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    Modular chemical production system incorporating a microreactor
    4.
    发明授权
    Modular chemical production system incorporating a microreactor 失效
    包含微反应器的模块化化学生产系统

    公开(公告)号：US07056477B1

    公开(公告)日：2006-06-06

    申请号：US09578224

    申请日：2000-05-24

    申请人： Thomas Schwalbe ,  Sebastian Oberbeck ,  Klaus Golbig ,  Michael Hohmann ,  Andreas Oberbeck

    发明人： Thomas Schwalbe ,  Sebastian Oberbeck ,  Klaus Golbig ,  Michael Hohmann ,  Andreas Oberbeck

    IPC分类号： B01J19/24 ,  B01J19/00 ,  B01J8/00

    CPC分类号： B01J19/0093 ,  B01J2219/0081 ,  B01J2219/00822 ,  B01J2219/00824 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00835 ,  B01J2219/00867 ,  B01J2219/00869 ,  B01J2219/00871 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/0095 ,  B01J2219/00984 ,  B01J2219/0099

    摘要： A modular chemical production system that preferably includes a microreactor for producing a product by reacting two or more reactants. Modularization enables components such as controllers, pumps, valves, microreactors, and processing modules to be added or removed from the system as required to produce a desired product. A minimum system includes a control module and a reaction module, which has a mixing volume and a reaction volume. Various pumping modules and residence time modules may also be included in the system. Modules can be changed if malfunctioning, or for producing a different product, or to change a quantity of the chemical produced. The control module preferably accesses a database in which data define parameters for a plurality of different reactions that are optimized for the production of different chemical products. The user selects the product desired and the amount of the product, provides the reactants, solvents, and heat transfer media supplies, and the control module operates the system to automatically produce the product until the desired amount is obtained. The reaction module preferably includes a microreactor, which can be replaced with a microreactor of a different configuration to produce a different product. Connections between modules are designed to enable quick connection and disconnection of modules, and fluid lines are self sealing to prevent leakage of fluids when changing modules.

    摘要翻译： 模块化化学生产系统，其优选包括用于通过使两种或更多种反应物反应来生产产物的微反应器。 模块化使控制器，泵，阀，微反应器和处理模块等组件可根据需要从系统中添加或移除，以产生所需产品。 最小系统包括具有混合体积和反应体积的控制模块和反应模块。 系统中还可以包括各种泵送模块和停留时间模块。 如果发生故障或生产不同的产品，或者改变生产的化学品的数量，可以改变模块。 控制模块优选地访问数据库，其中数据定义为针对不同化学产品的生产而优化的多个不同反应的参数。 用户选择所需的产品和产品的量，提供反应物，溶剂和传热介质供应，并且控制模块操作系统以自动生产产品，直到获得所需的量。 反应模块优选地包括微反应器，其可以用不同构型的微反应器代替以产生不同的产物。 模块之间的连接被设计成能够快速连接和断开模块，并且流体管线是自密封的，以防止在更换模块时泄漏流体。

    Miniaturized reaction apparatus
    5.
    发明授权
    Miniaturized reaction apparatus 失效
    小型化反应装置

    公开(公告)号：US06537506B1

    公开(公告)日：2003-03-25

    申请号：US09496999

    申请日：2000-02-03

    申请人： Thomas Schwalbe ,  Klaus Golbig ,  Michael Hohmann ,  Petra Georg ,  Andreas Oberbeck ,  Bernd Dittmann ,  Jiri Stastna ,  Sebastian Oberbeck

    发明人： Thomas Schwalbe ,  Klaus Golbig ,  Michael Hohmann ,  Petra Georg ,  Andreas Oberbeck ,  Bernd Dittmann ,  Jiri Stastna ,  Sebastian Oberbeck

