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公开(公告)号：US08822451B2
公开(公告)日：2014-09-02
申请号：US11438636
申请日：2006-05-22
申请人： Sara S. Hadida Ruah , Anna R. Hazlewood , Peter D. J. Grootenhuis , Ashvani Kumar Singh , Thomas Cleveland , Frederick F. Van-Goor
发明人： Sara S. Hadida Ruah , Anna R. Hazlewood , Peter D. J. Grootenhuis , Ashvani Kumar Singh , Thomas Cleveland , Frederick F. Van-Goor
IPC分类号： C07D239/42 , C07D403/04 , A61K31/505
CPC分类号： C07D405/12 , C07D239/42 , C07D403/02 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/02 , C07D417/02 , C07D491/10
摘要： 4-amido-pyrimidine compounds, derivatives and compositions thereof, and synthetic methods described herein are useful for modulating ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
摘要翻译： 4-氨基 - 嘧啶化合物，其衍生物和组合物以及本文所述的合成方法可用于调节ATP结合盒（“ABC”）转运蛋白或其片段，包括囊性纤维化跨膜电导调节剂（“CFTR”）。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号：US08741939B2
公开(公告)日：2014-06-03
申请号：US13848970
申请日：2013-03-22
申请人： Sara S. Hadida Ruah , Mark T. Miller , Ashvani K. Singh , Thomas Cleveland , Lewis R. Makings , Matthew Hamilton , Peter D. J. Grootenhuis
发明人： Sara S. Hadida Ruah , Mark T. Miller , Ashvani K. Singh , Thomas Cleveland , Lewis R. Makings , Matthew Hamilton , Peter D. J. Grootenhuis
IPC分类号： A61K31/427 , C07D277/20
CPC分类号： A61K31/426 , A61K31/4439 , A61K31/454 , A61K31/5377 , C07D263/48 , C07D277/46 , C07D277/82 , C07D295/15 , C07D417/04 , C07D417/06 , C07D417/12 , G01N33/5076
摘要： The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
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公开(公告)号：US08431605B2
公开(公告)日：2013-04-30
申请号：US13174844
申请日：2011-07-01
申请人： Sara S. Hadida Ruah , Mark T. Miller , Ashvani K. Singh , Thomas Cleveland , Lewis R. Makings , Matthew Hamilton , Peter D. J. Grootenhuis
发明人： Sara S. Hadida Ruah , Mark T. Miller , Ashvani K. Singh , Thomas Cleveland , Lewis R. Makings , Matthew Hamilton , Peter D. J. Grootenhuis
IPC分类号： A61K31/427 , C07D277/20
CPC分类号： A61K31/426 , A61K31/4439 , A61K31/454 , A61K31/5377 , C07D263/48 , C07D277/46 , C07D277/82 , C07D295/15 , C07D417/04 , C07D417/06 , C07D417/12 , G01N33/5076
摘要： The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
摘要翻译： 本发明涉及ATP结合盒（“ABC”）转运体或其片段的调节剂，包括CF跨膜调节剂（“CFTR”），其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号：US07973169B2
公开(公告)日：2011-07-05
申请号：US10936448
申请日：2004-09-07
申请人： Sara S. Hadida Ruah , Mark T. Miller , Ashvani K. Singh , Thomas Cleveland , Lewis R. Makings , Matthew Hamilton , Peter D. J. Grootenhuis
发明人： Sara S. Hadida Ruah , Mark T. Miller , Ashvani K. Singh , Thomas Cleveland , Lewis R. Makings , Matthew Hamilton , Peter D. J. Grootenhuis
IPC分类号： C07D277/20 , A61K31/427
CPC分类号： A61K31/426 , A61K31/4439 , A61K31/454 , A61K31/5377 , C07D263/48 , C07D277/46 , C07D277/82 , C07D295/15 , C07D417/04 , C07D417/06 , C07D417/12 , G01N33/5076
摘要： The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
摘要翻译： 本发明涉及ATP结合盒（“ABC”）转运体或其片段的调节剂，包括CF跨膜调节剂（“CFTR”），其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号：US08188283B2
公开(公告)日：2012-05-29
申请号：US12722642
申请日：2010-03-12
申请人： Hayley Binch , Peter D. J. Grootenhuis , Sara S. Hadida Ruah , Jinglan Zhou , Anna Hazlewood , Lev T. D. Fanning
发明人： Hayley Binch , Peter D. J. Grootenhuis , Sara S. Hadida Ruah , Jinglan Zhou , Anna Hazlewood , Lev T. D. Fanning
IPC分类号： C07K1/00
CPC分类号： A61K31/4375 , C07D471/04
摘要： The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
摘要翻译： 本发明涉及ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂，其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号：US08039491B2
