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公开(公告)号：US06236075B1
公开(公告)日：2001-05-22
申请号：US09266420
申请日：1999-03-10
申请人： Shen-Kan Hsiung , Jung-Chuan Chou , Tai-Ping Sun , Wen Yaw Chung , Hung-Kwei Liao , Chung-Lin Wu
发明人： Shen-Kan Hsiung , Jung-Chuan Chou , Tai-Ping Sun , Wen Yaw Chung , Hung-Kwei Liao , Chung-Lin Wu
IPC分类号： H01L2358
CPC分类号： G01N27/414
摘要： The present invention discloses a method of forming a metal layer by thermal evaporation or RF reactive sputtering in order to fabricate a light shielding layer for an ion sensitive field effect transistor. The multi-layered construction of the ion sensitive field effect transistor with a metal thin film as a light shielding layer is SnO2/metal/SiO2 or SnO2/metal/Si3N4/SiO2, and is able to lower the effect of light successfully.
摘要翻译： 本发明公开了一种通过热蒸镀或RF反应溅射形成金属层的方法，以制造用于离子敏感场效应晶体管的遮光层。 具有金属薄膜作为遮光层的离子敏感场效应晶体管的多层结构是SnO 2 /金属/ SiO 2或SnO 2 /金属/ Si 3 N 4 / SiO 2，并且能够成功地降低光的效果。
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2.发明授权Fabrication of a multi-structure ion sensitive field effect transistor with a pH sensing layer of a tin oxide thin film 有权制造具有氧化锡薄膜的pH感应层的多结构离子敏感场效应晶体管公开(公告)号：US06218208B1
公开(公告)日：2001-04-17
申请号：US09347226
申请日：1999-07-02
IPC分类号： H01L2100
CPC分类号： G01N27/414
摘要： A sensitive material-tin oxide (SnO2) obtained by thermal evaporation or by r.f. reactive sputtering is used as a high-pH-sensitive material for a Multi-Structure Ion Sensitive Field Effect Transistor. The multi-structure of this Ion Sensitive Field Effect Transistor (ISFET) includes SnO2/SiO2 gate ISFET or SnO2/Si3N4/SiO2 gate ISFET respectively, and which have high performances such as a linear pH sensitivity of approximately 56˜58 mV/pH in a concentration range between pH2 and pH10. A low drift characteristics of approximately 5 mv/day, response time is less than 0.1 second, and an isothermal point of this ISFET sensor can be obtained if the device operates with an adequate drain-source current. In addition, this invention has other advantages, such as the inexpensive fabrication system, low cost, and mass production characteristics. Based on these characteristics, a disposal sensing device can be achieved. Thus, this invention has a high feasibility in Ion Sensitive Field Effect Transistor.
摘要翻译： 通过热蒸发或r.f.获得的敏感材料 - 氧化锡（SnO 2）。 反应溅射用作多结构离子敏感场效应晶体管的高pH敏感材料。 该离子敏感场效应晶体管（ISFET）的多结构分别包括SnO 2 / SiO 2栅极ISFET或SnO 2 / Si 3 N 4 / SiO 2栅极ISFET，并且具有高性能，例如约56〜58mV / pH的线性pH灵敏度 pH2和pH10之间的浓度范围。 大约5mv /天的低漂移特性，响应时间小于0.1秒，如果器件以足够的漏源电流工作，则可以获得该ISFET传感器的等温点。 此外，本发明还具有廉价的制造系统，低成本和批量生产特性等其它优点。 基于这些特性，可以实现处置感测装置。 因此，本发明在离子敏感场效应晶体管中具有很高的可行性。
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公开(公告)号：US07638157B2
公开(公告)日：2009-12-29
申请号：US11533358
申请日：2006-09-19
申请人： Shen-Kan Hsiung , Jung-Chuan Chou , Tai-Ping Sun , Wen-Yaw Chung , Li-Te Yin , Chung-We Pan
发明人： Shen-Kan Hsiung , Jung-Chuan Chou , Tai-Ping Sun , Wen-Yaw Chung , Li-Te Yin , Chung-We Pan
IPC分类号： G01N1/28
CPC分类号： C12Q1/006 , C12N9/0006 , C12N11/08
摘要： A method of fabricating an electrode assembly of a sensor is described. The sensor has a field effect transistor. The electrode assembly is separated from the field effect transistor by only a conductive line. The sensor is functioned to detect different glucose concentrations. A solid layer of tin oxide is deposited on a substrate board. A β-D-glucose oxidase and polyvinyl alcohol bearing styrylpyridinium groups are placed in 100 μl of sulfuric acid, to form an enzyme mixture. The enzyme mixture is dropped on the solid layer of tin oxide. The enzyme mixture is dried. The enzyme mixture is exposed to a UV ray. The enzyme mixture is dried and stabilized. The enzyme mixture is immersed in a sulfuric buffer.
