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公开(公告)号：US5081264A
公开(公告)日：1992-01-14
申请号：US584278
申请日：1990-09-18
申请人： Shinichiro Toki , Mika Nozawa , Mayumi Yoshida , Hiroshi Sano , Katsuhiko Ando , Isao Kawamoto , Yuzuru Matsuda , Junichi Ikeda , Kazuhiro Kubo
发明人： Shinichiro Toki , Mika Nozawa , Mayumi Yoshida , Hiroshi Sano , Katsuhiko Ando , Isao Kawamoto , Yuzuru Matsuda , Junichi Ikeda , Kazuhiro Kubo
IPC分类号： C12P17/06 , A61K31/35 , A61K31/352 , A61P9/10 , A61P25/18 , A61P25/28 , C07D311/92 , C12P17/16 , C12R1/645
CPC分类号： C12P17/162 , C07D311/92
摘要： A compound of formula (I): ##STR1## wherein R.sub.1 represents hydrogen, hydroxy or acetoxy and R.sub.2 represents hydroxy or acetoxy.The compounds are capable of protecting the nerve cells and also antagonistic activity against N-methyl-D-aspartic acid receptors.They may be prepared by fermentation of a microorganism of the genus Verticillium or a mutant thereof.
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公开(公告)号：US5132112A
公开(公告)日：1992-07-21
申请号：US682349
申请日：1991-04-09
申请人： Yoshikazu Morishita , Mitsuru Takahashi , Koji Yamada , Tomoyuki Sano , Isao Kawamoto , Katsuhiko Ando , Hiroshi Sano , Yutaka Saito , Hiroshi Kase , Yuzuru Matsuda
发明人： Yoshikazu Morishita , Mitsuru Takahashi , Koji Yamada , Tomoyuki Sano , Isao Kawamoto , Katsuhiko Ando , Hiroshi Sano , Yutaka Saito , Hiroshi Kase , Yuzuru Matsuda
IPC分类号： A61K31/70 , A61K31/7024 , A61P9/02 , A61P13/02 , A61P15/00 , C07H13/06 , C08B37/00 , C12P19/04 , C12R1/645
CPC分类号： C08B37/0024 , C12P19/04
摘要： Compounds comprising a linear .beta.1.fwdarw.6 glucan esterified by caproic acid, the number of D-glucose residues being from 7 to 40 and the number of caproic acid residues being from 2 to 30, may be be obtained by fermentation of a microorganism of the genus Aureobasidium. These compounds are designated HS-142-1. Preferred microorganism is Aureobasidium pullulans var. melanigenum KAC-2383 (FERM-BP 2407).The compounds of the present invention exhibit excellent antagonistic activity to ANP and are capable of inhibiting the bonding of ANP to ANP receptors.
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公开(公告)号：US06194195B1
公开(公告)日：2001-02-27
申请号：US09181083
申请日：1998-10-27
申请人： Takeo Tanaka , Yoshikazu Morishita , Mika Makino , Shigeru Chiba , Isao Kawamoto , Eiji Tsukuda , Mayumi Yoshida , Chieko Bando , Kazuo Yamaguchi , Yuzuru Matsuda , Shigeto Kitamura , Toshihide Ikemura , Tatsuhiro Ogawa , Keiichi Yano , Toshiyuki Suzawa , Kenji Shibata , Motoo Yamasaki
发明人： Takeo Tanaka , Yoshikazu Morishita , Mika Makino , Shigeru Chiba , Isao Kawamoto , Eiji Tsukuda , Mayumi Yoshida , Chieko Bando , Kazuo Yamaguchi , Yuzuru Matsuda , Shigeto Kitamura , Toshihide Ikemura , Tatsuhiro Ogawa , Keiichi Yano , Toshiyuki Suzawa , Kenji Shibata , Motoo Yamasaki
IPC分类号： C12N120
CPC分类号： C07K7/06 , A61K38/00 , C07K5/1021 , C07K5/1024 , C07K7/08 , C07K14/36 , C07K14/57536 , C12R1/465
摘要： The invention relates to biologically pure cultures of Streptomyces sp. RE-701 (FERM BP-3624) and Streptomyces sp. RE-629 (FERM BP-4126) that produce endothelin antagonistic peptides.
