利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

78 条记录 (耗时 0.041 秒)

    Methods of screening for compounds which bind G protein-coupled receptors
    2.
    发明授权
    Methods of screening for compounds which bind G protein-coupled receptors 失效
    筛选结合G蛋白偶联受体的化合物的方法

    公开(公告)号：US07927821B2

    公开(公告)日：2011-04-19

    申请号：US11578325

    申请日：2005-04-11

    申请人： Ryo Fujii ,  Shoichi Okubo ,  Kazunori Nishi ,  Shuji Hinuma ,  Masaaki Mori

    发明人： Ryo Fujii ,  Shoichi Okubo ,  Kazunori Nishi ,  Shuji Hinuma ,  Masaaki Mori

    IPC分类号： G01N33/53 ,  G01N33/567 ,  G01N33/566 ,  C07K1/00 ,  C07K14/00 ,  C07K17/00

    CPC分类号： G01N33/76 ,  A61K31/403 ,  A61K31/4155 ,  A61K31/4523 ,  A61K38/1796 ,  C07K14/705 ,  G01N2333/726

    摘要： The present invention provides a method of screening an agonist or antagonist to a G protein-coupled receptor protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, or a salt thereof, which comprises using the receptor protein or a salt thereof and the ligand or a salt thereof; etc. The present invention is useful for screening agents for the prevention/treatment of, e.g., leukopenia, leukemia, lymphoma, malignant tumor, ulcerative colitis, rheumatoid arthritis, inflammatory bowel disorders, tonsil disorders, collagen disease, inflammatory disease, leukocytosis, heart failure, inherited muscle disorders, muscular dystrophy, neuromuscular degenerative disease, myocardial infarction, obesity, mellitus diabetes, hyperlipemia, arteriosclerosis, metabolic syndrome, thrombocytopenia, thrombocytosis, cancer, pulmonary edema, multiple organ failure, etc.

    摘要翻译： 本发明提供筛选G蛋白偶联受体蛋白的激动剂或拮抗剂的方法，其包含与SEQ ID NO：1所示的氨基酸序列相同或基本上相同的氨基酸序列，或其盐，其包含 使用受体蛋白或其盐和配体或其盐; 本发明可用于预防/治疗例如白细胞减少症，白血病，淋巴瘤，恶性肿瘤，溃疡性结肠炎，类风湿性关节炎，炎性肠病，扁桃体病，胶原病，炎性疾病，白细胞增多症，心脏病 失败，遗传性肌肉疾病，肌营养不良症，神经肌肉退行性疾病，心肌梗死，肥胖症，糖尿病，高脂血症，动脉硬化，代谢综合征，血小板减少症，血小板增多症，癌症，肺水肿，多器官衰竭等。

    Novel Ligand of G Protein Coupled Receptor Protein and Use Thereof
    3.
    发明申请
    Novel Ligand of G Protein Coupled Receptor Protein and Use Thereof 失效
    G蛋白偶联受体蛋白的新配体及其用途

    公开(公告)号：US20080305110A1

    公开(公告)日：2008-12-11

    申请号：US11578325

    申请日：2005-04-11

    申请人： Ryo Fujii ,  Shoichi Okubo ,  Kazunori Nishi ,  Shuji Hinuma ,  Masaaki Mori

    发明人： Ryo Fujii ,  Shoichi Okubo ,  Kazunori Nishi ,  Shuji Hinuma ,  Masaaki Mori

    IPC分类号： A61K39/395 ,  G01N33/566 ,  A61K31/415 ,  A61P37/00 ,  A61K38/00 ,  A61K31/7088

    CPC分类号： G01N33/76 ,  A61K31/403 ,  A61K31/4155 ,  A61K31/4523 ,  A61K38/1796 ,  C07K14/705 ,  G01N2333/726

    摘要： The present invention provides a method of screening an agonist or antagonist to a G protein-coupled receptor protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, or a salt thereof, which comprises using the receptor protein or a salt thereof and the ligand or a salt thereof; etc. The present invention is useful for screening agents for the prevention/treatment of, e.g., leukopenia, leukemia, lymphoma, malignant tumor, ulcerative colitis, rheumatoid arthritis, inflammatory bowel disorders, tonsil disorders, collagen disease, inflammatory disease, leukocytosis, heart failure, inherited muscle disorders, muscular dystrophy, neuromuscular degenerative disease, myocardial infarction, obesity, mellitus diabetes, hyperlipemia, arteriosclerosis, metabolic syndrome, thrombocytopenia, thrombocytosis, cancer, pulmonary edema, multiple organ failure, etc.

