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21 条记录 (耗时 0.019 秒)

    Process for preparing cephalosporanic acid derivatives
    4.
    发明授权
    Process for preparing cephalosporanic acid derivatives 失效
    制备头孢菌酸衍生物的方法

    公开(公告)号：US4175185A

    公开(公告)日：1979-11-20

    申请号：US892179

    申请日：1978-03-31

    申请人： Shigeo Seki ,  Satoru Nakabayashi ,  Toshinori Saito ,  Shunzo Fukatsu ,  Shokichi Nakajima ,  Toshiyasu Ishimaru

    发明人： Shigeo Seki ,  Satoru Nakabayashi ,  Toshinori Saito ,  Shunzo Fukatsu ,  Shokichi Nakajima ,  Toshiyasu Ishimaru

    IPC分类号： C07D501/20 ,  C07D501/26

    CPC分类号： C07D501/26

    摘要： A process for preparing a cephalosporanic acid derivative or a 7-acylaminocephalosporanic acid derivative which comprises subjecting an esterifying agent to reaction in liquid sulfur dioxide in the presence of a base with an N-protected-cephalosporin C to obtain a diester, subjecting the diester to reaction in an inert solvent with an iminohalide forming agent to produce an iminohalide, subjecting the iminohalide with a lower alcohol to produce an iminoether, subjecting the product produced, after subjecting the iminoether to reaction with a reactive derivative of an organic acid, to hydrolysis and further eliminating the ester group of the carboxylic acid.

    摘要翻译： 一种制备头孢菌酸衍生物或7-酰氨基头孢烷酸衍生物的方法，其包括在碱存在下，用N-保护型头孢菌素C使酯化剂在液态二氧化硫中进行反应，得到二酯， 在惰性溶剂中与亚氨基卤化物形成剂反应以产生亚氨基卤化物，使亚氨基卤化物与低级醇反应生成亚氨基醚，使亚氨基醚与有机酸的反应性衍生物反应后生成的产物水解和 进一步消除羧酸的酯基。

    Absolute signal detecting method and absolute encoder
    5.
    发明授权
    Absolute signal detecting method and absolute encoder 失效
    绝对信号检测方法和绝对编码器

    公开(公告)号：US5774068A

    公开(公告)日：1998-06-30

    申请号：US560575

    申请日：1995-11-20

    申请人： Shigeo Seki

    发明人： Shigeo Seki

    IPC分类号： G01D5/245 ,  H03M1/28 ,  H03M1/30 ,  G08C19/00

    CPC分类号： G01D5/2455 ,  H03M1/282 ,  H03M1/308

    摘要： A code plate has an m-bit signal track read out in parallel for providing the starting position of an AC servo motor for commencing rotation when power is first turned ON. An n-bit signal track accompanied by an incremental signal track is provided on the code plate with the n-bit track read out serially, converted to pure binary in parallel, and used once rotation of the servo motor commences to provide the initial absolute value of the encoder. To this n-bit initial value is added signals from the incremental track upon continued rotation of the code plate.

    摘要翻译： 代码板具有并行读出的m位信号轨道，用于在电源首次接通时提供用于开始旋转的AC伺服电动机的起始位置。 伴随着增量信号轨迹的n位信号轨迹被提供在码板上，其中n位磁道串行读出，并行转换成纯二进制，并且一旦伺服电动机的旋转开始提供初始绝对值， 的编码器。 对于该n位初始值，在代码板继续旋转时，从增量轨道添加信号。

    3',4'-Episulfido kanamycin B compounds
    6.
    发明授权
    3',4'-Episulfido kanamycin B compounds 失效
    3'，4'-二硫代卡那霉素B化合物

    公开(公告)号：US4195170A

    公开(公告)日：1980-03-25

    申请号：US880401

    申请日：1978-02-23

    申请人： Hamao Umezawa ,  Sumio Umezawa ,  Shigeo Seki ,  Shunzo Fukatsu ,  Shuntaro Yasuda

    发明人： Hamao Umezawa ,  Sumio Umezawa ,  Shigeo Seki ,  Shunzo Fukatsu ,  Shuntaro Yasuda

    IPC分类号： C07H15/236 ,  C07H15/22

    CPC分类号： C07H15/234 ,  Y02P20/55

    摘要： New routes are provided for the synthesis of 3',4'-dideoxykanamycin B which is effective in inhibiting kanamycin-resistant organisms from kanamycin B through new intermediate, of which a fundamental process comprises a new reaction of a 3',4'-epoxy derivative of amino- and hydroxyl-protected kanamycin B with a xanthate to form a corresponding 3',4'-dideoxy-3'-eno derivative followed by removal of the amino- and hydroxyl-protecting groups thereof and by hydrogenation of the resulting 3',4'-dideoxy-3'-eno-kanamycin B. A 3',4'-episulfide derivative corresponding to the 3',4'-epoxy derivative which is formed as second product in the reaction of 3',4'-epoxy derivative with xanthate is also used as intermediate for the preparation of 3',4'-dideoxykanamycin B.

