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    RNA virus vaccines and methods
    6.
    发明申请
    RNA virus vaccines and methods 有权
    RNA病毒疫苗和方法

    公开(公告)号：US20070292453A1

    公开(公告)日：2007-12-20

    申请号：US11639023

    申请日：2006-12-14

    申请人： Robert Floyd ,  Dirk Dittmer

    发明人： Robert Floyd ,  Dirk Dittmer

    IPC分类号： A61K39/00 ,  A61P43/00

    CPC分类号： A61K39/12 ,  A61K2039/5252 ,  C12N7/00 ,  C12N2770/24134 ,  C12N2770/24163 ,  Y02A50/394

    摘要： The invention is a vaccine, and method of vaccination, against RNA viruses, including RNA viruses in the family Flaviviridae, which includes for example West Nile Virus, Yellow fever virus, Dengue fever virus, Hepatitis C virus, Pestiviruses, Bovine viral diarrhea virus, and Classical Swine fever virus, wherein the vaccine comprises the RNA virus or immunogenic portions thereof, which have been treated with and rendered non-pathogenic by a phenothiazine dye and visible light, the phenothiazine dyes, including, but not limited to, Methylene Blue (MB), Methylene Green, 1-methyl MB, 1,9-dimethyl MB, Azure A, Azure B, Azure C, thionine, and toluidine blue, or by squalene. The invention includes novel strains of WNV for use in producing a vaccine, and novel primers and their use in recognizing and amplifying all of or portions of the WNV genome for diagnosing WNV infections, for quality control of the vaccine, or for identifying the presence of WNV in blood or blood products.

    摘要翻译： 本发明是一种针对RNA病毒的疫苗和疫苗接种方法，包括黄病毒科中的RNA病毒，其包括例如西尼罗河病毒，黄热病毒，登革热病毒，丙型肝炎病毒，瘟病毒，牛病毒性腹泻病毒， 和经典猪瘟病毒，其中疫苗包括已经用吩噻嗪染料和可见光处理并由其引起非致病性的RNA病毒或其免疫原性部分，吩噻嗪染料，包括但不限于亚甲蓝（ MB），亚甲基绿，1-甲基MB，1,9-二甲基MB，Azure A，Azure B，Azure C，硫堇和甲苯胺蓝，或角鲨烯。 本发明包括用于生产疫苗的新型WNV菌株，以及新型引物及其用于识别和扩增WNV基因组的全部或部分用于诊断WNV感染，用于质量控制疫苗或用于鉴定 血液或血液制品中的WNV。

    Spin trapping pharmaceutical compositions and methods for use thereof
    7.
    发明申请
    Spin trapping pharmaceutical compositions and methods for use thereof 审中-公开
    旋转捕获药物组合物及其使用方法

    公开(公告)号：US20050107366A1

    公开(公告)日：2005-05-19

    申请号：US10937804

    申请日：2004-09-10

    申请人： John Carney ,  Robert Floyd

    发明人： John Carney ,  Robert Floyd

    IPC分类号： A61K31/13 ,  A61K31/135 ,  A61K31/15 ,  A61K31/165 ,  A61K31/167 ,  A61K31/195 ,  A61K31/40 ,  A61K31/4172 ,  A61K31/44 ,  A61K31/445 ,  A61K31/5415 ,  C07C291/02

    CPC分类号： C07C291/02 ,  A61K31/13 ,  A61K31/135 ,  A61K31/15 ,  A61K31/165 ,  A61K31/167 ,  A61K31/195 ,  A61K31/40 ,  A61K31/4172 ,  A61K31/44 ,  A61K31/445 ,  A61K31/5415

    摘要： Spin trapping compositions in general have now been discovered to be effective in treating a variety of disorders, including disorders such as those arising from ischemia, infection, inflammation, exposure to radiation or cytotoxic compounds, not just of the central and peripheral nervous systems but of peripheral organ disease having a wide variety of etiologies. In the preferred embodiment, the compositions for treating tissue damage from ischemia contain PBN, or active derivatives thereof, in a suitable pharmaceutical carrier for intravenous oral, topical, or nasal/pulmonary administration. Other preferred spin-trapping agents include 5,5-dimethyl pyrrolidine N-oxide (DMPO), α-(4-pyridyl-1-oxide)-N-tert-butylnitrone (POBN), and (TEMPO) and spin-trapping derivatives, conjugates with drugs or targeting molecules, dimmers and cyclodextran polymers of PBN. Many different disorders can be treated using these compounds, including diseases or disorders of the central and peripheral nervous systems, and disorders arising from ischemia, infection, inflammation, oxidation from exposure to radiation or cytotoxic compounds, as well as due to naturally occurring processes such as aging.

    摘要翻译： 现在已经发现旋转捕获组合物现在已被发现有效地治疗各种疾病，包括诸如由局部缺血，感染，炎症，暴露于辐射或细胞毒性化合物引起的疾病，不仅仅是中枢和周围神经系统，而是 外周器官疾病具有多种病因。 在优选的实施方案中，用于治疗来自局部缺血的组织损伤的组合物在用于静脉内口服，局部或鼻/肺部施用的合适的药物载体中含有PBN或其活性衍生物。 其他优选的自旋捕获剂包括5,5-二甲基吡咯烷N-氧化物（DMPO），α-（4-吡啶基-1-氧化物）-N-叔丁基硝酮（POBN）和（TEMPO）和自旋捕获衍生物 与PBN的药物或靶向分子，二聚体和环糊精聚合物缀合。 可以使用这些化合物治疗许多不同的病症，包括中枢和周围神经系统的疾病或病症，以及由缺血，感染，炎症，暴露于辐射或细胞毒性化合物的氧化引起的疾病，以及由于天然存在的过程 作为老化。

    Oil absorbent wipe with high crumpability
    9.
    发明申请
    Oil absorbent wipe with high crumpability 审中-公开
    吸油性擦拭具有很高的可膨胀性

    公开(公告)号：US20060147503A1

    公开(公告)日：2006-07-06

    申请号：US11026853

    申请日：2004-12-30

    申请人： Robert Floyd

    发明人： Robert Floyd

    IPC分类号： A61K9/70

    CPC分类号： A61K8/0208 ,  A61K8/8111 ,  A61K8/92 ,  A61Q19/10

    摘要： There is provided an oil absorbing wipe material suitable for wiping a users' skin or hair and a method for their manufacture. The wipes comprise at least an oil absorbing porous coextruded film of a crystalline thermoplastic material with a solid diluant containing crumpable layer and a generally nontacky layer. Generally, the wipe changes transparency or color when loaded with oil to provide an oil absorption indication functionality. The wipe is capable of forming a compact ball by crumpling a 10 cm by 10 cm sample to a diameter of 3.0 cm or less.

    摘要翻译： 提供了适于擦拭使用者的皮肤或头发的吸油擦拭材料及其制造方法。 擦拭物至少包含结晶热塑性材料的吸油多孔共挤出膜，其中含有可膨胀层的固体稀释剂和一般非粘性层。 通常，当装载油时，擦拭物改变透明度或颜色以提供吸油指示功能。 擦拭物能够通过将10cm×10cm的样品弄皱到3.0cm以下的直径来形成紧凑的球。