公开(公告)号：US20120329046A1

公开(公告)日：2012-12-27

申请号：US13461075

申请日：2012-05-01

申请人： Shin'ichi Takeda ,  Akinori Nakamura ,  Masanori Kobayashi ,  Takashi Okada

发明人： Shin'ichi Takeda ,  Akinori Nakamura ,  Masanori Kobayashi ,  Takashi Okada

IPC分类号： G01N33/566 ,  C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5023 ,  G01N33/5061 ,  G01N33/6869 ,  G01N33/6872 ,  G01N2333/5412 ,  G01N2333/5421 ,  G01N2800/2878

摘要： Novel markers associated with the development of muscular dystrophy that elucidate the mechanisms of muscular dystrophy development and provide a means for diagnosis and treatment of muscular dystrophy are presented. The expression level of one or more markers selected from the group consisting of c-Fos, EGR1, IL-6, and IL-8 in a sample obtained from the subject can be compared with a reference value to diagnose muscular dystrophy in the subject.

摘要翻译： 提出了与肌营养不良发展相关的新型标志物，其阐明肌营养不良发展的机制并提供用于诊断和治疗肌营养不良症的手段。 可以将从受试者获得的样品中选自c-Fos，EGR1，IL-6和IL-8的一种或多种标志物的表达水平与参考值进行比较，以诊断受试者的肌营养不良症。

公开(公告)号：US09610354B2

公开(公告)日：2017-04-04

申请号：US14112317

申请日：2012-04-16

申请人： Takashi Okada ,  Shin'ichi Takeda ,  Hiromi Kinoh

发明人： Takashi Okada ,  Shin'ichi Takeda ,  Hiromi Kinoh

IPC分类号： A61K47/42 ,  A61K9/14 ,  A61K9/51 ,  A61K31/7088 ,  A61K31/713 ,  A61K47/26

CPC分类号： A61K9/5184 ,  A61K9/14 ,  A61K31/7088 ,  A61K31/713 ,  A61K47/26 ,  A61K47/42 ,  A61K48/0008 ,  A61K48/0091 ,  C12N5/00 ,  C12N7/00 ,  C12N15/113 ,  C12N2310/14 ,  C12N2320/32 ,  C12N2510/02 ,  C12N2710/10042 ,  C12N2750/00042 ,  C12N2750/00051 ,  C12N2750/14142

摘要： An object of the present invention is to develop and provide a method for conveniently introducing a nucleic acid, a peptide, and/or a low-molecular-weight compound into an empty capsid with viral early infection activities kept. The present invention provides a method for producing a drug delivery particle, comprising the steps of: mixing an empty capsid or an empty particle with a drug including a nucleic acid, a peptide, and/or a low-molecular-weight compound in a solution comprising 0.1 to 20% of a surfactant; and keeping the obtained mixed solution at −5 to 50° C. to introduce the drug into the empty capsid or the empty particle.

公开(公告)号：US20140044794A1

公开(公告)日：2014-02-13

申请号：US14112317

申请日：2012-04-16

申请人： Takashi Okada ,  Shin'ichi Takeda ,  Hiromi Kinoh

发明人： Takashi Okada ,  Shin'ichi Takeda ,  Hiromi Kinoh

IPC分类号： A61K47/42 ,  A61K9/14

CPC分类号： A61K9/5184 ,  A61K9/14 ,  A61K31/7088 ,  A61K31/713 ,  A61K47/26 ,  A61K47/42 ,  A61K48/0008 ,  A61K48/0091 ,  C12N5/00 ,  C12N7/00 ,  C12N15/113 ,  C12N2310/14 ,  C12N2320/32 ,  C12N2510/02 ,  C12N2710/10042 ,  C12N2750/00042 ,  C12N2750/00051 ,  C12N2750/14142

摘要： An object of the present invention is to develop and provide a method for conveniently introducing a nucleic acid, a peptide, and/or a low-molecular-weight compound into an empty capsid with viral early infection activities kept. The present invention provides a method for producing a drug delivery particle, comprising the steps of: mixing an empty capsid or an empty particle with a drug including a nucleic acid, a peptide, and/or a low-molecular-weight compound in a solution comprising 0.1 to 20% of a surfactant; and keeping the obtained mixed solution at −5 to 50° C. to introduce the drug into the empty capsid or the empty particle.

