公开(公告)号：US07090886B2

公开(公告)日：2006-08-15

申请号：US10343748

申请日：2001-08-07

申请人： Shin Koike ,  Takeshi Yasumasu ,  Tadashi Hase ,  Takatoshi Murase ,  Yoshihisa Katsuragi ,  Akira Takei

发明人： Shin Koike ,  Takeshi Yasumasu ,  Tadashi Hase ,  Takatoshi Murase ,  Yoshihisa Katsuragi ,  Akira Takei

IPC分类号： A23D9/007

CPC分类号： A23G3/40 ,  A21D2/16 ,  A23D7/011 ,  A23D7/013 ,  A23D7/015 ,  A23D9/013 ,  A23G3/346 ,  A23G2200/08 ,  A23K20/158 ,  A23L27/60 ,  A23L33/11 ,  A23L33/115 ,  A23L33/12 ,  A23L33/40 ,  A23V2002/00 ,  C11B5/0092 ,  C11C1/04 ,  C11C3/02 ,  C11C3/06 ,  A23V2250/182 ,  A23V2250/194 ,  A23V2250/1874 ,  A23V2250/188 ,  A23V2250/1882

摘要： Abstract Provided is an oil/fat composition comprising 60 to 100 wt. % of a diglyceride wherein the diglyceride has, as the fatty acid constituent thereof, 15 to 90 wt. % of an ω 3-unsaturated fatty acid having less than 20 carbon atoms and a cis ω 3-unsaturated fatty acid/(cis ω 6-unsaturated fatty acid+saturated fatty acid+trans unsaturated fatty acid) at a weight ratio of 1 to 6. The composition is excellent in visceral fat burning property, body fat burning property and stability against autoxidation.

摘要翻译： 提供一种油/脂肪组合物，其包含60至100重量％ 甘油二酯的百分比，其中甘油二酯作为其脂肪酸组分具有15至90重量％ ％的少于20个碳原子的ω-3-不饱和脂肪酸和顺式ω3-不饱和脂肪酸/（顺式ω6-不饱和脂肪酸+饱和脂肪酸+反式不饱和脂肪酸）的重量比为1〜 6.内脏脂肪燃烧性能，身体脂肪燃烧性能和抗氧化稳定性优良。

公开(公告)号：US07008661B2

公开(公告)日：2006-03-07

申请号：US10343831

申请日：2001-08-07

申请人： Shin Koike ,  Takeshi Yasumasu ,  Tadashi Hase ,  Takatoshi Murase ,  Yoshihisa Katsuragi ,  Akira Takei

发明人： Shin Koike ,  Takeshi Yasumasu ,  Tadashi Hase ,  Takatoshi Murase ,  Yoshihisa Katsuragi ,  Akira Takei

IPC分类号： A23D9/007

CPC分类号： A21D13/068 ,  A21D2/16 ,  A21D13/02 ,  A21D13/80 ,  A23D7/011 ,  A23D7/013 ,  A23D7/015 ,  A23D9/013 ,  A23K20/158 ,  A23L15/20 ,  A23L27/60 ,  A23L33/115 ,  A23L33/12 ,  A23L33/40 ,  A23V2002/00 ,  A61K31/232 ,  A61K31/56 ,  A61K45/06 ,  A61K2300/00 ,  A23V2250/1882 ,  A23V2250/182 ,  A23V2250/192 ,  A23V2250/194 ,  A23V2250/5108 ,  A23V2250/1874 ,  A23V2250/156 ,  A23V2250/70 ,  A23V2250/5118 ,  A23V2250/54246

摘要： Provided is an oil/fat composition comprising 10.1 to 94.9 wt. % of a triglyceride, 0.1 to 30 wt. % of a monoglyceride and 5 to 59.9 wt. % of a diglyceride which has, as a fatty acid constituent thereof, 15 to 90 wt. % of an ω3-unsaturated fatty acid having less than 20 carbon atoms. The oil/fat composition of the present invention has excellent heat stability, has body-fat-accumulation resisting action, visceral-fat-accumulation resisting action, blood-sugar-level lowering action, insulin resistance improving action and leptin lowering action and is useful for, as well as pharmaceuticals, preventive or remedial food for diabetes or obesity, and feed.

