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公开(公告)号：US07678576B2
公开(公告)日：2010-03-16
申请号：US11319680
申请日：2005-12-29
申请人： Shigeyuki Sasaki , Yoshihiro Nagaoka , Noriyo Nishijima , Naruo Watanabe , Michihiro Saito , Taisaku Seino , Satoshi Takahashi
发明人： Shigeyuki Sasaki , Yoshihiro Nagaoka , Noriyo Nishijima , Naruo Watanabe , Michihiro Saito , Taisaku Seino , Satoshi Takahashi
CPC分类号： B01F11/0071 , B01F13/0059 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/1816 , B01L2400/0409 , B01L2400/0442 , B01L2400/0475 , G01N21/0332 , G01N21/07 , G01N21/645 , G01N2021/0325 , G01N2035/00148 , G01N2035/00495 , G01N2035/00534 , Y10T436/111666
摘要： The invention provides a chemical analysis apparatus which easily agitates and warms up. A chemical analysis apparatus has a motor, a retaining disc which can be rotated by the motor, a plurality of inspection cartridges which are arranged on the retaining disc, a punching machine for punching the inspection cartridges, a warming apparatus and a detection apparatus. The inspection cartridge includes a container formed by a concave portion and a base plate having a flow path. A cover covering the container and the flow path is installed to the base plate. A liquid solution is moved to the container in an outer peripheral side with respect to a rotation axis from the container in an inner peripheral side with respect to the rotation axis via the flow path, by utilizing a centrifugal force generated on the basis of the rotation of the retaining disc. The inspection cartridge is provided with an agitating means for agitating the liquid solution within the container and a warming means for warming up the liquid solution within the container.
摘要翻译： 本发明提供一种容易搅动和加热的化学分析装置。 化学分析装置具有电动机，可由电动机旋转的保持盘，设置在保持盘上的多个检查筒，冲压检查筒的冲孔机，加温装置和检测装置。 检查筒包括由凹部形成的容器和具有流路的基板。 覆盖容器和流路的盖子安装在基板上。 通过利用基于旋转产生的离心力，液体溶液在相对于旋转轴线的旋转轴线的相对于旋转轴线的内周侧的外周侧经由流路被移动到容器 的保持盘。 检查筒设置有用于搅拌容器内的液体溶液的搅拌装置和用于预热容器内的液体溶液的加温装置。
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公开(公告)号：US20060159586A1
公开(公告)日：2006-07-20
申请号：US11319680
申请日：2005-12-29
申请人： Shigeyuki Sasaki , Yoshihiro Nagaoka , Noriyo Nishijima , Naruo Watanabe , Michihiro Saito , Taisaku Seino , Satoshi Takahashi
发明人： Shigeyuki Sasaki , Yoshihiro Nagaoka , Noriyo Nishijima , Naruo Watanabe , Michihiro Saito , Taisaku Seino , Satoshi Takahashi
IPC分类号： G01N31/22
CPC分类号： B01F11/0071 , B01F13/0059 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/1816 , B01L2400/0409 , B01L2400/0442 , B01L2400/0475 , G01N21/0332 , G01N21/07 , G01N21/645 , G01N2021/0325 , G01N2035/00148 , G01N2035/00495 , G01N2035/00534 , Y10T436/111666
摘要： The invention provides a chemical analysis apparatus which easily agitates and warms up. A chemical analysis apparatus has a motor, a retaining disc which can be rotated by the motor, a plurality of inspection cartridges which are arranged on the retaining disc, a punching machine for punching the inspection cartridges, a warming apparatus and a detection apparatus. The inspection cartridge includes a container formed by a concave portion and a base plate having a flow path. A cover covering the container and the flow path is installed to the base plate. A liquid solution is moved to the container in an outer peripheral side with respect to a rotation axis from the container in an inner peripheral side with respect to the rotation axis via the flow path, by utilizing a centrifugal force generated on the basis of the rotation of the retaining disc. The inspection cartridge is provided with an agitating means for agitating the liquid solution within the container and a warming means for warming up the liquid solution within the container.
