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104 条记录 (耗时 0.029 秒)

    2,3-disubstituted cyclopentanone derivatives, process for producing the same, and medicinal use thereof
    3.
    发明授权
    2,3-disubstituted cyclopentanone derivatives, process for producing the same, and medicinal use thereof 失效
    2,3-二取代环戊酮衍生物，其制备方法及其医药用途

    公开(公告)号：US6114364A

    公开(公告)日：2000-09-05

    申请号：US117411

    申请日：1998-10-05

    申请人： Seiichi Saito ,  Tomio Morino ,  Kuniko Masuda

    发明人： Seiichi Saito ,  Tomio Morino ,  Kuniko Masuda

    IPC分类号： C07C49/517 ,  C07C62/26 ,  C07C323/22 ,  C07C323/41 ,  C07C323/59 ,  C07D213/80 ,  C07D239/38 ,  C07D317/22 ,  C07D317/72 ,  A61K31/44 ,  C07D213/60

    CPC分类号： C07D213/80 ,  C07C323/22 ,  C07C323/41 ,  C07C323/59 ,  C07C49/517 ,  C07C62/26 ,  C07D239/38 ,  C07D317/22 ,  C07D317/72 ,  C07C2101/08

    摘要： The present invention relates to a compound represented by the following general formula (1) ##STR1## (wherein X represents O, S, SO, SO.sub.2, or NH, Y is a substituted or unsubstituted hydrocarbon residue containing 1 through 6 carbon atoms and having an overall molecular weight of not less than 15 and not more than 400, and the hydrocarbon residue, when the residue is ring, may contain one or two hetero-atoms in the ring, and Z is a carboxyl group, a group derived therefrom or an aliphatic hydrocarbon residue having from 1 to 4 carbon atoms which may be substituted or unsabstituted) or a pharmacologically acceptable salt thereof (excluding (1R,2S)-2-[(2R)-(2-acetyl-amino-2-carboxyethyl)thiomethyl]-3-oxo-1-cyclopentane-carboxylic acid (cystacyclin)), a method for production thereof and a medicinal use thereof. The compound of the present invention is useful as a neuron differentiation accelerator.

    摘要翻译： PCT No.PCT / JP97 / 00247 Sec。 371日期：1998年10月5日 102（e）日期1998年10月5日PCT 1997年1月31日PCT PCT。 公开号WO97 / 28114 PCT 日期：1997年8月7日本发明涉及由以下通式（1）表示的化合物（其中X表示O，S，SO，SO 2或NH，Y是取代或未取代的含有1至6个碳原子的烃基 并且总分子量不小于15且不大于400，并且当残基为环时，烃残基在环中可以含有一个或两个杂原子，Z为羧基，衍生自 或其药理学上可接受的盐（不包括（1R，2S）-2 - [（2R） - （2-乙酰基 - 氨基-2- 羧乙基）硫代甲基] -3-氧代-1-环戊烷 - 羧酸（cystacyclin）），其制备方法及其医药用途。 本发明的化合物可用作神经元分化促进剂。

    Antibiotics NK374186A, NK374186B, NK374186B3 and NK374186C3, process for producing the same, and use of the same
    4.
    发明授权
    Antibiotics NK374186A, NK374186B, NK374186B3 and NK374186C3, process for producing the same, and use of the same 失效
    抗生素NK374186A，NK374186B，NK374186B3和NK374186C3​​，其制备方法及其用途

    公开(公告)号：US5306496A

    公开(公告)日：1994-04-26

    申请号：US896676

    申请日：1992-06-10

    申请人： Tomio Morino ,  Masakazu Nishimoto ,  Mituyuki Nishide ,  Akira Masuda ,  Masatoshi Yamada ,  Eiji Kawano ,  Takaaki Nishikiori ,  Seiichi Saito

    发明人： Tomio Morino ,  Masakazu Nishimoto ,  Mituyuki Nishide ,  Akira Masuda ,  Masatoshi Yamada ,  Eiji Kawano ,  Takaaki Nishikiori ,  Seiichi Saito

    IPC分类号： C12P1/02 ,  A61K35/70

    CPC分类号： C12P1/02

    摘要： Novel antibiotics NK374186A, NK374186B, NK374186B3 and NK374186C3 having antibacterial, antineoplastic, immunomodulation, and liver regeneration promoting activities are provided.NK374186A, NK374186B, NK374186B3 and NK374186C3 are obtained by culturing NK374186 strain (FERM P-12285) (FERM-BP 3870) belonging to the genus Penicillium. NK374186A is a compound represented by a rational formula of C.sub.34 H.sub.61 N.sub.3 O.sub.12 S.sub.9 and having a molecular weight of M+ 735 (FD-MS m/z); NK374186B is a compound represented by a rational formula of C.sub.34 H.sub.61 N.sub.3 O.sub.9 and having a molecular weight of M+ 655 (FD-MS m/z); NK374186B3 is a compound represented by a rational formula of C.sub.34 H.sub.61 N.sub.3 O.sub.9 and having a molecular weight of M+ 655 (FD-MS m/z); and NK374186C3 is a compound represented by a rational formula of C.sub.32 H.sub.59 N.sub.3 O.sub.7 and having a molecular weight of M+ 597 (FD-MS m/z).

    摘要翻译： 提供具有抗菌，抗肿瘤，免疫调节和肝再生促进活性的新型抗生素NK374186A，NK374186B，NK374186B3和NK374186C3​​。 通过培养属于青霉属的NK374186菌株（FERM P-12285）（FERM-BP 3870）获得NK374186A，NK374186B，NK374186B3和NK374186C3​​。 NK374186A是由C34H61N3O12S9的合理式表示的化合物，其分子量为M + 735（FD-MS m / z）; NK374186B是由合理式C34H61N3O9表示的化合物，分子量为M + 655（FD-MS m / z）; NK374186B3是由合成式C34H61N3O9表示的化合物，其分子量为M + 655（FD-MS m / z）; 并且NK374186C3​​是由合成式C32H59N3O7表示的化合物，其分子量为M + 597（FD-MS m / z）。