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公开(公告)号：US20150031708A1
公开(公告)日：2015-01-29
申请号：US12117941
申请日：2008-05-09
申请人： Sara Hadida-Ruah , Mark Miller , Brian Bear , Jinglan Zhou , Jason McCartney , Peter Grootenhuis
发明人： Sara Hadida-Ruah , Mark Miller , Brian Bear , Jinglan Zhou , Jason McCartney , Peter Grootenhuis
IPC分类号： C07D405/14 , A61K45/06 , G01N33/68 , A61K31/497 , G06F19/18 , A61K31/444 , C07D401/04
CPC分类号： C07D405/14 , A61K31/444 , C07D213/75 , C07D401/04 , G01N33/502 , G01N2333/705 , G01N2500/04 , G01N2500/10
摘要： Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating CFTR mediated diseases using compounds of the present invention.
摘要翻译： 本发明的化合物及其药学上可接受的组合物可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTR”）。 本发明还涉及使用本发明化合物治疗CFTR介导的疾病的方法。
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公开(公告)号：US20080019915A1
公开(公告)日：2008-01-24
申请号：US11804726
申请日：2007-05-18
申请人： Sara Hadida-Ruah , Matthew Hamilton , Mark Miller , Peter Grootenhuis , Brian Bear , Jason McCartney , Jinglan Zhou , Frederick van Goor
发明人： Sara Hadida-Ruah , Matthew Hamilton , Mark Miller , Peter Grootenhuis , Brian Bear , Jason McCartney , Jinglan Zhou , Frederick van Goor
IPC分类号： A61K49/00 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/4525 , A61K31/454 , A61P21/00 , A61P25/28 , A61P35/00 , C07D405/12 , C07D405/04 , C07D401/14 , C07D401/02 , C07D211/04 , A61P7/12 , A61P7/02 , A61P7/00 , A61P43/00 , C12Q1/18 , C07D413/14 , C07D413/02 , C07D405/14 , A61P3/10 , A61P25/16 , A61K31/4545 , A61K31/4709 , A61K31/497 , A61K31/506 , A61K31/5377
CPC分类号： C07D405/12 , A61K31/443 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D405/14
摘要： Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
摘要翻译： 本发明的化合物及其药学上可接受的组合物可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTR”）。 本发明还涉及使用本发明化合物治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号：US20070244159A1
公开(公告)日：2007-10-18
申请号：US11786001
申请日：2007-04-09
申请人： Sara Hadida Ruah , Peter Grootenhuis , Frederick Van Goor , Jinglan Zhou , Brian Bear , Mark Miller , Jason McCartney , Mehdi Numa
发明人： Sara Hadida Ruah , Peter Grootenhuis , Frederick Van Goor , Jinglan Zhou , Brian Bear , Mark Miller , Jason McCartney , Mehdi Numa
IPC分类号： A61K31/454 , A61K31/42 , A61K31/4178 , A61K31/405 , C07D413/02 , C07D403/02
CPC分类号： C07D405/12 , C07B59/002 , C07B2200/05 , C07D403/12 , C07D405/14 , C07D471/04 , C07D487/04 , G01N33/5008 , G01N33/6872 , G01N2333/705 , G01N2500/02 , G01N2500/10
摘要： Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
摘要翻译： 本发明的化合物及其药学上可接受的组合物可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTR”）。 本发明还涉及使用本发明化合物治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号：US08969386B2
公开(公告)日：2015-03-03
申请号：US12117941
申请日：2008-05-09
申请人： Sara Hadida-Ruah , Mark Miller , Brian Bear , Jinglan Zhou , Jason McCartney , Peter Grootenhuis
发明人： Sara Hadida-Ruah , Mark Miller , Brian Bear , Jinglan Zhou , Jason McCartney , Peter Grootenhuis
IPC分类号： A61K31/44 , C07D401/00 , C07D401/04 , A61K31/444
CPC分类号： C07D405/14 , A61K31/444 , C07D213/75 , C07D401/04 , G01N33/502 , G01N2333/705 , G01N2500/04 , G01N2500/10
摘要： Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating CFTR mediated diseases using compounds of the present invention.
