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公开(公告)号：US10302641B2
公开(公告)日：2019-05-28
申请号：US14766377
申请日：2014-01-23
申请人： Shunichiro Nobuki , Muneo Maeshima , Terumi Tamura , Kenta Imai
发明人： Shunichiro Nobuki , Muneo Maeshima , Terumi Tamura , Kenta Imai
IPC分类号： G01N21/05 , G01N21/69 , G01N21/76 , G01N27/74 , G01N35/00 , G01N33/543 , G01N33/561
摘要： An analyzing device of the present invention is provided with a flow chamber that a fluid including magnetic particles associated with a labeling substance flows from a fluid inlet to a fluid outlet, magnetic trap means to apply a magnetic field for trapping the magnetic particles to the fluid in the flow chamber, a working electrode and a counter electrode to apply a voltage to the magnetic particles trapped by the magnetic trap means, and to emit a luminescence, a light detection element to detect a luminescence derived from the labeling substance on the magnetic particles trapped in the flow chamber, and regulating means to regulate a region that the light detection element detects the luminescence derived from the labeling substance on a part of magnetic particles of them trapped by the magnetic trap means.
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2.发明授权公开(公告)号：US06936152B2
公开(公告)日：2005-08-30
申请号：US09852029
申请日：2001-05-10
IPC分类号： G01N27/447 , C25B13/02 , G01N27/27
CPC分类号： G01N27/44782 , G01N27/44704
摘要： At a wall constituting a space for a thermostatic oven in an electrophoresis apparatus, a capillary array attachment portion is formed which permits attachment of a plurality of capillary arrays having different length. Thereby, a selected capillary array constituted by collecting a plurality of capillaries can be easily attached to the electrophoresis apparatus depending on measurement purpose.
摘要翻译： 在构成电泳装置中的恒温箱的空间的壁上形成毛细管阵列附着部，其可以附着多个不同长度的毛细管阵列。 由此，根据测定目的，可以容易地将通过收集多个毛细管构成的所选毛细管阵列附着于电泳装置。
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公开(公告)号：US06191849B1
公开(公告)日：2001-02-20
申请号：US09219873
申请日：1998-12-24
申请人： Muneo Maeshima , Kazuo Takeda , Shigeru Matsui
发明人： Muneo Maeshima , Kazuo Takeda , Shigeru Matsui
IPC分类号： G01N2147
CPC分类号： G01N21/9501 , G01N21/9505
摘要： Disclosed is a wafer inspecting apparatus suitable to determine whether a scattering substance is a surface foreign matter or an internal defect even if the particle size of the scattering substance is smaller than the wavelength of irradiation rays used for inspection. The wafer is obliquely irradiated with irradiation rays at the Brewster angle, and scattered rays which are scattered from a scattering substance on or in the wafer are detected at and angle 0° and an angle of the Brewster angle or more by detectors. Then, it is determined whether the scattering substance is a surface foreign matter or an internal defect on the basis of a ratio between the intensities of the scattered rays detected by the detectors. The intensity of scattered rays which are scattered from a surface foreign matter and detected at an angle of the Brewster angle or more is larger than the intensity of scattered rays which are scattered from the foreign matter and detected at an angle 0°, and the intensity of scattered rays which are scattered from an internal defect and detected at an angle of the Brewster angle or more is smaller than the intensity of scattered rays which are scattered from the internal defect and detected at an angle 0°. This makes it possible to distinguish the surface foreign matter and the internal defect from each other.
摘要翻译： 公开了一种适用于确定散射物质是表面异物还是内部缺陷的晶片检查装置，即使散射物质的粒径小于用于检查的照射射线的波长。 以布鲁斯特角度的照射光线倾斜照射晶片，从晶片上或晶片上的散射物质散射的散射光线以0°的角度和布鲁斯特角度以上的角度检测。 然后，基于由检测器检测到的散射光线的强度之间的比例来确定散射物质是表面异物还是内部缺陷。 从表面异物散射并以布鲁斯特角度以上的角度检测的散射光的强度大于从异物散射并以0°的角度检测的散射光的强度，强度 从内部缺陷散射并以布鲁斯特角度以上的角度检测的散射光的散射光小于从内部缺陷散射并以0°的角度检测的散射光的强度。 这使得可以将表面异物和内部缺陷彼此区分开。
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公开(公告)号：US6160615A
公开(公告)日：2000-12-12
申请号：US255766
申请日：1999-02-23
申请人： Shigeru Matsui , Muneo Maeshima , Isao Nemoto
发明人： Shigeru Matsui , Muneo Maeshima , Isao Nemoto
IPC分类号： H01L21/66 , G01N21/94 , G01N21/95 , G01N21/956 , H01L21/00 , G01N21/00 , C23C16/00 , G01B11/06
CPC分类号： H01L21/67288 , G01N21/94 , G01N21/9501
摘要： A sample is supported flat in high precision by a sample chuck, and is easily mounted and dismounted.A wafer lifting mechanism is arranged in a position separated from a rotating system of a rotatable wafer chuck, and a wafer is lifted from a supporting surface by moving the wafer lifting mechanism upward to let pins penetrate through through holes of the wafer chuck under a state that the wafer chuck is stopped at a sample mounting-and-dismounting position.