摘要翻译： 本发明涉及链霉菌属的生物纯培养物。 RE-701（FERM BP-3624）和Streptomyces sp。 产生内皮素拮抗肽的RE-629（FERM BP-4126）。
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公开(公告)号：US5639860A
公开(公告)日：1997-06-17
申请号：US321625
申请日：1994-10-12
申请人： Takeo Tanaka , Yoshikazu Morishita , Mika Makino , Shigeru Chiba , Isao Kawamoto , Eiji Tsukuda , Mayumi Yoshida , Chieko Bando , Kazuo Yamaguchi , Yuzuru Matsuda , Shigeto Kitamura , Toshihide Ikemura , Tatsuhiro Ogawa , Keiichi Yano , Toshiyuki Suzawa , Kenji Shibata , Motoo Yamasaki
发明人： Takeo Tanaka , Yoshikazu Morishita , Mika Makino , Shigeru Chiba , Isao Kawamoto , Eiji Tsukuda , Mayumi Yoshida , Chieko Bando , Kazuo Yamaguchi , Yuzuru Matsuda , Shigeto Kitamura , Toshihide Ikemura , Tatsuhiro Ogawa , Keiichi Yano , Toshiyuki Suzawa , Kenji Shibata , Motoo Yamasaki
CPC分类号： C07K7/06 , C07K14/57536 , C07K5/1021 , C07K5/1024 , C07K7/08
摘要： Peptides represented by the following formula (I): ##STR1## wherein A represents Asn or Asp; B represents His or Lys; and E represents Ala or Ser;(1) X.sup.1 and Y.sup.1 are combined together to form a single bond as X.sup.1 --Y1, or (2) X.sup.1 represents hydrogen and Y.sup.1 represents hydroxy;and Z represents, in case of (1),Trp-Phe-Phe-Asn-Tyr-Tyr-7Hyt-Z.sup.1Trp-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-Z.sup.1,Trp-Val-Tyr-Tyr-Ala-His-Leu-Asp-Ile-Ile-Trp-Z.sup.1,Trp-Leu-Tyr-Phe-Ala-His-Gln-Asp-Val-Ile-Trp-Z.sup.1,Trp-Phe-Phe-Asn-Tyr-R-T-Z.sup.1wherein Z.sup.1 is an organic moiety,wherein R is Tyr or a covalent bond,T is Trp, Ala, Phe, Tyr, Trp-Trp, Asn-Tyr-Tyr-Trp, Trp-Asn-Tyr-Tyr-Trp, Trp-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp,or in case of (2), Z representsTrp-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-Z.sup.1Trp-Val-Tyr-Tyr-Ala-His-Leu-Asp-Ile-Ile-Trp-Z.sup.1Trp-Leu-Tyr-Phe-Ala-His-Gln-Asp-Val-Ile-Trp-Z.sup.1.These peptides have endothelin-antagonizing activity, and are useful for treating hypertension, asthma, cerebral apoplexy, angina pectoris, acute renal failure, cardiac infarction and cerebral vasospasm.