摘要翻译： 描述了制造传感器的电极组件的方法。 该传感器具有场效应晶体管。 电极组件仅通过导线与场效应晶体管分离。 该传感器用于检测不同的葡萄糖浓度。 在基板上沉积固体氧化锡层。 将β-D-葡萄糖氧化酶和含有苯乙烯基吡啶鎓基团的聚乙烯醇基团置于100毫升硫酸中以形成酶混合物。 将酶混合物滴在氧化锡的固体层上。 将酶混合物干燥。 将酶混合物暴露于紫外线。 将酶混合物干燥并稳定。 将酶混合物浸入硫酸缓冲液中。
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公开(公告)号：US20070023286A1
公开(公告)日：2007-02-01
申请号：US11533358
申请日：2006-09-19
申请人： Shen-Kan Hsiung , Jung-Chuan Chou , Tai-Ping Sun , Wen-Yaw Chung , Li-Te Yin , Chung-We Pan
发明人： Shen-Kan Hsiung , Jung-Chuan Chou , Tai-Ping Sun , Wen-Yaw Chung , Li-Te Yin , Chung-We Pan
IPC分类号： C12Q1/00 , C12M1/00 , C12N11/00 , C12N9/00 , C25B11/00 , C25B13/00 , C25B9/00 , G01N1/00 , G01N27/26 , G01N31/00 , G01N33/50
CPC分类号： C12Q1/006 , C12N9/0006 , C12N11/08
摘要： A method of fabricating an electrode assembly of a sensor is described. The sensor has a field effect transistor. The electrode assembly is separated from the field effect transistor by only a conductive line. The sensor is functioned to detect different glucose concentrations. A solid layer of tin oxide is deposited on a substrate board. A β-D-glucose oxidase and polyvinylalchol bearing styrylpyridinium groups are placed in 100 μl of sulfuric acid, to form an enzyme mixture. The enzyme mixture is dropped on the solid layer of tin oxide. The enzyme mixture is dried. The enzyme mixture is exposed to a UV ray. The enzyme mixture is dried and stabilized. The enzyme mixture is immersed in a sulfuric buffer.
摘要翻译： 描述了制造传感器的电极组件的方法。 传感器具有场效应晶体管。 电极组件仅通过导线与场效应晶体管分离。 该传感器用于检测不同的葡萄糖浓度。 在基板上沉积固体氧化锡层。 将含有苯乙烯基吡啶鎓基团的β-D-葡萄糖氧化酶和聚乙烯基基团置于100毫升硫酸中以形成酶混合物。 将酶混合物滴在氧化锡的固体层上。 将酶混合物干燥。 将酶混合物暴露于紫外线。 将酶混合物干燥并稳定。 将酶混合物浸入硫酸缓冲液中。
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公开(公告)号：US07736478B2
公开(公告)日：2010-06-15
申请号：US11515727
申请日：2006-09-06
IPC分类号： G01N27/333
CPC分类号： G01N27/4035
摘要： An ion solution concentration-detecting device includes a working electrode, a reference electrode, and a link element. The working electrode and the reference electrode are inserted into the link element. The working electrode, inserted into the link element, is replaceable, for the better sensitivity to the different ion solution. The working electrode being a contact-detecting electrode can be replaced by another contact-detecting electrode with different sensing membrane. The reference electrode includes a polymeric membrane with ion material covering silver/silver chloride (Ag/AgCl) electrode to provide a fixed and stable electrical potential. The working electrode may be a contact-detecting electrode having a sensing membrane. The sensing membrane may be a metal oxide or a polymer with ion material for measuring different ion solution effectively.