    摘要翻译： 本发明提供筛选G蛋白偶联受体蛋白的激动剂或拮抗剂的方法，其包含与SEQ ID NO：1所示的氨基酸序列相同或基本上相同的氨基酸序列，或其盐，其包含 使用受体蛋白或其盐和配体或其盐; 本发明可用于预防/治疗例如白细胞减少症，白血病，淋巴瘤，恶性肿瘤，溃疡性结肠炎，类风湿性关节炎，炎性肠病，扁桃体病，胶原病，炎性疾病，白细胞增多症，心脏病 失败，遗传性肌肉疾病，肌营养不良症，神经肌肉退行性疾病，心肌梗死，肥胖症，糖尿病，高脂血症，动脉硬化，代谢综合征，血小板减少症，血小板增多症，癌症，肺水肿，多器官衰竭等。

    Novel method of screening
    5.
    发明申请
    Novel method of screening 有权
    新型筛选方法

    公开(公告)号：US20070117160A1

    公开(公告)日：2007-05-24

    申请号：US11587285

    申请日：2005-04-22

    申请人： Ryo Fujii ,  Kazunori Nishi ,  Yasuhiro Tanaka ,  Masaaki Mori

    发明人： Ryo Fujii ,  Kazunori Nishi ,  Yasuhiro Tanaka ,  Masaaki Mori

    IPC分类号： G01N33/567 ,  G01N33/53

    CPC分类号： G01N33/566 ,  G01N2333/726 ,  G01N2500/00 ,  Y10S435/975

    摘要： The present invention relates to screening of an agonist/antagonist, etc. Specifically, the present invention provides a method of screening an agonist or antagonist of a G protein-coupled receptor protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, or a salt thereof, which comprises using the receptor protein or a salt thereof and a cholesterol metabolism-related substance, and so on.

    摘要翻译： 本发明涉及激动剂/拮抗剂等的筛选。具体而言，本发明提供筛选G蛋白偶联受体蛋白的激动剂或拮抗剂的方法，其包含与氨基酸相同或基本上相同的氨基酸序列 由SEQ ID NO：1表示的序列或其盐，其包括使用受体蛋白质或其盐和胆固醇代谢相关物质等。

    Method of exhaled gas measurement and analysis and apparatus therefor
    6.
    发明授权
    Method of exhaled gas measurement and analysis and apparatus therefor 有权
    呼出气体测量和分析方法及其设备

    公开(公告)号：US09591992B2

    公开(公告)日：2017-03-14

    申请号：US13565437

    申请日：2012-08-02

    申请人： Yasuhiro Kubo ,  Masaaki Mori

    发明人： Yasuhiro Kubo ,  Masaaki Mori

    IPC分类号： A61B5/08 ,  A61B5/083 ,  G01N1/22 ,  G01N21/3504 ,  G01N33/497 ,  A61B5/097

    CPC分类号： A61B5/0836 ,  A61B5/097 ,  G01N1/22 ,  G01N21/3504 ,  G01N33/497

    摘要： An exhalation collected in a breath bag capable of expanding and contracting is sucked into a gas inlet vessel 21 with a given volume (Va), and then the gas inlet vessel 21 is communicated by means of valve V2 with a cell 11 that is maintained at an atmospheric pressure by being pre-filled with a sample gas or reference gas. After the communication, the gas pressure is measured by a pressure sensor 16 attached to the cell 11. Whether the exhalation collected in the breath bag is below a given amount or not can be accurately judged.

    摘要翻译： 将收集在能够膨胀和收缩的呼吸袋中的呼气吸入具有给定体积（Va）的气体入口容器21中，然后气体入口容器21通过阀V2与保持在 通过预先填充有样品气体或参考气体的大气压力。 在通信之后，气体压力通过安装在电池单元11上的压力传感器16来测量。可以准确地判断呼吸袋中收集的呼气是否低于给定量。

    Screening method
    7.
    发明授权
    Screening method 失效
    筛选方法

    公开(公告)号：US08057990B2

    公开(公告)日：2011-11-15

    申请号：US11885781

    申请日：2006-03-07

    申请人： Masaaki Mori ,  Kimiko Kanehashi

    发明人： Masaaki Mori ,  Kimiko Kanehashi

    IPC分类号： G01N33/53 ,  C07D219/00 ,  C07D219/08 ,  C07D219/10 ,  C07K14/00

    CPC分类号： A61K31/473 ,  G01N2500/02

    摘要： The present invention provides a medicament for preventing/treating cancer, comprising a tacrine compound, or a compound promoting the binding between the tacrine compound and a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1.

    摘要翻译： 本发明提供了用于预防/治疗癌症的药物，其包含他克林化合物或促进他克林化合物与包含与SEQ ID NO所示氨基酸序列相同或基本相同的氨基酸序列的蛋白质之间的结合的化合物 ：1。

    FILTER MEDIUM AND METHOD OF MANUFACTURING THE SAME AND FILTER UNIT
    8.
    发明申请
    FILTER MEDIUM AND METHOD OF MANUFACTURING THE SAME AND FILTER UNIT 有权
    过滤介质及其制造方法和过滤器单元

    公开(公告)号：US20100269464A1

    公开(公告)日：2010-10-28

    申请号：US12742625

    申请日：2008-11-11

    申请人： Masaaki Mori ,  Masatoshi Suzuki

    发明人： Masaaki Mori ,  Masatoshi Suzuki

    IPC分类号： B01D39/20 ,  B32B37/04

    CPC分类号： B01D39/1692 ,  B01D69/12 ,  B01D71/36 ,  B01D2239/0654

    摘要： Provided is a filter medium including a porous polytetrafluoroethylene (PTFE) membrane and a gas-permeable supporting member that are integrated to ensure sufficient stiffness, having excellent gas permeability, and providing excellent bonding between respective layers included in the filter medium. The gas-permeable supporting member includes: a substrate having gas-permeability; and a fiber layer that is placed on the substrate so as to be in contact with the porous PTFE membrane. The gas-permeable supporting member has a structure in which fibers of the fiber layer enter into the substrate and are entangled with the substrate so that the fiber layer is bonded to the substrate. The fiber layer contains polyolefin-containing fibers that are bonded to the porous membrane.

