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    Implantation of encapsulated biological materials for treating diseases
    3.
    发明授权
    Implantation of encapsulated biological materials for treating diseases 失效
    植入包封的生物材料用于治疗疾病

    公开(公告)号：US07427415B2

    公开(公告)日：2008-09-23

    申请号：US10684859

    申请日：2003-10-14

    申请人： David Scharp ,  Paul Latta ,  Chengyun Yue ,  Xiaojie Yu ,  Jeffrey Alan Hubbell

    发明人： David Scharp ,  Paul Latta ,  Chengyun Yue ,  Xiaojie Yu ,  Jeffrey Alan Hubbell

    IPC分类号： A61K9/16

    CPC分类号： C12N11/08 ,  A61K9/0024 ,  A61K9/5031 ,  A61K9/5036 ,  A61K2035/126 ,  C12N5/0012 ,  C12N5/0677 ,  C12N11/04 ,  C12N2533/30 ,  C12N2533/74

    摘要： The present invention relates to compositions and methods of treating a disease, such as diabetes, by implanting encapsulated biological material into a patient in need of treatment. This invention provides for the placement of biocompatible coating materials around biological materials using photopolymerization while maintaining the pre-encapsulation status of the biological materials. Several methods are presented to accomplish coating several different types of biological materials. The coatings can be placed directly onto the surface of the biological materials or onto the surface of other coating materials that hold the biological materials. The components of the polymerization reactions that produce the coatings can include natural and synthetic polymers, macromers, accelerants, cocatalysts, photoinitiators, and radiation. This invention also provides methods of utilizing these encapsulated biological materials to treat different human and animal diseases or disorders by implanting them into several areas in the body including the subcutaneous site. The coating materials can be manipulated to provide different degrees of biocompatibility, protein diffusivity characteristics, strength, and biodegradability to optimize the delivery of biological materials from the encapsulated implant to the host recipient while protecting the encapsulated biological materials from destruction by the host inflammatory and immune protective mechanisms without requiring long-term anti-inflammatory or anti-immune treatment of the host.

    摘要翻译： 本发明涉及通过将包封的生物材料植入需要治疗的患者中来治疗疾病如糖尿病的组合物和方法。 本发明提供了使用光聚合在生物材料周围放置生物相容性涂层材料，同时保持生物材料的预包封状态。 提出了几种方法来完成涂覆几种不同类型的生物材料。 涂层可以直接放置在生物材料的表面上或其它涂覆材料的表面上。 产生涂层的聚合反应的组分可以包括天然和合成聚合物，大分子单体，促进剂，助催化剂，光引发剂和辐射。 本发明还提供了利用这些封装的生物材料通过将它们植入包括皮下部位在内的身体的若干区域来治疗不同的人和动物疾病或病症的方法。 可以操作涂层材料以提供不同程度的生物相容性，蛋白质扩散性特征，强度和生物降解性，以优化从包封的植入物到宿主受体的生物材料递送，同时保护封装的生物材料免受宿主炎症和免疫的破坏 不需要对宿主进行长期抗炎或抗免疫治疗的保护机制。

    IMPLANTATION OF ENCAPSULATED BIOLOGICAL MATERIALS FOR TREATING DISEASES
    4.
    发明申请
    IMPLANTATION OF ENCAPSULATED BIOLOGICAL MATERIALS FOR TREATING DISEASES 审中-公开
    用于治疗疾病的包埋生物材料的植入

    公开(公告)号：US20090004238A1

    公开(公告)日：2009-01-01

    申请号：US12197040

    申请日：2008-08-22

    申请人： David Scharp ,  Paul Latta ,  Chengyun Yue ,  Xiaojie Yu ,  Jeffrey Alan Hubbell

    发明人： David Scharp ,  Paul Latta ,  Chengyun Yue ,  Xiaojie Yu ,  Jeffrey Alan Hubbell

    IPC分类号： A61K45/00 ,  A61P25/00 ,  A61P9/00 ,  A61P17/00 ,  A61P3/00 ,  A61P37/00 ,  A61K9/48

    CPC分类号： C12N11/08 ,  A61K9/0024 ,  A61K9/5031 ,  A61K9/5036 ,  A61K2035/126 ,  C12N5/0012 ,  C12N5/0677 ,  C12N11/04 ,  C12N2533/30 ,  C12N2533/74

    摘要： Methods of applying biocompatible coating materials around biological materials using photopolymerization while maintaining the pre-encapsulation status of the biological materials are disclosed. The coatings can be placed directly onto the surface of the biological materials or onto the surface of other coating materials that hold the biological materials. The components of the polymerization reactions that produce the coatings can include natural and synthetic polymers, macromers, accelerants, cocatalysts, photoinitiators, and radiation. Methods of utilizing these encapsulated biological materials to treat different human and animal diseases or disorders by implanting them into several areas in the body including the subcutaneous site are also disclosed. The coating materials can be manipulated to provide different degrees of biocompatibility, protein diffusivity characteristics, strength, and biodegradability to optimize the delivery of biological materials from the encapsulated implant to the host recipient while protecting the encapsulated biological materials from destruction by the host inflammatory and immune protective mechanisms without requiring long-term anti-inflammatory or anti-immune treatment of the host.

    摘要翻译： 公开了在保持生物材料的预包封状态的同时使用光聚合在生物材料周围应用生物相容性涂层材料的方法。 涂层可以直接放置在生物材料的表面上或其它涂覆材料的表面上。 产生涂层的聚合反应的组分可以包括天然和合成聚合物，大分子单体，促进剂，助催化剂，光引发剂和辐射。 还公开了利用这些包封的生物材料通过将它们植入体内包括皮下部位的几个区域来治疗不同的人和动物疾病或病症的方法。 可以操作涂层材料以提供不同程度的生物相容性，蛋白质扩散性特征，强度和生物降解性，以优化从包封的植入物到宿主受体的生物材料递送，同时保护封装的生物材料免受宿主炎症和免疫的破坏 不需要对宿主进行长期抗炎或抗免疫治疗的保护机制。