摘要翻译： 由下式（I）表示的肽：其中A表示Asn或Asp; B代表His或Lys; E表示Ala或Ser; （1）将X1和Y1组合在一起形成单键作为X1-Y1，或（2）X1表示氢，Y1表示羟基; 而在（1）的情况下，Z表示Trp-Phe-Phe-Asn-Tyr-Tyr-7Hyt-Z1 Trp-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-Z1， Trp-Val-Tyr-Tyr-Ala-His-Leu-Asp-Ile-Ile-Trp-Z1，Trp-Leu-Tyr-Phe-Ala-His-Gln-Asp-Val-Ile-Trp-Z1，Trp- Phe-Phe-Asn-Tyr-RT-Z1，其中Z1是有机部分，其中R是Tyr或共价键，T是Trp，Ala，Phe，Tyr，Trp-Trp，Asn-Tyr-Tyr-Trp，Trp -Tn-Tyr-Tyr-Trp，Trp-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp，或在（2）的情况下，Z表示Trp-Val-Tyr-Phe-Ala -His-Leu-Asp-Ile-Ile-Trp-Z1 Trp-Val-Tyr-Tyr-Ala-His-Leu-Asp-Ile-Ile-Trp-Z1 Trp-Leu-Tyr-Phe-Ala-His-Gln -Asp-Val-Ile-Trp-Z1。 这些肽具有内皮素拮抗作用，可用于治疗高血压，哮喘，脑中风，心绞痛，急性肾功能衰竭，心肌梗死和脑血管痉挛。
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公开(公告)号：US06642355B2
公开(公告)日：2003-11-04
申请号：US09750754
申请日：2001-01-02
申请人： Takeo Tanaka , Yoshikazu Morishita , Mika Makino , Shigeru Chiba , Isao Kawamoto , Eiji Tsukuda , Mayumi Yoshida , Chieko Bando , Kazuo Yamaguchi , Yuzuru Matsuda , Shigeto Kitamura , Toshihide Ikemura , Tatsuhiro Ogawa , Keiichi Yano , Toshiyuki Suzawa , Kenji Shibata , Motoo Yamasaki
发明人： Takeo Tanaka , Yoshikazu Morishita , Mika Makino , Shigeru Chiba , Isao Kawamoto , Eiji Tsukuda , Mayumi Yoshida , Chieko Bando , Kazuo Yamaguchi , Yuzuru Matsuda , Shigeto Kitamura , Toshihide Ikemura , Tatsuhiro Ogawa , Keiichi Yano , Toshiyuki Suzawa , Kenji Shibata , Motoo Yamasaki
IPC分类号： C07K700
CPC分类号： C07K7/06 , A61K38/00 , C07K5/1021 , C07K5/1024 , C07K7/08 , C07K14/36 , C07K14/57536 , C12R1/465
摘要： The invention relates to an endothelin antagonistic peptide of the formula (I): X-A-Trp-B-Gly-Thr-E-G-Y (I) SEQ ID NO: 2 wherein represents Asn or Asp; B represents His or Lys; E represents Ala or Ser; G represents Ala or Pro; X represents X1-Gly or and Y represents hydroxy, lower alkoxy, amino, wherein X1, X3, Y1, Y2 and Z are further defined, or a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明涉及式（I）的内皮素拮抗肽：其中代表Asn或Asp; B代表His或Lys; E表示Ala或Ser; G表示Ala或Pro; X表示X 1 -Gly或Y表示羟基，低级烷氧基，氨基，其中X 1，X 3，Y 1，Y 2和Z进一步定义，或 其药学上可接受的盐。
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公开(公告)号：US4914198A
公开(公告)日：1990-04-03
申请号：US946842
申请日：1986-12-29
申请人： Hirofumi Nakano , Mitsunobu Hara , Yoshinori Yamashita , Isao Kawamoto , Katsuhiko Ando , Hiroshi Sano , Toru Yasuzawa , Katsuichi Shuto
发明人： Hirofumi Nakano , Mitsunobu Hara , Yoshinori Yamashita , Isao Kawamoto , Katsuhiko Ando , Hiroshi Sano , Toru Yasuzawa , Katsuichi Shuto
CPC分类号： C12P33/00 , C07J71/001
摘要： Novel substance UCY1003 produced by culturing of a microorganism has the following chemical structure and analgesic, hypotensive and antifungal activities: ##STR1##
摘要翻译： 通过培养微生物产生的新物质UCY1003具有以下化学结构和镇痛，降血压和抗真菌活性：
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公开(公告)号：US5223637A
公开(公告)日：1993-06-29
申请号：US889388
申请日：1992-05-28
申请人： Kazutoshi Kuroda , Hiroshi Kase , Katsuhiko Ando , Isao Kawamoto , Toru Yasuzawa , Hiroshi Sano , Joji Goto , Koji Yamada
发明人： Kazutoshi Kuroda , Hiroshi Kase , Katsuhiko Ando , Isao Kawamoto , Toru Yasuzawa , Hiroshi Sano , Joji Goto , Koji Yamada
IPC分类号： C07C323/20 , C07C327/26 , C12P7/00
CPC分类号： C07C323/20 , C07C327/26 , C12P7/00
摘要： KS-506a, KS-506x and KS-506g having an activity to inhibit cyclic nucleotide phosphodiesterase and KS-506m and KS-506h having an activity to inhibit histamine release are produced by culturing a microorganism belonging to the genus Mortierella.