摘要翻译： 本发明的目的是开发并提供一种便利地将核酸，肽和/或低分子量化合物引入具有保持的病毒性早期感染活性的空衣壳中的方法。 本发明提供一种制备药物递送颗粒的方法，其包括以下步骤：将空衣壳或空粒子与包含核酸，肽和/或低分子量化合物的药物在溶液中混合 包含0.1-20％的表面活性剂; 并将所得混合溶液保持在-5至50℃以将药物引入空的衣壳或空的颗粒中。

公开(公告)号：US20200038310A1

公开(公告)日：2020-02-06

申请号：US16441844

申请日：2019-06-14

申请人： Takenori SUENAGA ,  Masahide Kobayashi ,  Mitsunobu Morita ,  Takashi Okada ,  Soh Noguchi ,  Tatsuki Yamaguchi

发明人： Takenori SUENAGA ,  Masahide Kobayashi ,  Mitsunobu Morita ,  Takashi Okada ,  Soh Noguchi ,  Tatsuki Yamaguchi

IPC分类号： A61K8/87 ,  A61Q3/02

摘要： Provided is a composition including: an acrylamide compound represented by general formula (1) below; urethane (meth)acrylate having a SI value of 3 or less in a skin sensitization test; and a polymerization initiator having a molecular weight of 800 or greater, where in general formula (1), R1 represents an alkyl group containing 1 through 6 carbon atoms, X represents an alkylene group containing 1 through 6 carbon atoms, and Y represents any one selected from the group consisting of general formula (2) below and general formula (3) below, where in general formula (2), R2 represents an alkyl group containing 1 through 10 carbon atoms, and * represents a binding site with X above, where in general formula (3), R2 represents an alkyl group containing 1 through 10 carbon atoms, and * represents a binding site with X above.

公开(公告)号：US20200032089A1

公开(公告)日：2020-01-30

申请号：US16426523

申请日：2019-05-30

申请人： Masahide KOBAYASHI ,  Mitsunobu Morita ,  Takenori Suenaga ,  Soh Noguchi ,  Takashi Okada ,  Tatsuki Yamaguchi

发明人： Masahide KOBAYASHI ,  Mitsunobu Morita ,  Takenori Suenaga ,  Soh Noguchi ,  Takashi Okada ,  Tatsuki Yamaguchi

IPC分类号： C09D11/38 ,  B41M7/00

摘要： Provided is a composition including an acrylamide compound (A1) having a molecular weight of 150 or greater but 250 or less, and a trifunctional or higher polymerizable compound (A2), wherein an amount of the trifunctional or higher polymerizable compound (A2) is 1% by mass or greater but 30% by mass or less relative to a total amount of the composition.

公开(公告)号：US10093693B2

公开(公告)日：2018-10-09

申请号：US14433176

申请日：2013-11-01

申请人： Toshiya Sagisaka ,  Hiroyuki Takahashi ,  Takashi Okada ,  Shigenobu Hirano ,  Tohru Yashiro ,  Koh Fujimura ,  Yoshihisa Naijo ,  Yoshinori Okada ,  Kazuaki Tsuji ,  Sukchan Kim ,  Keiichiroh Yutani ,  Tamotsu Horiuchi ,  Mamiko Inoue

发明人： Toshiya Sagisaka ,  Hiroyuki Takahashi ,  Takashi Okada ,  Shigenobu Hirano ,  Tohru Yashiro ,  Koh Fujimura ,  Yoshihisa Naijo ,  Yoshinori Okada ,  Kazuaki Tsuji ,  Sukchan Kim ,  Keiichiroh Yutani ,  Tamotsu Horiuchi ,  Mamiko Inoue

IPC分类号： C07D401/10 ,  C07D401/14 ,  C07F9/6558 ,  C09K9/02 ,  C07F9/58 ,  C07F7/08 ,  G02F1/15

摘要： To provide an electrochromic compound, represented by the following general formula (I): General Formula (I) where X1, X2, X3, X4, X5, X6, X7 and X8 are each independently a hydrogen atom or a monovalent substituent; R1 and R2 are each independently a monovalent substituent; A− and B− are each independently a monovalent anion; and Y is represented by the following general formula (II) or (III): General Formula (II) General Formula (III) where X9, X10, X11, X12, X13, X14, X15, X16, X17, and X18 are each independently a hydrogen atom or a monovalent substituent.

公开(公告)号：US09288811B2

公开(公告)日：2016-03-15

申请号：US13500511

申请日：2010-10-06

申请人： Hiromasa Umeda ,  Takashi Okada ,  Hiroyuki Ishii

发明人： Hiromasa Umeda ,  Takashi Okada ,  Hiroyuki Ishii

IPC分类号： H04L12/28 ,  H04W72/08 ,  H04W88/08 ,  H04W72/04

CPC分类号： H04W72/082 ,  H04L5/001 ,  H04W72/0446 ,  H04W72/0453 ,  H04W88/08

摘要： To reduce deterioration of a downlink signal when a multicarrier transmission is performed. A base station device eNB according to the present invention communication system includes: an uplink signal reception unit 17 configured to receive an uplink signal in a first carrier and an uplink signal in a second carrier, the uplink signal being transmitted from a user equipment UE; and a downlink signal transmission unit 15 configured to transmit a downlink signal in the first carrier and a downlink signal in the second carrier to the user equipment UE, wherein the downlink signal transmission unit 15 is configured to decide whether to transmit the downlink signal in the first carrier based on whether the uplink signal reception unit 17 receives the uplink signal in the second carrier.

