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    Apparatus and method for measuring micro area in specimen
    4.
    发明授权
    Apparatus and method for measuring micro area in specimen 失效
    用于测量样品中微区的装置和方法

    公开(公告)号：US07064813B2

    公开(公告)日：2006-06-20

    申请号：US10253479

    申请日：2002-09-25

    申请人： Satoshi Takahashi ,  Kenji Yasuda ,  Yoshitada Oshida ,  Taisaku Seino

    发明人： Satoshi Takahashi ,  Kenji Yasuda ,  Yoshitada Oshida ,  Taisaku Seino

    IPC分类号： G01N21/00

    CPC分类号： G01N1/312

    摘要： Disclosed is an apparatus for measuring a micro area in a specimen in which a reagent necessary for observation and examination of a cell smear specimen or a tissue specimen is dropped to cause a reaction for a measurement and an analysis by way of an image. The apparatus includes: a micro reaction unit that is able to select a specific micro area in the specimen and to subject the specific micro area to a reaction-operation; a unit that measures; records and displays an image of the micro area; and a control unit that controls the measuring, recording, and displaying unit. Reactions can be effected quickly on such specimens as smear cell specimens and tissue slice specimens. The application of the reagent solution can be saved. A comparison between local presence of a gene or anti-body and a cell image can be made quickly and easily.

    摘要翻译： 公开了一种用于测量样本中的微小区域的装置，其中用于观察和检查细胞涂片或组织样本的试剂下降以引起测量反应和通过图像进行分析。 该装置包括：微反应单元，其能够选择样品中的特定微区域并使特定微区域进行反应操作; 衡量单位 记录并显示微区图像; 以及控制单元，其控制测量，记录和显示单元。 反应可以在诸如涂片细胞标本和组织切片标本的样品上快速实现。 可以节省试剂溶液的应用。 基因或抗体的局部存在与细胞图像的比较可以快速且容易地进行。

    Method of inspecting a DNA chip
    5.
    发明授权
    Method of inspecting a DNA chip 有权
    检查DNA芯片的方法

    公开(公告)号：US07217573B1

    公开(公告)日：2007-05-15

    申请号：US09678652

    申请日：2000-10-04

    申请人： Yoshitada Oshida ,  Toshihiko Nakata ,  Tomoaki Sakata ,  Kenji Yasuda ,  Satoshi Takahashi

    发明人： Yoshitada Oshida ,  Toshihiko Nakata ,  Tomoaki Sakata ,  Kenji Yasuda ,  Satoshi Takahashi

    IPC分类号： G01N33/00 ,  G01N33/53 ,  C12Q1/68 ,  C12M3/00 ,  C07H21/04 ,  H01J3/14

    CPC分类号： G01N21/6428 ,  G01N21/6452 ,  G01N21/6456 ,  Y10S436/80 ,  Y10T436/143333

    摘要： A method of inspecting a DNA chip and an apparatus therefor that allow a picture to be reconstructed in the following steps: A plurality of irradiation spots are formed on a DNA probe array mounted on a stage. Then, the stage is displaced in X, Y directions so as to execute a scanning, thereby irradiating substantially all the entire surface of the DNA probe array. Next, a plurality of emitted fluorescent lights, which are generated from the plurality of irradiation spot portions on the DNA probe array, are converged and are then detected simultaneously by multi detectors. Finally, a data processing apparatus processes the detected signals, thereby reconstructing the picture.

    摘要翻译： 一种用于检查DNA芯片的方法及其装置，其允许以下列步骤重建图像：在安装在平台上的DNA探针阵列上形成多个照射点。 然后，在X，Y方向上移位台，以进行扫描，从而基本上照射DNA探针阵列的整个表面。 接下来，从DNA探针阵列上的多个照射点部分产生的多个发射荧光灯被会聚，然后由多个检测器同时检测。 最后，数据处理装置处理检测到的信号，从而重建图像。

    Method of inspecting a DNA chip and apparatus thereof
    6.
    发明授权
    Method of inspecting a DNA chip and apparatus thereof 有权
    检查DNA芯片的方法及其装置

    公开(公告)号：US08361784B2

    公开(公告)日：2013-01-29

    申请号：US11709120

    申请日：2007-02-22

    申请人： Yoshitada Oshida ,  Toshihiko Nakata ,  Tomoaki Sakata ,  Kenji Yasuda ,  Satoshi Takahashi

    发明人： Yoshitada Oshida ,  Toshihiko Nakata ,  Tomoaki Sakata ,  Kenji Yasuda ,  Satoshi Takahashi

    IPC分类号： C12M1/34 ,  G01N21/64

    CPC分类号： G01N21/6428 ,  G01N21/6452 ,  G01N21/6456 ,  Y10S436/80 ,  Y10T436/143333

    摘要： A DNA inspecting apparatus including driving means for relatively changing positions of the multi-spot lights and a position of the DNA chip so as to detect the fluorescent lights in such a manner that a desired area on the DNA chip is irradiated with the multi-spot lights, and a control system for determining and inspecting DNA information about the to-be-inspected DNA chip from fluorescent light intensities and fluorescent light positions of the desired area on the DNA chip, the fluorescent light intensities and the fluorescent light positions being detected by the driving means and the fluorescent light detecting means.