公开(公告)号：US07056949B2

公开(公告)日：2006-06-06

申请号：US10343742

申请日：2001-08-07

申请人： Shin Koike ,  Takeshi Yasumasu ,  Tadashi Hase ,  Takatoshi Murase

发明人： Shin Koike ,  Takeshi Yasumasu ,  Tadashi Hase ,  Takatoshi Murase

IPC分类号： A61K31/22 ,  A61K31/20 ,  C11B5/00 ,  A23D7/00 ,  A23D9/013

CPC分类号： A23G1/36 ,  A21D2/16 ,  A21D2/165 ,  A23D9/00 ,  A23D9/013 ,  A23G3/40 ,  A23G9/327 ,  A23K20/158 ,  A23L7/111 ,  A23L13/428 ,  A23L13/43 ,  A23L13/60 ,  A23L33/11 ,  A23L33/115 ,  A23L33/12 ,  A23V2002/00 ,  A61K45/06 ,  C11C3/02 ,  C11C3/06 ,  A23V2250/1882 ,  A23V2250/2136 ,  A23V2250/6422 ,  A23V2250/642 ,  A23V2250/032 ,  A23V2250/182 ,  A23V2250/192 ,  A23V2250/194 ,  A23V2250/5108 ,  A23V2250/1874 ,  A23V2250/156 ,  A23V2250/70 ,  A23V2250/5118 ,  A23V2250/54246 ,  A23V2250/628

摘要： An oil/fat composition comprising 5 to 99.9 wt. % of a monoglyccride having, as fatty acid constituents thereof, 15 to 90 wt % of an ω 3-unsaturated fatty acid having less than 20 carbon atoms, 1 to 80 wt. % of an ω 9-unsaturated fatty acid and 2 to 50 wt. % of an ω 9-unsaturated fatty acid; and 0.1 to 49.9 wt. % of a diglyceride, wherein a weight ratio of the diglyceride to the monoglyceride is less than 1 and the content of a polyunsaturated fatty acid having at least 4 carbon-to-carbon double bonds is 20% or less in all the fatty acid constituents. The oil/fat composition according to the present invention has excellent processing properties, good taste and excellent lowering action against glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) levels in blood. It is useful not only for pharmaceuticals but also for preventive or remedial foods of feeds effective for hepatic function disturbances or obesity.

摘要翻译： 一种油/脂肪组合物，其包含5至99.9wt。 作为其脂肪酸组分，具有少于20个碳原子的ω-3-不饱和脂肪酸为15〜90重量％，1〜80重量％ ％的不饱和脂肪酸和2〜50重量％ ％的不饱和脂肪酸的％; 和0.1〜49.9wt。 甘油二酯的百分比，其中甘油二酯与单酸甘油酯的重量比小于1，并且在所有脂肪酸组分中具有至少4个碳 - 碳双键的多不饱和脂肪酸的含量为20％以下。 根据本发明的油/脂肪组合物具有优异的加工性能，良好的味道和对谷氨酸草酰乙酸转氨酶（GOT）和谷氨酸丙酮酸转氨酶（GPT）水平的降低作用。 它不仅用于药物，而且对于有用于肝功能障碍或肥胖的饲料的预防或补救食物是有用的。

公开(公告)号：US06844021B2

公开(公告)日：2005-01-18

申请号：US10132504

申请日：2002-04-26

申请人： Shin Koike ,  Takatoshi Murase ,  Tadashi Hase

发明人： Shin Koike ,  Takatoshi Murase ,  Tadashi Hase

IPC分类号： A21D2/14 ,  A21D2/16 ,  A21D13/00 ,  A23D7/01 ,  A23D9/007 ,  A23K1/16 ,  A23L1/30 ,  A23L1/302 ,  A23L1/307 ,  A61K31/231 ,  A61K31/575 ,  A61P3/04 ,  C11B5/00 ,  C11C3/00 ,  A61K31/202

CPC分类号： A23D7/011 ,  A23K20/158 ,  A23L33/105 ,  A23L33/11 ,  A23L33/12 ,  A23L33/15 ,  A23V2002/00 ,  Y10S514/909 ,  A23V2250/1882 ,  A23V2250/1868 ,  A23V2250/1874 ,  A23V2250/187

摘要： The oil or fat composition of the invention contains a monoacylglycerol and/or a diacylglycerol in a total amount of 5-100 wt. % and which exhibits an index of stability against oxidation (induction time as measured through a Rancimat test conducted at 100° C.) of 7 or higher, wherein the monoacylglycerol and/or the diacylglycerol contain, as fatty acid constituents, ω3 unsaturated fatty acids in amounts of 15-90 wt. %. Through ingestion thereof in a small amount without drastically changing the person's lifestyle, the highly harmless oil/fat composition of the present invention provides effects for reducing and preventing accumulation of body fat, for reducing and preventing accumulation of visceral fat, and for prevention and treatment of obesity; and exerts an excellent prevention and treatment effect on life-style related diseases through long-term ingestion. Thus, the composition of the present invention is useful for foods, pharmaceuticals and pet food or feed.