摘要翻译： 本发明提供一种容易搅动和加热的化学分析装置。 化学分析装置具有电动机，可由电动机旋转的保持盘，设置在保持盘上的多个检查筒，冲压检查筒的冲孔机，加温装置和检测装置。 检查筒包括由凹部形成的容器和具有流路的基板。 覆盖容器和流路的盖子安装在基板上。 通过利用基于旋转产生的离心力，液体溶液在相对于旋转轴线的旋转轴线的相对于旋转轴线的内周侧的外周侧经由流路被移动到容器 的保持盘。 检查筒设置有用于搅拌容器内的液体溶液的搅拌装置和用于预热容器内的液体溶液的加温装置。
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公开(公告)号：US20070025876A1
公开(公告)日：2007-02-01
申请号：US11493751
申请日：2006-07-27
IPC分类号： G01N35/00
CPC分类号： G01N35/00029 , B01L3/502715 , B01L3/50273 , B01L2200/027 , B01L2200/028 , B01L2200/10 , B01L2200/16 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2400/0409 , B01L2400/0487 , G01N1/40 , G01N21/07 , G01N33/4875 , G01N2035/00148 , G01N2035/00257 , G01N2035/00504
摘要： An analysis cartridge for use in a chemical analysis device comprises a reagent cartridge having a plurality of reagent containers formed therein to be able to contain reagents, and a reaction cartridge connected to the reagent cartridge and having a reaction container formed therein. The reagent cartridge and the reaction cartridge are each made up of a base plate and a cover covering recesses formed in a surface of the base plate. Channels for interconnecting the plurality of reagent containers and the reaction container are formed in the reagent cartridge and the reaction cartridge. The channels are formed inside the base plates of the reagent cartridge and the reaction cartridge in their connected portions. The structure of the analysis cartridge for mixing and reacting a specimen and reagents can be simplified.
摘要翻译： 用于化学分析装置的分析盒包括：试剂盒，其具有形成在其中的多个试剂容器以能够容纳试剂;以及反应盒，连接到试剂盒并具有形成在其中的反应容器。 试剂盒和反应盒各自由基板和形成在基板的表面中的盖覆盖凹部构成。 用于互连多个试剂容器和反应容器的通道形成在试剂盒和反应盒中。 通道形成在试剂盒的基板和反应盒的连接部分内。 可以简化用于混合和反应样品和试剂的分析盒的结构。
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公开(公告)号：US20060159588A1
公开(公告)日：2006-07-20
申请号：US11319159
申请日：2005-12-28
申请人： Noriyo Nishijima , Yoshihiro Nagaoka , Toshiaki Yokobayashi , Michihiro Saito , Nobuyuki Maki , Satoshi Takahashi
发明人： Noriyo Nishijima , Yoshihiro Nagaoka , Toshiaki Yokobayashi , Michihiro Saito , Nobuyuki Maki , Satoshi Takahashi
IPC分类号： G01N9/30
CPC分类号： B01L3/502753 , B01L3/502723 , B01L3/502738 , B01L7/00 , B01L2200/10 , B01L2200/16 , B01L2300/0672 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0409 , B01L2400/0688 , B01L2400/0694
摘要： A chemical analysis device has a motor, a holder disk to be rotated by the motor, a plurality of inspection cartridges, a penetrator for penetrating the inspection cartridges, a heater and a detector. The inspection cartridge has a substrate including containers formed as recesses and a flow path, and a cover is mounted on the substrate to cover the containers and flow path. By a centrifugal force generated by a rotation of the holder disk, a liquid is moved through the flow path from the container at a radially inner side with respect to a rotational axis to the container at a radially outer side with respect to the rotational axis.
摘要翻译： 化学分析装置具有电动机，由电动机旋转的保持盘，多个检查筒，穿透检查筒的穿透器，加热器和检测器。 检查盒具有包括形成为凹部和流路的容器的基板，并且在基板上安装盖以覆盖容器和流路。 通过由保持盘旋转产生的离心力，使液体相对于旋转轴在径向外侧从相对于旋转轴的径向内侧的容器移动通过容器。
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公开(公告)号：US07309568B2
公开(公告)日：2007-12-18
申请号：US10229204
申请日：2002-08-26
CPC分类号： G01N21/6428 , G01J3/4406 , G01N21/6452
摘要： A method and apparatus of stably obtaining fluorescent images of two or more fluorescent samples includes disposing the samples onto compartments defined on a substrate. The compartments are sequentially irradiated with an exciting light where the intensity varies. A value of fluorescence as generated from each of the samples is determined, and a fluorescent image is obtained based on the value of fluorescence.