    摘要翻译： 一种DNA检查装置，包括用于相对改变多点灯位置的驱动装置和DNA芯片的位置，以便以这样的方式检测荧光，使得DNA芯片上的期望区域被多点照射 灯和用于从DNA芯片上的期望区域的荧光强度和荧光灯位置确定和检查关于待检查DNA芯片的DNA信息的控制系统，荧光强度和荧光灯位置由 驱动装置和荧光检测装置。

    Method of inspecting a DNA chip and apparatus thereof
    7.
    发明申请
    Method of inspecting a DNA chip and apparatus thereof 有权
    检查DNA芯片的方法及其装置

    公开(公告)号：US20070154938A1

    公开(公告)日：2007-07-05

    申请号：US11709120

    申请日：2007-02-22

    申请人： Yoshitada Oshida ,  Toshihiko Nakata ,  Tomoaki Sakata ,  Kenji Yasuda ,  Satoshi Takahashi

    发明人： Yoshitada Oshida ,  Toshihiko Nakata ,  Tomoaki Sakata ,  Kenji Yasuda ,  Satoshi Takahashi

    IPC分类号： C12Q1/68 ,  G01J3/42

    CPC分类号： G01N21/6428 ,  G01N21/6452 ,  G01N21/6456 ,  Y10S436/80 ,  Y10T436/143333

    摘要： A DNA inspecting apparatus including driving means for relatively changing positions of the multi-spot lights and a position of the DNA chip so as to detect the fluorescent lights in such a manner that a desired area on the DNA chip is irradiated with the multi-spot lights, and a control system for determining and inspecting DNA information about the to-be-inspected DNA chip from fluorescent light intensities and fluorescent light positions of the desired area on the DNA chip, the fluorescent light intensities and the fluorescent light positions being detected by the driving means and the fluorescent light detecting means.

    摘要翻译： 一种DNA检查装置，包括用于相对改变多点灯位置的驱动装置和DNA芯片的位置，以便以这样的方式检测荧光，使得DNA芯片上的期望区域被多点照射 灯和用于从DNA芯片上的期望区域的荧光强度和荧光灯位置确定和检查关于待检查DNA芯片的DNA信息的控制系统，荧光强度和荧光灯位置由 驱动装置和荧光检测装置。

    Electrophoretic antigen-antibody determination with laminate of multiple membranes
    10.
    发明授权
    Electrophoretic antigen-antibody determination with laminate of multiple membranes 失效
    电泳抗原 - 抗体用多层膜叠层测定

    公开(公告)号：US5057438A

    公开(公告)日：1991-10-15

    申请号：US31665

    申请日：1987-03-30

    申请人： Kazumichi Imai ,  Daizo Tokinaga ,  Teruaki Kobayashi ,  Kenji Yasuda ,  Keiichi Nagai ,  Satoshi Takahashi

    发明人： Kazumichi Imai ,  Daizo Tokinaga ,  Teruaki Kobayashi ,  Kenji Yasuda ,  Keiichi Nagai ,  Satoshi Takahashi

    IPC分类号： G01N33/561

    CPC分类号： G01N33/561 ,  Y10S436/809 ,  Y10S436/824

    摘要： Determination of a plurality of species of antibodies or antigens is attained by a method which comprises forming a plurality of different kinds of reaction membranes each having a different species of antibody or antigen on an electrophoretic carrier, superposing these reaction membranes, optionally superposing a filter on the laminate of reaction membranes, inserting the laminate in an electrolyte, adding a plurality of different species of antigens or antibodies corresponding to the plurality of species of antibodies or antigens supported in the aforementioned reaction membranes, electrophoretically moving the added antigens or antibodies through the electrolyte and enabling them to react with the antibodies or antigens supported on the reaction membranes, and measuring the concentrations of either the antigens or antibodies resulting from the reaction or the antibodies or antigens supported in an unreacted form on the reaction membranes.

    摘要翻译： 通过包括在电泳载体上形成多个不同种类的抗体或抗原的不同种类的反应膜，叠加这些反应膜，任选地将过滤器叠加在一起的方法来实现多种抗体或抗原的测定 反应膜的层压体，将层压体插入电解质中，加入与上述反应膜中支持的多种抗体或抗原相对应的多种不同种类的抗原或抗体，通过电解质电泳移动加入的抗原或抗体 并使其能够与支持在反应膜上的抗体或抗原反应，并测量由反应产生的抗原或抗体的浓度，或反应膜上以未反应形式负载的抗体或抗原的浓度。