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11 条记录 (耗时 0.032 秒)

    GENE DELIVERY OF OCT4 AND SIRT1 AND PHARMACEUTICAL COMPOSITIONS THEREOF
    2.
    发明申请
    GENE DELIVERY OF OCT4 AND SIRT1 AND PHARMACEUTICAL COMPOSITIONS THEREOF 有权
    OCT4和SIRT1的基因递送及其药物组合物

    公开(公告)号：US20130052238A1

    公开(公告)日：2013-02-28

    申请号：US13600842

    申请日：2012-08-31

    申请人： Shih-Hwa Chiou ,  Jong-Yuh Cherng

    发明人： Shih-Hwa Chiou ,  Jong-Yuh Cherng

    IPC分类号： C12N15/85 ,  C12N15/63 ,  C12N15/54 ,  A61K31/711 ,  A61K9/00

    CPC分类号： C12N15/87 ,  A61K31/711 ,  A61K48/005 ,  C07K14/4702

    摘要： The present invention provides a method for decreasing the level of methylation of Oct4 promoter in a target cell, comprising transfecting the target cell with the combination of Oct4 cDNA and SirT1 cDNA. The invention also provides a method for inducing cytoprotective responses of a target cell, comprising transfecting the target cell with the combination of Oct4 cDNA and SirT1 cDNA. The invention further provides a pharmaceutical composition comprising Oct4 cDNA and SirT1 cDNA, or a polynucleotide comprising Oct4 cDNA and SirT1 cDNA.

    摘要翻译： 本发明提供了降低靶细胞中Oct4启动子的甲基化水平的方法，包括用Oct4 cDNA和SirT1 cDNA的组合转染靶细胞。 本发明还提供了诱导靶细胞的细胞保护反应的方法，包括用Oct4 cDNA和SirT1 cDNA的组合转染靶细胞。 本发明还提供包含Oct4 cDNA和SirT1 cDNA的药物组合物，或包含Oct4 cDNA和SirT1 cDNA的多核苷酸。

    Composite for Thermo-Sensitive Cell-Tissue Transplanted Scaffold and Use thereof
    4.
    发明申请
    Composite for Thermo-Sensitive Cell-Tissue Transplanted Scaffold and Use thereof 审中-公开
    用于热敏细胞组织移植支架的复合材料及其用途

    公开(公告)号：US20080274054A1

    公开(公告)日：2008-11-06

    申请号：US11742963

    申请日：2007-05-01

    申请人： Shih-Hwa Chiou ,  Cherng-Kang Perng ,  Han-Tzo Lin ,  Yi-Ping Yang

    发明人： Shih-Hwa Chiou ,  Cherng-Kang Perng ,  Han-Tzo Lin ,  Yi-Ping Yang

    IPC分类号： A61K35/12 ,  A61K49/00 ,  A61P17/02 ,  C12Q1/02

    CPC分类号： A61F2/105 ,  A61K35/12 ,  A61L27/3834 ,  A61L27/50 ,  A61L27/60 ,  C12N5/0068 ,  C12N2533/52 ,  C12N2539/10 ,  Y10T442/2525 ,  Y10T442/2926

    摘要： A composite comprising a stem cell; a biodegradable layer, which can provide an environment for the stem cell to grow and to differentiate, and; a N-isopropylacrylamide (NIPAAm), which can polymerize with the biodegradable layer and possess the temperature-responsive character for easy stripping. This invention also provides a method of treating a subject with a skin defect by covering the composite of the present invention on the skin defect of the subject in need of such treatment. Furthermore, using this composite with different growth factors, stem cells can be induced to differentiate into skin-related, neuronal cells, neuron, and insulin-positive cells in biodegradable scaffolds as well as transplanted graft. Finally, this invention also provides a quick and convenient method of monitoring cell growth or tissue engineering in an animal.

    摘要翻译： 一种包含干细胞的复合材料; 可生物降解的层，其可以为干细胞生长和分化提供环境; N-异丙基丙烯酰胺（NIPAAm），其可与生物降解层聚合并具有温度响应特性以便于剥离。 本发明还提供了通过将本发明的复合物覆盖在需要这种治疗的受试者的皮肤缺陷上来治疗患有皮肤缺陷的受试者的方法。 此外，使用具有不同生长因子的这种复合材料，可以诱导干细胞分化成可生物降解的支架中的皮肤相关的，神经元细胞，神经元和胰岛素阳性细胞以及移植的移植物。 最后，本发明还提供了一种监测动物细胞生长或组织工程的快速方便的方法。

    Composite for Thermo-Sensitive Cell-Tissue Transplanted Scaffold and Use thereof
    5.
    发明申请
    Composite for Thermo-Sensitive Cell-Tissue Transplanted Scaffold and Use thereof 有权
    用于热敏细胞组织移植支架的复合材料及其用途