摘要翻译： 为了减少执行多载波传输时的下行链路信号的恶化。 根据本发明的通信系统的基站设备eNB包括：上行链路信号接收单元17，被配置为在第一载波中接收上行链路信号，并在第二载波中接收上行链路信号，所述上行链路信号从用户设备UE发送; 以及下行链路信号发送单元15，被配置为向所述用户设备UE发送所述第一载波中的下行链路信号和所述第二载波中的下行链路信号，其中，所述下行链路信号发送单元15被配置为决定是否发送所述下行链路信号 第一载波基于上行链路信号接收单元17是否在第二载波中接收到上行链路信号。

公开(公告)号：US09224959B2

公开(公告)日：2015-12-29

申请号：US14172572

申请日：2014-02-04

申请人： Daisuke Goto ,  Satoshi Yamamoto ,  Toshiya Sagisaka ,  Takuji Kato ,  Takashi Okada ,  Masato Shinoda ,  Shinji Matsumoto ,  Masataka Mohri ,  Keiichiro Yutani

发明人： Daisuke Goto ,  Satoshi Yamamoto ,  Toshiya Sagisaka ,  Takuji Kato ,  Takashi Okada ,  Masato Shinoda ,  Shinji Matsumoto ,  Masataka Mohri ,  Keiichiro Yutani

IPC分类号： C07D495/02 ,  H01L51/00 ,  C07C1/213 ,  C07C15/20 ,  C07C15/24 ,  C07C15/28 ,  C07C15/38 ,  C07C15/56 ,  C07C15/58 ,  C07C15/60 ,  C07C17/093 ,  C07C17/10 ,  C07C17/361 ,  C07C25/22 ,  C07C69/013 ,  C07C69/18 ,  C07C69/63 ,  C07D321/00 ,  C07D409/14 ,  C07D495/04 ,  C07D495/06 ,  H01L51/05

CPC分类号： H01L51/0052 ,  C07C1/213 ,  C07C15/20 ,  C07C15/24 ,  C07C15/28 ,  C07C15/38 ,  C07C15/56 ,  C07C15/58 ,  C07C15/60 ,  C07C17/093 ,  C07C17/10 ,  C07C17/361 ,  C07C25/22 ,  C07C69/013 ,  C07C69/18 ,  C07C69/63 ,  C07C2602/10 ,  C07C2603/24 ,  C07C2603/44 ,  C07C2603/50 ,  C07C2603/52 ,  C07D321/00 ,  C07D409/14 ,  C07D495/04 ,  C07D495/06 ,  H01L51/0074 ,  H01L51/0558

摘要： A leaving substituent-containing compound including a partial structure represented by the following General Formula (I): where a pair of X1 and X2 or a pair of Y1 and Y2 each represent a hydrogen atom; the other pair each represent a group selected from the group consisting of a halogen atom and a substituted or unsubstituted acyloxy group having one or more carbon atoms; a pair of the acyloxy groups represented by the pair of X1 and X2 or the pair of Y1 and Y2 may be identical or different, or may be bonded together to form a ring; R1 to R4 each represent a hydrogen atom or a substituent; and Q1 and Q2 each represent a hydrogen atom, a halogen atom or a monovalent organic group, and may be bonded together to form a ring.

摘要翻译： 含有由以下通式（I）表示的部分结构的含有取代基的化合物：其中一对X1和X2或一对Y1和Y2各自表示氢原子; 另一对各自表示选自卤原子和具有一个或多个碳原子的取代或未取代的酰氧基的基团; 由一对X1和X2表示的一对酰氧基或一对Y1和Y2可以相同或不同，或者可以结合在一起形成环; R 1〜R 4各自表示氢原子或取代基; 并且Q1和Q2各自表示氢原子，卤素原子或一价有机基团，并且可以结合在一起形成环。

公开(公告)号：US09028949B2

公开(公告)日：2015-05-12

申请号：US13503023

申请日：2010-10-20

申请人： Motoki Okaniwa ,  Toshimitsu Kikuchi ,  Takaaki Uno ,  Takashi Okada

发明人： Motoki Okaniwa ,  Toshimitsu Kikuchi ,  Takaaki Uno ,  Takashi Okada

IPC分类号： C08G65/40 ,  H05K1/03 ,  C08G75/23

CPC分类号： H05K1/0326 ,  C08G65/40 ,  C08G65/4006 ,  C08G75/23 ,  C08G2650/40 ,  Y10S428/901 ,  Y10T428/24802 ,  Y10T428/31678

摘要： There are provided a substrate for printed wiring excellent in light transmission property, heat resistance, mechanical strength and resistance to thermal coloration; a printed wiring laminate; and a resin composition used to produce the substrate and the laminate. The substrate for printed wiring comprises an aromatic polyether-typed polymer having a glass transition temperature, as measured by differential scanning calorimetry (DSC, heating rate: 20° C./minute), of from 230° C. to 350° C.