摘要翻译： 样品通过样品卡盘以高精度平坦地支撑，并且易于安装和拆卸。 将晶片升降机构设置在与旋转晶片卡盘的旋转系统分离的位置，通过向上移动晶片升降机构使晶片从支撑面抬起，以使引脚在状态下穿过晶片卡盘的通孔 晶片卡盘停在样品安装和拆卸位置。
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公开(公告)号：US6157444A
公开(公告)日：2000-12-05
申请号：US198644
申请日：1998-11-24
申请人： Koji Tomita , Muneo Maeshima , Shigeru Matsui , Hitoshi Komuro , Kazuo Takeda
发明人： Koji Tomita , Muneo Maeshima , Shigeru Matsui , Hitoshi Komuro , Kazuo Takeda
CPC分类号： G01N21/9505 , G01N21/9501
摘要： In order to easily evaluate defects of the silicon wafer affecting the characteristic of a device, the present invention provides a defect inspection apparatus for detecting defects existing on a surface of a sample and/or inside the sample, which comprises a display apparatus for displaying a distribution of the defects on a graph having coordinate axes of distance from a central position of the sample and the depth where the defect exists based on the depth information and the positional information obtained by a detecting means.
摘要翻译： 为了容易地评估影响器件特性的硅晶片的缺陷，本发明提供了一种用于检测存在于样品表面和/或样品内部的缺陷的缺陷检查装置，其包括显示装置 基于由检测装置获得的深度信息和位置信息，在具有距离样本的中心位置的距离的坐标轴和存在缺陷的深度的图形上的缺陷的分布。
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公开(公告)号：US10294519B2
公开(公告)日：2019-05-21
申请号：US14233256
申请日：2012-05-16
申请人： Toshiro Saito , Koshin Hamasaki , Satoshi Takahashi , Muneo Maeshima , Kyoko Imai , Kazumichi Imai , Ryuji Tao
发明人： Toshiro Saito , Koshin Hamasaki , Satoshi Takahashi , Muneo Maeshima , Kyoko Imai , Kazumichi Imai , Ryuji Tao
IPC分类号： C12Q1/6834 , C12N15/10
摘要： A convenient method for nucleic acid analysis is provided, which enables 1000 or more types of nucleic acid to be analyzed collectively with high comprehensiveness and with a dynamic range of at least four digits. In particular, provided is a very effective analytical method especially for untranslated RNAs and microRNAs, of which the types of target nucleic acids is 10000 or lower. Nucleic acids can be analyzed conveniently and rapidly with high comprehensiveness and quantitative performance at single-molecule sensitivity and resolution by following the steps of: preparing a group of target nucleic acid fragments one molecule at a time and hybridizing the nucleic acid molecules, which have known base sequences and have been labeled with the fluorescence substances, with the group of the target nucleic acid fragments to detect the fluorescence substances labeling the hybridized nucleic acid molecules.
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公开(公告)号：US09109194B2
公开(公告)日：2015-08-18
申请号：US13505803
申请日：2010-11-05
申请人： Toshifumi Honda , Hiroko Fujita , Muneo Maeshima , Akira Maekawa , Yoshiko Ishida , Yuta Urano , Shinya Murakami
发明人： Toshifumi Honda , Hiroko Fujita , Muneo Maeshima , Akira Maekawa , Yoshiko Ishida , Yuta Urano , Shinya Murakami
摘要： When multiple kinds of bacterial colonies are present in a petri dish and, for example, a drug tolerance is to be measured, harvesting of mixed colonies of different types of bacteria makes it impossible to accurately determine the drug tolerance. Also, it is required to improve the throughput of a device for harvesting a bacterial colony. From images illuminated from multiple directions, isolating bacterial colonies are automatically extracted. Next, the image feature amounts are calculated from the multiple images that are illuminated from multiple directions and colonies are grouped depending on the feature amounts. Then, bacterial colonies to be harvested are determined based on the results of the grouping.
