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    Strain belonging to the genus streptomyces and being capable of producing nemadictin and process for producing nemadictin using the strain
    1.
    发明申请
    Strain belonging to the genus streptomyces and being capable of producing nemadictin and process for producing nemadictin using the strain 失效
    属于链霉菌属的菌株并且能够产生神经胶质瘤和使用该菌株产生奈马丁的方法

    公开(公告)号：US20060234353A1

    公开(公告)日：2006-10-19

    申请号：US10535263

    申请日：2003-06-11

    申请人： Satoshi Omura ,  Haruo Ikeda ,  Yumiko Ogasawara

    发明人： Satoshi Omura ,  Haruo Ikeda ,  Yumiko Ogasawara

    IPC分类号： C12P19/62 ,  C12N1/21

    CPC分类号： C12N1/20 ,  C12N15/52 ,  C12P17/181

    摘要： In the present invention, a recombination of gene groups of nemadectin aglycon biosynthesis is performed for obtaining C-13 hydroxylnemadectin, to which sugar groups can be attached, and a production strain which produces C-13 hydroxylnemadectin is produced. Further, C-13 glycosylnemadectin producing strain is prepared by introducing aveBI-BVIII genes involving glycosidation of avermectin and biosynthesis of oleandrose. As described, C-13 hydroxylnemadectin and C-13 glycosidated nemadectin can be obtained effectively by using the producing strain prepared by means of the molecular genetic technology, and improvement in the biological activity thereof can be expected.

    摘要翻译： 在本发明中，进行奈马替丁糖苷配基生物合成的基因组的重组，得到可以附着糖基的C-13羟基去神道菌素，生成产生C-13羟基神马丁的生产菌株。 此外，通过引入涉及除虫菌素糖基化和含有甘油糖的生物合成的aveBI-BVIII基因来制备C-13糖基胚乳肽生成菌株。 如上所述，可以通过使用通过分子遗传技术制备的生产菌株有效地获得C-13羟基去神道肽和C-13糖苷化的奈马克丁，并且可以预期其生物活性的改善。

    Strain belonging to the genus Streptomyces and being capable of producing nemadictin and process for producing nemadictin using the strain
    2.
    发明授权
    Strain belonging to the genus Streptomyces and being capable of producing nemadictin and process for producing nemadictin using the strain 失效
    属于链霉菌属的菌株，并且能够使用该菌株产生新霉素和制备nemadictin的方法

    公开(公告)号：US07670827B2

    公开(公告)日：2010-03-02

    申请号：US10535263

    申请日：2003-06-11

    申请人： Satoshi Omura ,  Haruo Ikeda ,  Yumiko Ogasawara

    发明人： Satoshi Omura ,  Haruo Ikeda ,  Yumiko Ogasawara

    IPC分类号： C12N1/21

    CPC分类号： C12N1/20 ,  C12N15/52 ,  C12P17/181

    摘要： In the present invention, a recombination of gene groups of nemadectin aglycon biosynthesis is performed for obtaining C-13 hydroxylnemadectin, to which sugar groups can be attached, and a production strain which produces C-13 hydroxylnemadectin is produced. Further, C-13 glycosylnemadectin producing strain is prepared by introducing aveBI-BVIII genes involving glycosidation of avermectin and biosynthesis of oleandrose. As described, C-13 hydroxylnemadectin and C-13 glycosidated nemadectin can be obtained effectively by using the producing strain prepared by means of the molecular genetic technology, and improvement in the biological activity thereof can be expected.

    摘要翻译： 在本发明中，进行奈马替丁糖苷配基生物合成的基因组的重组，得到可以附着糖基的C-13羟基去神道菌素，生成产生C-13羟基神马丁的生产菌株。 此外，通过引入涉及除虫菌素糖基化和含有甘油糖的生物合成的aveBI-BVIII基因来制备C-13糖基胚乳肽生成菌株。 如上所述，可以通过使用通过分子遗传技术制备的生产菌株有效地获得C-13羟基去神道肽和C-13糖苷化的奈马克丁，并且可以预期其生物活性的改善。

    Avermectin aglycon synthase genes
    4.
    发明授权
    Avermectin aglycon synthase genes 失效
    阿维菌素糖苷配基合成酶基因

    公开(公告)号：US07371548B2

    公开(公告)日：2008-05-13

    申请号：US11005196

    申请日：2004-12-07

    申请人： Satoshi Omura ,  Haruo Ikeda

    发明人： Satoshi Omura ,  Haruo Ikeda

    IPC分类号： C12N9/00 ,  C12N1/20 ,  C07H21/04

    CPC分类号： C12P19/623 ,  C12N15/52

    摘要： The present invention relates to an isolated DNA which comprises a DNA sequence encoding avermectin aglycon synthase domains that corresponds to multifunctional enzyme proteins involved in the biosynthesis of a polyketide compound, or its mutants having avermectin aglycon synthase activity, particularly functional modules and submodules in the DNA sequence derived from Streptomyces avermitilis, a polypeptide or mutants thereof encoded by the DNA or the mutants, a vector containing the DNA or the mutants, a host cell transformed with the DNA, the mutants thereof, or the vector, and a method for producing avermectin.