    摘要翻译： 提供了用于合成3'，4'-双脱氧卡那霉素B的新途径，其通过新的中间体有效抑制卡那霉素B的卡那霉素抗性生物，其中基本方法包括3'，4'-环氧基 氨基和羟基保护的卡那霉素B与黄原酸酯的衍生物形成相应的3'，4'-二脱氧-3'-烯衍生物，然后除去其氨基和羟基保护基团，并通过氢化得到的3 '，4'-二脱氧-3'-烯 - 卡那霉素B.对应于3'，4'-环氧衍生物的3'，4'-环硫化物衍生物，其在3'，4' 含有黄原酸酯的环氧衍生物也用作制备3'，4'-双脱氧卡那霉素B的中间体。

    3-Halo-cephalosporins
    7.
    发明授权
    3-Halo-cephalosporins 失效
    3-卤代头孢菌素

    公开(公告)号：US3963712A

    公开(公告)日：1976-06-15

    申请号：US350199

    申请日：1973-04-11

    申请人： Masao Koyama ,  Shigeo Seki

    发明人： Masao Koyama ,  Shigeo Seki

    IPC分类号： A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D501/10 ,  C07D501/14

    CPC分类号： C07D501/10 ,  C07D501/14

    摘要： A novel ester of 7-acylamido-3-methyl-cepham-4-carboxylic acid derivative and a process for the preparation thereof which comprises reacting penicillin sulfoxide ester with the metal halide, and a novel 7-acylamido-3-methyl-cepham-4-carboxylic acid derivative and a process for the preparation thereof which comprises reacting penicillin sulfoxide ester with the metal halide and decomposing the resultant in a reductive atmosphere.

    摘要翻译： 一种7-酰基氨基-3-甲基 - 头孢烯-4-羧酸衍生物的新型酯及其制备方法，其包括使青霉素亚砜酯与金属卤化物反应，以及新的7-酰基氨基-3-甲基 - 头孢烯-4-羧酸衍生物， 4-羧酸衍生物及其制备方法，其包括使青霉素亚砜酯与金属卤化物反应并在还原气氛中分解所得物。

    Process for the preparation of 7-amino-cephem compounds using mold fungi
    8.
    发明授权
    Process for the preparation of 7-amino-cephem compounds using mold fungi 失效
    使用霉菌制备7-氨基头孢烯化合物的方法

    公开(公告)号：US4141790A

    公开(公告)日：1979-02-27

    申请号：US796194

    申请日：1977-05-12

    申请人： Tomizo Niwa ,  Chuhei Nojiri ,  Hitoshi Goi ,  Shinji Miyado ,  Fumio Kai ,  Shigeo Seki ,  Yujiro Yamada ,  Taro Niida

    发明人： Tomizo Niwa ,  Chuhei Nojiri ,  Hitoshi Goi ,  Shinji Miyado ,  Fumio Kai ,  Shigeo Seki ,  Yujiro Yamada ,  Taro Niida

    IPC分类号： C07D501/20 ,  C07D501/18 ,  C12P35/02 ,  C12D9/04

    CPC分类号： C12P35/02 ,  Y10S435/911 ,  Y10S435/913

    摘要： Compounds are provided having the general formula I: ##STR1## wherein X represents an hydroxyl group, an acetoxy group or a thiosulfuric acid residue. The formula I compounds are prepared from compounds of the general formula II: ##STR2## wherein R.sub.1 represents hydrogen, a lower alkanoyl group, an arylalkanoyl group, an alkoxycarbonyl group, a lower haloalkoxycarbonyl group, a substituted or unsubstituted aroyl group, a N-arylcarbamoyl group of a substituted or unsubstituted aryl group; R.sub.2 either represents hydrogen or, together with the ##STR3## group, represents a phthalimido group; and X represents an hydroxyl group, an acetoxy group or a thiosulfuric acid residue, or their metal salts or their salts with organic bases, by causing the culture of a cephalosporin C acylase-producing strain of a microorganism, especially a mold, fungus, or the secondary preparation therefrom, to act on the latter compounds II in the presence of an aqueous medium.

