公开(公告)号：US08057990B2

公开(公告)日：2011-11-15

申请号：US11885781

申请日：2006-03-07

申请人： Masaaki Mori ,  Kimiko Kanehashi

发明人： Masaaki Mori ,  Kimiko Kanehashi

IPC分类号： G01N33/53 ,  C07D219/00 ,  C07D219/08 ,  C07D219/10 ,  C07K14/00

CPC分类号： A61K31/473 ,  G01N2500/02

摘要： The present invention provides a medicament for preventing/treating cancer, comprising a tacrine compound, or a compound promoting the binding between the tacrine compound and a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1.

摘要翻译： 本发明提供了用于预防/治疗癌症的药物，其包含他克林化合物或促进他克林化合物与包含与SEQ ID NO所示氨基酸序列相同或基本相同的氨基酸序列的蛋白质之间的结合的化合物 ：1。

公开(公告)号：US20080280938A1

公开(公告)日：2008-11-13

申请号：US11885781

申请日：2006-03-07

申请人： Masaaki Mori ,  Kimiko Kanehashi

发明人： Masaaki Mori ,  Kimiko Kanehashi

IPC分类号： A61K31/473 ,  G01N33/566 ,  G01N33/53

CPC分类号： A61K31/473 ,  G01N2500/02

摘要： The present invention provides a medicament for preventing/treating cancer, comprising a tacrine compound, or a compound promoting the binding between the tacrine compound and a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1.

摘要翻译： 本发明提供了用于预防/治疗癌症的药物，其包含他克林化合物或促进他克林化合物与包含与SEQ ID NO所示氨基酸序列相同或基本相同的氨基酸序列的蛋白质之间的结合的化合物 ：1。

公开(公告)号：US09591992B2

公开(公告)日：2017-03-14

申请号：US13565437

申请日：2012-08-02

申请人： Yasuhiro Kubo ,  Masaaki Mori

发明人： Yasuhiro Kubo ,  Masaaki Mori

IPC分类号： A61B5/08 ,  A61B5/083 ,  G01N1/22 ,  G01N21/3504 ,  G01N33/497 ,  A61B5/097

CPC分类号： A61B5/0836 ,  A61B5/097 ,  G01N1/22 ,  G01N21/3504 ,  G01N33/497

摘要： An exhalation collected in a breath bag capable of expanding and contracting is sucked into a gas inlet vessel 21 with a given volume (Va), and then the gas inlet vessel 21 is communicated by means of valve V2 with a cell 11 that is maintained at an atmospheric pressure by being pre-filled with a sample gas or reference gas. After the communication, the gas pressure is measured by a pressure sensor 16 attached to the cell 11. Whether the exhalation collected in the breath bag is below a given amount or not can be accurately judged.

摘要翻译： 将收集在能够膨胀和收缩的呼吸袋中的呼气吸入具有给定体积（Va）的气体入口容器21中，然后气体入口容器21通过阀V2与保持在 通过预先填充有样品气体或参考气体的大气压力。 在通信之后，气体压力通过安装在电池单元11上的压力传感器16来测量。可以准确地判断呼吸袋中收集的呼气是否低于给定量。

公开(公告)号：US20100269464A1

公开(公告)日：2010-10-28

申请号：US12742625

申请日：2008-11-11

申请人： Masaaki Mori ,  Masatoshi Suzuki

发明人： Masaaki Mori ,  Masatoshi Suzuki

IPC分类号： B01D39/20 ,  B32B37/04

CPC分类号： B01D39/1692 ,  B01D69/12 ,  B01D71/36 ,  B01D2239/0654

摘要： Provided is a filter medium including a porous polytetrafluoroethylene (PTFE) membrane and a gas-permeable supporting member that are integrated to ensure sufficient stiffness, having excellent gas permeability, and providing excellent bonding between respective layers included in the filter medium. The gas-permeable supporting member includes: a substrate having gas-permeability; and a fiber layer that is placed on the substrate so as to be in contact with the porous PTFE membrane. The gas-permeable supporting member has a structure in which fibers of the fiber layer enter into the substrate and are entangled with the substrate so that the fiber layer is bonded to the substrate. The fiber layer contains polyolefin-containing fibers that are bonded to the porous membrane.