摘要翻译： 离子溶液浓度检测装置包括工作电极，参考电极和连接元件。 工作电极和参考电极插入到连接元件中。 插入连接元件的工作电极是可更换的，以便更好地对不同离子溶液的敏感性。 作为接触检测电极的工作电极可以由具有不同传感膜的另一接触检测电极代替。 参考电极包括具有覆盖银/氯化银（Ag / AgCl）电极的离子材料的聚合物膜，以提供固定和稳定的电势。 工作电极可以是具有感测膜的接触检测电极。 感测膜可以是金属氧化物或具有用于有效测量不同离子溶液的离子材料的聚合物。
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公开(公告)号：US20090119026A1
公开(公告)日：2009-05-07
申请号：US11933809
申请日：2007-11-01
IPC分类号： G01N31/00 , G01N27/416 , G06F19/00
CPC分类号： G01N27/4148 , G01N27/333
摘要： A portable multi-ions sensing system is provided. The sensing system includes: a sensing unit for sensing a pH value and a plurality of ion concentrations of a solution and outputting a sensing signal, wherein the sensing unit includes: a substrate; an ITO layer on the substrate; a sensing layer on the ITO layer and connected with an extended lead; a packaging layer encapsulating the sensing layer, the ITO layer and a portion of the substrate with a sensing window for exposing a portion of the sensing layer; a multi-ions selective layer on the portion of the sensing layer exposed by the sensing window for sensing the ion concentrations; and a reference electrode for providing a reference potential for the sensing layer; an analog signal processing unit for receiving, filtering, amplifying and adjusting the level of the sensing signal and outputting a front-end signal; a microcontroller unit for receiving and performing analog/digital converting and two-point correcting processes on the front-end signal and outputting a measurement data; and a real-time display unit for receiving and displaying the measurement data.
摘要翻译： 提供便携式多离子感测系统。 感测系统包括：感测单元，用于感测溶液的pH值和多个离子浓度并输出感测信号，其中感测单元包括：基底; 衬底上的ITO层; ITO层上的传感层，并与延伸引线连接; 封装层，其将所述感测层，所述ITO层和所述衬底的一部分封装以具有用于暴露所述感测层的一部分的感测窗口; 感测层暴露在感测窗口的部分上的多离子选择层，用于感测离子浓度; 以及用于为感测层提供参考电位的参考电极; 模拟信号处理单元，用于接收，滤波，放大和调整感测信号的电平并输出前端信号; 微控制器单元，用于接收并执行前端信号的模拟/数字转换和两点校正处理，并输出测量数据; 以及用于接收和显示测量数据的实时显示单元。
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公开(公告)号：US20060021874A1
公开(公告)日：2006-02-02
申请号：US11137551
申请日：2005-05-26
IPC分类号： G01N27/327 , H01R43/16
CPC分类号： G01N27/401 , Y10T29/49206
摘要： In this present invention it was fabricated to be relates to manufacturing a ceramic interface electrochemical reference electrode for use together with biomedical sensors. Most potentiometric biomedical sensors must have the need to be connected to a reference electrode to offer the readout circuit a stable voltage in the different solutions when measuring for providing that can provide a standard comparing voltage to avoid measuring errors caused by an unstable environment. Usually, However, the presently available commercial reference electrode we used is too big in size and inconvenient to store. For this reason we develop the ceramic interface electrochemical reference electrode which can minimize volume and need not to be preserved in the saturated solution for biosensor. Therefore, the ceramic interface electrochemical reference electrode of the present invention does not need to be stored in solution and can be minimized for use in future sensors. In addition, the present invention also relates to a ceramic interface electrochemical reference electrode.
