Modulation of miRNA Activity
    3.
    发明申请
    Modulation of miRNA Activity 审中-公开
    调节miRNA活性

    公开(公告)号:US20120184457A1

    公开(公告)日:2012-07-19

    申请号:US13389159

    申请日:2010-08-06

    CPC classification number: C12Q1/485 G01N33/573 G01N2333/9125 G01N2500/02

    Abstract: Provided is a method of identifying a compound which modulates miRNA activity comprising (i) determining the ability of a test compound to alter the polyuridylation activity of a ZCCHC polypeptide wherein a test compound which alters the polyuridylation activity is useful in modulating miRNA activity; or (ii) determining the ability of a test compound to alter the binding of a ZCCHC polypeptide to a LIN28 polypeptide, wherein a test compound which alters said binding may be useful in modulating miRNA activity; or (iii) determining the ability of a test compound to bind to a ZCCHC polypeptide, wherein a test compound which binds to the ZCCHC polypeptide may be useful in modulating miRNA activity.

    Abstract translation: 提供了鉴定调节miRNA活性的化合物的方法,其包括(i)测定测试化合物改变ZCCHC多肽的多聚尿苷酸化活性的能力,其中改变多聚尿苷酸化活性的测试化合物可用于调节miRNA活性; 或(ii)测定测试化合物改变ZCCHC多肽与LIN28多肽的结合的能力,其中改变所述结合的测试化合物可用于调节miRNA活性; 或(iii)测定测试化合物结合ZCCHC多肽的能力,其中与ZCCHC多肽结合的测试化合物可用于调节miRNA活性。

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