    IPC分类号： B01J1900

    CPC分类号： B01F13/0066 ,  B01F5/0604 ,  B01F13/0059 ,  B01F13/0064 ,  B01F13/0093 ,  B01F13/0094 ,  B01F13/1013 ,  B01F13/1022 ,  B01F15/06 ,  B01J19/0093 ,  B01J19/249 ,  B01J2219/00783 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00961 ,  B01J2219/2453 ,  B01J2219/2456 ,  B01J2219/246 ,  B01J2219/2462 ,  B01J2219/2464 ,  B01J2219/247 ,  B01J2219/2485 ,  B01J2219/2486 ,  B01J2219/2487 ,  B01J2219/2488 ,  B01J2219/249 ,  B01J2219/2493 ,  B01J2219/2495 ,  B01J2219/2496 ,  B01J2219/2497 ,  F28D9/0093 ,  F28F2260/02

    摘要： A stacked plate chemical reactor in which simple plates, each incorporating no surface features other that an opening, are stacked together. When openings in adjacent plates are properly aligned, a fluid pathway is defined between inlet ports for each chemical reactant and an outlet port for a chemical product. In one embodiment of the invention, sixteen simple plates are stacked to provide a reactor incorporating three heat transfer fluid pathways, two reactant fluid pathways, one product fluid pathway, multiple mixing chambers, multiple reaction chambers, two reactant pretreatment heat exchangers, two reaction chamber heat exchangers, and multiple temperature sensor pathways. Precise dimensional control of the reactant fluid pathway height enables stacked laminar flow paths for the reactants to be achieved, allowing efficient and rapid diffusion mixing to occur. Because the simple plates incorporate no features other than openings, fabrication of such plates is easily achieved. Different reactor designs, having additional reactant pathways, more or fewer heat transfer fluid pathways, more or fewer heat exchangers, more or fewer mixing chambers, more of fewer reaction chambers, and more or fewer sensor pathways can readily be achieved by adding or removing plates from the stack, and or by changing the pattern and number of openings in the simple plates that are used. The simple plates can be field in the stack during use of the chemical reactor using pressure exerted on opposite outer simple plates of the stack, or can be permanently joined. A preferred material for the fabrication of the plates is stainless steel, although other materials such as glass, plastic, and other metals can alternatively be used, which are compatible with the selected reactants and the desired product.

    摘要翻译： 堆叠板式化学反应器，其中每个不具有开口的表面特征的简单板堆叠在一起。 当相邻板中的开口正确对准时，在每个化学反应物的入口和用于化学产品的出口之间限定流体通道。 在本发明的一个实施方案中，堆叠十六个简单的板以提供一个结合有三个传热流体路径，两个反应物流体路径，一个产物流体路径，多个混合室，多个反应室，两个反应物预处理热交换器，两个反应室 热交换器和多个温度传感器通路。 反应物流体通道高度的精确尺寸控制能够实现用于反应物的堆叠层流路径，从而允许发生高效和快速的扩散混合。 由于简单的板不包含开口以外的特征，所以容易实现这种板的制造。 不同的反应器设计，具有额外的反应物途径，更多或更少的传热流体途径，更多或更少的热交换器，更多或更少的混合室，更多的更少的反应室和更多或更少的传感器通路可以容易地通过添加或去除板 并且或通过改变所使用的简单板中的开口的图案和数量。 在使用化学反应器的过程中，简单的板可以使用施加在堆叠的相对的外部简单板上的压力，或者可以永久地连接在堆叠中。 用于制造板的优选材料是不锈钢，尽管可以替代地使用其它材料如玻璃，塑料和其它金属，其与选择的反应物和所需产物相容。

    Sequential reaction system
    6.
    发明授权
    Sequential reaction system 失效
    顺序反应体系

    公开(公告)号：US07413714B1

    公开(公告)日：2008-08-19

    申请号：US09617068

    申请日：2000-07-16

    申请人： Thomas Schwalbe ,  Klaus Golbig ,  Michael Hohmann ,  Andreas Oberbeck ,  Shahriyar Taghavi-Moghadam

    发明人： Thomas Schwalbe ,  Klaus Golbig ,  Michael Hohmann ,  Andreas Oberbeck ,  Shahriyar Taghavi-Moghadam