公开(公告)日：2011-10-18
申请号：US12683457
申请日：2010-01-07
IPC分类号： A61K31/085 , A61K31/167 , A61K31/343 , A61K31/425 , A61K31/4418
CPC分类号： C07D317/68
摘要： Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
摘要翻译： 本发明的化合物及其药学上可接受的组合物可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTR”）。 本发明还涉及使用本发明化合物治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号：US07776905B2
公开(公告)日：2010-08-17
申请号：US11786001
申请日：2007-04-09
申请人： Sara S. Hadida Ruah , Peter D. J. Grootenhuis , Frederick Van Goor , Jinglan Zhou , Brian Bear , Mark T. Miller , Jason McCartney , Mehdi Michel Jamel Numa , Xiaoqing Yang
发明人： Sara S. Hadida Ruah , Peter D. J. Grootenhuis , Frederick Van Goor , Jinglan Zhou , Brian Bear , Mark T. Miller , Jason McCartney , Mehdi Michel Jamel Numa , Xiaoqing Yang
IPC分类号： A61K31/404 , C07D209/40
CPC分类号： C07D405/12 , C07B59/002 , C07B2200/05 , C07D403/12 , C07D405/14 , C07D471/04 , C07D487/04 , G01N33/5008 , G01N33/6872 , G01N2333/705 , G01N2500/02 , G01N2500/10
摘要： Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
摘要翻译： 本发明的化合物及其药学上可接受的组合物可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTR”）。 本发明还涉及使用本发明化合物治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号：US08993600B2
公开(公告)日：2015-03-31
申请号：US12114935
申请日：2008-05-05
申请人： Sara S. Hadida Ruah , Matthew Hamilton , Mark Miller , Peter D. J. Grootenhuis , Brian Bear , Jason McCartney , Jinglan Zhou
发明人： Sara S. Hadida Ruah , Matthew Hamilton , Mark Miller , Peter D. J. Grootenhuis , Brian Bear , Jason McCartney , Jinglan Zhou
IPC分类号： A61K31/443 , C07D405/12 , A61K45/06 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , C07D405/14
CPC分类号： C07D405/12 , A61K31/443 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D405/14
摘要： Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
摘要翻译： 本发明的化合物及其药学上可接受的组合物可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTR”）。 本发明还涉及使用本发明化合物治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号：US08415387B2
公开(公告)日：2013-04-09
申请号：US12619412
申请日：2009-11-16
申请人： Sara S. Hadida Ruah , Peter D. J. Grootenhuis , Mark T Miller , Jason McCartney , Fredrick van Goor , Mehdi Michel Djamel Numa , Jinglan Zhou , Brian Bear
发明人： Sara S. Hadida Ruah , Peter D. J. Grootenhuis , Mark T Miller , Jason McCartney , Fredrick van Goor , Mehdi Michel Djamel Numa , Jinglan Zhou , Brian Bear
IPC分类号： A61K31/36 , C07D405/12
CPC分类号： A61K31/47 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/407 , A61K31/41 , A61K31/4184 , A61K31/4192 , A61K31/454 , A61K31/5377 , A61K45/06 , C07D209/08 , C07D233/64 , C07D403/12 , C07D405/12 , C07D405/14 , C07D471/04 , C07D487/04 , G01N33/5035 , G01N2333/705 , G01N2500/10
摘要： Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
摘要翻译： 本发明化合物及其药学上可接受的组合物可用作ATP结合盒（ABC）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（CFTR）。 本发明还涉及使用本发明化合物治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号：US07973038B2
公开(公告)日：2011-07-05
申请号：US12768894
申请日：2010-04-28
申请人： Sara S. Hadida Ruah , Matthew Hamilton , Mark T. Miller , Peter D. J. Grootenhuis , Brian Richard Bear , Jason McCartney , Jinglan Zhou
发明人： Sara S. Hadida Ruah , Matthew Hamilton , Mark T. Miller , Peter D. J. Grootenhuis , Brian Richard Bear , Jason McCartney , Jinglan Zhou
IPC分类号： A61K31/5377 , A61K31/497 , A61K31/506 , A61K31/4418 , A61K31/443
CPC分类号： C07D405/12 , A61K31/443 , A61K31/444 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D405/14
摘要： Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
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