摘要翻译： 通过培养属于被孢霉属属的微生物来产生具有抑制环核苷酸磷酸二酯酶的活性的KS-506a，KS-506x和KS-506g以及具有抑制组胺释放活性的KS-506m和KS-506h。
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公开(公告)号：US4990693A
公开(公告)日：1991-02-05
申请号：US465892
申请日：1990-01-16
申请人： Satoshi Nakanishi , Koji Yamada , Katsuhiko Ando , Isao Kawamoto , Toru Yasuzawa , Hiroshi Sano , Noriaki Hirayama , Hiroshi Kase , Joji Goto , Etsuyo Shimizu
发明人： Satoshi Nakanishi , Koji Yamada , Katsuhiko Ando , Isao Kawamoto , Toru Yasuzawa , Hiroshi Sano , Noriaki Hirayama , Hiroshi Kase , Joji Goto , Etsuyo Shimizu
CPC分类号： C12R1/645 , C07C35/48 , C07C45/58 , C07C47/46 , C07D303/48 , C12P17/02 , C12P7/02 , C12P7/24
摘要： Novel physiologically active substances KS-504a, KS-504b and KS-504d having a vasodilative activity and a novel physiologically active substance KS-504e having an activity to inhibit histamine secretion are produced by culturing a microorganism of the genus Mollisia.
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公开(公告)号：US5142096A
公开(公告)日：1992-08-25
申请号：US329329
申请日：1989-03-27
申请人： Kazutoshi Kuroda , Hiroshi Kase , Katsuhiko Ando , Isao Kawamoto , Toru Yasuzawa , Hiroshi Sano , Joji Goto , Koji Yamada
发明人： Kazutoshi Kuroda , Hiroshi Kase , Katsuhiko Ando , Isao Kawamoto , Toru Yasuzawa , Hiroshi Sano , Joji Goto , Koji Yamada
IPC分类号： C07C323/20 , C07C327/26 , C12P7/00
CPC分类号： C07C327/26 , C07C323/20 , C12P7/00
摘要： KS-506a, KS-506x and KS-506g having an activity to inhibit cyclic nucleotide phosphodiesterase and KS-506m and KS-506h having an activity to inhibit histamine release are produced by culturing a microorganism belonging to the genus Mortierella.
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10.发明授权Novel substances KS-504a, KS-504b, KS-504d and KS-504e and process for their preparation 失效新型物质KS-504a，KS-504b，KS-504d和KS-504e及其制备方法
公开(公告)号：US4983775A
公开(公告)日：1991-01-08
申请号：US465893
申请日：1990-01-16
申请人： Satoshi Nakanishi , Koji Yamada , Katsuhiko Ando , Isao Kawamoto , Toru Yasuzawa , Hiroshi Sano , Noriaki Hirayama , Hiroshi Kase , Joji Goto , Etsuyo Shimizu
发明人： Satoshi Nakanishi , Koji Yamada , Katsuhiko Ando , Isao Kawamoto , Toru Yasuzawa , Hiroshi Sano , Noriaki Hirayama , Hiroshi Kase , Joji Goto , Etsuyo Shimizu
CPC分类号： C12R1/645 , C07C35/48 , C07C45/58 , C07C47/46 , C07D303/48 , C12P17/02 , C12P7/02 , C12P7/24
摘要： Novel physiologically active substances Ks-504a, KS-504b and KS-504d having a vasodilative activity and a novel physiologically active substance KS-504e having an activity to inhibit histamine secretion are produced by culturing a microorganism of the genus Mollisia.
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