    IPC分类号： B01J19/24

    CPC分类号： C07C233/00 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00337 ,  B01J2219/00389 ,  B01J2219/00495 ,  B01J2219/0059 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00704 ,  B01J2219/0072 ,  C40B40/04 ,  C40B50/08 ,  C40B60/14 ,  Y10T436/115831 ,  Y10T436/12

    摘要： An automated sequential reaction system that can be used to either sequentially produce a plurality of different products each requiring a single reaction, or to produce a desired product that requires a series of sequential reactions. A system controller controls an automated reactant supply, a solvent supply, a reaction module, a detector, and a product collector. Prior to initiating any reaction, the system is flushed with solvent and a heat exchanger supplies the reaction module with a temperature-conditioned fluid to maintain the reaction module at a desired temperature. For single reactions, a plurality of reactants are injected into a chemical reactor included in the reaction module. As fluid exits the chemical reactor, the detector determines if the fluid is a desired chemical product or solvent, and routes the fluid to the appropriate receptacle. Once a predetermined volume of a desired product is obtained, the system is flushed with solvent, and a different set of reactants are injected into the chemical reactor to produce the next desired product. The process is repeated until a substance library of the desired products is obtained. For products requiring sequential reaction steps, either a plurality of reactors are employed, or an intermediate product produced by a previous reaction is reintroduced into the reaction module with an appropriate reactant to complete the next sequential reaction.

    摘要翻译： 一种自动化顺序反应系统，其可用于顺序地产生多个不同的产物，每个产物需要单次反应，或产生需要一系列顺序反应的所需产物。 系统控制器控制自动反应物供应源，溶剂供应源，反应模块，检测器和产品收集器。 在开始任何反应之前，系统用溶剂冲洗，热交换器向反应模块提供温度调节的流体，以将反应模块保持在所需温度。 对于单次反应，将多个反应物注入包含在反应模块中的化学反应器中。 当流体离开化学反应器时，检测器确定流体是否是期望的化学产品或溶剂，并将流体引导到适当的容器。 一旦获得了预定体积的所需产物，则用溶剂冲洗该系统，并将不同组的反应物注入化学反应器以产生下一个所需产物。 重复该过程，直到获得所需产物的物质文库。 对于需要顺序反应步骤的产物，使用多个反应器，或者通过先前反应产生的中间产物用适当的反应物引入反应模块中以完成下一个顺序反应。

    METHOD FOR THE TARGETED EXECUTION OF A REACTION TAKING PLACE ALONGSIDE SEVERAL COMPETING CHEMICAL REACTIONS
    7.
    发明申请
    METHOD FOR THE TARGETED EXECUTION OF A REACTION TAKING PLACE ALONGSIDE SEVERAL COMPETING CHEMICAL REACTIONS 审中-公开
    方法进行反应的方法采用位于几个竞争的化学反应

    公开(公告)号：US20110306799A1

    公开(公告)日：2011-12-15

    申请号：US12307489

    申请日：2007-05-25

    申请人： Rainer Schenk ,  Michael Küpper ,  Thomas Schwalbe

    发明人： Rainer Schenk ,  Michael Küpper ,  Thomas Schwalbe

    IPC分类号： C07C45/29

    CPC分类号： C07C45/29 ,  C07C49/403

    摘要： A method for the targeted execution of a reaction taking place alongside several competing chemical reactions is described, wherein the speeds of the competing reactions are set by the selection of the reaction conditions in such a way that the desired main reaction is not adversely affected. The invention further describes a new method for the oxidation of primary or secondary alcohols into aldehydes or ketones in the presence of dimethyl sulfoxide, a carboxylic acid anhydride or halogenide, and an amine in an organic solvent, in a continuous processing system (Moffatt-Swern oxidation).

    摘要翻译： 描述了与多个相互竞争的化学反应一起进行的反应的目标执行的方法，其中竞争反应的速度通过反应条件的选择来设定，使​​得所需的主反应不受不利影响。 本发明进一步描述了在连续处理系统（Moffatt-Swern）中在二甲基亚砜，羧酸酐或卤化物和有机溶剂中的胺存在下将伯醇或仲醇氧化成醛或酮的新方法 氧化）。