摘要翻译： 本发明的油脂组合物含有总量为5-100重量％的单酰基甘油和/或二酰基甘油。 ％，其表现出对氧化的稳定性指标（通过在100℃下进行的Rancimat测试的诱导时间）为7或更高，其中单酰基甘油和/或二酰基甘油含有作为脂肪酸成分的ω3不饱和脂肪酸 用量为15-90wt。 ％ 通过摄取少量而不会剧烈改变人的生活方式，本发明的高度无害的油/脂肪组合物提供了降低和防止体脂堆积，减少和防止内脏脂肪累积以及预防和治疗的效果 的肥胖; 通过长期摄入对生活方式相关疾病具有极好的预防和治疗效果。 因此，本发明的组合物可用于食品，药品和宠物食品或饲料。

公开(公告)号：US07182971B2

公开(公告)日：2007-02-27

申请号：US10488251

申请日：2002-09-12

申请人： Hideto Takase ,  Shin Koike ,  Hideaki Sakai ,  Tsutomu Nishide ,  Tadashi Hase ,  Takatoshi Murase

发明人： Hideto Takase ,  Shin Koike ,  Hideaki Sakai ,  Tsutomu Nishide ,  Tadashi Hase ,  Takatoshi Murase

IPC分类号： A23D7/005

CPC分类号： A23K20/158 ,  A21D2/16 ,  A23D7/0053 ,  A23D7/0056 ,  A23D9/007 ,  A23L27/60 ,  A23L33/105 ,  A23L33/11 ,  A23L33/12

摘要： Disclosed herein is an oil composition comprising the following components (A) and (B):(A) 15 to 70% by weight of diglycerides in which less than 15% by weight of the constitutive fatty acids are (3 type unsaturated fatty acids; and (B) 30 to 85% by weight of a triglyceride in which at least 15% by weight of the constitutive fatty acids are (3 type unsaturated fatty acids. The oil composition is good in flavor, hard to be colored, excellent in hydrolytic stability and resistance to oxidation, good in emulsion stability and excellent in intake balance among fatty acids even under severe conditions that heating is performed at a high temperature for a long period of time, can be widely developed to medicinal preparations and foods and moreover exhibit an excellent inhibitory effect on accumulation of body fat by ingestion of a small amount of diglycerides.

摘要翻译： 本文公开了一种油组合物，其包含以下组分（A）和（B）：（A））15至70重量％的甘油二酸酯，其中小于15重量％的组成型脂肪酸为（3型不饱和脂肪酸; 和（B）30-85重量％的甘油三酯，其中至少15重量％的组成型脂肪酸是（3型不饱和脂肪酸），油组合物的味道好，难以着色，水解性优异 稳定性和耐氧化性，乳化稳定性好，即使在长时间在高温下进行加热的苛刻条件下，脂肪酸的摄取量平衡优异，可以广泛地发展成药用制剂和食品， 通过摄取少量甘油二酯对身体脂肪的积累具有优异的抑制作用。

公开(公告)号：US5160759A

公开(公告)日：1992-11-03

申请号：US824866

申请日：1992-01-22

申请人： Masaki Nomura ,  Shin Koike ,  Ko Yamashita ,  Koichi Okisaka ,  Yoshito Sano ,  Hisao Omura ,  Yuuichi Irinatsu ,  Kenji Masui ,  Takeshi Yasumasu

发明人： Masaki Nomura ,  Shin Koike ,  Ko Yamashita ,  Koichi Okisaka ,  Yoshito Sano ,  Hisao Omura ,  Yuuichi Irinatsu ,  Kenji Masui ,  Takeshi Yasumasu

IPC分类号： A23D7/005 ,  A23L9/20 ,  A23L27/60 ,  A23L35/00

CPC分类号： A23D7/0053 ,  A23L27/60 ,  A23L35/10 ,  A23L9/22

摘要： An oil-in-water emulsion comprises an aqueous phase of water and an oil phase comprising an edible oil composition comprising 10 to 99 percent by weight, based on the entire oils and fats of the emulsion, of a diglyceride mixture containing the diglycerides having an increasing melting point of 20 degree centigrade or less. It may be mixed with a protein, lecithin or phospholipid.

