利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

20 条记录 (耗时 0.023 秒)

    Surface modification to improve lubricity, abrasion resistance and temperature resilience of leads
    2.
    发明授权
    Surface modification to improve lubricity, abrasion resistance and temperature resilience of leads 有权
    表面改性以提高导线的润滑性，耐磨性和温度弹性

    公开(公告)号：US08372468B2

    公开(公告)日：2013-02-12

    申请号：US12547839

    申请日：2009-08-26

    申请人： Shrojalkumar Desai ,  Leslie J. Carion ,  Larry L. Hum

    发明人： Shrojalkumar Desai ,  Leslie J. Carion ,  Larry L. Hum

    IPC分类号： B05D5/08 ,  B05D3/00

    CPC分类号： B05D5/08 ,  A61L31/10 ,  A61L31/14 ,  A61L2400/18 ,  C08J3/245 ,  C08J7/06 ,  C08L23/0853 ,  C08L83/04 ,  C08L2666/04

    摘要： A medical electrical lead body having an outer surface and including at least one lumen having an inner surface treated with a silane surface modifying agent to form a three-dimensional, densely cross-linked lubricious coating over at least a portion of the inner surface of the lumen. The outer surface of the lead body also may be similarly treated. The lubricious silane coating may reduce the coefficient of friction of the coated surface of the lead body by as much as 80% when compared to an uncoated surface. A reduction in the coefficient of friction may enhance the stringing efficiency of a conductor through the lead body lumen and may enhance its abrasion resistance.

    摘要翻译： 一种具有外表面并且包括具有用硅烷表面改性剂处理的内表面的至少一个内腔的医疗电引线体，以在所述内表面的至少一部分上形成三维密集交联的光滑涂层 流明。 引线体的外表面也可以被类似地处理。 与未涂覆的表面相比，润滑硅烷涂层可以将引线体的涂覆表面的摩擦系数降低多达80％。 摩擦系数的降低可以提高导体通过引线体腔的穿线效率并且可以提高其耐磨性。

    Seal for use with medical device and system
    3.
    发明授权
    Seal for use with medical device and system 失效
    用于医疗器械和系统的密封

    公开(公告)号：US07412290B2

    公开(公告)日：2008-08-12

    申请号：US10968305

    申请日：2004-10-20

    申请人： Aaron W. Janke ,  Larry L. Hum ,  Randy Westlund ,  Ronald W. Heil, Jr. ,  Bruce Tockman

    发明人： Aaron W. Janke ,  Larry L. Hum ,  Randy Westlund ,  Ronald W. Heil, Jr. ,  Bruce Tockman

    IPC分类号： A61N1/372

    CPC分类号： A61N1/0573 ,  A61N1/0565

    摘要： A seal adapted for use with medical devices is provided with a lead having a distal tip electrode. The distal tip of the lead is adapted for implantation on or about the heart and for connection to a system for monitoring or stimulating cardiac activity. The lead can include a fixation helix for securing the electrode to cardiac tissue. The lead assembly can alternatively include an open lumen lead tip. A seal is provided within the lead tip assembly such that the seal is expanded to prevent or limit further entry of fluids through the lead tip. The seal includes an expandable matrix, such as a hydrogel. The seal is formed on or within the lead when the lead and the seal comes into contact with a fluid and expands. The seal is also formed as a plug which is deployed through the medical device, and expands as the plug absorbs fluid. A housing incorporating the seal can also be attached to a portion of the medical device to provide the seal.

    摘要翻译： 适于与医疗装置一起使用的密封件设置有具有远端尖端电极的引线。 引线的远端适于植入在心脏上或其周围，并用于连接到用于监测或刺激心脏活动的系统。 引线可以包括用于将电极固定到心脏组织的固定螺旋。 导线组件可以替代地包括开放的管腔引线端头。 在引线端头组件内设置密封件，使得密封件被膨胀以防止或限制流体进一步通过引线头进入。 密封件包括可膨胀基质，例如水凝胶。 当铅和密封件与流体接触并膨胀时，密封件形成在引线上或内部。 密封件还形成为通过医疗装置展开的塞子，并且当塞子吸收流体时膨胀。 结合密封件的壳体也可以附接到医疗装置的一部分以提供密封。