摘要翻译： 提供了透光性，耐热性，机械强度和耐热着色性优异的印刷配线用基板。 印刷布线层压板; 以及用于制造基材和层压体的树脂组合物。 印刷布线用基材包括通过差示扫描量热法（DSC，加热速度：20℃/分钟）测定的玻璃化转变温度为230℃〜350℃的芳香族聚醚型聚合物。

公开(公告)号：US08956589B2

公开(公告)日：2015-02-17

申请号：US13203589

申请日：2010-02-26

申请人： Ikuo Tooyama ,  Hiroyasu Taguchi ,  Shigehiro Morikawa ,  Makoto Urushitani ,  Daijiro Yanagisawa ,  Tomone Nagae ,  Nobuaki Shirai ,  Koichi Hirao ,  Masanari Kato ,  Hirohiko Kimura ,  Takashi Okada

发明人： Ikuo Tooyama ,  Hiroyasu Taguchi ,  Shigehiro Morikawa ,  Makoto Urushitani ,  Daijiro Yanagisawa ,  Tomone Nagae ,  Nobuaki Shirai ,  Koichi Hirao ,  Masanari Kato ,  Hirohiko Kimura ,  Takashi Okada

IPC分类号： A61K49/06 ,  C07C69/738 ,  A61K31/12 ,  G01N33/68 ,  A61K49/10 ,  A61K51/04 ,  C07C49/255 ,  C07C59/70 ,  C07C59/90 ,  C07C225/22 ,  C07C235/78 ,  C07C255/40 ,  C07D213/50 ,  C07D307/46

CPC分类号： G01N33/6896 ,  A61K49/10 ,  A61K51/04 ,  C07C49/255 ,  C07C59/70 ,  C07C59/90 ,  C07C69/738 ,  C07C225/22 ,  C07C235/78 ,  C07C255/40 ,  C07D213/50 ,  C07D307/46 ,  G01N33/6839 ,  G01N2800/2821

摘要： Disclosed are a curcumin derivative or a salt thereof, which contains a fluorine atom, represented by formula (I): (wherein R1a and R1b are each independently a hydrogen atom, alkyl, acetyl, or methoxycarbonyl; R2s are each independently a fluorine atom, CHF2—, CF3—, CHF2O—, or CF3O—; R3s are each independently a hydrogen atom or a fluorine atom; A is alkyl, cyano, carboxyl, alkoxycarbonyl, or R4—(CH2)m—; R4 is hydroxy, carboxy, cyano, acetyloxy, alkoxycarbonyl, alkoxyalkoxy, hydroxyalkoxy, or CONR5R6; R5 and R6 are each independently a hydrogen atom or alkyl; and m is an integer from 1 to 5), and a diagnostic imaging agent for diagnosing a disease in which an amyloid β peptide aggregate accumulates, the diagnostic imaging agent containing a compound having a 1,3-dicarbonyl structure, wherein the compound exists in a keto form and an enol form, and the keto form and the enol form have different affinities, respectively, to the amyloid β peptide aggregate.

摘要翻译： 公开了含有由式（I）表示的氟原子的姜黄素衍生物或其盐：其中R 1a和R 1b各自独立地为氢原子，烷基，乙酰基或甲氧基羰基; R 2各自独立地为氟原子， CH 2 - ，CF 3 - ，CHF 2 O-或CF 3 O-; R 3各自独立地为氢原子或氟原子; A为烷基，氰基，羧基，烷氧基羰基或R 4 - （CH 2）m - ; R 4为羟基， 氰基，乙酰氧基，烷氧基羰基，烷氧基烷氧基，羟基烷氧基或CONR5R6; R5和R6各自独立地为氢原子或烷基; m为1至5的整数），以及用于诊断淀粉样蛋白和bgr的疾病的诊断显像剂 ; 肽聚集体积累，诊断成像剂含有具有1,3-二羰基结构的化合物，其中化合物以酮形式和烯醇形式存在，酮形式和烯醇形式分别具有与淀粉样蛋白不同的亲和力 ＆bgr 肽聚集体。