    摘要翻译： 本发明涉及分离的DNA，其包含编码与参与聚酮化合物的生物合成的多功能酶蛋白相对应的除虫菌素糖苷配基合成酶结构域的DNA序列，或其具有除虫菌素糖苷配基合成酶活性的突变体，特别是DNA中的功能性模块和子模块 衍生自阿维链霉菌的序列，由DNA或突变体编码的多肽或其突变体，含有DNA或突变体的载体，用DNA转化的宿主细胞，其突变体或载体，以及生产除虫菌素的方法 。

    Avermectin aglycon synthase genes
    5.
    发明申请
    Avermectin aglycon synthase genes 失效
    阿维菌素糖苷配基合成酶基因

    公开(公告)号：US20050158749A1

    公开(公告)日：2005-07-21

    申请号：US11005196

    申请日：2004-12-07

    申请人： Satoshi Omura ,  Haruo Ikeda

    发明人： Satoshi Omura ,  Haruo Ikeda

    IPC分类号： C12N15/00 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  C07D493/22 ,  C12N1/15 ,  C12N1/21 ,  C12N9/88 ,  C12N15/52 ,  C12P19/62 ,  C12Q1/68 ,  C12R1/465 ,  C07H21/04 ,  C12N9/10 ,  C12N15/74 ,  C12P19/60

    CPC分类号： C12P19/623 ,  C12N15/52

    摘要： The present invention relates to an isolated DNA which comprises a DNA sequence encoding avermectin aglycon synthase domains that corresponds to multifunctional enzyme proteins involved in the biosynthesis of a polyketide compound, or its mutants having avermectin aglycon synthase activity, particularly functional modules and submodules in the DNA sequence derived from Streptomyces avermitilis, a polypeptide or mutants thereof encoded by the DNA or the mutants, a vector containing the DNA or the mutants, a host cell transformed with the DNA, the mutants thereof, or the vector, and a method for producing avermectin.

    摘要翻译： 本发明涉及分离的DNA，其包含编码与参与聚酮化合物的生物合成的多功能酶蛋白相对应的除虫菌素糖苷配基合成酶结构域的DNA序列，或其具有除虫菌素糖苷配基合成酶活性的突变体，特别是DNA中的功能性模块和子模块 衍生自阿维链霉菌的序列，由DNA或突变体编码的多肽或其突变体，含有DNA或突变体的载体，用DNA转化的宿主细胞，其突变体或载体，以及生产除虫菌素的方法 。

    Control system for a linear synchronous motor
    10.
    发明授权
    Control system for a linear synchronous motor 失效
    线性同步电机控制系统

    公开(公告)号：US4381478A

    公开(公告)日：1983-04-26

    申请号：US241372

    申请日：1981-03-06

    申请人： Takashige Saijo ,  Haruo Ikeda ,  Kiyoshi Nakamura ,  Shigeyoshi Koike

    发明人： Takashige Saijo ,  Haruo Ikeda ,  Kiyoshi Nakamura ,  Shigeyoshi Koike

    IPC分类号： B60L15/00 ,  H02P5/40 ,  H02K41/00

    CPC分类号： B60L15/005 ,  B60L2200/26 ,  B60L2220/14 ,  Y02T10/644 ,  Y02T10/645

    摘要： In a magnetic floating type of super high speed transportation system using a linear synchronous motor system as its drive system in which a field magnet is carried on a train and a series of armature coils are provided along a track, a speed of a train is regulated under control of a frequency converter of the variable frequency and voltage type for supplying power to the armature coils. For the speed regulation, a relative position of the field magnet to the armature coils is detected to form a train of position detecting pulses. A reference frequency pattern with a frequency corresponding to a speed command is formed. A phase difference between the reference frequency pattern and the position detecting pulse train is detected. A propulsion force command of a linear motor is obtained by setting different limit values in the positive and negative parts of the phase difference signal. A sinusoidal current waveform pattern is formed in synchronism with the position detecting pulse train. By multiplying the current waveform pattern by the propulsion force command, a sinusoidal armature current pattern is obtained of which the frequency and the crest value are fixed. The cycloconverter is controlled so as to provide an armature current following the armature current pattern, whereby the vehicle speed accurately follows the speed command.

    摘要翻译： 在使用线性同步电动机系统作为驱动系统的磁浮式超高速运输系统中，轨道上设有励磁电磁体和一系列电枢线圈，列车的速度被调节 在用于向电枢线圈供电的可变频率和电压类型的变频器的控制下。 对于速度调节，检测到场磁体与电枢线圈的相对位置，以形成一列位置检测脉冲。 形成具有对应于速度指令的频率的参考频率模式。 检测参考频率图案和位置检测脉冲串之间的相位差。 通过在相位差信号的正，负部分设定不同的极限值来获得线性电动机的推进力指令。 与位置检测脉冲串同步地形成正弦电流波形图案。 通过将电流波形图乘以推进力指令，获得频率和波峰值固定的正弦电枢电流模式。 控制循环换流器以提供跟随电枢电流图案的电枢电流，由此车速准确地跟随速度指令。