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    Process for production of ether amine
    5.
    发明授权
    Process for production of ether amine 有权
    醚胺生产工艺

    公开(公告)号：US06576794B2

    公开(公告)日：2003-06-10

    申请号：US10015657

    申请日：2001-12-17

    申请人： Tetsuaki Fukushima ,  Hiroyuki Masuda ,  Uichiro Nishimoto ,  Hiroshi Abe

    发明人： Tetsuaki Fukushima ,  Hiroyuki Masuda ,  Uichiro Nishimoto ,  Hiroshi Abe

    IPC分类号： C07C25330

    CPC分类号： C07C253/30 ,  C07C213/02 ,  C07C255/13 ,  C07C217/08

    摘要： A process for producing an ether amine (3), which comprises reacting a primary or secondary alcohol (1), ROH, with acrylonitrile in an amount of 0.8 to 1.2 equivalents of the alcohol (1) in the presence of an alkali metal hydroxide in an amount of not less than 0.01 part by weight, but less than 0.05 part by weight per 100 parts by weight of the alcohol (1) to obtain an alkyloxypropionitrile (2), and then adding water to the reaction system without removing the alkali metal hydroxide therefrom and effecting hydrogenation using a hydrogenation catalyst: ROH(1)+CH2=CHCN→ROCH2CH2CN(2)→ROCH2CH2CH2NH2(3) wherein R denotes a linear or branched alkyl or alkenyl group having 6 to 24 carbon atoms. Also disclosed are a process for producing an ether tertiary amine (5), R—O—CH2—CH2—CH2—N(CH2R1)2, which comprises adding an aldehyde to the resulting ether amine (3) in the presence of a metal catalyst or a Raney nickel catalyst, and a process for producing an ether quaternary ammonium salt (6), R—O—CH2—CH2—CH2—N(CH2R1)2(R2), which comprises reacting a quaternizing agent with the ether tertiary amine (5).

    摘要翻译： 一种制备醚胺（3）的方法，其包括在碱金属氢氧化物存在下，将伯醇或仲醇（1），ROH与丙烯腈的量为0.8至1.2当量的醇（1） 相对于每100重量份的醇（1），不少于0.01重量份，但小于0.05重量份，得到烷氧基丙腈（2），然后向反应体系中加入水而不除去碱金属 使用氢化催化剂氢化，其中R表示碳原子数为6〜24的直链或支链烷基或链烯基。 还公开了制备醚叔胺（5），RO-CH2-CH2-CH2-N（CH2R1）2的方法，其包括在金属催化剂存在下将醛加到得到的醚胺（3）中，或 阮内镍催化剂和制备醚季铵盐（6），RO-CH2-CH2-CH2-N（CH2R1）2（R2）的方法，其包括使季铵化剂与醚叔胺（5）反应， 。

    Process for producing aliphatic nitrile
    6.
    发明授权
    Process for producing aliphatic nitrile 失效
    生产脂族腈的方法

    公开(公告)号：US5703264A

    公开(公告)日：1997-12-30

    申请号：US670787

    申请日：1996-06-24

    申请人： Wataru Yoshida ,  Tetsuaki Fukushima ,  Hideki Taniguchi ,  Hiroshi Abe

    发明人： Wataru Yoshida ,  Tetsuaki Fukushima ,  Hideki Taniguchi ,  Hiroshi Abe

    IPC分类号： B01J23/89 ,  C07B61/00 ,  C07C253/00 ,  C07C255/03

    CPC分类号： B01J23/8933 ,  B01J23/8926 ,  C07C253/00

    摘要： The process for producing an aliphatic nitrile comprising reacting an aliphatic alcohol having 6 to 40 carbon atoms with ammonia (a) in the presence of a copper/transition metal element in the fourth period other than Cr/platinum group element in the eighth group catalyst, (b) under a reaction system pressure in the range of from atmospheric pressure to 100 atm, (c) at a reaction system temperature in the range of from 100.degree. to 250.degree. C., (d) while introducing at least one gas selected from the group consisting of inert gases and hydrogen gas into the reaction system, (e) removing water formed by the reaction out of the reaction system, and (f) controlling the amount of the ammonia contained in the gas (exclusive of the water formed by the reaction) discharged out of the reaction system to 5 to 50% by volume based on the volume of the gas discharged (exclusive of the water formed by the reaction) makes it possible to produce various kinds of aliphatic nitriles.

