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    Preparation of submicron solid particle suspensions by sonication of multiphase systems
    1.
    发明申请
    Preparation of submicron solid particle suspensions by sonication of multiphase systems 审中-公开
    通过超声处理多相体系制备亚微米固体颗粒悬浮液

    公开(公告)号：US20060003012A9

    公开(公告)日：2006-01-05

    申请号：US09964273

    申请日：2001-09-26

    申请人： Sean Brynjelsen ,  Shmuel Sternberg ,  Andy Dunham

    发明人： Sean Brynjelsen ,  Shmuel Sternberg ,  Andy Dunham

    IPC分类号： A61K9/14 ,  B01J13/02 ,  B01J13/04

    CPC分类号： A61K9/5169 ,  A61K9/5192

    摘要： The present invention provides a method for preparing submicron-sized particles. The method includes the steps of: (1) providing a multiphase system having an organic phase and an aqueous phase, the organic phase having a pharmaceutically effective compound therein; and (2) sonicating the system to evaporate a portion of the organic phase to cause precipitation of the compound in the aqueous phase and having an average effective particle size of less than about 2 m.

    摘要翻译： 本发明提供一种制备亚微米尺寸颗粒的方法。 该方法包括以下步骤：（1）提供具有有机相和水相的多相体系，有机相在其中具有药学上有效的化合物; 和（2）超声处理该系统以蒸发有机相的一部分以使化合物在水相中沉淀并具有小于约2μm的平均有效粒度。

    INTRAVENOUS PUMPING AIR MANAGEMENT SYSTEMS AND METHODS
    3.
    发明申请
    INTRAVENOUS PUMPING AIR MANAGEMENT SYSTEMS AND METHODS 失效
    空调泵送空气管理系统及方法

    公开(公告)号：US20120172800A1

    公开(公告)日：2012-07-05

    申请号：US12981152

    申请日：2010-12-29

    申请人： Thomas Dudar ,  Ross Krogh ,  James Martucci ,  Shmuel Sternberg

    发明人： Thomas Dudar ,  Ross Krogh ,  James Martucci ,  Shmuel Sternberg

    IPC分类号： A61M5/36 ,  A61M5/38

    CPC分类号： A61M5/172 ,  A61M5/36 ,  A61M5/365 ,  A61M5/38 ,  A61M5/385 ,  A61M2205/60

    摘要： An intravenous (“IV”) liquid delivery system includes: an IV pump tubing set; a shuttle pump or membrane pump actuator operable with the IV pump tubing set; upstream and downstream valve actuators operable with the IV pump tubing set; the IV pump tubing set including an air removal device; an air detector configured to sense air in the IV pump tubing set; a control unit configured and arranged to (i) open the upstream valve actuator and close the downstream valve actuator to allow the pump actuator to draw liquid into a pump actuation portion of the IV pump tubing set, and (ii) close the upstream valve actuator and open the downstream valve actuator to allow the pump actuator to push liquid out of the pump actuation portion, the system configured to attempt to remove the air via the air removal device while operating the upstream and downstream valve actuators according to (i) and (ii).

    摘要翻译： 静脉内（“IV”）液体输送系统包括：IV泵管组; 一个穿梭泵或膜泵驱动器，可与IV泵管组一起操作; 上游和下游阀致动器可与IV泵管组一起操作; 所述IV泵管组包括排气装置; 空气检测器，被配置为感测IV泵管组中的空气; 控制单元，其配置和布置成（i）打开上游阀致动器并关闭下游阀致动器以允许泵致动器将液体引入IV泵管组的泵致动部分，以及（ii）关闭上游阀致动器 并且打开下游阀致动器以允许泵致动器将液体推出泵致动部分，该系统构造成在根据（i）和（i）和（i））操作上游和下游阀致动器期间尝试经由除气装置去除空气， ii）。

    Device to Indicate Priming of an Infusion Line
    4.
    发明申请
    Device to Indicate Priming of an Infusion Line 有权
    指示灌注线灌注的装置

    公开(公告)号：US20100063445A1

    公开(公告)日：2010-03-11

    申请号：US12555606

    申请日：2009-09-08

    申请人： Shmuel Sternberg ,  Siddharth B. Desai ,  Larry Black ,  Robin G. Pauley

    发明人： Shmuel Sternberg ,  Siddharth B. Desai ,  Larry Black ,  Robin G. Pauley

    IPC分类号： A61J1/18 ,  A61M39/00 ,  G08B21/00

    CPC分类号： G01D7/005 ,  A61M5/141 ,  A61M5/3146 ,  A61M5/385 ,  A61M39/10 ,  A61M39/20 ,  A61M2005/1402 ,  A61M2005/3125 ,  A61M2039/205 ,  A61M2205/331 ,  A61M2205/7536