摘要翻译： 在本发明中，其制造涉及制造与生物医学传感器一起使用的陶瓷界面电化学参考电极。 大多数电位生物医学传感器必须需要连接到参考电极，以便在测量时提供不同解决方案中的稳定电压，以提供可提供标准比较电压以避免由不稳定环境引起的测量误差。 通常，然而，我们使用的目前可用的商业参考电极的尺寸太大并且不方便存储。 为此，我们开发了陶瓷界面电化学参比电极，可以使体积最小化，不需要保留在生物传感器的饱和溶液中。 因此，本发明的陶瓷界面电化学参考电极不需要存储在溶液中，并且可以最小化以用于将来的传感器。 此外，本发明还涉及陶瓷界面电化学参考电极。
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公开(公告)号：US20090038940A1
公开(公告)日：2009-02-12
申请号：US12168992
申请日：2008-07-08
IPC分类号： G01N27/30
CPC分类号： G01N27/301
摘要： The present invention discloses a reference electrode. According to the invention, a capillary structure is plugged in a solid state electrolyte layer of the reference electrode. By capillary phenomenon, a test solution is sucked to the solid state electrolyte layer to have reaction. Therefore, according to the invention, a test solution can be measured by simply placing the capillary structure of the reference electrode into the test solution. The lifetime of the reference electrode can be greatly extended.
摘要翻译： 本发明公开了一种参比电极。 根据本发明，毛细管结构被插入参考电极的固态电解质层中。 通过毛细管现象，将测试溶液吸入固态电解质层进行反应。 因此，根据本发明，可以通过简单地将参考电极的毛细结构置于测试溶液中来测量测试溶液。 参考电极的寿命可以大大延长。
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公开(公告)号：US20090021740A1
公开(公告)日：2009-01-22
申请号：US11778672
申请日：2007-07-17
CPC分类号： G01N33/4915 , G01N21/78 , G01N33/4925
摘要： The present invention discloses an optical sensor for measuring blood gas, used to measure gas concentration in a liquid, comprising: an indicator solution; a first conduit for filling with the indicator solution wherein the first conduit passes through the liquid and the gas in the liquid can diffuse into the first conduit to react with the indicator solution so as to change the color of the indicator solution; a second conduit for receiving the reacted indicator solution in the first conduit; and a light emitter and a photodetector provided in opposition to each other at the two sides of the second conduit wherein the light emitter emits light towards the second conduit and the photodetector receives the light passing through the second conduit and the reacted indicator solution and thereby outputs a sensing signal depending on the received light intensity.
摘要翻译： 本发明公开了一种用于测量血液中的气体浓度的血液测量用光学传感器，包括：指示剂溶液; 用于填充指示剂溶液的第一管道，其中第一管道通过液体并且液体中的气体可以扩散到第一管道中以与指示剂溶液反应以改变指示剂溶液的颜色; 用于在第一导管中接收反应的指示剂溶液的第二导管; 以及在第二导管的两侧彼此相对设置的光发射器和光电检测器，其中光发射器朝向第二导管发射光，并且光电检测器接收通过第二导管和反应的指示剂溶液的光，从而输出 感测信号取决于接收的光强度。
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公开(公告)号：US20080194040A1
公开(公告)日：2008-08-14
申请号：US11949563
申请日：2007-12-03
IPC分类号： G01N21/00
CPC分类号： G01N21/783
摘要： An optical gas concentration sensor and method for measuring blood gas based on the light adsorption sensing technique are disclosed. The optical gas concentration sensor comprises a light source, a photo detector, and a gas filtering membrane for separating the indicator and a liquid. A gas in the liquid diffuses to the indicator through the gas filtering membrane so as to change the color of the indicator due to the chemical reaction occurred between the indicator and the gas. Then, the photo detector receives the light passing though the reacted indicator from the light source. The gas concentration is determined based on pH-sensitive absorbance spectrum of the indicator.
摘要翻译： 公开了一种基于光吸收传感技术测量血液气体的光学气体浓度传感器和方法。 光学气体浓度传感器包括用于分离指示剂和液体的光源，光电检测器和气体过滤膜。 液体中的气体通过气体过滤膜扩散到指示器，以便由于指示剂和气体之间发生化学反应而改变指示器的颜色。 然后，光检测器从光源接收通过反应指示器的光。 基于指示剂的pH敏感吸收光谱确定气体浓度。
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