    SURFACE MODIFICATION TO IMPROVE LUBRICITY, ABRASION RESISTANCE AND TEMPERATURE RESILIENCE OF LEADS
    5.
    发明申请
    SURFACE MODIFICATION TO IMPROVE LUBRICITY, ABRASION RESISTANCE AND TEMPERATURE RESILIENCE OF LEADS 有权
    表面改性以提高导线的润滑性，耐磨性和温度耐久性

    公开(公告)号：US20100075018A1

    公开(公告)日：2010-03-25

    申请号：US12547839

    申请日：2009-08-26

    申请人： Shrojalkumar Desai ,  Leslie J. Carion ,  Larry L. Hum

    发明人： Shrojalkumar Desai ,  Leslie J. Carion ,  Larry L. Hum

    IPC分类号： B05D5/08 ,  B05D3/00

    CPC分类号： B05D5/08 ,  A61L31/10 ,  A61L31/14 ,  A61L2400/18 ,  C08J3/245 ,  C08J7/06 ,  C08L23/0853 ,  C08L83/04 ,  C08L2666/04

    摘要： A medical electrical lead body having an outer surface and including at least one lumen having an inner surface treated with a silane surface modifying agent to form a three-dimensional, densely cross-linked lubricious coating over at least a portion of the inner surface of the lumen. The outer surface of the lead body also may be similarly treated. The lubricious silane coating may reduce the coefficient of friction of the coated surface of the lead body by as much as 80% when compared to an uncoated surface. A reduction in the coefficient of friction may enhance the stringing efficiency of a conductor through the lead body lumen and may enhance its abrasion resistance.

    摘要翻译： 一种具有外表面并且包括具有用硅烷表面改性剂处理的内表面的至少一个内腔的医疗电引线体，以在所述内表面的至少一部分上形成三维密集交联的光滑涂层 流明。 引线体的外表面也可以被类似地处理。 与未涂覆的表面相比，润滑硅烷涂层可以将引线体的涂覆表面的摩擦系数降低多达80％。 摩擦系数的降低可以提高导体通过引线体腔的穿线效率并且可以提高其耐磨性。

    Solventless method for forming a coating on a medical electrical lead body
    8.
    发明授权
    Solventless method for forming a coating on a medical electrical lead body 有权
    在医用电引线体上形成涂层的无溶剂方法

    公开(公告)号：US08753708B2

    公开(公告)日：2014-06-17

    申请号：US12832635

    申请日：2010-07-08

    申请人： Larry L. Hum ,  James Q. Feng ,  Arienne P. Simon ,  Tolga Tas

    发明人： Larry L. Hum ,  James Q. Feng ,  Arienne P. Simon ,  Tolga Tas

    IPC分类号： A61L33/00

    CPC分类号： A61L31/16 ,  A61L31/10 ,  A61L31/18 ,  C09D5/38 ,  C08L83/04

    摘要： A solventless method for forming a coating on a medical electrical lead is described. The method includes combining particles of a therapeutic agent with a polymeric material in a flowable form in the absence of a solvent to form a uniform suspension. A predetermined amount of the suspension is dispensed onto a portion of the lead and is then cured to form the therapeutic agent eluting layer. Additional layers such as a primer layer, fluoro-opaque layer and/or a topcoat layer can be formed using the solventless method. Employing a solventless method may avoid contraction of the layer being formed due to solvent evaporation during the curing process, and may facilitate greater control over the thickness of the therapeutic agent eluting coating.

    摘要翻译： 描述了用于在医用电线上形成涂层的无溶剂方法。 该方法包括在不存在溶剂的情况下将治疗剂的颗粒与可流动形式的聚合物材料组合以形成均匀的悬浮液。 将预定量的悬浮液分配到引线的一部分上，然后固化以形成治疗剂洗脱层。 可以使用无溶剂法形成附加层，例如底漆层，氟不透明层和/或顶涂层。 使用无溶剂方法可以避免在固化过程中由于溶剂蒸发而形成的层的收缩，并且可以有助于更好地控制治疗剂洗脱涂层的厚度。

    Removable cap for tissue-insertable connections
    9.
    发明授权
    Removable cap for tissue-insertable connections 有权
    用于组织可插入连接的可拆卸盖