摘要翻译： 当培养皿中存在多种细菌菌落时，例如测定药物耐受性时，收集不同类型细菌的混合菌落使得不可能准确地确定药物耐受性。 此外，需要提高用于收获细菌菌落的装置的产量。 从多个方向照射的图像，分离细菌菌落被自动提取。 接下来，根据从多个方向照明的多个图像计算图像特征量，并且根据特征量对殖民地进行分组。 然后，基于分组的结果确定要收获的细菌菌落。
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公开(公告)号：US20120141330A1
公开(公告)日：2012-06-07
申请号：US13382316
申请日：2010-07-05
IPC分类号： G01N21/00
CPC分类号： G01N21/51 , G01N15/0205 , G01N21/253 , G01N2015/0065 , G01N2035/00396 , G01N2035/0453
摘要： To be adapted to various types of latex reagents for detecting scattered light and thereby measuring agglutination reactions with high sensitivity while sufficiently ensuring integration time. To be adapted to various types of latex particles of different particle sizes, a plurality of light receivers are arranged in a plane perpendicular to the direction of cell movement by rotation of a cell disk. To ensure sufficient integration time, the angle between the optical axis of the irradiation light and each of a plurality of optical axes of scattered light viewed from above the cell is made equal to or less than 17.7° including a mounting error.
摘要翻译： 适用于各种类型的用于检测散射光的乳胶试剂，从而以高灵敏度测量凝集反应，同时充分确保积分时间。 为了适应于各种类型的不同粒度的胶乳颗粒，多个光接收器通过旋转细胞盘而布置在垂直于细胞移动方向的平面中。 为了确保足够的积分时间，使得照射光的光轴与从电池单元的上方观察的散射光的多个光轴中的每一个之间的角度等于或小于包括安装误差的17.7°。
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公开(公告)号：US20050196778A1
公开(公告)日：2005-09-08
申请号：US11013403
申请日：2004-12-17
CPC分类号： C12Q1/6834 , G01N21/6452 , G01N21/6456 , G01N2201/062 , C12Q2565/619
摘要： An apparatus measures individual measurement sites on a DNA chip in a short period of time. The DNA chip is irradiated by light-emitting diodes (LEDs) so as to excite fluorescent dye at each measurement site, and fluorescence emitted from the individual measurement sites is detected all at once. Since substantially uniform measurement conditions can be obtained for each measurement site, measurement accuracy increases. The read mechanism requires less space and is less costly, thereby decreasing the failure rate and virtually eliminating the need for maintenance of the apparatus.
摘要翻译： 一种装置在短时间内测量DNA芯片上的各个测量位置。 DNA芯片被发光二极管（LED）照射，以便在每个测量部位激发荧光染料，并且一次检测到从各测量点发射的荧光。 由于每个测量点可以获得大致均匀的测量条件，所以测量精度提高。 读取机构需要更少的空间并且成本更低，从而降低故障率并且几乎消除了维护设备的需要。
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公开(公告)号：US06572752B1
公开(公告)日：2003-06-03
申请号：US09671818
申请日：2000-09-27
IPC分类号： G01N27453
CPC分类号： G01N27/44713 , G01N27/447 , G01N27/44704 , G01N27/44743 , G01N27/44782
摘要： The troublesomeness during the setting of a plurality of capillaries is eliminated by composing pairs of electrodes, which are electrically connected to the common electrode, and capillaries. By bringing electrodes installed in the vicinity of each capillary disposed at the pitch of wells on the side of sample plate (within the area of the wells) into electrical contact with a common electrode, the capillaries and electrodes are made integral in construction. When a voltage is applied to the electrophoretic instrument via a common electrode portion, the voltage is applied to the electrodes for each capillary. This enables an inexpensive microtiter plate, etc. to be used and a multiple of capillaries to be simultaneously inserted, attached and detached.
摘要翻译： 通过构成电连接到公共电极的电极对和毛细管来消除在多个毛细管的设置期间的麻烦。通过将设置在每个毛细管附近的电极安装在位于 样品板（在孔的区域内）与公共电极电接触，毛细管和电极在结构上是一体的。 当通过公共电极部分向电泳仪施加电压时，对每个毛细管的电极施加电压。 这使得可以使用廉价的微量滴定板等，同时插入，附着和分离多个毛细管。
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