    公开(公告)号：US20110159051A1

    公开(公告)日：2011-06-30

    申请号：US13008760

    申请日：2011-01-18

    申请人： Shih-Hwa Chiou ,  Cherng-Kang Perng ,  Han-Tzo Lin ,  Yi-Ping Yang

    发明人： Shih-Hwa Chiou ,  Cherng-Kang Perng ,  Han-Tzo Lin ,  Yi-Ping Yang

    IPC分类号： A61K9/00 ,  A61K35/28 ,  A61P17/00 ,  A61P17/02

    CPC分类号： A61F2/105 ,  A61K35/12 ,  A61L27/3834 ,  A61L27/50 ,  A61L27/60 ,  C12N5/0068 ,  C12N2533/52 ,  C12N2539/10 ,  Y10T442/2525 ,  Y10T442/2926

    摘要： A composite comprising a stem cell; a biodegradable layer, which can provide an environment for the stem cell to grow and to differentiate, and; a N-isopropylacrylamide (NIPAAm), which can polymerize with the biodegradable layer and possess the temperature-responsive character for easy stripping. The present invention further provides a method for treating a patient with a skin defect, consisting of (a) providing said patient with a composite consisting of a N-isopropylacrylamide (NIPAAm) layer polymerized with a biodegradable layer containing gelatin and a layer of polypropylene (PP) non-woven, wherein a bone marrow derived mononuclear cell with CD45 negative and glycophorin A negative is cultivating on the biodegradable layer; (b) covering said composite on the skin defect of the patient; and (c) treating the composite with water below 25° C. to strip off the layer of polypropylene (PP) non-woven.

    摘要翻译： 一种包含干细胞的复合材料; 可生物降解的层，其可以为干细胞生长和分化提供环境; N-异丙基丙烯酰胺（NIPAAm），其可与生物降解层聚合并具有温度响应特性以便于剥离。 本发明还提供了一种用于治疗患有皮肤缺损的患者的方法，其包括（a）向所述患者提供由与包含明胶的生物可降解层聚合的N-异丙基丙烯酰胺（NIPAAm）层和聚丙烯层 PP）无纺布，其中具有CD45阴性的骨髓衍生的单核细胞和血型糖蛋白A阴性在生物降解层上培养; （b）覆盖所述复合材料对患者的皮肤缺陷; 和（c）用低于25℃的水处理该复合材料以剥离无纺布的聚丙烯（PP）层。

    Composite for thermo-sensitive cell-tissue transplanted scaffold and use thereof
    7.
    发明授权
    Composite for thermo-sensitive cell-tissue transplanted scaffold and use thereof 有权
    用于热敏细胞移植支架的复合材料及其用途

    公开(公告)号：US08470597B2

    公开(公告)日：2013-06-25

    申请号：US13008760

    申请日：2011-01-18

    申请人： Shih-Hwa Chiou ,  Cherng-Kang Perng ,  Han-Tzo Lin ,  Yi-Ping Yang

    发明人： Shih-Hwa Chiou ,  Cherng-Kang Perng ,  Han-Tzo Lin ,  Yi-Ping Yang

    IPC分类号： A61F13/00 ,  C12N5/0775 ,  C12N5/07 ,  A61K38/17 ,  A61L15/32

    CPC分类号： A61F2/105 ,  A61K35/12 ,  A61L27/3834 ,  A61L27/50 ,  A61L27/60 ,  C12N5/0068 ,  C12N2533/52 ,  C12N2539/10 ,  Y10T442/2525 ,  Y10T442/2926

    摘要： A composite comprising a stem cell; a biodegradable layer, which can provide an environment for the stem cell to grow and to differentiate, and; a N-isopropylacrylamide (NIPAAm), which can polymerize with the biodegradable layer and possess the temperature-responsive character for easy stripping. The present invention further provides a method for treating a patient with a skin defect, consisting of (a) providing said patient with a composite consisting of a N-isopropylacrylamide (NIPAAm) layer polymerized with a biodegradable layer containing gelatin and a layer of polypropylene (PP) non-woven, wherein a bone marrow derived mononuclear cell with CD45 negative and glycophorin A negative is cultivating on the biodegradable layer; (b) covering said composite on the skin defect of the patient; and (c) treating the composite with water below 25° C. to strip off the layer of polypropylene (PP) non-woven.

    摘要翻译： 一种包含干细胞的复合材料; 可生物降解的层，其可以为干细胞生长和分化提供环境; N-异丙基丙烯酰胺（NIPAAm），其可与生物降解层聚合并具有温度响应特性以便于剥离。 本发明还提供了一种用于治疗患有皮肤缺损的患者的方法，其包括（a）向所述患者提供由与包含明胶的生物可降解层聚合的N-异丙基丙烯酰胺（NIPAAm）层和聚丙烯层 PP）无纺布，其中具有CD45阴性的骨髓衍生的单核细胞和血型糖蛋白A阴性在生物降解层上培养; （b）覆盖所述复合材料对患者的皮肤缺陷; 和（c）用低于25℃的水处理该复合材料以剥离无纺布的聚丙烯（PP）层。