摘要翻译： 提供了一种过滤介质，其包括多孔聚四氟乙烯（PTFE）膜和气体可渗透的支撑构件，其一体化以确保足够的刚度，具有优异的气体渗透性，并且在包含在过滤介质中的各个层之间提供优异的粘合。 透气性支撑构件包括：具有透气性的基板; 以及放置在基板上以与多孔PTFE膜接触的纤维层。 透气性支撑构件具有纤维层的纤维进入基板并与基板缠结的结构，使得纤维层与基板结合。 纤维层含有与多孔膜结合的含有聚烯烃的纤维。

公开(公告)号：US20090306527A1

公开(公告)日：2009-12-10

申请号：US12223539

申请日：2007-01-31

申请人： Yasuhiro Kubo ,  Masaaki Mori

发明人： Yasuhiro Kubo ,  Masaaki Mori

IPC分类号： A61B5/097

CPC分类号： A61B5/0836 ,  A61B5/097 ,  G01N1/22 ,  G01N21/3504 ,  G01N33/497

摘要： An exhalation collected in a breath bag capable of expanding and contracting is sucked into a gas inlet vessel 21 with a given volume (Va), and then the gas inlet vessel 21 is communicated by means of valve V2 with a cell 11 that is maintained at an atmospheric pressure by being pre-filled with a sample gas or reference gas. After the communication, the gas pressure is measured by a pressure sensor 16 attached to the cell 11. Whether the exhalation collected in the breath bag is below a given amount or not can be accurately judged.

摘要翻译： 将收集在能够膨胀和收缩的呼吸袋中的呼气吸入具有给定体积（Va）的气体入口容器21中，然后气体入口容器21通过阀V2与保持在 通过预先填充有样品气体或参考气体的大气压力。 在通信之后，气体压力通过安装在电池单元11上的压力传感器16来测量。可以准确地判断呼吸袋中收集的呼气是否低于给定量。

公开(公告)号：US07323541B2

公开(公告)日：2008-01-29

申请号：US10489537

申请日：2002-09-13

申请人： Masaaki Mori ,  Kozo Hayashi ,  Hiroyuki Miya ,  Shuji Sato ,  Chieko Kitada ,  Hirokazu Matsumoto ,  Toshimi Nagi ,  Yukio Shimomura

发明人： Masaaki Mori ,  Kozo Hayashi ,  Hiroyuki Miya ,  Shuji Sato ,  Chieko Kitada ,  Hirokazu Matsumoto ,  Toshimi Nagi ,  Yukio Shimomura

IPC分类号： A61K38/04

CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K48/00

摘要： The present invention aims at providing a novel polypeptide, a receptor, a DNA thereof, and the like. Specifically, the present invention provides a polypeptide having a binding ability to the protein represented by SEQ ID NO: 1 or SEQ ID NO: 3, or its amide, its ester or its salt, a polynucleotide encoding the polypeptide, an antisense polynucleotide or an antibody to the polypeptide, a screening of agent for prevention and/or treatment of cancer, obesity, etc., which comprises using the above, and the like.The polypeptide, receptor, polynucleotide, antisense polynucleotide, antibody and the like are useful for an agent of prevention and/or treatment of cancer, obesity and the like. Further, they are useful for a screening of an agent for prevention and/or treatment of cancer, obesity and the like.

摘要翻译： 本发明的目的在于提供新的多肽，受体及其DNA等。 具体地说，本发明提供了具有与SEQ ID NO：1或SEQ ID NO：3所代表的蛋白结合能力的多肽或其酰胺，其酯或其盐，编码多肽的多核苷酸，反义多核苷酸或 对多肽的抗体，筛选用于预防和/或治疗癌症，肥胖症等的药剂，其包括使用上述方法等。 多肽，受体，多核苷酸，反义多核苷酸，抗体等可用于预防和/或治疗癌症，肥胖症等。 此外，它们可用于筛选用于预防和/或治疗癌症，肥胖症等的药剂。

公开(公告)号：US07273710B2

公开(公告)日：2007-09-25

申请号：US10332082

申请日：2001-07-04

申请人： Masaaki Mori ,  Yukio Shimomura ,  Mioko Harada ,  Tsukasa Sugo ,  Yasushi Shintani

发明人： Masaaki Mori ,  Yukio Shimomura ,  Mioko Harada ,  Tsukasa Sugo ,  Yasushi Shintani

IPC分类号： C07K11/02 ,  C07K14/705 ,  G01N33/566

CPC分类号： G01N33/566 ,  A61K38/00 ,  G01N33/74 ,  G01N2333/726

摘要： The present invention relates to a screening method for a compound or a salt thereof that alters the binding property of MCH or a salt thereof to SLT or a salt thereof, or a partial peptide thereof, an amide or an ester thereof, or a salt thereof, characterized by using MCH, a derivative or a salt thereof and SLT or a salt thereof, or a partial peptide thereof, an amide or an ester thereof, or a salt thereof. The screening method of the present invention is useful for screening an SLT agonist, which can be used as an agent for promoting appetite (eating), and an SLT antagonist, which can be used as a prophylactic and/or therapeutic agent for obesity.