摘要翻译： 本发明的化合物及其药学上可接受的组合物可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTR”）。 本发明还涉及使用本发明化合物治疗CFTR介导的疾病的方法。
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公开(公告)号：US20100087435A1
公开(公告)日：2010-04-08
申请号：US12630874
申请日：2009-12-04
申请人： Sara Hadida Ruah , Matthew Hamilton , Mark Miller , Peter D.J. Grootenhuis , Brian Bear , Jason McCartney , Jinglan Zhou , Fredrick van Goor
发明人： Sara Hadida Ruah , Matthew Hamilton , Mark Miller , Peter D.J. Grootenhuis , Brian Bear , Jason McCartney , Jinglan Zhou , Fredrick van Goor
IPC分类号： A61K31/4439 , A61K31/4418 , A61K31/496 , A61K31/443 , A61K31/5377 , A61K31/506 , A61K31/497 , A61P43/00 , A61P11/00
CPC分类号： C07D405/12 , A61K31/443 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D405/14
摘要： Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
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公开(公告)号：US07659268B2
公开(公告)日：2010-02-09
申请号：US11804726
申请日：2007-05-18
申请人： Sara Hadida-Ruah , Matthew Hamilton , Mark Miller , Peter D. J. Grootenhuis , Brian Bear , Jason McCartney , Jinglan Zhou , Frederick van Goor
发明人： Sara Hadida-Ruah , Matthew Hamilton , Mark Miller , Peter D. J. Grootenhuis , Brian Bear , Jason McCartney , Jinglan Zhou , Frederick van Goor
IPC分类号： A61K31/5377 , A61K31/497 , A61K31/506 , A61K31/4418 , A61K31/443 , C07D413/00 , C07D401/00 , C07D213/02 , C07D405/00
CPC分类号： C07D405/12 , A61K31/443 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D405/14
摘要： Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
摘要翻译： 本发明的化合物及其药学上可接受的组合物可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTR”）。 本发明还涉及使用本发明化合物治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号：US20120232059A1
公开(公告)日：2012-09-13
申请号：US13475388
申请日：2012-05-18
申请人： Sara Hadida-Ruah , Matthew Hamilton , Mark Miller , Peter D.J. Grootenhuis , Brian Bear , Jason McCartney , Jinglan Zhou , Frederick van Goor
发明人： Sara Hadida-Ruah , Matthew Hamilton , Mark Miller , Peter D.J. Grootenhuis , Brian Bear , Jason McCartney , Jinglan Zhou , Frederick van Goor
IPC分类号： A61K31/443 , A61K31/5377 , A61K31/444 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/497 , A61K31/4709 , A61K31/4439 , A61K31/47 , A61K31/538 , A61K31/55 , A61K31/5415 , A61P43/00 , A61K31/4545
CPC分类号： C07D405/12 , A61K31/443 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D405/14 , C07D413/14 , G01N33/5035 , G01N2333/705
摘要： Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
摘要翻译： 本发明的化合物及其药学上可接受的组合物可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTR”）。 本发明还涉及使用本发明化合物治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号：US20110172229A1
公开(公告)日：2011-07-14
申请号：US13069889
申请日：2011-03-23
申请人： Sara Hadida-Ruah , Matthew Hamilton , Mark Miller , Peter D.J. Grootenhuis , Brian Bear , Jason McCartney , Jinglan Zhou , Fredrick van Goor
发明人： Sara Hadida-Ruah , Matthew Hamilton , Mark Miller , Peter D.J. Grootenhuis , Brian Bear , Jason McCartney , Jinglan Zhou , Fredrick van Goor
IPC分类号： A61K31/5377 , A61K31/4418 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/4965 , A61P25/28 , A61P25/16 , A61P27/02 , A61P3/06 , A61P3/10
CPC分类号： C07D405/12 , A61K31/443 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D405/14
摘要： Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
摘要翻译： 本发明的化合物及其药学上可接受的组合物可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTR”）。 本发明还涉及使用本发明化合物治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号：US20080009524A1
公开(公告)日：2008-01-10
申请号：US11824606
申请日：2007-06-29
IPC分类号： A61K31/357 , A61K31/167 , A61K31/428 , A61P11/00 , A61P25/00 , A61P35/00 , C07C311/16 , C07D405/12 , C07D513/00 , C07D317/46 , C07C233/65 , A61P3/00 , A61P21/00 , A61K31/443 , A61K31/18
CPC分类号： C07D317/68
摘要： Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
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公开(公告)号：US08829204B2
公开(公告)日：2014-09-09
申请号：US11841646
申请日：2007-08-20
申请人： Sara Hadida-Ruah , Anna Hazlewood , Peter Grootenhuis , Fred Van Goor , Ashvani Singh , Jinglan Zhou , Jason McCartney
发明人： Sara Hadida-Ruah , Anna Hazlewood , Peter Grootenhuis , Fred Van Goor , Ashvani Singh , Jinglan Zhou , Jason McCartney
IPC分类号： C07D209/04 , C07D217/06 , C07D215/56 , C07D413/12 , C07D215/233 , C07D417/12 , C07D409/12 , C07D215/38 , C07D223/16 , C07D405/12 , C07D311/58 , C07D215/227 , C07D209/18 , C07D213/73 , C07D209/42 , C07D213/20 , C07D209/14 , C07D209/08 , C07D279/16 , C07D265/36 , C07D209/94 , C07D471/10 , C07D401/12 , C07C215/76 , C07D401/14
CPC分类号： C07D471/10 , A61K8/4926 , A61K31/04 , A61K31/136 , A61K31/265 , A61K31/27 , A61K31/277 , A61K31/352 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/44 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/4747 , A61K31/538 , A61K31/5415 , A61K31/55 , A61K45/06 , C07C205/11 , C07C205/58 , C07C209/00 , C07C211/17 , C07C211/50 , C07C211/52 , C07C215/28 , C07C215/70 , C07C215/76 , C07C215/78 , C07C217/76 , C07C217/80 , C07C217/84 , C07C219/34 , C07C229/52 , C07C255/58 , C07C271/20 , C07C311/08 , C07C311/39 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07C2603/74 , C07D209/04 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/18 , C07D209/20 , C07D209/42 , C07D209/94 , C07D209/96 , C07D213/20 , C07D213/73 , C07D215/227 , C07D215/233 , C07D215/38 , C07D215/56 , C07D217/04 , C07D217/06 , C07D223/16 , C07D265/36 , C07D279/16 , C07D311/58 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , G01N33/48728 , G01N33/5035 , G01N33/566 , G01N33/6872 , G01N2333/705
摘要： The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
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