    摘要翻译： 提供了一种过滤介质，其包括多孔聚四氟乙烯（PTFE）膜和气体可渗透的支撑构件，其一体化以确保足够的刚度，具有优异的气体渗透性，并且在包含在过滤介质中的各个层之间提供优异的粘合。 透气性支撑构件包括：具有透气性的基板; 以及放置在基板上以与多孔PTFE膜接触的纤维层。 透气性支撑构件具有纤维层的纤维进入基板并与基板缠结的结构，使得纤维层与基板结合。 纤维层含有与多孔膜结合的含有聚烯烃的纤维。

    Method of Exhaled Gas Measurement and Analysis and Apparatus Therefor
    9.
    发明申请
    Method of Exhaled Gas Measurement and Analysis and Apparatus Therefor 审中-公开
    呼气测量与分析方法及其设备

    公开(公告)号：US20090306527A1

    公开(公告)日：2009-12-10

    申请号：US12223539

    申请日：2007-01-31

    申请人： Yasuhiro Kubo ,  Masaaki Mori

    发明人： Yasuhiro Kubo ,  Masaaki Mori

    IPC分类号： A61B5/097

    CPC分类号： A61B5/0836 ,  A61B5/097 ,  G01N1/22 ,  G01N21/3504 ,  G01N33/497

    摘要： An exhalation collected in a breath bag capable of expanding and contracting is sucked into a gas inlet vessel 21 with a given volume (Va), and then the gas inlet vessel 21 is communicated by means of valve V2 with a cell 11 that is maintained at an atmospheric pressure by being pre-filled with a sample gas or reference gas. After the communication, the gas pressure is measured by a pressure sensor 16 attached to the cell 11. Whether the exhalation collected in the breath bag is below a given amount or not can be accurately judged.

    摘要翻译： 将收集在能够膨胀和收缩的呼吸袋中的呼气吸入具有给定体积（Va）的气体入口容器21中，然后气体入口容器21通过阀V2与保持在 通过预先填充有样品气体或参考气体的大气压力。 在通信之后，气体压力通过安装在电池单元11上的压力传感器16来测量。可以准确地判断呼吸袋中收集的呼气是否低于给定量。

    Polypeptide DNA thereof and use of the same
    10.
    发明授权
    Polypeptide DNA thereof and use of the same 失效
    其多肽DNA及其用途

    公开(公告)号：US07323541B2

    公开(公告)日：2008-01-29

    申请号：US10489537

    申请日：2002-09-13

    申请人： Masaaki Mori ,  Kozo Hayashi ,  Hiroyuki Miya ,  Shuji Sato ,  Chieko Kitada ,  Hirokazu Matsumoto ,  Toshimi Nagi ,  Yukio Shimomura

    发明人： Masaaki Mori ,  Kozo Hayashi ,  Hiroyuki Miya ,  Shuji Sato ,  Chieko Kitada ,  Hirokazu Matsumoto ,  Toshimi Nagi ,  Yukio Shimomura

    IPC分类号： A61K38/04

    CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K48/00

    摘要： The present invention aims at providing a novel polypeptide, a receptor, a DNA thereof, and the like. Specifically, the present invention provides a polypeptide having a binding ability to the protein represented by SEQ ID NO: 1 or SEQ ID NO: 3, or its amide, its ester or its salt, a polynucleotide encoding the polypeptide, an antisense polynucleotide or an antibody to the polypeptide, a screening of agent for prevention and/or treatment of cancer, obesity, etc., which comprises using the above, and the like.The polypeptide, receptor, polynucleotide, antisense polynucleotide, antibody and the like are useful for an agent of prevention and/or treatment of cancer, obesity and the like. Further, they are useful for a screening of an agent for prevention and/or treatment of cancer, obesity and the like.

    摘要翻译： 本发明的目的在于提供新的多肽，受体及其DNA等。 具体地说，本发明提供了具有与SEQ ID NO：1或SEQ ID NO：3所代表的蛋白结合能力的多肽或其酰胺，其酯或其盐，编码多肽的多核苷酸，反义多核苷酸或 对多肽的抗体，筛选用于预防和/或治疗癌症，肥胖症等的药剂，其包括使用上述方法等。 多肽，受体，多核苷酸，反义多核苷酸，抗体等可用于预防和/或治疗癌症，肥胖症等。 此外，它们可用于筛选用于预防和/或治疗癌症，肥胖症等的药剂。