摘要翻译： 本发明涉及一种化合物或其盐的筛选方法，其改变MCH或其盐与SLT或其盐或其部分肽，酰胺或其酯或其盐的结合性 其特征在于使用MCH，其衍生物或其盐，SLT或其盐或其部分肽，酰胺或其酯或其盐。 本发明的筛选方法可用于筛选可用作促进食欲的药物（进食）的SLT激动剂和可用作肥胖症的预防和/或治疗剂的SLT拮抗剂。

公开(公告)号：US07268212B2

公开(公告)日：2007-09-11

申请号：US10480739

申请日：2002-06-13

申请人： Shuji Hinuma ,  Ryo Fujii ,  Shoji Fukusumi ,  Masaaki Mori ,  Hiromi Yoshida

发明人： Shuji Hinuma ,  Ryo Fujii ,  Shoji Fukusumi ,  Masaaki Mori ,  Hiromi Yoshida

IPC分类号： C07K14/47

CPC分类号： G01N33/566 ,  C07K14/47 ,  C07K14/705 ,  C07K14/723 ,  G01N33/92

摘要： A GPR7 ligand containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:1 wherein the N-terminal amino acid residue may optionally be brominated, is useful in developing a receptor-binding assay system with the use of the GPR7 expression system, in screening a candidate compound for a drug such as an antiobestic, etc.

摘要翻译： 含有与SEQ ID NO：1所示的氨基酸序列相同或基本上相同的氨基酸序列的GPR7配体，其中N-末端氨基酸残基可任选被溴化，可用于开发受体结合测定系统，其中 使用GPR7表达系统，筛选候选化合物用于药物如抗生物等。

公开(公告)号：US06940083B2

公开(公告)日：2005-09-06

申请号：US10381314

申请日：2001-09-19

申请人： Masaaki Mori ,  Yasuhiro Kubo ,  Masahiko Miyoshi ,  Tamotsu Hamao ,  Hiroaki Mizui

发明人： Masaaki Mori ,  Yasuhiro Kubo ,  Masahiko Miyoshi ,  Tamotsu Hamao ,  Hiroaki Mizui

IPC分类号： A61B5/083 ,  G01N21/35 ,  G01N33/00 ,  G01N15/06

CPC分类号： A61B5/0836 ,  G01N21/3504 ,  G01N33/004 ,  G01N2021/3536 ,  Y02A50/2342

摘要： In an isotopic gas analyzer, a gas injector (21) is provided for pressurizing a gas specimen in cells (11a,11b). The pressurization of the gas specimen virtually produces the same effect as increasing the concentration of carbon dioxide in the gas specimen, thereby improving an S/N ratio for the analysis and hence data reproducibility.

摘要翻译： 在同位素气体分析仪中，设置有气体注入器（21），用于对单元（11a，11b）中的气体样本进行加压。 气体样本的加压实际上产生与增加气体样本中二氧化碳浓度相同的效果，从而提高了分析的S / N比，从而提高了数据再现性。

公开(公告)号：US20050154190A1

公开(公告)日：2005-07-14

申请号：US10499172

申请日：2002-12-13

申请人： Masaaki Mori ,  Tomoko Chikatsu ,  Shuji Sato ,  Toshimi Nagi ,  Tsukasa Sugo

发明人： Masaaki Mori ,  Tomoko Chikatsu ,  Shuji Sato ,  Toshimi Nagi ,  Tsukasa Sugo

IPC分类号： A61K31/00 ,  A61P25/00 ,  A61P29/00 ,  A61P37/00 ,  A61P43/00 ,  C07K14/705 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N15/12 ,  G01N33/53 ,  A01K67/00 ,  C07F9/10 ,  C07H21/04 ,  G01N33/567

CPC分类号： C07K14/705 ,  A61K31/00 ,  G01N2500/02 ,  Y10S435/975

摘要： The present invention relates to a screening method/screening kit for screening a compound or its salt that changes the binding properties of (a) a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1 or SEQ ID NO: 19, its partial peptides, or salts thereof, and (b) a ligand capable of binding specifically to the protein; compounds obtained by the screening or salts thereof; pharmaceuticals comprising the compounds or salts thereof; a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 19; etc. The compounds obtained by the screening of the present invention are useful as agents for the prevention/treatment of, for example, neurodegenerative diseases, immunological diseases, edema, acid indigestion, etc.

摘要翻译： 本发明涉及一种用于筛选化合物或其盐的筛选方法/筛选试剂盒，其改变（a）含有与SEQ ID NO：1所示的氨基酸序列相同或基本相同的氨基酸序列的蛋白质的结合特性。 1或SEQ ID NO：19，其部分肽或其盐，和（b）能够特异性结合蛋白质的配体; 通过筛选获得的化合物或其盐; 包含其化合物或其盐的药物; 含有与SEQ ID NO：19所示的氨基酸序列相同或基本相同的氨基酸序列的蛋白质; 通过本发明的筛选获得的化合物可用作预防/治疗例如神经变性疾病，免疫疾病，水肿，酸消化不良等的试剂。