    摘要翻译： 在第八组催化剂中除了Cr /铂族元素以外的第四期间，在铜/过渡金属元素的存在下，使具有6〜40个碳原子的脂肪醇与氨（a）反应的方法， （b）在大气压至100大气压范围内的反应体系压力下，（c）反应体系温度为100-250℃，（d）同时引入至少一种选择的气体 从由惰性气体和氢气组成的组中进入反应体系，（e）将由反应形成的水除去反应体系，和（f）控制气体中所含的氨的量（不包括形成的水 通过反应）从排出的气体的体积（不包括由反应形成的水）排出反应体系的5〜50体积％使得可以生产各种脂族腈。

    Process for producing N,N-dimethyl-N-alkylamine or N,N-dimethyl-N-alkenylamine
    7.
    发明授权
    Process for producing N,N-dimethyl-N-alkylamine or N,N-dimethyl-N-alkenylamine 失效
    制备N，N-二甲基-N-烷基胺或N，N-二甲基-N-链烯基胺的方法

    公开(公告)号：US5696294A

    公开(公告)日：1997-12-09

    申请号：US716521

    申请日：1996-09-19

    申请人： Hiroshi Abe ,  Hideki Taniguchi ,  Tetsuaki Fukushima

    发明人： Hiroshi Abe ,  Hideki Taniguchi ,  Tetsuaki Fukushima

    IPC分类号： B01J23/755 ,  B01J23/89 ,  C07B61/00 ,  C07C209/16 ,  C07C211/08

    CPC分类号： C07C209/16

    摘要： N,N-Dimethyl-N-alkylamine or -alkenylamine is prepared by reacting a higher alcohol and dimethylamine by passing hydrogen gas and dimethylamine into a reactor containing a catalyst for the reaction at a pressure of atmospheric pressure to 100 atm. at 150.degree. C. to 250.degree. C. and removing water produced in the reaction as a component of the mixed hydrogen and unreacted dimethylamine gas which is discharged from the reactor, wherein at the point in the reaction at which from 90 to 99% of the higher alcohol has reacted with dimethylamine, one of the following procedures is followed: i) the introduction of only dimethylamine gas into the reactor is stopped, and the reaction is allowed to continue at a temperature 20.degree. to 150.degree. C. lower than the reaction temperature recited above; ii) the introduction of only dimethylamine gas into the reactor is stopped while the temperature is decreased to a level of 20.degree. to 150.degree. C. lower than the temperature recited above, and the reaction is allowed to proceed at the reduced temperature; or iii) the introduction of only dimethylamine gas into the reactor is stopped immediately after decreasing the temperature to a level of 20.degree. to 150.degree. C. lower than the temperature recited above, and the reaction is allowed to continue at the reduced temperature.

    摘要翻译： N，N-二甲基-N-烷基胺或链烯基胺是通过使氢气和二甲胺在大气压至100atm的压力下通入氢气和二甲胺进入反应器的反应器中而制备的。 在150℃至250℃下，将从反应器中排出的混合氢和未反应的二甲胺气体的组分中的反应中除去的水除去，其中在反应中的90-99％ 高级醇与二甲基胺反应，遵循以下步骤之一：i）仅将二甲胺气体引入反应器停止，并使反应继续在比20℃至150℃的温度低 上述反应温度; ii）仅将二甲胺气体引入反应器中，同时将温度降低至比上述温度低20至150℃的水平，并使反应在降低的温度下进行; 或iii）在将温度降低到比上述温度低20至150℃的水平之后，立即停止向反应器中引入仅二甲胺气体，并使反应在降低的温度下继续进行。

    Hair cosmetic compositions
    8.
    发明授权
    Hair cosmetic compositions 有权
    头发化妆品组合物

    公开(公告)号：US06737050B2

    公开(公告)日：2004-05-18

    申请号：US10026641

    申请日：2001-12-27

    申请人： Yasuhiro Doi ,  Keiko Hasebe ,  Hiroyuki Masuda ,  Tetsuaki Fukushima ,  Uichiro Nishimoto ,  Hiroshi Abe

    发明人： Yasuhiro Doi ,  Keiko Hasebe ,  Hiroyuki Masuda ,  Tetsuaki Fukushima ,  Uichiro Nishimoto ,  Hiroshi Abe

    IPC分类号： A61K7075

    CPC分类号： A61K8/898 ,  A61K8/416 ,  A61K8/44 ,  A61K8/463 ,  A61K8/60 ,  A61K8/73 ,  A61K8/891 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q5/12

    摘要： Provided are a hair cosmetic composition comprising an ether type cationic surfactant represented by the following formula (1): wherein, R1 represents a linear or branched C6-24 alkyl or alkenyl group, R2 and R4 each represents a C1-6 alkyl group or —(AO)nH (A: a C2-4 alkylene group, n: a number of from 1 to 6 with the proviso that n pieces of A may be the same or different and their sequence is optional), R3 represents a C1-6 alkyl group or —(A′O)mH (A′: a C2-4 alkylene group, m: a number of from 1 to 6 with the proviso that m pieces of A may be the same or different and their sequence is optional), and X− represents an anion; a hair cleansing composition containing the cationic surfactant(1); and a method of treating hair with these compositions. The hair cosmetic composition of the present invention can impart good flexibility and smoothness to hair not only when it is wetted but also after drying. When used as a hair cleansing composition, it provides excellent quality of foam and feeling upon use and exhibits good low-temperature stability.