摘要翻译： 稳定地获得两个或多个荧光样品的荧光图像的方法和装置包括将样品设置在限定在基底上的隔室上。 这些隔室用强度变化的激发光依次照射。 确定从每个样品产生的荧光值，并且基于荧光值获得荧光图像。
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6.发明授权Biological sample optical measuring method and biological sample optical measuring apparatus 有权生物样品光学测量方法和生物样品光学测量仪器公开(公告)号：US07400753B2
公开(公告)日：2008-07-15
申请号：US10482614
申请日：2001-07-03
IPC分类号： G06K9/00
CPC分类号： G01N21/6456 , G01N15/1475 , G01N21/6428 , G01N21/76 , G01N2021/1734 , G01N2021/6439 , G01N2021/6491
摘要： A fluorescent or luminescence image of at least part of a biological sample is imaged, then a transmission light image of at least part of the biological sample is imaged, and thereafter the fluorescent or luminescence image and the transmission light image are overlaid such that the identical area of the sample is coincided to display. The present invention allows detecting the accurate location of fluorescence or luminescence in a given part of the biological sample.
摘要翻译： 将生物样品的至少一部分的荧光或发光图像成像，然后对生物样品的至少一部分的透射光图像进行成像，然后将荧光或发光图像和透射光图像重叠，使得相同 样品的面积一致显示。 本发明允许检测生物样品的给定部分中的荧光或发光的准确位置。
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7.发明授权公开(公告)号：US06760105B2
公开(公告)日：2004-07-06
申请号：US10053976
申请日：2002-01-18
IPC分类号： G01N2164
CPC分类号： G01N21/6452 , G01N21/6428 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441
摘要： A DNA sample added with a plurality of fluorescent marks is irradiated with excitation lights having a plurality of wavelengths and when fluorescence intensities are detected separately, the excitation light and a position on the sample are relatively changed over a desired area once to thereby detect the plurality of fluorescent marks at high speed.
摘要翻译： 用多个荧光标记添加的DNA样品用具有多个波长的激发光照射，并且当单独检测荧光强度时，激发光和样品上的位置在期望的区域上相对地改变一次，从而检测多个 的荧光标记。
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公开(公告)号：US07064813B2
公开(公告)日：2006-06-20
申请号：US10253479
申请日：2002-09-25
IPC分类号： G01N21/00
CPC分类号： G01N1/312
摘要： Disclosed is an apparatus for measuring a micro area in a specimen in which a reagent necessary for observation and examination of a cell smear specimen or a tissue specimen is dropped to cause a reaction for a measurement and an analysis by way of an image. The apparatus includes: a micro reaction unit that is able to select a specific micro area in the specimen and to subject the specific micro area to a reaction-operation; a unit that measures; records and displays an image of the micro area; and a control unit that controls the measuring, recording, and displaying unit. Reactions can be effected quickly on such specimens as smear cell specimens and tissue slice specimens. The application of the reagent solution can be saved. A comparison between local presence of a gene or anti-body and a cell image can be made quickly and easily.
摘要翻译： 公开了一种用于测量样本中的微小区域的装置，其中用于观察和检查细胞涂片或组织样本的试剂下降以引起测量反应和通过图像进行分析。 该装置包括：微反应单元，其能够选择样品中的特定微区域并使特定微区域进行反应操作; 衡量单位 记录并显示微区图像; 以及控制单元，其控制测量，记录和显示单元。 反应可以在诸如涂片细胞标本和组织切片标本的样品上快速实现。 可以节省试剂溶液的应用。 基因或抗体的局部存在与细胞图像的比较可以快速且容易地进行。
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9.发明授权Light measuring device avoiding influence of fluorescence or phosphorescence of lenses and filters in optical path 失效光学测量装置避免透镜和滤光片在光路中的荧光或磷光的影响公开(公告)号：US06839134B2
公开(公告)日：2005-01-04
申请号：US10255623
申请日：2002-09-27
CPC分类号： G01N21/6452 , G01J3/08 , G01J3/4406
摘要： At the time of analytical measurement of a sample by the fluorescence measuring device or the phosphorescence measuring device, both the optical path of exciting light emitted from the light source to the sample and the optical path of fluorescence or phosphorescence emitted from the sample to the detection unit are shut off. Both are shut off by one chopper.
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公开(公告)号：US10451989B2
公开(公告)日：2019-10-22
申请号：US16119653
申请日：2018-08-31
摘要： Provided is a toner including toner base particles and an external additive, wherein each of the toner base particles includes a binder resin, a release agent, and silica, an average abundance ratio (Xsurf) of the silica on a region adjacent to a surface of the toner base particle is from 70% through 90%, and a projected area average value S(180) per particle of the toner when the toner is heated to 180° C. and a projected area average value S(30) per particle of the toner when the toner is 30° C. satisfy Formula (1) below, 1.4≤S(180)/S(30)≤1.7 Formula (1).
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