    摘要翻译： 提供具有通式I的化合物：其中X表示羟基，乙酰氧基或硫代硫酸残基。 式I化合物由通式II的化合物制备：其中R 1表示氢，低级烷酰基，芳基烷酰基，烷氧基羰基，低级卤代烷氧基羰基，取代或未取代的芳酰基，N 取代或未取代的芳基的芳基氨基甲酰基; R2或者表示氢，或者与组一起代表苯二甲酰亚氨基; X表示羟基，乙酰氧基或硫代硫酸残基，或其与有机碱的金属盐或其盐，通过使微生物的头孢菌素C酰基转移酶生产菌株，特别是霉菌，真菌或 其中的二次制剂在水性介质的存在下作用于后面的化合物II。

    3',4'-Diedeoxykanamycin B derivatives
    9.
    发明授权
    3',4'-Diedeoxykanamycin B derivatives 失效
    3'，4'-脱氧卡那霉素B衍生物

    公开(公告)号：US4357465A

    公开(公告)日：1982-11-02

    申请号：US187014

    申请日：1980-09-15

    申请人： Hamao Umezawa ,  Sumio Umezawa ,  Shigeo Seki ,  Shunzo Fukatsu ,  Shuntaro Yasuda

    发明人： Hamao Umezawa ,  Sumio Umezawa ,  Shigeo Seki ,  Shunzo Fukatsu ,  Shuntaro Yasuda

    IPC分类号： C07H15/236 ,  A61K31/71 ,  C07H15/22

    CPC分类号： C07H15/234 ,  Y02P20/55

    摘要： New routes are provided for the synthesis of 3',4'-dideoxykanamycin B which is effective in inhibiting kanamycin-resistant organisms from kanamycin B through new intermediate, of which a fundamental process comprises a new reaction of a 3',4'-epoxy derivative of amino- and hydroxyl-protected kanamycin B with a xanthate to form a corresponding 3',4'-dideoxy-3'-eno derivative followed by removal of the amino- and hydroxyl-protecting groups thereof and by hydrogenation of the resulting 3',4'-dideoxy-3'-eno-kanamycin B. A 3',4'-episulfide derivative corresponding to the 3',4'-epoxy derivative which is formed as second product in the reaction of 3',4'-epoxy derivative with xanthate is also used as intermediate for the preparation of 3',4'-dideoxykanamycin B.

    摘要翻译： 提供了用于合成3'，4'-双脱氧卡那霉素B的新途径，其通过新的中间体有效抑制卡那霉素B的卡那霉素抗性生物，其中基本方法包括3'，4'-环氧基 氨基和羟基保护的卡那霉素B与黄原酸酯的衍生物形成相应的3'，4'-二脱氧-3'-烯衍生物，然后除去其氨基和羟基保护基团，并通过氢化得到的3 '，4'-二脱氧-3'-烯 - 卡那霉素B.对应于3'，4'-环氧衍生物的3'，4'-环硫化物衍生物，其在3'，4' 含有黄原酸酯的环氧衍生物也用作制备3'，4'-双脱氧卡那霉素B的中间体。

    "> Process for the production of a 9,3
    10.
    发明授权
    Process for the production of a 9,3"-di-acyl derivative of a macrolide antibiotic 失效
    用于生产大环内酯类抗生素的9,3“ - 二 - 酰基衍生物的方法

    公开(公告)号：US4188480A

    公开(公告)日：1980-02-12

    申请号：US933188

    申请日：1978-08-10

    申请人： Takeshi Nakamura ,  Satoru Nakabayashi ,  Shunzo Fukatsu ,  Shigeo Seki

    发明人： Takeshi Nakamura ,  Satoru Nakabayashi ,  Shunzo Fukatsu ,  Shigeo Seki

    IPC分类号： A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  C07H1/00

    CPC分类号： C07H17/08

    摘要： A 9,3"-di-acyl derivative of a macrolide antibiotic can be readily produced by reacting a macrolide antibiotic or an acyl derivative thereof with an organic acid halide, particularly an alkanoic acid halide, in a solvent and in the presence of a molecular sieve consisting of a synthetic zeolite and then de-acylating partially the resultant acylation products by a partial hydrolysis in an aqueous alcohol to give the 9,3"-di-acyl derivative of the macrolide antibiotic.

    摘要翻译： 通过使大环内酯类抗生素或其酰基衍生物与有机酰卤，特别是链烷酰卤反应，在溶剂中，并存在下可以容易地制备大环内酯类抗生素的9,3“ - 二 - 酰基衍生物 分子筛由合成沸石组成，然后通过在含水醇中部分水解将所得酰化产物部分脱酰化，得到大环内酯类抗生素的9,3“ - 二 - 酰基衍生物。