    摘要翻译： 提供一种包含由下式（1）表示的醚型阳离子表面活性剂的毛发化妆品组合物：其中，R 1表示直链或支链的C 6-24烷基或链烯基，R 2和R 4各自 表示C 1-6烷基或 - （AO）n H（A：C 2-4亚烷基，n：1至6的数，条件是n个A可以相同或不同，它们的顺序为 可选），R 3表示C 1-6烷基或 - （A'O）m H（A'：C 2-4亚烷基，m：1至6的数，条件是m个A 可以相同或不同，它们的顺序是任选的），而X“表示阴离子; 含有阳离子表面活性剂（1）的毛发清洁组合物; 以及使用这些组合物处理毛发的方法。本发明的毛发化妆品组合物可以赋予头发良好的柔韧性和光滑性，不仅当其被润湿时，而且在干燥之后。 当用作头发清洁组合物时，它提供优异的泡沫质量和使用感，并表现出良好的低温稳定性。

    Process for producing aliphatic amine derivative
    9.
    发明授权
    Process for producing aliphatic amine derivative 有权
    脂肪族胺衍生物的制造方法

    公开(公告)号：US6117948A

    公开(公告)日：2000-09-12

    申请号：US192385

    申请日：1998-11-16

    申请人： Tetsuaki Fukushima ,  Wataru Yoshida ,  Hiroshi Abe

    发明人： Tetsuaki Fukushima ,  Wataru Yoshida ,  Hiroshi Abe

    IPC分类号： C07C213/04 ,  C07C217/08 ,  C07C217/50 ,  C08G65/32 ,  C08L71/02

    CPC分类号： C07C213/04

    摘要： The present invention provides a process for easily producing an alkylene oxide adduct to an aliphatic amine compound which has a fully excellent color, is not turbid, and does not deteriorate in color even through long-term storage. That is, the present invention provides a process for producing an alkylene oxide adduct to a primary or secondary amine compound having an aliphatic, saturated or unsaturated, hydrocarbon radical having 8 to 22 carbon atoms, having an excellent color, by reacting an alkyene oxide to the amine compound, characterized by comprising the step of adding a base or an aqueous solution thereof to the amine compound and then heating the mixture.

    摘要翻译： 本发明提供一种容易地制备脂肪族胺化合物的烯化氧加合物的方法，其具有完全优异的颜色，不混浊，即使长期保存也不会劣化颜色。 也就是说，本发明提供了通过使氧化烯与氧化烯反应生成具有碳原子数为8〜22的脂肪族，饱和或不饱和的烃基的伯或仲胺化合物的烯化氧加合物，具有优异的颜色的方法 所述胺化合物的特征在于包括将碱或其水溶液加入到所述胺化合物中，然后加热所述混合物的步骤。

    Fluorescent molecule and method for detecting target nucleic acid
    10.
    发明授权
    Fluorescent molecule and method for detecting target nucleic acid 有权
    荧光分子和检测靶核酸的方法

    公开(公告)号：US08709721B2

    公开(公告)日：2014-04-29

    申请号：US13499826

    申请日：2010-10-01

    申请人： Hiroshi Abe ,  Yoshihiro Ito ,  Aya Shibata ,  Mika Ito

    发明人： Hiroshi Abe ,  Yoshihiro Ito ,  Aya Shibata ,  Mika Ito

    IPC分类号： C12Q1/68 ,  C07D409/00 ,  C07H19/04

    CPC分类号： G01N33/582 ,  C07D311/16 ,  C07D405/12 ,  C07H21/02 ,  C12Q1/6816 ,  C12Q1/6818 ,  G01N33/533 ,  Y02P20/55 ,  Y10T436/143333 ,  C12Q2523/107 ,  C12Q2563/107 ,  C12Q2565/101

    摘要： Provided are a fluorescent on/off switchable compound for a gene analysis, which is highly stable and highly sensitive, and enables amplification and observation of a trace gene signal, and a labeling reagent for detection of a bio-related material, which uses the fluorescent on/off switchable compound. A compound represented by the following formula (I′): wherein X is a hydrogen atom or a carboxylic acid-protecting group, Y is a 2,4-dinitrobenzenesulfonyl group, a 2-cyano-4-nitrobenzenesulfonyl group or a 5-nitropyridin-2-ylsulfonyl group, R1, R2, R3 and R4 are each independently a hydrogen atom, a halogen atom, a hydroxyl group, an alkyl group having a carbon number of 1 to 6, an alkoxy group having a carbon number of 1 to 6, an aryl group having a carbon number of 6 to 10, or a cyano group.

    摘要翻译： 提供了用于基因分析的荧光开/关可切换化合物，其高度稳定和高度灵敏，并且能够扩增和观察微量基因信号，以及用于检测生物相关材料的标记试剂，其使用荧光 开/关切换组合。 由下式（I'）表示的化合物：其中X是氢原子或羧酸保护基，Y是2,4-二硝基苯磺酰基，2-氰基-4-硝基苯磺酰基或5-硝基吡啶 -2-基磺酰基，R 1，R 2，R 3和R 4各自独立地为氢原子，卤素原子，羟基，碳数为1至6的烷基，碳数为1至 6，碳数为6〜10的芳基或氰基。