摘要翻译： 水包油乳液包含水相和油相，所述油相包含食用油组合物，所述食用油组合物包含10至99重量％，基于乳液的整个油和脂肪，甘油二酯混合物含有甘油二酯，其具有 增加熔点在20摄氏度以下。 它可以与蛋白质，卵磷脂或磷脂混合。

公开(公告)号：US06448292B2

公开(公告)日：2002-09-10

申请号：US09809192

申请日：2001-03-16

申请人： Shin Koike ,  Naoki Hosoya ,  Takeshi Yasumasu

发明人： Shin Koike ,  Naoki Hosoya ,  Takeshi Yasumasu

IPC分类号： A61K3120

CPC分类号： C11C3/10 ,  A23D9/00 ,  A23D9/007 ,  A23L33/12 ,  A23V2002/00 ,  A61K31/23 ,  C11C3/06 ,  A23V2250/54246 ,  A23V2250/1868 ,  A23V2250/70 ,  A23V2250/156 ,  A23V2250/5118

摘要： Disclosed herein is an oil composition containing a diglyceride, in which at least 55% by weight of the constitutive acyl groups are unsaturated acyl groups, and 15 to 100% by weight thereof are &ohgr;3 type unsaturated acyl groups having at least 20 carbon atoms, in an amount of not less than 10% by weight, but less than 40% by weight, and a triglyceride, in which at least 70% by weight of the constitutive acyl groups are unsaturated acyl groups, and 5 to 80% by weight thereof are a linoleyl group, in an amount of 40.1 to 89.8% by weight. The composition effectively develops the physiological functions derived from &ohgr;3 type unsaturated fatty acids, such as antiarteriosclerotic effect, and is excellent in oxidation stability, flavor and the like. Foods and medicines containing such an oil composition are provided.

摘要翻译： 本文公开了含有甘油二酯的油组合物，其中至少55重量％的组成酰基是不饱和酰基，并且其15至100重量％是具有至少20个碳原子的ω3型不饱和酰基， 不小于10重量％但小于40重量％的量，和其中至少70重量％的组成酰基为不饱和酰基的甘油三酸酯和5至80重量％ 亚油酰基，其量为40.1至89.8重量％。 该组合物有效地发展出来自ω-3型不饱和脂肪酸的生理功能，如抗动脉硬化作用，氧化稳定性，风味等优异。 提供含有这种油组合物的食品和药物。

公开(公告)号：US06852758B2

公开(公告)日：2005-02-08

申请号：US10061286

申请日：2002-02-04

申请人： Shin Koike ,  Naoki Hosoya ,  Takeshi Yasumasu

发明人： Shin Koike ,  Naoki Hosoya ,  Takeshi Yasumasu

IPC分类号： A23D9/00 ,  A23D9/007 ,  A23D9/013 ,  A23L1/24 ,  A23L1/30 ,  A61K31/202 ,  C11C3/06 ,  C11C3/10 ,  A61K31/20 ,  A61K31/22 ,  A61K31/225

CPC分类号： C11C3/10 ,  A23D9/00 ,  A23D9/007 ,  A23D9/013 ,  A23L27/60 ,  A23L33/115 ,  A23V2002/00 ,  A61K31/202 ,  C11C3/06 ,  A23V2250/1868

摘要： The invention relates to oil composition comprising 0.1 to 59.8% by weight of a triglyceride, 40 to 99.7% by weight of a diglyceride, 0.1 to 10% by weight of a monoglyceride and at most 5% by weight of a free fatty acid, wherein contents of ω3 type unsaturated acyl groups having at least 20 carbon atoms and monoenoic acyl groups in acyl groups constituting the diglyceride are 15 to 89.5% by weight and 10 to 84.5% by weight, respectively; and oral medicinal compositions and foods comprising such an oil composition.The oil composition effectively develops physiological functions derived from ω3 type unsaturated fatty acids, such as inhibition of platelet aggregation, and is excellent in effect of facilitating combustion of body fat, oxidation stability, flavor and the like, and also excellent in flowability.

