renate Grassl , Roman Meyer , Sibylle Frick , Ingrid Robl , Thomas Zander , Stefan Miller
发明人： Michael Schutz , Renate Grassl , Roman Meyer , Sibylle Frick , Ingrid Robl , Thomas Zander , Stefan Miller
CPC分类号： C07K14/005 , C12N15/1013 , C12N2795/10222 , Y10S436/802 , Y10T436/10
摘要： The present invention relates to a method for the selective purification of bacterial cells and/or cell components, whereby the purification is performed by means of a solid support.
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公开(公告)号：US20110053188A1
公开(公告)日：2011-03-03
申请号：US10583415
申请日：2004-12-20
申请人： Roman Meyer , Michael Schütz , Holger Grallert , Renate Grassl , Stefan Miller
发明人： Roman Meyer , Michael Schütz , Holger Grallert , Renate Grassl , Stefan Miller
CPC分类号： G01N33/92 , G01N33/56911 , G01N2400/50 , Y10T436/10
摘要： The invention relates to a method for detecting endotoxins in a sample.
摘要翻译： 本发明涉及检测样品中内毒素的方法。
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公开(公告)号：US08394597B2
公开(公告)日：2013-03-12
申请号：US10583415
申请日：2004-12-20
申请人： Roman Meyer , Michael Schütz , Holger Grallert , Renate Grassl , Stefan Miller
发明人： Roman Meyer , Michael Schütz , Holger Grallert , Renate Grassl , Stefan Miller
CPC分类号： G01N33/92 , G01N33/56911 , G01N2400/50 , Y10T436/10
摘要： The invention relates to a method for detecting endotoxins in a sample.
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公开(公告)号：US08609348B2
公开(公告)日：2013-12-17
申请号：US13002465
申请日：2009-07-03
申请人： Manfred Biebl , Renate Grassl , Monika Walter , Stefan Miller
发明人： Manfred Biebl , Renate Grassl , Monika Walter , Stefan Miller
CPC分类号： C07K14/005 , C07K2319/21 , C07K2319/22 , C07K2319/40 , C12N2700/00 , C12N2795/10322 , G01N33/56911 , G01N2333/005
摘要： Bacteriophage adhesion proteins binding to the O-antigen of gram negative bacteria, but lacking the ability of binding to a bacteriophage and of hydrolysing lipopolysaccharides, are described, as well as nucleic acid molecules encoding the proteins. In addition, methods for generating the bacteriophage adhesion proteins and their use in detection, purification and enrichment of bacteria are described.
摘要翻译： 描述了与革兰氏阴性细菌的O-抗原结合但是缺乏结合噬菌体和水解脂多糖的能力的噬菌体粘附蛋白以及编码蛋白质的核酸分子。 此外，描述了用于产生噬菌体粘附蛋白的方法及其在细菌的检测，纯化和富集中的用途。
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公开(公告)号：US08329393B2
公开(公告)日：2012-12-11
申请号：US13181199
申请日：2011-07-12
申请人： Stefan Miller , Roman Meyer , Renate Grassl , Manfred Biebl , Holger Grallert
发明人： Stefan Miller , Roman Meyer , Renate Grassl , Manfred Biebl , Holger Grallert
IPC分类号： C12Q1/70 , G01N33/53 , C07K14/005 , C07K17/00
CPC分类号： G01N33/566 , B01D15/08 , C07K1/13 , C07K1/22 , C07K14/005 , C12N7/00 , C12N2795/00022 , C12N2795/00031 , G01N30/00 , G01N33/56911 , G01N33/92 , G01N2333/005 , G01N2400/50
摘要： The present invention relates to bacteriophage tail proteins and the derivatives and fragments thereof that are capable of binding endotoxins in the absence of bivalent positive ions, especially Ca2+ or Mg2+. Further, the present invention relates to methods for depleting endotoxins from solutions and samples using the bacteriophage tail proteins according to the present invention and to a detection method for endotoxins.
摘要翻译： 本发明涉及在没有二价阳离子，特别是Ca 2+或Mg 2+的情况下能够结合内毒素的噬菌体尾蛋白及其衍生物和片段。 此外，本发明涉及使用根据本发明的噬菌体尾蛋白从溶液和样品中消耗内毒素的方法以及内毒素的检测方法。
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公开(公告)号：US20090017445A1
公开(公告)日：2009-01-15
申请号：US11814358
申请日：2006-01-23
申请人： Stefan Miller , Roman Meyer , Renate Grassl , Manfred Biebl , Holger Graller
发明人： Stefan Miller , Roman Meyer , Renate Grassl , Manfred Biebl , Holger Graller
CPC分类号： G01N33/566 , B01D15/08 , C07K1/13 , C07K1/22 , C07K14/005 , C12N7/00 , C12N2795/00022 , C12N2795/00031 , G01N30/00 , G01N33/56911 , G01N33/92 , G01N2333/005 , G01N2400/50
摘要： The present invention relates to bacteriophage tail proteins and the derivatives and fragments thereof that are capable of binding endotoxins in the absence of bivalent positive ions, especially Ca2+ or Mg2+. Further, the present invention relates to methods for depleting endotoxins from solutions and samples using the bacteriophage tail proteins according to the present invention and to a detection method for endotoxins.
摘要翻译： 本发明涉及在没有二价阳离子，特别是Ca 2+或Mg 2+的情况下能够结合内毒素的噬菌体尾蛋白及其衍生物和片段。 此外，本发明涉及使用根据本发明的噬菌体尾蛋白从溶液和样品中消耗内毒素的方法以及内毒素的检测方法。
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