    公开(公告)号：US07089046B2

    公开(公告)日：2006-08-08

    申请号：US10187514

    申请日：2002-07-02

    申请人： Ronald W. Heil, Jr. ,  Gregory R. Ley ,  Dwight Skinner ,  Larry L. Hum

    发明人： Ronald W. Heil, Jr. ,  Gregory R. Ley ,  Dwight Skinner ,  Larry L. Hum

    IPC分类号： A61B5/04

    CPC分类号： A61N1/0573

    摘要： A helical element for insertion into tissue comprises a helical element having an insertion end, a protruding end and an open central area within the wire, rods, filaments, cables or the like that form the helix. The helical element has at least its insertion end covered by a cap of a water-soluble or water-dispersible composition. The cap is provided with a surface shape in a cross-section in which surface variations are present in the cross-section which create a surface orientation where a line from the center of the cross-section can intersect the surface, and a line perpendicular to said radius at a point of intersection with said surface forms four quadrants, three of said quadrants containing water-soluble or water-dispersible cap material. There is either a hollow area within the composition within the open central area or the material is more porous than the remaining material. The helical element preferably comprises an electrical lead, such as a positive endocardial lead, with an electrode at the protruding or distal end of the lead.The helical element may comprise any biocompatable material with sufficient structural integrity to provide a secure attachment to tissue in a patient. Where the helical element is also to provide an active (electrically active) function, the composition of the helical element should also be electrically conductive.

    摘要翻译： 用于插入组织的螺旋元件包括螺旋元件，其具有插入端，突出端和形成螺旋的线内的开口中心区域，杆，细丝，电缆等。 螺旋元件的至少其插入端被水溶性或水分散性组合物的盖子覆盖。 该盖在横截面中具有表面形状，其中在横截面中存在表面变化，其形成表面取向，其中横截面中心的线可以与表面相交，并且垂直于 在与所述表面的交点处的所述半径形成四个象限，所述象限中的三个包含水溶性或水分散性盖材料。 组合物中的中空区域在开放的中心区域内，或者材料比剩余的材料多孔。 螺旋元件优选地包括电引线，例如正心内膜引线，在引线的突出或远端具有电极。

    Removable cap for tissue-insertable connections
    10.
    发明授权
    Removable cap for tissue-insertable connections 失效
    用于组织可插入连接的可拆卸盖

    公开(公告)号：US06473633B1

    公开(公告)日：2002-10-29

    申请号：US09363477

    申请日：1999-07-29

    申请人： Ronald W. Heil, Jr. ,  Gregory R. Ley ,  Dwight Skinner ,  Larry L. Hum

    发明人： Ronald W. Heil, Jr. ,  Gregory R. Ley ,  Dwight Skinner ,  Larry L. Hum

    IPC分类号： A61B5042

    CPC分类号： A61N1/0573

    摘要： A helical element for insertion into tissue comprises a helical element having an insertion end, a protruding end and an open central area within the wire, rods, filaments, cables or the like that form the helix. The helical element has at least its insertion end covered by a cap of a water-soluble or water-dispersible composition. The cap is provided with a surface shape in a cross-section in which surface variations are present in the cross-section which create a surface orientation where a line from the center of the cross-section can intersect the surface, and a line perpendicular to said radius at a point of intersection with said surface forms four quadrants, three of said quadrants containing water-soluble or water-dispersible cap material. There is either a hollow area within the composition within the open central area or the material is more porous than the remaining material. The helical element preferably comprises an electrical lead, such as a positive endocardial lead, with an electrode at the protruding or distal end of the lead. The helical element may comprise any biocompatable material with sufficient structural integrity to provide a secure attachment to tissue in a patient. Where the helical element is also to provide an active (electrically active) function, the composition of the helical element should also be electrically conductive.

    摘要翻译： 用于插入组织的螺旋元件包括螺旋元件，其具有插入端，突出端和形成螺旋的线内的开口中心区域，杆，细丝，电缆等。 螺旋元件的至少其插入端被水溶性或水分散性组合物的盖子覆盖。 盖在横截面中设置有表面形状，其中在横截面中存在表面变化，其产生表面取向，其中横截面中心的线可以与表面相交，并且垂直于 在与所述表面的交点处的所述半径形成四个象限，所述象限中的三个包含水溶性或水分散性盖材料。 组合物中的中空区域在开放的中心区域内，或者材料比剩余的材料多孔。 螺旋元件优选地包括电引线，例如正性心内膜引线，在引线的突出或远端具有电极。螺旋元件可以包括具有足够结构完整性的任何可生物相容的材料，以提供与 患者。 当螺旋元件也提供活性（电活性）功能时，螺旋元件的组成也应当是导电的。