摘要:
Bone-associated proteins derived from bone of mammals, including mice and human beings, named OSF-6. The protein is the novel natural type mammal protein, which can play an important role in bone formation, and belongs to a group of transcription control factors.OSF-6 can be used as a therapeutic agent for bone metabolic diseases, and also as a diagnostic agent for bone metabolic diseases, since it may demonstrate a high organ specificity to bone.
摘要:
A bone-related protein named OSF-4 which is obtained from bone tissue of a mammal including mouse or human, and a process for its production. This protein is a novel naturally occurring mammal protein of the cadherin family.OSF-4 acts as an adhesion molecule or a growth factor which takes part in the process of osteogenesis at the site of bone induction. OSF-4 can be used as an agent for treating bone metabolic diseases, and its high organ specificity for bones enables its use as a diagnostic reagent for bone metabolic diseases.
摘要:
A bone-related carboxypeptidase-like protein named OSF-5 which is obtained from bone tissue of a mammal including mouse or human, and a process for its production. This protein is a novel naturally occurring mammal protein which belongs to a group of carboxypeptidase molecules.OSF-5 acts as an adhesion molecule or a growth factor which takes part in the process of osteogenesis at the site of bone induction. OSF-5 can be used as an agent for treating bone metabolic diseases, and its high organ specificity for bones enables its use as a diagnostic reagent for bone metabolic diseases.
摘要:
The present invention provides a method for exploring low molecular weight compounds which regulate positively or negatively the expression of human BMP-4 with reference to a reporter activity by using 5′ upstream region gene containing the human BMP-4 promoter and an animal cell introduced with a recombinant expression vector that has been connected to an appropriate reporter gene. The low molecular weight compounds and their derivatives obtained by the present method have morphogenetic activity and inhibiting activity for bone and cartilage through the expression of human BMP-4 and are useful as preventive or therapeutic agents for cartilage and bone diseases.
摘要:
An n channel driver circuit comprised of an N channel MOS transistor is provided in parallel to a driver circuit comprised of a P channel MOS transistor. Normally, n channel driver circuit supplies an internal supply voltage, to activate driver circuit only at the time of current peak. Thus, an insufficient capability of n.sup.- channel driver circuit to supply current is supplemented.
摘要:
A semiconductor integrated circuit device comprising an internal reset circuit generating one shot pulse for resetting an internal circuit upon a power on. In the internal reset circuit, inputted to a two-input NOR gate are an output potential of an inverter inverting a first node coupled to a power supply through a capacitor, and an internal clock signal which level inverts at a predetermined timing after rising to a "H" level upon the power on. Then, the output of the NOR gate is applied to a second node in an internal circuit to be reset. The internal reset circuit outputs one shot pulses synchronizing with the first fall of the internal clock signal after the power on irrespective of a potential change rate of the first node after the power on. The first node is set to more easily attain a "H" level than the second node to be reset to a "L" level at the power on by adjusting characteristics of circuit elements connected to the first node and those of circuit elements connected to the second node. As a result, the second node is set to be without fail at a "L" level requiring no resetting when the inverted potential of the first node has a value allowing a generation of one shot pulses at the NOR gate, thereby preventing malfunction of the internal circuit due to erroneous resetting.
摘要:
A semicondcutor memory device includes an array of a plurality of memory cells arranged in a matrix manner, and a row or column decoder responsive to an external address signal for generating a row or column selecting signal. The memory cell array comprises (n+1) rows or columns. The row or column decoder comprises n output nodes. Transmission gates are provided between the decoder output node and row lines or column selecting lines for connecting each output node and each row line or column selecting line. The transmission gates are formed of a pair of CMOS transmission gates, whereby one output node is connected to two adjacent row lines or column selecting lines. This memory device further includes a circuit defining the connection manner of the transmission gate. This defining circuit turns one pair of CMOS transmission gates ON and OFF complementally. When there is a defective memory cell, the decoder output nodes are grouped into a first group including the output node corresponding to the faulty row or column having the defective memory cell, and a second group formed of the remaining output nodes. The defining circuit applies control signals to the CMOS transmission gates so that the ON/OFF states of the CMOS transmission gate pair related to the first group of output nodes and the CMOS transmission gate pair related to the second group of output node differ. The memory device further includes switching devices provided corresponding to each row line or column selecting line, responsive to the control signal from the defining cirucit to be turned on/off. This switching device connects only the faulty row line or the faulty column selecting line to the reference potential fixedly.
摘要:
In a washing device for parts of body including first cylinder means comprising a first cylinder and a first piston to be operated in the front end direction thereof by introducing pressurized water onto the first cylinder and a second piston to be operated in the front end direction thereof by introducing pressurized water into the second cylinder; pressurized water control means for selectively supplying pressurized water to both of the first and second cylinders, or to any one of them; and pressurized water supply means for supplying pressurized water to the pressurized water control means: the washing device further including sensor means for sensing that any one of the first and second pistons is operated over a predetermined operating position in the front end direction thereof. As one aspect of the invention, the pressurized water control means may be provided with a control member for controlling a supply amount pressurized water and which member is operated based on an input signal of the sensor means to supply a small amount of pressurized water. While, as another aspect of the invention, the pressurized water supply means may comprise pump means the capacity of which is variable to vary the capacity of pump means so as to reduce based on an input signal in the sensor means. The washing device of this invention can spout a weaken fountain for the purpose of bidet-washing with reliability, while it can spout an intensive fountain for the purpose of anus-washing. Also, there is no fear that a person who undergoes the anus or bidet-washing feels unpleasant.
摘要:
A side-light type spread illuminating apparatus includes a light guiding plate; a light source arranged along a light entering face of the light guiding plate; a double-sided prism sheet arranged at a light emitted face side of the light guiding plate; and an optical member arranged at a back face side facing the light emitted face of the light guiding plate. The optical member includes a light absorption member allowing prevention of reflection of light that has been introduced into the optical member.
摘要:
A throttle control device includes a throttle body (1). In the throttle body, an intake passage (1a), a first space (24a), and a second space (44) are formed. In the intake passage, a throttle valve (2) is rotatably arranged. The throttle valve is rotated by a motor (4). The motor is accommodated in the first space. The second space communicates with the first space. In addition, the second space is adjacent to the intake passage through the intermediation of a wall portion (20a). This makes it possible for the heat generated in the motor to be effectively dissipated from the first space into the intake passage via the second space and the wall portion.