    摘要： A priming indicator for a fluid infusion system includes a luer cap or other component of the infusion system having an indicator surface covered by a membrane. The membrane exhibits a first visual characteristic, such as being opaque, when dry and exhibits a second characteristic, such as becoming less opaque, when wet. Once the membrane becomes wet, indicia on the surface, which may be provided on a rod at least partially covered by the membrane, becomes visible, thereby indicating an intravenous tube to which the luer cap is secured has been primed or is nearly primed. The indicator may alternately be employed at an upstream end of an infusion set, such as at the port of a medical bag providing a supply of fluid, to indicate a low level of fluid in the medical bag.

    摘要翻译： 用于流体输注系统的起动指示器包括输注系统的路厄帽或其他组件，其具有由膜覆盖的指示器表面。 当膜干燥时，膜呈现第一视觉特征，例如不透明的，并且当湿时呈现第二特性，例如变得不透明。 一旦膜变湿，可以设置在至少部分地被膜覆盖的杆上的表面上的标记变得可见，从而指示固定有鲁尔帽的静脉内管已经被引发或几乎被引发。 可以在输液器的上游端（例如在提供流体供应的医疗袋的端口处）使用指示器，以指示医疗袋中的低水平的流体。

    Blood collection systems and methods using a porous membrane element
    5.
    发明授权
    Blood collection systems and methods using a porous membrane element 有权
    使用多孔膜元件的采血系统和方法

    公开(公告)号：US06824688B2

    公开(公告)日：2004-11-30

    申请号：US10606589

    申请日：2003-06-26

    申请人： Julian P. Breillatt, Jr. ,  Shmuel Sternberg

    发明人： Julian P. Breillatt, Jr. ,  Shmuel Sternberg

    IPC分类号： B01D3700

    CPC分类号： B01D69/12 ,  A61M1/3633 ,  A61M1/3636 ,  B01D61/18 ,  B01D63/081 ,  B01D65/00

    摘要： A filter for removing leukocytes from blood comprises a filter media enclosed in a housing. The filter media includes a main filter region comprising a porous membrane structure extending between first and second skin surfaces. The porous membrane structure is formed by intersecting cells having a range of diameters. The cells adjacent to the first skin surface have diameters generally smaller than the diameters of the cells adjacent to the second skin surface. The first skin surface includes an open area defined by pores, which are formed by the intersection of cells with the first skin surface. The majority of the open area is defined by pores having a diameter of between about 12 &mgr;m and 28 &mgr;m.

    摘要翻译： 用于从血液中除去白细胞的过滤器包括封装在壳体中的过滤介质。 过滤介质包括主过滤器区域，其包括在第一和第二表皮之间延伸的多孔膜结构。 多孔膜结构由具有一定范围的直径的细胞相交形成。 与第一皮肤表面相邻的细胞的直径通常小于与第二皮肤表面相邻的细胞的直径。 第一皮肤表面包括由细胞与第一皮肤表面相交形成的由孔限定的开放区域。 开放区域的大部分由具有约12μm和28μm之间的直径的孔限定。

    Device and method for pathogen inactivation of therapeutic fluids with sterilizing radiation
    6.
    发明授权
    Device and method for pathogen inactivation of therapeutic fluids with sterilizing radiation 有权
    用灭菌辐射使病原体灭活治疗液的装置和方法

    公开(公告)号：US06596230B1

    公开(公告)日：2003-07-22

    申请号：US09494338

    申请日：2000-01-28

    申请人： Lecon Woo ,  Daniel R. Boggs ,  Shmuel Sternberg ,  Craig Sandford ,  Atul Khare ,  Julian Breillatt

    发明人： Lecon Woo ,  Daniel R. Boggs ,  Shmuel Sternberg ,  Craig Sandford ,  Atul Khare ,  Julian Breillatt

