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15 条记录 (耗时 0.024 秒)

    Hollow sphere from amphiphilic chitosan derivatives and method of preparing amiphiphilic chitosan derivative complex for medical use
    4.
    发明授权
    Hollow sphere from amphiphilic chitosan derivatives and method of preparing amiphiphilic chitosan derivative complex for medical use 有权
    来自两亲壳聚糖衍生物的空心球和制备用于医疗用途的亲水性壳聚糖衍生物复合物的方法

    公开(公告)号：US08263130B2

    公开(公告)日：2012-09-11

    申请号：US12379880

    申请日：2009-03-04

    申请人： San-Yuan Chen ,  Kun-Ho Liu ,  Dean-Mo Liu

    发明人： San-Yuan Chen ,  Kun-Ho Liu ,  Dean-Mo Liu

    IPC分类号： A61K9/14

    CPC分类号： A61K9/5036 ,  A61K9/5161

    摘要： A hollow sphere from amphiphilic chitosan derivatives and a method of preparing an amphiphilic chitosan derivative complex for medical use are disclosed, and the hollow sphere from amphiphilic chitosan derivatives comprises: chitosan derivatives represented by the following formula (I), which self-assemble and form a hollow sphere in a solvent; wherein, each R1 is independently hydrogen, C1˜C4 alkyl, C1˜C6 carboxyl, sulfate group, or phosphate group, each R2 is independently hydrogen, C1˜C12 alkyl, C1˜C6 carboxyl, or C2˜C12 acyl group, and m is an integer of 100-2000.

    摘要翻译： 公开了两亲壳聚糖衍生物的空心球体和制备用于医疗用途的两亲性壳聚糖衍生物复合物的方法，并且来自两亲壳聚糖衍生物的中空球体包括：由下式（I）表示的壳聚糖衍生物，其自组装形成 在溶剂中的空心球体; 其中每个R 1独立地是氢，C 1 -C 4烷基，C 1 -C 6羧基，硫酸基或磷酸基，每个R 2独立地是氢，C 1 -C 12烷基，C 1 -C 6羧基或C 2 -C 12酰基，m 是100-2000的整数。

    Method of forming a drug nanocarrier having a magnetic shell
    8.
    发明申请
    Method of forming a drug nanocarrier having a magnetic shell 审中-公开
    形成具有磁性壳的药物纳米载体的方法

    公开(公告)号：US20090285885A1

    公开(公告)日：2009-11-19

    申请号：US12230973

    申请日：2008-09-09

    申请人： San-Yuan Chen ,  Shang-Hsiu Hu ,  Dean-Mo Liu

    发明人： San-Yuan Chen ,  Shang-Hsiu Hu ,  Dean-Mo Liu

    IPC分类号： A61K9/51 ,  A61K47/32 ,  A61K47/02

    CPC分类号： A61K9/5094 ,  A61K9/0009 ,  A61K9/5115 ,  A61K9/5138 ,  A61K9/5192

    摘要： The invention discloses the synthesis and manufacturing of a novel core-shell nano-carrier with a drug-containing nanocomposite core surrounding with a single crystalline magnetic iron oxide shell. With a unique core-shell configuration, active agents such as drugs and biomolecules encapsulated in the core with an outer single-crystalline thin iron oxide shell can be perfectly protected from environmental damages and in the meantime, eliminating un-desirable release due to un-controllable diffusion of the active molecules from the nanocapsules during the course of delivery in patient's body, before reaching the disease sites.

    摘要翻译： 本发明公开了一种新型核 - 壳纳米载体的合成与制备，其中含有含有单晶磁性氧化铁壳的药物纳米复合核。 通过独特的核 - 壳配置，可以完全保护包封在芯中的外部单晶薄氧化铁壳的活性剂如药物和生物分子免受环境损害，同时消除由于不合适的脱壳引起的不期望的释放， 在到达疾病部位之前，在患者体内的递送过程中活性分子从纳米胶囊中可控扩散。

    Flexible Drug Delivery Chip, its Fabrication Method and Uses Thereof
    10.
    发明申请
    Flexible Drug Delivery Chip, its Fabrication Method and Uses Thereof 审中-公开
    柔性药物输送芯片，其制造方法及其用途

    公开(公告)号：US20110059148A1

    公开(公告)日：2011-03-10

    申请号：US12554935

    申请日：2009-09-07

    申请人： San-Yuan Chen ,  Wei-Chen Huang ,  Dean-Mo Liu

    发明人： San-Yuan Chen ,  Wei-Chen Huang ,  Dean-Mo Liu

    IPC分类号： A61F2/00 ,  A61K31/4015 ,  A61P25/08 ,  C25D13/00

    CPC分类号： C25D13/14 ,  A61K9/0009 ,  A61K9/0024 ,  A61K31/4015 ,  A61M37/00 ,  C25D13/04

    摘要： Nanodevice and method for in vivo monitoring and release of drugs are provided. The disclosed nanodevice is characterized in having a drug-loaded nanosphere that is capable of releasing the encapsulated drugs upon magnetically stimulation. The nanodevice may also be used as a contrast agent for in vivo imaging and monitoring the concentration and distribution of the released drugs and/or active compounds injected separately into a target site of a subject.

    摘要翻译： 提供了用于体内监测和释放药物的纳米设备和方法。 所公开的纳米装置的特征在于具有药物负载纳米球，其能够在磁刺激时释放包封的药物。 纳米装置还可以用作造影剂，用于体内成像和监测单独注射到受试者的靶位点中的释放的药物和/或活性化合物的浓度和分布。