摘要翻译： 本发明涉及包含0.1至59.8重量％的甘油三酯，40至99.7重量％的甘油二酯，0.1至10重量％的单酸甘油酯和至多5重量％的游离脂肪酸的油组合物，其中 构成甘油二酯的酰基中具有至少20个碳原子的ω3型不饱和酰基和单烯酰基的含量分别为15〜89.5重量％和10〜84.5重量％ 口服药物组合物和包含这样的油组合物的食品。油组合物有效地发展出来自ω-3型不饱和脂肪酸的生理功能，例如抑制血小板聚集，并且有利于促进身体脂肪燃烧，氧化稳定性，风味 并且流动性也优异。

公开(公告)号：US06762203B2

公开(公告)日：2004-07-13

申请号：US10032493

申请日：2002-01-02

申请人： Shin Koike ,  Naoki Hosoya ,  Takeshi Yasumasu

发明人： Shin Koike ,  Naoki Hosoya ,  Takeshi Yasumasu

IPC分类号： A61K3122

CPC分类号： C11C3/10 ,  A23D9/00 ,  A23D9/007 ,  A23D9/013 ,  A23L27/60 ,  A23L33/115 ,  A23V2002/00 ,  A61K31/202 ,  C11C3/06 ,  A23V2250/1868

摘要： The invention relates to oil composition comprising 0.1 to 59.8% by weight of a triglyceride, 40 to 99.7% by weight of a diglyceride, 0.1 to 10% by weight of a monoglyceride and at most 5% by weight of a free fatty acid, wherein contents of &ohgr;3 type unsaturated acyl groups having at least 20 carbon atoms and monoenoic acyl groups in acyl groups constituting the diglyceride are 15 to 89.5% by weight and 10 to 84.5% by weight, respectively; and oral medicinal compositions and foods comprising such an oil composition. The oil composition effectively develops physiological functions derived from &ohgr;3 type unsaturated fatty acids, such as inhibition of platelet aggregation, and is excellent in effect of facilitating combustion of body fat, oxidation stability, flavor and the like, and also excellent in flowability.

摘要翻译： 本发明涉及包含0.1至59.8重量％的甘油三酯，40至99.7重量％的甘油二酯，0.1至10重量％的单酸甘油酯和至多5重量％的游离脂肪酸的油组合物，其中 构成甘油二酯的酰基中具有至少20个碳原子的ω3型不饱和酰基和单烯酰基的含量分别为15〜89.5重量％和10〜84.5重量％ 口服药物组合物和包含这样的油组合物的食品。油组合物有效地发展出来自ω-3型不饱和脂肪酸的生理功能，例如抑制血小板聚集，并且有利于促进身体脂肪燃烧，氧化稳定性，风味 并且流动性也优异。

公开(公告)号：US07410663B2

公开(公告)日：2008-08-12

申请号：US11049975

申请日：2005-02-04

申请人： Shin Koike ,  Takatoshi Murase ,  Takanori Nii ,  Toshihiro Tanaka

发明人： Shin Koike ,  Takatoshi Murase ,  Takanori Nii ,  Toshihiro Tanaka

IPC分类号： A23D9/007

CPC分类号： A61K31/215 ,  A23D7/013 ,  A23D9/013 ,  A23K20/158 ,  A23L17/70 ,  A23L33/12 ,  A23V2002/00 ,  A61K31/19 ,  A61K31/23 ,  A61K31/565 ,  A61K2300/00 ,  A23V2250/1868 ,  A23V2250/712 ,  A23V2250/21 ,  A23V2250/2116 ,  A23V2250/187 ,  A23V2250/192 ,  A23V2250/182 ,  A23V2250/2136

摘要： The present invention relates to an oil or fat composition containing the following components (A) and (B): (A) from 80 to 99.9 wt. % of a monoglyceride containing 20 to 75 wt. % of docosahexaenoic acid (DHA) and 0.1 to 25 wt. % of icosapentaenoic acid (IPA), as the constituent fatty acids thereof, wherein the weight ratio of DHA/IPA being 2 or more; and (B) from 0.1 to 20 wt. % of a diglyceride.

摘要翻译： 本发明涉及含有以下组分（A）和（B）的油或脂肪组合物：（A）80-99.9重量％ ％的单酸甘油酯含有20〜75wt。 二十二碳六烯酸（DHA）的百分比和0.1至25wt。 ％的二十碳五烯酸（IPA）作为其构成脂肪酸，其中DHA / IPA的重量比为2以上; 和（B）0.1至20wt。 ％的甘油二酯。