    IPC分类号： A61L208

    CPC分类号： A61M1/3681 ,  A61L2/0011 ,  A61L2/10 ,  A61M1/0281 ,  A61M2202/0415 ,  A61M2205/053

    摘要： A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous thin fluid flow arrangement that exhibits radiation dose uniformity for fluids having high optical densities. Radiation dose uniformity is achieved in part through a “carrying” mechanism that moves or carries the fluid, thereby eliminating a channel flow velocity profile where flow volumes near the channel walls run the risk of overexposure to the radiation due to very large residence times within the channel. The device comprises a relatively flat belt chamber (22) connected to a fluid flow through an inlet (24) and an outlet (26) on the belt chamber (22). The belt chamber (22) has a top surface (28) and a bottom surface (30). A radiation permeable plate (32) is disposed adjacent the top surface (28) of the belt chamber (22) and is in contact with the belt chamber (22). A radiation source (42) is provided adjacent to the plate (32) adjacent to a side opposite the belt chamber (22). A belt (34) having a plurality of flexible vanes (36) is disposed adjacent the bottom surface (30) of the belt chamber (22) such that the vanes (36) make contact with the belt chamber (22). The belt is driven by a roller mechanism (38) in the direction of the fluid flow. As the fluid flows through the belt chamber (22), the flexible vanes (36) provide a squeegee-like mechanism to move the fluid through the belt chamber (22) in discrete packets (40) defined by a pair of vanes (36). As the packets of fluid move through the belt chamber, they are exposed to sterilizing radiation passing through the plate (32).

    摘要翻译： 一种在具有对具有高光密度的流体显示辐射剂量均匀性的连续薄流体流动布置中灭菌治疗性流体中的灭菌辐射的装置和方法。 辐射剂量均匀性部分地通过移动或携带流体的“携带”机构实现，从而消除了通道流速分布，其中通道壁附近的流量具有过度暴露于辐射的风险，这是由于内部的非常大的停留时间 渠道。 该装置包括连接到通过入口（24）的流体流和带室（22）上的出口（26）的相对平坦的带室（22）。 带室（22）具有顶表面（28）和底表面（30）。 辐射透射板（32）邻近带室（22）的顶表面（28）设置并与带室（22）接触。 辐射源（42）邻近于与带室（22）相对的一侧邻近板（32）设置。 具有多个柔性叶片（36）的带（34）邻近带室（22）的底表面（30）设置，使得叶片（36）与带室（22）接触。 皮带由辊机构（38）沿着流体流动的方向驱动。 当流体流过皮带室（22）时，柔性叶片（36）提供刮板状机构，以使流体通过一对叶片（36）限定的离散的分组（40）移动通过皮带室（22） 。 当流体包装移动通过皮带室时，它们暴露于穿过板（32）的灭菌辐射。

    Multiple-layer, formed-in-place immunoisolation membrane structures for implantation of cells in host tissue
    7.
    发明授权
    Multiple-layer, formed-in-place immunoisolation membrane structures for implantation of cells in host tissue 失效
    用于在宿主组织中植入细胞的多层形成的免疫隔离膜结构

    公开(公告)号：US6060640A

    公开(公告)日：2000-05-09

    申请号：US446210

    申请日：1995-05-19

    申请人： Robin G. Pauley ,  Donna L. McLarty ,  Atul R. Khare ,  Shmuel Sternberg ,  Daniel R. Boggs ,  Steven Neuenfeldt ,  Mark Jones ,  James H. Brauker ,  Laura A. Martinson

    发明人： Robin G. Pauley ,  Donna L. McLarty ,  Atul R. Khare ,  Shmuel Sternberg ,  Daniel R. Boggs ,  Steven Neuenfeldt ,  Mark Jones ,  James H. Brauker ,  Laura A. Martinson

    IPC分类号： A61F2/02 ,  A61K9/00 ,  A61L27/38 ,  C12N5/08 ,  A61D7/00 ,  A61M31/00

    CPC分类号： A61K9/0024 ,  A61F2/022 ,  A61L27/38

    摘要： A permeable structure forms a chamber to hold living cells. The structure includes a first permeable region surrounding at least a portion of the chamber having a conformation that, when implanted in host tissue, substantially blocks penetration of host cells into the chamber while permitting solute transport. The structure also includes a second permeable region overlying the first permeable region having a conformation that, when implanted in host tissue, forms a permeable interface with host tissue that permits solute transport. A third permeable region is located between the first and second permeable regions. The third region comprises a solution of polymer material formed in place between the first and second permeable regions. The third permeable region bonds the first and second permeable regions together. The third permeable region also has a conformation that, when implanted in host tissue, permits solute transport between the first and second permeable regions. The third, formed-in-place region bonds the first and second permeable regions together, providing a robust, laminated structure that resists delamination during implantation caused by cellular infiltration into discontinuous spaces between the first and second regions. The third, formed-in-place region can also have a conformation providing an immunoisolation effect. Furthermore, the permeability of the third, formed-in-place membrane is sufficient high that it does not adversely effect the permeability value desired for the overall multiple layer membrane structure.

    摘要翻译： 可渗透结构形成容纳活细胞的室。 所述结构包括围绕所述腔室的至少一部分的第一可渗透区域，其具有当植入宿主组织时基本上阻挡宿主细胞渗入所述腔室同时允许溶质运输的构象。 该结构还包括覆盖第一可渗透区域的第二可渗透区域，其具有当植入宿主组织中时形成允许溶质运输的宿主组织的可渗透界面的构象。 第三可渗透区域位于第一和第二可渗透区域之间。 第三区域包括在第一和第二可渗透区域之间形成的聚合物材料溶液。 第三可渗透区域将第一和第二可渗透区域结合在一起。 第三可渗透区域还具有当植入宿主组织时允许溶质在第一和第二可渗透区域之间传输的构象。 第三个就地区域将第一和第二可渗透区域结合在一起，提供坚固的层压结构，其抵抗由于细胞浸润到第一和第二区域之间的不连续空间而在植入过程中的分层。 第三个就地区域也可以具有提供免疫隔离作用的构象。 此外，第三成形膜的渗透性足够高，使得其不会对整个多层膜结构所期望的渗透性值产生不利影响。

    Device and method for pathogen inactivation of therapeutic fluids with sterilizing radiation
    10.
    发明授权
    Device and method for pathogen inactivation of therapeutic fluids with sterilizing radiation 有权
    用灭菌辐射使病原体灭活治疗液的装置和方法

    公开(公告)号：US06576201B1

    公开(公告)日：2003-06-10

    申请号：US09493848

    申请日：2000-01-28

    申请人： Lecon Woo ,  Daniel R. Boggs ,  Shmuel Sternberg ,  Craig Sandford ,  Atul Khare ,  Julian Breillatt

    发明人： Lecon Woo ,  Daniel R. Boggs ,  Shmuel Sternberg ,  Craig Sandford ,  Atul Khare ,  Julian Breillatt

    IPC分类号： B01J1908

    CPC分类号： A61L2/10 ,  A61L2/0011 ,  A61M1/0281 ,  A61M1/3681 ,  A61M2202/0415 ,  A61M2205/053

    摘要： A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous flow arrangement while exhibiting radiation dose uniformity and narrow residence time distribution of the fluid within the device. The device (10) comprises a radiation permeable cylindrical tube (12) having a concentric cylindrical rotor (14) disposed therein, thereby providing a thin gap (16) therebetween. A top plate (18) having a fluid outlet (26) and a bottom plate (20) having a fluid inlet (24) seal the cylindrical tube (12). The inlet (24) and outlet (26) are both in fluid communication with the thin gap (16). A rotor shaft (36) is disposed axially through the cylindrical rotor (14) and is connected to a motor (30). A pump provides fluid flow through the device (10). A radiation source provides sterilizing radiation to the fluid through the cylindrical tube (12). As the fluid flows, the motor (30) drives the rotor (14) to impart Taylor vortices to the fluid flow, which exchanges the fluid closer to the cylindrical tube (12) with the fluid closer to the rotor (14).

    摘要翻译： 一种用于在连续流动布置中灭菌治疗流体中的病原体灭活的装置和方法，同时具有辐射剂量均匀性和在装置内的流体的滞留时间分布。 装置（10）包括具有设置在其中的同心圆柱形转子（14）的透射性圆柱形管（12），从而在它们之间提供薄的间隙（16）。 具有流体出口（26）的顶板（18）和具有密封圆柱形管（12）的流体入口（24）的底板（20）。 入口（24）和出口（26）都与薄间隙（16）流体连通。 转子轴（36）轴向设置在圆柱形转子（14）上并与马达（30）连接。 泵提供流过装置（10）的流体。 辐射源通过圆柱形管（12）向流体提供灭菌辐射。 当流体流动时，马达（30）驱动转子（14）以向流体流传递泰勒涡流，流体更接近圆柱形管（12），流体更靠近转子（14）。